Pain | Pathway and Analgesics (NSAIDs, Opioids, Antidepressants, and Anticonvulsants)

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  • Опубліковано 28 тра 2018
  • Everything you need to know about pain! Well, nearly...
    - Pain pathways (spinothalamic) versus fine touch (dorsal column) pathway to the brain.
    - A delta versus C fibres
    - Painful stimuli (mechanical, thermal, chemical)
    - Brown-sequard syndrome (clinical implications)
    - Pain gate theory
    - Endogenous Opioid system (endorphin, enkephalin, dynorphin)
    - Non-steroidal antiinflammatory drugs (NSAIDs) (aspirin, ibuprofen, celecoxib, paracetamol)
    - Opiates (Morphine)
    - Antidepressants (Tricyclics, SSRIs, SNRIs)
    - Anticonvulsants (Gabapentin)
    - And more!!
    Listen to our podcast for more info: podcasts.apple.com/au/podcast...
    Instagram: / channel

КОМЕНТАРІ • 174

  • @kenfine1469
    @kenfine1469 6 років тому +161

    This is a Command Performance: It's so incredibly good. I'll be watching this one several times over to get the detail. There should be a UA-cam award for educational videos like this.

    • @DrMattDrMike
      @DrMattDrMike  6 років тому +15

      Thank you, Ken. That is very kind.

    • @chrishenly9728
      @chrishenly9728 3 роки тому +1

      I think crash course would win lol

    • @marksawatzky8562
      @marksawatzky8562 Рік тому

      Yes!! Excellent presentation.😆❤

    • @craigyoung6371
      @craigyoung6371 Місяць тому

      These dudes are probably full time doctors and/or lecturers, so pretty impressive to get this material up with a proficient explanation, cheers fullas.

  • @kannupoonia7523
    @kannupoonia7523 Рік тому +14

    I can’t believe you did this for free ..
    omg what a great lecture.!!
    So well put together.
    Thank you so much.

  • @thebluemonkey100
    @thebluemonkey100 3 роки тому +35

    I watched this video last year when we were talking about pain & painkillers in my second year of MED school. Now, in my third year, we are talking about it again, and this video saved me for the second time. Thank you so much for this, and all your other amazing lectures!

    • @DrMattDrMike
      @DrMattDrMike  3 роки тому +5

      😊 🙏

    • @jukodebu
      @jukodebu 2 роки тому +1

      dont let people suffer because some abuse it.

  • @philipmaxwell669
    @philipmaxwell669 5 років тому +32

    Thank you Dr Matt. It is a shame that uni lecturers sometimes forget that unless the information is interesting and coherently presented it’s really difficult to absorb or even stay awake.

    • @DrMattDrMike
      @DrMattDrMike  5 років тому +7

      Very true!!

    • @marksawatzky8562
      @marksawatzky8562 Рік тому +2

      @@DrMattDrMike And very easy on the eyes doesn't hurt either!!🎼🎵🎶🌞♨🔊

  • @sadehavvad
    @sadehavvad 6 місяців тому +2

    Fantastic. I've prepared my thesis on pain and was watching to prepare my mind for the thesis defense. I realized my mind was unclear on many small topics until I watched your video. Thank you very much.

  • @mezza2920
    @mezza2920 3 роки тому +16

    I was literally having so much anxiety over this topic! Watched the lectures and tutorial, read over lecture notes multiple times, did the readings and it was like a big info jumble and fog in my head! Was feeling really stressed until I found your video. Thank you so much for this!

  • @yachiapatel
    @yachiapatel 2 роки тому +9

    Can't imagine how would I can understand such complicated theories with simple explanations..... All credit goes to Dr. Mike and his team.... Thank-you very much sir for letting us know all such theories with absolute concepts. Your commendable efforts are just speechless.

  • @ghazalataskeen1618
    @ghazalataskeen1618 4 роки тому +5

    After watching your videos
    I have changed my mind set
    now I want to become a teacher like you
    I have one more thing to say seriously I have no doubts regarding this topic
    Thank you very much

  • @sameeds.8270
    @sameeds.8270 4 роки тому +11

    Wow what a lecture! now even a non medical person like me knows what is pain and how we feel pain. More power to you doc. Thanks alot!

  • @healthscoutptwernergrosse1579
    @healthscoutptwernergrosse1579 Рік тому +1

    There seems to be so much intention out there right now to confuse us about the simplest 'things' ongoing in our body ... but THANKS to God we have Dr. Mike to keep it easy and us informed properly 🙏🙏🙏

  • @Thefoxesden77
    @Thefoxesden77 4 роки тому +11

    Words cannot describe how grateful I am to you for making this excellent education video! Your deep knowledge and logic explanation is respectable! I am in nursing program and have to do a lot of assignments & textbook reading today; but I feel like watching your video is more important. Thank you so much!

  • @Nanobot888
    @Nanobot888 Рік тому +2

    Wow, this is some genius level explanation right here. They teach us neuroanatomy + pain pathways in dentistry school and it has never made sense together like after watching this video. I cannot capture in words the usefulness of this. Thank you so much.

  • @mariyazaman5946
    @mariyazaman5946 Рік тому +1

    Excellent teaching method. Hatts off to you 👏👏👏 I am Mariya Shah your fan from Pakistan🇵🇰, a BSC Nursing student. You made all topics so easy for me. Lots of prayers and well wishes 👍🏻🤲🏻

  • @shreyabhowmik5510
    @shreyabhowmik5510 6 років тому +26

    Sir, you are an amazing teacher! Your videos are the best in you tube. Thank u soo much for your efforts. Really helpful and life saving!!

    • @howtomedicate
      @howtomedicate 5 років тому +5

      Yea, I really enjoy them to! They are informative, but also fun to watch!

    • @DrMattDrMike
      @DrMattDrMike  5 років тому +2

      Thanks!!!

  • @rachell4576
    @rachell4576 Рік тому +1

    Hi Dr. Mike,
    I'm freaking out after two weeks of nursing class because I can't manage all the new knowledge in my assigned textbook. Then I thought, let's seek the issue I don't comprehend on your channel like I did in physiology class. And now I'm watching this video, even though it's been 4 years, but I appreciate your time and effort, which never expired even 20 more years because without your channel my nursing profession would never start.
    Even if the Pain gate theory fooled me the first time I read it in a study guide, I now find it quite enjoyable. Your explanation makes a lot of sense to me, and it makes me want to learn more.
    If you have time, could you correlate "first pass effect, bioavailability, protein binding" with "pharmacokinetics' vs "pharmacodynamic"?
    Thank you so much for this helpful video!

  • @daska1410
    @daska1410 Рік тому +3

    I am currently studying for pharmacology exams and this video (among your others) has been so helpful. Thank you :-)

  • @SG333_
    @SG333_ Рік тому +1

    Dr Mike I genuinely don't know what we'd do without you. This is such an excellent video, so clearly explained and helpful. Your knowledge and passion for teaching comes across and I wish we had more educators like you! Thank you so much! (You don't know how much you're helping me get through this med degree 😂)

  • @scokim
    @scokim 3 роки тому +1

    Wow - comprehensive and yet simple to understand. Thank you.

  • @Kat-zc4lt
    @Kat-zc4lt 4 роки тому +2

    WOW. Very well explained. Thank you!! Will definitely be watching more of your videos.

  • @philipmaxwell669
    @philipmaxwell669 5 років тому +4

    Thank you so much for your videos. The depth and clarity of knowledge presentation is superb

  • @dessertthingy
    @dessertthingy 5 років тому +2

    This is an awesome explanation, thank you!

  • @phill6159
    @phill6159 3 роки тому +3

    Excellent execution, of detailed information, I learned so much, such an important subject. Thank you.

  • @shanazporter2417
    @shanazporter2417 3 роки тому +2

    This was an excellent lecture. Thank you sooo much for creating it. You have one of the best channels!

  • @TheBeatjunkee
    @TheBeatjunkee 2 роки тому +1

    Thank you for this incredibly informative video. I was searching the internet on why when I stopped my SSRI that I have been on for 18 years I had an exponential increase in my back pain. I finally made the connection to the SSRI after months of suffering, and I am now back on it for only 3 days, and my pain seems to be under control again. I guess I am now an SSRI lifer even tho I no longer need it for what it was originally perscribed for.

    • @Bigbang_Tripz
      @Bigbang_Tripz 2 роки тому

      🔝🔝🔝for all your shrooms, DMT, Lsd,MdmA, ketamine, psilocybin infused bar, wock, ayahuasca, xtc and other opioids

    • @p.kallas6692
      @p.kallas6692 5 місяців тому

      What did the ssri effect the pain? I have oxicodon for nervpirrande and when I raised the amount ssri the oxicodon stopped work the same. What ssri do you use?

  • @cristianmurar3185
    @cristianmurar3185 2 роки тому

    Thank you, doctor Matt. You rock! You made my life much easier. I wish I had you as my professor.

  • @gregkass2010
    @gregkass2010 4 роки тому +4

    Literally stubbed my toe watching this video. Really brought everything together -___-

  • @GhanaboyPharmD
    @GhanaboyPharmD 4 роки тому +2

    Man this is the best pain pathway video I have ever seen... thanks!!

  • @penelopebaba
    @penelopebaba Рік тому

    I am so grateful for your videos... My Physiology instructor is so hard to follow, I love physiology now, watching the videos you put out that clarify everything.... So Great!!!!!!!!!

  • @ATINUKE67
    @ATINUKE67 Місяць тому

    thank you Dr Mike

  • @nicoleverinumbe5838
    @nicoleverinumbe5838 4 місяці тому

    Hello Dr Matt
    It's 2024 and your video has literally saved my life
    Thankyouu

  • @zarakaushik2206
    @zarakaushik2206 2 роки тому +2

    This was awesome, you are an amazing teacher and I learnt so much. Please keep making such videos. I am doing my Masters and this really helped me understand pain so easily, rather painlessly.

  • @paulbarron2796
    @paulbarron2796 5 років тому +3

    wow!!! thank you so much. I have watched my lectures over and over and read and read and in 1 hour you have made it all so clear. I will definitely be watching your other videos. Thank you so very much for taking the time to produce these video's

    • @DrMattDrMike
      @DrMattDrMike  5 років тому +1

      Paul Barron Thanks for watching, Paul!

  • @m.a6894
    @m.a6894 3 місяці тому

    The way I pay £9000 a yr for education but those idiots can’t even teach close to how u teach. This video was phenomenal. Ur saving me literally

  • @howtomedicate
    @howtomedicate 5 років тому +6

    An other fantastic video! I do not know how you guys keep it up?!

  • @dawndomenico1377
    @dawndomenico1377 5 років тому +2

    Thank you!

  • @jessicaelliot2031
    @jessicaelliot2031 2 роки тому +1

    You. are. AMAZING!!! REWATCHING X100000000000000 TIMES! THANK YOU!

  • @taif5570
    @taif5570 5 років тому +2

    This is amazinnng!!! thank youu so muchhh. keep going the world's best teacher .

  • @ravindarbethi8675
    @ravindarbethi8675 Рік тому

    One sincere request. Kindly edit the transcript . It has no punctuation marks. Also there are spelling errors (paying is mentioned in place of pain here in this video transcript) that makes one difficult to catch the new terms of technology. All this is probably due to auto-generated text. UA-cam too must develop auto-punctuation, automatic capitalisation, and continuous updating of technical terms and acronyms.
    This is otherwise a “must watch” video about pain. Excellent, and very much informative. Thanks for updating our knowledge. Simply superb.

  • @kyriakeka4447
    @kyriakeka4447 3 роки тому +2

    Thank you Dr Matt, amazing video as always. Could you please explain how medications such as Lyrica work in pain management?

  • @ruditesalina4973
    @ruditesalina4973 3 роки тому +1

    Brilliant!!! Thank you so much!

  • @sophiegroom5285
    @sophiegroom5285 9 місяців тому

    Explained so well!!! Thank you ☺️

  • @drshetewy
    @drshetewy 5 років тому +2

    Excellent
    Thanks a million 🌹🌹🌹

  • @wendelasan7299
    @wendelasan7299 5 років тому +1

    Amazingly simplified 😊

  • @buombothmut
    @buombothmut 5 місяців тому

    You're smart Doctor
    Thanks so much

  • @scrub_itoff9849
    @scrub_itoff9849 5 років тому +4

    This was so helpful 👍🏻👍🏻👍🏻

  • @rebeccabecca6468
    @rebeccabecca6468 4 роки тому

    Excellent resource for my nurse prescribing pharmacology exam! thank you

  • @dipenshakya2184
    @dipenshakya2184 2 роки тому

    Exceptional work. Your videos always help me to clearly understand the concepts. Thank you for your work

  • @emulychan
    @emulychan 5 років тому +26

    thank you for using a whiteboard and drawing! i'm so sick of powerpoint graphics to explain anatomy

  • @rajivanand236
    @rajivanand236 2 роки тому +2

    Awesome lecture bro 👌👍1st time ⏲️ 1 hr I didn't lost my concentration and you have a great future in teaching profession. I wish you all the best and make some more videos 📹 keep continue the videos

  • @user-xd5jy8mp4q
    @user-xd5jy8mp4q 7 місяців тому

    you made it very clear , thank you doctor you helped me❤❤

  • @kaiwt2133
    @kaiwt2133 2 роки тому +1

    Thank you for this. It helps a lot 👍🏾

  • @sarahabed805
    @sarahabed805 6 місяців тому

    Thank you for the clear explanations 🥲🙏🏻

  • @nstats3250
    @nstats3250 10 місяців тому +1

    Great content thank you. Would you consider generating some content regarding the use of Naltrexone for chronic pain treatment? Cheers

  • @adelaredding1594
    @adelaredding1594 4 роки тому

    THank you!!! very nice class!!!

  • @heatherd8924
    @heatherd8924 3 роки тому

    This has really helped my understanding, thank you! (1st year physio). Need to nail this in my exam

  • @roland.j.ruttledge
    @roland.j.ruttledge 2 роки тому +1

    Excellent, many thanks

  • @mohamedabomera5598
    @mohamedabomera5598 3 роки тому +2

    Man you have just saved my life ❤

  • @user-vdjxbwkskbc
    @user-vdjxbwkskbc 9 місяців тому +1

    really great video, very helpful thank you! but why is there an advert like every 2 minutes or so

  • @sarayounis9776
    @sarayounis9776 3 роки тому +1

    This is so good it has brought me back hope that I can pass med school

  • @tha_lit_ent
    @tha_lit_ent 2 роки тому +1

    thanks Doc.

  • @enlightholisticfitness4996
    @enlightholisticfitness4996 3 роки тому +1

    Dr Matt is a god send!!!

  • @emilychiechi4446
    @emilychiechi4446 2 роки тому +1

    Thank you! Much appreciated :)

    • @Bigbang_Tripz
      @Bigbang_Tripz 2 роки тому

      🔝🔝🔝for all your shrooms, DMT, Lsd,MdmA, ketamine, psilocybin infused bar, wock, ayahuasca, xtc, psychedelics and opioids.

  • @cmble1147
    @cmble1147 2 роки тому

    You are amazing!! This is amazing! Really helped me to understand a topic that just made no sense on paper! Thank you so much!!!

  • @johntom2362
    @johntom2362 6 місяців тому

    Thank you 🙏🏽

  • @metoo9795
    @metoo9795 3 роки тому

    Thanks you so much I am inspired to keep on learning

  • @springsh6678
    @springsh6678 4 роки тому +1

    Thanks alot perfectly done...

  • @summergirl198
    @summergirl198 2 роки тому +1

    Amazing!! Thank you so much!!!

  • @sayaniumanda9076
    @sayaniumanda9076 10 місяців тому

    Thank you so much ❤

  • @sarvinozakhadova
    @sarvinozakhadova 4 роки тому +1

    thank you so much for information

  • @marksawatzky8562
    @marksawatzky8562 Рік тому

    Fascinating!!😆😆 Just subscribed from Canada.👍👊✌

  • @dynamaraferreira7279
    @dynamaraferreira7279 Рік тому

    Fantastic!! I'm so thankful for this amazing class. 👏👏

  • @lilywhite8123
    @lilywhite8123 Рік тому

    Thanks a lot. I appreciate your work. You made me understand more than my lecturer God bless

  • @anut32
    @anut32 4 роки тому +1

    Thanks for such a wonderful video.

  • @jennagraham4039
    @jennagraham4039 2 роки тому

    Amazing! Thank you!

    • @Bigbang_Tripz
      @Bigbang_Tripz 2 роки тому

      🔝🔝🔝for all your shrooms, DMT, Lsd, MdmA, ketamine, psilocybin infused bar, wock, ayahuasca xtc and other opioids

  • @sineadohara4085
    @sineadohara4085 3 роки тому

    Brilliant! So well explained and for the first time I now understand why opioids don’t work for neuropathic pain 👍

  • @ramaothman7053
    @ramaothman7053 Рік тому

    Thank you Dr

  • @wonholden3430
    @wonholden3430 Рік тому

    The explanation is pretty good, Thank you.💯

  • @dhillonamarsingh5033
    @dhillonamarsingh5033 2 роки тому +2

    Fantastic Explanation Thanks

  • @vaishnaviramakrishna265
    @vaishnaviramakrishna265 3 роки тому +2

    You nailed it Sir! Thank you so much!!!!! :-D

  • @simonbutler3261
    @simonbutler3261 4 роки тому

    Excellent. I have just shared the link for my second-year student paramedics do view. Thank you.

  • @ME-xh5zq
    @ME-xh5zq 4 роки тому

    This is a really condensed topic wow

  • @jenniferlyke9608
    @jenniferlyke9608 11 місяців тому

    Thanks!

  • @shihab8448
    @shihab8448 4 роки тому

    Thanks for this nice and comprehensive lecture , just i want to ask is it going the same way when discussing sensation and pain at face cause as I know sensation of face by 5th cranial nerve ? Is it the same pathway???

  • @kulejoseph8766
    @kulejoseph8766 5 років тому +1

    Good work big man

  • @dinanassar4008
    @dinanassar4008 5 років тому

    EXcellent lecture thanks a lot

  • @FatemePishgooei
    @FatemePishgooei Місяць тому

    Thanks a lot❤❤❤❤❤❤

  • @drastichaudhari
    @drastichaudhari 5 років тому +1

    SOOOO helpful!!!

  • @amiruladib9760
    @amiruladib9760 3 роки тому +1

    superbly good. easy to understand. TQVM

  • @H-Nawafleh
    @H-Nawafleh Рік тому

    Very useful content, many thanks 🇯🇴🇯🇴❤

  • @j.sbhandari8813
    @j.sbhandari8813 3 роки тому

    new subscriber here, very well discussed, thanks man, God bless

  • @fareehaadnanali1019
    @fareehaadnanali1019 2 роки тому +1

    Amazing video!! Thank You

  • @soul1315
    @soul1315 5 років тому +1

    Thank you Thank you Thank you♥️♥️♥️

  • @wanfeunloo7066
    @wanfeunloo7066 4 роки тому

    thank you so much !!!!!!!! i love your video. great explanation

  • @gehadhalawa2697
    @gehadhalawa2697 3 роки тому

    this is very helpful thank you so much

  • @jessicacorley
    @jessicacorley 3 роки тому +1

    Thank you for this!! I am set to conquer my exam

  • @sarayounis9776
    @sarayounis9776 3 роки тому +1

    Thank you so much sir you are amazing

  • @littleshaikh4116
    @littleshaikh4116 3 роки тому

    Love your lectures .big fan.

  • @Tobias27_
    @Tobias27_ 4 роки тому

    Very informative video, also you looks great and you are very fit. Appreciate sir. Love from Turkey.

  • @dhyaneshvu6390
    @dhyaneshvu6390 3 роки тому

    Sir thanks much for posting the lecture
    Your videos helps me to get deeper subject grip in very clear manner that too in this lock down scenario
    Moreover ur videos became a part of preparations for my boards
    I am very much thankful
    Hope u will be continuing this with the same best .....

  • @doctorcool1071
    @doctorcool1071 4 роки тому

    good job mate.