Pharmacokinetic (ADME) | Excretion of Drug From Body | Drug Excretion | Kinetics of Elimination
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- Опубліковано 29 вер 2024
- Route of Drug Elimination- • Pharmacokinetics | ADM...
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Pharmacokinetics is currently defined as the study of the
time course of drug absorption, distribution, metabolism, and excretion.
Pharmacokinetics of a drug depends on patient-related factors as well as on the drug’s chemical properties. Some patient-related factors (eg, renal function, genetic makeup, sex, age) can be used to predict the pharmacokinetic parameters in populations. For example, the half-life of some drugs, especially those that require both metabolism and excretion, may be remarkably long in the elderly
In pharmacology (and more specifically pharmacokinetics), absorption is the movement of a drug from the site of administration to the bloodstream.
Before drugs can be clinically effective, they must be absorbed. Absorption is the process of a drug moving from its site of delivery into the bloodstream. The chemical composition of a drug, as well as the environment into which a drug is placed, work together to determine the rate and extent of drug absorption. Absorption involves several phases. First, the drug needs to be introduced via some route of administration (oral, topical-dermal, etc.) and in a specific dosage form such as a tablet, capsule, solution and so on. Drug absorption is determined by the drug’s physicochemical properties, formulation, and route of administration. Dosage forms (eg, tablets, capsules, solutions), consisting of the drug plus other ingredients, are formulated to be given by various routes (eg, oral, buccal, sublingual, rectal, parenteral, topical, inhalational). Regardless of the route of administration, drugs must be in solution to be absorbed. Thus, solid forms (eg, tablets) must be able to disintegrate and deaggregate.
Pharmacokinetic- “What does BODY 1 do to the DRUG 2” we have simple interchanged the BODY and DRUG to make a definition. And as per the definition, our body responds to any drug by giving ADME effects.
1. A Stands for - Absorption
2. D stands for - Distribution
3. M stands for - Metabolism
4. E stands for- Elimination
Drug excretion is the process of eliminating a drug from the body. A drug, which is either biologically active itself or a prodrug, may be excreted in its original chemical state. Alternatively, all or a portion of a drug may undergo chemical modification and be eliminated as biologically active, or inactive, metabolites (see the record on Drug Biotransformation) renal excretion plays an important role in eliminating unchanged drugs or their metabolites into the urine. A major characteristic of compounds excreted in urine is that they are polarized (i.e., charged) and water-soluble. Drugs that are lipid-soluble are not readily removed by the kidneys and require hepatic metabolism (e.g., phase I and phase II biotransformation reactions) to increase their water solubility for possible urinary excretion.
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really helping me alot.. thumbs up from Pakistan
Sid Raa Thank you
Thanks sir for helping us ...plz plz plz cover all topics of kd Tripathi for helping MBBS students also plz sir
Manish Chikna Thanks alot. Sure i will cover all topics.
Yes sir for mbbs prefer KDT
Yes sir kdt.. Please explain this book
Nice explanation. 🙏❤❤
Thanks alot
@@solutionpharmacy sir.. K. D. T. Me kinetics of elimination भी दे रखा h..
1sr & o order kinetic..
With plateau principal....
Ha usko bhi banaunga. Par usme thoda time hai
U said some drugs are eliminated directly without metabolism
Kindly explain
U said in parentral route also drugs are metabolized
Sometime drugs get eliminated as such for exam. In case of liver disease or diarrhoea. Route may be different but they have to go for metabolism.
thanks lottttt sir...
My pleasure
Thank you sir.........😊
I need a nots of this topic..
Welcome
Sir mje bhi notes Lena h
How to Download Notes in PDF from Solution Pharmacy Facebook Group ua-cam.com/video/cE5MAt0J6hs/v-deo.html
How to Download Notes in PDF from Solution Pharmacy Facebook Group ua-cam.com/video/cE5MAt0J6hs/v-deo.html
Sorry sir best
Sir ,I need notes on excretion
ANKUR SHARMA we dont have specific notes but have a look on this video- How to Download Notes in PDF from Solution Pharmacy Facebook Group. Hindi
ua-cam.com/video/cE5MAt0J6hs/v-deo.html
Sir plzz cover topic for mbbs students also..
Please make lecture on first pass metabolism and Kinetics of elimination.
Sir I am a MBBS student, and I want to you cover all tooics of medical pharma bcz your teaching standard is so easy and understanding
Thank you✨
Finished all topics
@@solutionpharmacy sir I didn't find your lecture on "kinetics of elimination "
@@marwahkemanegi3391 its not available. Sorry
Really u n Ur teaching is amazing sir ....tysm....becaz of teachers like uh....we students can learn ....tysm🙏...
Thank you so much for your vauable feedback
Thank you sir🎉🎉🎉❤
Sir please upload the video on Biopharmaceutics and pharmacokinectics concepts
Sir kya ADME ke question me final exam me kvl chart bna skty h kya (d pharm 2 year)
once again excellent lecture, please tell simple book with diagrams
Jagdish prasad
I'm so excited
Thank u so much sir
Meri class me 60 student hai un sbko mene solution pharmacy Chanel k bare m btaya
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Sir 1 problem hai...
Hum first time pdh rhe hai pharmacology..
Humare liye sbhi topics new hote hai... Hme pta nahi chal pata hai ki is video ke bad agla video konsa dekhe .. please sir video ke order dedo..
Please...
Aap playlist me jaaie waha sab sequence me hai
Thank you so much sir ♥️
Umesh Raisanya most welcome
Thanku sir...great 👍 work😊
Thank you
Our liver detoxifies any toxin. Does our liver see any drug as toxin? If so liver destroys drug seeing it as toxin. Then how drug reaches to target or brain and works?
Thats a very interesting and good question sir/madam. See our body has a specific nature to identify harmful substance does mean toxic like if we eat too much of street food it will start vomiting but if we talk about drug then its metabolite which get converted by metabolism have some soecific functional group and that can trigger harmful effect and recognized by body and try to convert it into polar so that eliminate by urine. And there are some drugs which some how destroyed will not be able to produce its full efect called 1st pass metabolism
Hello sir super video thankyou sooooomuch
vijay patel Most welcome sir
I see today ur vedios ur topics are very helpful am glad to subscribe ur channel thanku want b wd in contact ur vedio
Thank you so much
This help us a lot sir
Thank you so much for such a adorable lecture ❤️❤️🙏🙏
My pleasure. Thank you for your kind feedback and love
Sir plzz pharmacodynamics chapter p video upload karo mera syllabus p hai pharmacokinetics kiya cmplte
Uploaded.
Thank uh sir,, u r outstanding ☺ bcz of uh im easy to improve my pharma,, sir could you plz make videos about mechanism of antibiitic,antifungl,antipyretuc,antiviral,corticosteroid uses,,
ahmer patoli Thank you. I have already uploaded antibiotic and other are in sequence and soon available
Sir app facebook par bhi isi nam se haii easy solution nam se please bataye sir i need to PDF
Yhi pdaya gya h or distribution+metabolism+ excretion =dispositioning bolte h
You are a amazing sir!!
Roronoa Zoro thank you
This help us alot sir
Thanku so much sir for such a adorable lecture ❤️
Thank you so much
sir ji aap aise hi hard work karte raho aapko humari tarhph se bahut bahut dhanyavad 💕🙏🙏
Thank you so much
Superb explanation
Sir i have my exams now.....i m prepairing from your lectures ..after this topic renal excretion in kd tripathi a topic is kinetics of elimination...do you have any lecture or notes for that.topic pls sir a humble request to you ...thnku and all the best for your upcoming success ! ☺
Thank you so much. We have a detail notes on kinetic and dynamic which you cna download for free from our facebook group. Please watch this video for more help ua-cam.com/video/cE5MAt0J6hs/v-deo.html
Thnku sir.....a little thing i want to say that matter are also available in kd tripathi ....but need your explaination and lecture...you explain so thoroughly and i understand each and every word from your explaination video and specially i m learing and making notes from your video bhut bhut acha pdhate ho sir
@@kartikgill8453 Thanks alot dear. In my notes i also tried to put things in easy way.
Sir i try to reach pdf but i m not bcz i dont have laptop or pc to open your group properly not finding the pdf sir getting so much frustrated help me out pls .....and tell me how can i contact you personaly?
Not getting files option in my phone interface not getting pdf sir 😔
Plaese do it in English sir.....please.......🙏🙏....even people of other languages can enjoy your extraordinary teaching 🙏
Please visit our new channel for pharmacology lectures in English (Started From 01/12/2020). Link- Complete Pharmacology Topics (English)
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Thanku so much sir for all vedios ...these vedios is very helpful for me...In this time for my exam ...
My pleasure
Thank you sir ji acha laga 🌹
Sir is there video on kinetics of elimination ???
Thank you. So much sir very nice video watching sir . welcome to salutation of pharmacology lI Thanks
Thank you so much
Sir,Which book should be preferred for selection in aiims Msc pharmacology?
POOJA choudhary Pharmacology review by spersh and gupta along with conceptual pharmacology by P Jagdish Kumar.
Thankk u so much sir...I listened all ADME viedos which was smply awesome
Thank you so much
Thank you sir. Sir please do video on kinetics of elimination
Ty
Shayad aapko Bhi andaza nhi hai...aap kitne students k liye devta hain sir 🌞
Nahi dost mai ek sadharan sa insaan hu. Aapke pyaar ne bada bana dia
love from Ambikapur (Chhattisgarh)
#stay at home
Great. I know ambikapur. I am also from Chhattisgah. Stay safe
Sir I'm a veterinary student and it's very very helpful for me. Thnk u so much sir.......
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Sir whatsapp group nhi h kya apka ...mai fb nhi chalati
Please download solution pharmacy app
You are amazing sir👍🙏
Thank you
Thank u so much sir for clearing my concepts
Muskan Rai my pleasure
Gajab sir Pura mast video hai sir ji .aap jiyo hazaro saal
Bahut bahut dhanyawaad. Aap bhi khush rahein.
Pl answer my question, what is excretion and what are the verious processes used in the excretion of crude drugs??
Thanks sir ,respect from Pakistan
Thank you. Return love from the INDIA
Thanks Sir
You are great sir
Mcq KA link....
Great 👍
Getting interest in Pharma due to u
Thank you
Best explanation sir 🙏 thank u
Really good videos sir 👌 Hatts off to your efforts.
Varsha B Thank you so much
Kudos to your efforts Sir🙌🙌....(that I am not PharmacoPhobic now)
Thank you
Sir, the description of the process in description box is wonderful
Thank you
Thanks a lot for the videos sir aaj exam mai bohot helpful tha apka video. Sur ek question aaya tha jo nahi ho paya aVOD . Ye kya hota hai sir ?
Volume of distribution of drug in different compartment of body
@@solutionpharmacy thanks sir 🙏🏻.
Super sir
Nice ....
Nice video sir ji 👍👍 bt pharmakodinemics ka video nhi mila sir ji please bataye kha h ya link de dijiye
Please check
@@solutionpharmacy abi mil gya sir ji thanks for reply🤗🤗
Great method to understand ❤️ I love it.. thank you so much sir ....
Thank you
Very good video sir
Plz cover all topic
And also make all video which help MBBS students
akask jain Thank you sir. Sure i will
@@solutionpharmacy I'm not sir
I'm 2 year MBBS student
akask jain Every single person is respected for us. 👍
good
Sir me hindi medium student..
Please me kosi book pdhu jisse mere ko easy language me acha content mil ske... Second-year MBBS ke liye
KDT AND Lippincott
Thanks sir♥️
Thank you so much sir ji ❤
Most welcome
Thank you so much sir 🙌
Sir plz upload a video on topic-" drug disposition "
sir i have a small doubt .. after absorption of drug, distribution is maximum in the part of brain , kidney and liver as the blood is higher in these compartments .sir I want to know to cross the brain barrier drugs need to be lipid soluble in nature . but liver try to make it water soluble so after metabolism how drug will act on brain . i am really confused in this section sir please help me .
Yes you are right but lipid soluble drugs are given by parenteral so they distributed to brain then go for metabolism
Thankyou sir for flow chart
From Pakistan... Thank u so much Dear Sir
Assalamoalikum Sir,
Koi drug humari body mai Kitna ersa rehtti hai?
Thanku for helping it means alot
My pleasure
Very excellent teacher 💯♥️
Sir please clear my confusion about distribution of dopamine from levoda inactive prodrug ? ...
Please sir
From Nepal
We have many animation video on levodopa. Please watch.
Sir indian pharmacopeia legal issues topics ka video nhi sirji
awesome love from nepal
Thank you
Glumeruler filteration rate is 125ml/min or 180L/day
Both because younare talking about per mint and per day which are in ml and L
Sir aap ke friends me koi BSC nursing ka syllabus nhi padhate he kya
Sir aapne isme cleareance Miss krdiya plz btade usky bare me thora aura plasma half life bhi nahi btaya ?
Ok sir aage kisi video me aapke suggestion ko follow karne ki kosis karunga. Thoda time lagega par jarur kar lunga. Thank you for suggestion
Sir white board ki pdf discription pr dal diya kijiye plzzzzz sir
Sir AAP notes bhi provide Kara de plzz aapki video bahuttt help full Hoti hai
Sir bahutt helpful video my study . thanku sir
@@bhavanagangwar6241 shayad aapne description check nahi kia hi. Please check it carefully
Sir, agar koi drug parentral liya h to wo liver m metabolise nhi hoga to kya Sare parentral drugs bina metabolise hue excreate honge?
Archana Patidar Nahi sare drugs ka metabolism hoga. Parenteral me dene se post systemic metabolism hoga aur uske baad elimination hoga
Thanks a lot sir.👍
My pleasure
Thank you so much sir. thanks and love from pharmdians. Sir aap kinetics of elimination pe video nhi banaye
Thank you
Sir you didn’t explain about poisoning cases of salicylate and barbiturates how PH affects rate of excretion
Watch poisoning topic. Its not poisoning topic
Sir koi ase drug hai jo humari body se eliminate na ho?
Thank u sir...🙏🙏
My pleasure
Sir kinetics of elimination?
Why drug eliminate from the body without metabolism 🤔🤔 any reasons
Because of many reasions like - Absence of metabolizing enzyme, high elimination, rapid gastric emptying, liver dissease etc
Sir..your intire Topic has not been uploaded plzz sir 🙏🙏🙏🙏
Recheck.
Thankyou sir for this helpful video..😇sir whatshap ka group bna hai kyaa 😅
Thank you. Nahi whatsapp group nahi hai
@@solutionpharmacy ok sir
In tubular reabsorption, lipid soluble drugs are reabsorbed but how after even going through metabolism, drugs still lipid soluble
In phase of merabolism they try to convert it into polar
Pura semester maxii 😂😂😜😜our study UA-cam se karty Hai.... Allah Kary Jann chot Jaye is pharmacy se (pharm D 5 year degree😢😢) qistmat ko dekho... Kiya sochata our Kiya ho raha Hai..... Zindagi me... 😢😢😢Ham kaminy friends UA-cam se study karty Hai 😜😜😜😜
Best msg. Kya reply karu samjh hi nhi aaya.
@@solutionpharmacy Meri Jan.... Study se tang hogiya hoonn😢😢.... PHARM D se.... 5 year degree complete karty karty hamy mout aygi...
Sir those drug which not metabolic occure and eliminate from body this drug show effect or not 🤔🤔
No they will not show effect
Sir exceation ka yai only one part hai ?
Thank you sir
My pleasure
Thank you sir
Welcome
Thankyou sir
My pleasure
Sir please explain me about the absorption procedure of prodrugs... (Inactive form of drugs to active form of drugs).
Ok let me try .. when prodrug is taken orally then follows the first pass metabolism in the liver and the inactive drug or prodrug is metabolized with the help of enzyme and then converted into active form .. now this active drug enters the systemic circulation and is distributed to target cells or organs .. now metabolism had already taken place so directly follow s excretion ... ?
Sorry if I am wrong
From Nepal
@@munabhandari4366ookk...but after conversion which path follows by active form to reach the systemic circulation??
Via kidney (reabsorption) or any other??
This is right answer
For more you can watch our enzyme inhibition and induction parts
@@solutionpharmacy Okk..Thanks a lot sir.
I have my exam next month nd I'm so scared of special pharmacology 😭😭
You should scare if not started your preparation in advance. Please don’t take any subject light. Watch our videos to manage those losses