Lauren Kennedy West you are bipolar, you will fall like everyone else... I'm waiting calmly, I also have bipolarity, you will see how nice it is to be without medication..
Hi Lauren, I wanted to add my voice to this discussion and point out a few potential issues with your analysis from the most recent video. For the emergent-5 trial, I think you might have interpreted the data in an incorrect way. These are people with a lower PANSS baseline who were already stabilized on their medications. If I read it right its that 30% of people experienced 30%, or higher further reduction of symtpoms from their already less symptomatic, more stable baseline. This is very different than 30% of people experienced 30% reduction in symtpoms overall. To compare it to the systematic review is wrong because that's a very specific set of circumstances that I don't believe were replicated in the systematic review. Also that 10% is still statistically significant. This is amplified in my mind because even if there was a 0% reduction from baseline for all participants and cobenfy just kept them stable at the level they were already at, cobenfy carries so much less risk to overall health than many current antipsychotics. I'd rather my tummy hurt than have lifelong struggles with diabetes, metabolic syndrome, or tardive dyskenesia. I also think its worth noting that many people in the community have tried keto and experienced a 0% reduction in symtpoms or active worsening of symtpoms as compared to long term medication use and stabilization. I think its incorrect to compare these two treatments without data similar to the PANSS baseline data from the other antipsychotic studies. I myself will be trying cobenfy in the winter of this year so I'll let you know how it goes! I hope this message doesn't come off as mean in any way, I dont intend that at all, I just wanted to provide my perspective on the issue and encourage furthur discussion in the community
This is the kind of feedback I was looking for in the comments. I’ve learned that interpreting clinical studies and trials is tricky, and as a layperson there are many, many pitfalls. I’d love to see someone in the field do a critical review of the data, or even just a response to Lauren’s analysis. Been following the channel for a couple years, always glad to hear from Lauren. ❤️
Hi Shaina, I appreciate you sharing your insights. I think something that’s missing from this picture is a better understanding about when and how baseline was measured. I don’t think the full trial study information is publicly available yet. However, clinicaltrials.gov does show what the inclusion criteria were (clinicaltrials.gov/study/NCT04820309?term=emergent-5&rank=1). One of the criteria is that “Subject is willing and able, in the opinion of the investigator, to discontinue all antipsychotic medications prior to baseline visit.”. Another inclusion criteria is “Subjects taking a long-acting injectable antipsychotic could not have received a dose of medication for at least 12 weeks (24 weeks for paliperidone palmitate) before Day 0”. Is day zero the day they took baseline? What this could be establishing is that patients may have been required to have been off their medication long enough for it to clear their system BEFORE a baseline was taken (it makes sense to me that baseline would be taken on day zero). (Side anecdote: Lauren was on a monthly (4-week) injectable for Abilify. Often symptoms were so bad by week 3 she needed an emergency injection.) This is a bit of a tough situation to balance, especially around ethics. On the one hand researchers probably don’t want to have participants entering the study in a psychotic state or in withdrawal because they’ve had to go off medication. On the other hand in terms of being able to properly assess baseline, they would obviously need to be off medication - my guess is this is why they selected people who didn’t have as severe acute symptoms as the previous trials. I think based on the inclusion criteria, at least around discontinuing LAIs, that for those people baseline assessment would be closer to essentially being unmedicated. And so the statistic of 30% of people seeing at least a 30% reduction in symptoms would be valid (not an additional 30% improvement from their already stable situation on medication). Now when it comes to comparing Cobenfy to the systematic reviews. I believe what you’re talking about is our comparison of placebo in the systematic review (30% of the population with at least a 20% reduction) compared to Emergent-5 (30% of the population with at least a 30% reduction)? I agree that 10% is still statistically significant. But again, I don’t believe that baseline for Emergent-5 was measured with people currently stable and on their medication. Appreciate your perspective of preferring the Cobenfy side effects over other antipsychotics if they end up having the same efficacy in symptom reduction for you. The point we were trying to make is that it doesn’t seem like it’s more effective at symptom reduction than currently available antipsychotics, which is why we cautioned against switching to it if people are stable on their current medications. We’re trying to address the narrative that has been building in the community that this drug is more effective at addressing symptoms. We do also mention though that it is an individual choice around which side effects are more tolerable for each individual. I’m not sure it’s fair to chalk Cobenfy’s side effects up to a “sore tummy” when nearly 1 out of 5 people had to discontinue during the trial. My guess is these people were dealing with more than a tummy ache. Regarding the efficacy of medical keto this study is interesting: pubmed.ncbi.nlm.nih.gov/35873236/ The study shows an average reduction of PANSS of -42.1. I don’t think it’s totally fair to compare this to Cobenfy (If we did it would be blowing Cobenfy away. To be honest though our personal experience with keto has blown anti-psychotics away!). This medical keto study wasn’t a large study, and it was people with various persistent mental illness (only 10 people with schizoaffective disorder). Still, I think studies like this are evidence informing conversation about how effective the medical keto diet can be. (Also, of note in the study was: “Significant improvements were also observed in metabolic health measures including weight, blood pressure, blood glucose, and triglycerides.” - I think this really speaks to the connection of improved mental health, with improved metabolic health). I’m interested to hear about your experience with Cobenfy (as hearing real world experience is valuable), and truly do wish for you the improvements you’re hoping for. Thank you again for sharing your thoughts here, Lauren & Rob
@@LivingWellAfterSchizophrenia Lauren and Rob, As someone who works in mental health, I can tell you that from my experience, medical keto has caused horrible issues in the patients that tried it. I would love nothing more than to have this work. If medical keto could actually treat schizophrenia, the mental health community would be absolutely willing to use it. We watch so many patients struggle with schizophrenia and it’s horrendous and heartbreaking. Most of us would love nothing more than to have a safe and effective treatment. It’s what some of us want more than anything in the world. I have mourned people I love before their death because of schizophrenia. This idea you perpetuate that medical keto is a wonder cure makes me truly sick. You are selling people a fantasy that isn’t true. Your own doctors think you’re wrong and find you difficult to work with. It is so so scary to watch you continue on this path when I already know where it’s going to end.
The study that you cite as evidence of PANSS reduction by keto was a retrospective study. The authors write”Neither the treating psychiatrist responsible for assessing outcomes nor the patients themselves were blinded to the intervention, therefore there is a risk that impressions of clinical progress may have been biased. While patients may have benefited simply from having been hospitalized,..” Waiting for a well done study. I am very glad Keto works for you!
Psychiatry has been infiltrated to profit big pharma. Meds are needed for some people, but a lot of research which provides a foundation for the decisions that psychiatrists make is funded by pharmaceutical companies interested more in profits than seeing people well. Many good psychiatrists have much to say about this - Bessel van der Kolk, Daniel Amen, and James Davies to name a few. In most cases, psychiatrists are given 15 minute windows of time to formulate their decisions for their clients when realistically they need hours. How do I know this doesn't work? My brother self-admitted to a mental health facility before being cleared to leave by a psychiatrist the very next day, he passed an hour after being released. Very few psychiatrists currently endorse metabolic therapies because there is less research in this area. Why is there less research? Big pharma has no incentive to sponsor research they can make little money from. They don't care about the people, yet they have such a heavy hand in what psychiatrists believe and how they treat people.
I understand your opinion on cobenfy and antispsychotics since you have had so drastic improvements on keto. I follow every video of yours and hope that this is a long lasting improvment with hopfully no symptoms coming back. 🙏
In treatment resistant schizophrenia, this client has had to be on clozapine for many years. The side effects are barely tolerable. So for side effects alone, this is a game changer. Side effects are key component when discussing schizophrenic medications.
The trial papers are available to read. You can find them easily. Idk why you asked questions based on the press release and didn't even attempt to answer the questions.
Because that doesn’t fit her narrative. Lauren is hell bent on refusing medication because she has a delusion specific to believing medication is poisoned. This is just an extension of that delusion for her. She has found a way to claim she doesn’t need the medication because of this diet. She probably truly believes this because Lauren is a very sick woman. I think we need to be compassionate while also reminding people that Lauren is not someone that can be trusted because her mind is not well and her reality is not always aligned with the real world.
Hi Lauren, I think you need to consider something. You may not be the correct person to discuss what other people should be doing to treat their mental health. I realize you think medical keto is some life changing revolution. I know you want more than anything to just be normal and have a fully functioning brain. I get it. I struggled for decades to help a loved one deal with his paranoid schizophrenia diagnosis and I have seen first hand how devastating the disease is. He also had a period where he was convinced that his illness was controlled with a keto diet. Unfortunately, just like everything else we tried, this eventually failed. He refused to try traditional medication again even after it was clear that he needed to give up on the medical keto route . I feel like you are not recognizing your own limitations when you come on UA-cam and tout your new medical cure. I used to watch you because I trusted that you were honest and measured in the way you discussed your illness. Lately, what I have noticed more than anything is you disregarding medical opinions and making decisions that have the potential to ruin your life. I felt this when you chose to have a baby but I feel it even more so now. You coming on here and trying to knock on a medication that you clearly don’t understand is troubling. You clearly don’t even understand how to interpret the data which isn’t your fault. You’re not a medical researcher. I feel your mental illness comes with a lot of delusions of grandeur. You may be over estimating your ability to decide your treatment as well as your ability to speak on these treatments with others. I don’t blame you at all. I understand the magnitude of what you’re dealing with mentally. I just hope you are truly doing the right thing here. Miscalculating what the proper treatment is could have deadly repercussions for you. More so than those with milder mental health issues. I sincerely hope this diet works for you. I also hope that when you realize this isn’t the miracle you wanted it to be, that you are open to trying other avenues.
@@NormaJean951 Yes I agree with you 100% ever since she started Keto diet, she has really changed and I know one of her delusions is that she’s being poisoned by her medication. She has a big platform and she seems to push this keto diet on people that seemingly cures schizophrenia and to turn away from medication. It’s not good to fuel your own delusions onto others who suffer with other delusions as well. I just hope things get better.
It is legitimate to criticize the content of this video. However, this should be done with objectivity and respect. Regarding grandiosity, I can’t help but notice that it is you who is thoughtlessly crossing several boundaries here.
@@Susanne-qp8vj I don’t think you’re doing well. I’m not going to continue discussing anything with you because what you say is not based in reality. Good luck. I hope you get your illness under control.
@@Susanne-qp8vj We aren’t being mean and rude towards Lauren. We are concerned about her and the content that she is pushing out to the mental health community. It can be very dangerous to some people who suffer from delusions to push out their own delusions and beliefs that this keto diet is a cure for schizophrenia/schizoaffective disorder
@@jsokalski123 It's not a delusion; she's been asymptomatic for about a year. She's made these changes in her life under the guidance of accredited medical professionals. In addition, Rob seems pretty sharp, and I seriously doubt he would allow someone who'd been actively delusional for a year to care for the children. I also don't think he would allow Lauren to endanger her well-being. You seem like a condescending prick.
Thank you for making this video! I have been doing medical keto for a little over 3 months now with promising results. After hearing about cobenfy and all the positive opinions on it I started to question whether i should keep going with medical keto or just take this new medication. It even made me start to question my future career as a metabolic therapy dietitian! But after hearing you dissect the results of the trials I am no longer thinking of this drug as the wonder drug it has been hyped up to be. My resolve for continuing medical keto is strong and I will keep keto-ing on!(:
Can you @ me when you’ve completely or are almost off your current anti-psychotic med so i can know how it turned out for you. I agree if you are willing & health wise able to do medical keto (with proper dr supervision), that is a better option to do vs trying cobenfy. @lexisjones8109
I feel like it'd be better to go to a scientist or doctor for this kind of information if it's really informing your medical decisions and career choice!
Ive been following this drug release for past 2-3 years. Cobenfy seems like exciting stuff but I am even more excited about emraclidine which works with same mechanics and might have a lot better side effect profile + its taken only once day. I Definetly think its a step to the right direction.
No one thinks Cobenfy is a miracle treatment, but it is so wonderful that it DOES have comparable efficacy to other antipsychotic studies with a totally different mechanism of action which could mean people who never improved on existing mechanisms of action could find massive results with Cobenfy. Likewise if people prefer certain side effects. You continue to downplay this importance and try to act like you temper that in this video but you in fact do not. To the people reading this -- if prior antipsychotics did not work for you or you don't like their side effect profiles of weight gain, this could be a great option to talk to your psychiatrist about. 18% of people yes had side effects, which is consistent with other antipsychotics sadly. Don't let her fear monger you.
Lauren's approach is a sober one. Many people unfortunately will jump on new medication like on last train from hell. People need to be well informed, not amazed that FDA approved it. FDA approved mRNA as well. Current data shows that there are "turbo cancers". You can check it on Dr Campbell's channel, where he delves into medical papers. Were people well infromed about the jabs?
I understand that jjjjrrrr11111 seems to disagree with the approach with which the great Lauren Kennedy West explains her point of view on this particular drug. Pretty sure no one who is watching this video is being forced to watch it or is in a distressing enough situation where they feel like she’s fear mongering them either. Please keep the comments to a grade that actually helps your fellow man and just say you disagree and move on.
I do not share your sentiment at all. I felt no fear-mongering or "downplaying" of the importance of the drug from her, simply a pragmatic and as objective as possible way to convey her interpretation of these findings... if anything I think she agrees with you that it can benefit a lot of people who have not yet found success with other treatments. Also, you said "no one thinks Cobenfy is a miracle treatment", but it's literally what many of the headlines and media conveyed, with other exaggerated phrases like "best of class" and "game changing" literally heard in the snippets she put in the beginning of the video. But yeah I think it's more you projecting that onto her, than her actually doing any fear-mongering 🤷
She is very very sick. She has schizoaffective disorder. Not only that but she’s completely off treatment. Her current delusions about metabolic therapies are just part of her illness. I can’t blame her because by the very nature of her disease, she’s not in her right mind. She is spouting very dangerous stuff but she is not to blame here. The woman has been actively psychotic and delusional in the past few months. No one should be listening to her opinions on how to treat mental illness. We should make sure people understand how very ill she is before they listen to anything she says.
I used to enjoy your channel, but nowadays it all turned into praising ketogenic diet and defending it. And now bashing other options I guess. I've never been in your shoes, but psychological illnesses are especially harder to accept. Many people don't want treatment or therapy. I honestly am not sure if your content helps people, or just confuses them about their medication. I don't think I want to follow along anymore, have a good one.
Agree. She is not qualified to speak on this topic and it very much reads like she is pushing keto diet and discouraging the use of medication management. Scary and dangerous for those who are following her advice.
While I understand your constant referral to the open-label numbers of EMERGENT-5, the 30% reduction of PANSS scores < 80 is still pretty significant. I agree that the most “game changing” part of Cobenfy is the receptor pathway. Not necessarily that it’s more effective, but that it’s just as effective as 2nd gen APD. Would be very interested to see if/when there is a comparative study done between the 2nd gen APDs and Cobenfy.
i agree with all your points but to me i’m happy because the side effects arent insane i often see horror stories with permanent tardive dyskinesia + horrible weight and metabolism issues with common antipsychotics so i think to me it’s moreso just the step in the right direction and better side effects in general for the average person on AS who deal with already bad side effects
it’s also important for me to mention is suffered from very fleeting tardive dyskinesia and metabolic issues + immense weight gain in just the couple months i was first introduced to AS
I actually was apart of a clinical trial for this drug and had bad side effects of my joints being tight. It worked like any other medication for me, not completely getting rid of symptoms. But now I've started Medical Keto, thanks to you Lauren, and that has been a huge game changer. Life keeps getting sweeter and sweeter.
It’s hard to stay strong and to think it will get better! The meds aren’t really working for me and I don’t know how everything will be in the future for me.But the psychiatrists in my area seem all to prescribe the same. There is no growing and real interest from their sides. The wards are here like prisons and dangerous. When there would be a med who could free me from this hell. Of course I would be happy and grateful to take it! So many times I was off meds and I wasn’t function at all ..a pure mess. Of course you feel better when you eat better( only you know what it is for you) But in my opinion only a change of diet…will not cure you. I tried so many ways of eating. God bless all who suffer❤ and much love
I don't have schizophrenia but I'm watching those kind a video to understand and somehow to help them. Thank you for explain this new medication and schizophrenia level or score.
The thing that gets me is the disconnect in the accusation of potentially giving people false hope about Keto because it might not help everyone, and the percentage of people that weren't helped by cobensy
I think a lot of us have issue with this keto thing because a lot of people who need to be medicated have tried to use this diet as an excuse to refuse treatment and there have been some really horrific results due to this.
@@NormaJean951 Every experience, also yours, is anecdotal and so you should also acknowledge different experiences. There are as well people who are resistant to medical treatments and might profit immensely of the information provided on this channel. Maybe many of the people that you think need to be medicated (I don't like this language - they might need to take medicine) might as well stabilize on a ketogenic diet without medication. There are several clinical trials on the way and more will follow and there will soon be more evidence on which patient groups profit most of a ketogenic diet.
@@Susanne-qp8vj actually, my experience is not anecdotal. I work in mental health. I have worked with hundreds of patients with different types of schizophrenia. A lot of them are now dead. The issue here is that Lauren is not the first person to come up with this “cure”. Plenty of other people have tried this with different levels of efficacy. There are doctors and researchers that have already studied this. This is not something new. This is not something that hasn’t been tried. Lauren is extremely sick. She could end up dead if this situation doesn’t work out well. This woman has been hospitalized in the very recent past and she comes off her medications against medical advice. Her husband is not holding her accountable. This is not safe and all of you cheering her on will feel really guilty when you realize that schizoaffective disorder is so dangerous and deadly that no one escapes it.
Wow, 1850 a month. Good point on the medical keto thing. Unfortunately it seems like if there is no profit to be made from the keto approach, even if it looks to be the most efficacious, less research will go into it because it would be hard for pharma to harness the keto diet to make money. If they really cared about peoples health, they would spend money in both directions and disregard the losses. Love your journey Lauren!
Medical keto has already been tried by companies in the United States. Billions have been made selling foods marketed towards health. I don’t think treating the schizophrenic community is something anyone would ignore if it was effective. Lauren is severely mentally ill and she has no education on this topic. Basing your opinions on this topic on someone who is claiming a diet cured her extremely severe mental illness is not a good way to approach life. I don’t doubt that she believes what she is saying. The issue is she also believes people are poisoning her food. She believes a lot of things that are not true. Just like everyone else with her disorder. That doesn’t mean these things are true. This is also a woman who chose to have children despite knowing she has a 50% chance of passing her illness on to her child. She’s not exactly a beacon of great life choices.
People in a clozapine group I am in are excited about this new drug. My son as been doing so well on clozapine for the last 5 years, I would never want to chance him becoming unstable to try a new drug when ot took him being on 13 different Antipsychotics before clozapine to get him were he is. He did well pn Keto but at 24 it was hard to keep him on it. I wish she had your dedication and insight.
My son is taking clozapine which saved his life! Now almost 3 years on CLZ and quite stable he is trying keto but his ketones levels vary a lot.... I will never risk his life to reduce meds unless he is experiencing potentiation. Even though he is not "there" I consider a win, he is losing weight and experiencing more mental clarity, energy (in his words). I embarked on this two, and my eczema flares are subsided and lost weight
Thank you for the informative video about Cobenfy. But I feel ever since you started doing medical keto, it seems like you are very against all psychiatric drugs. I know so many people struggle to find the right medication or combination and for some people they are just med resistant but I wouldn’t be anti medication. It’s great that medical keto has improved your symptoms of schizophrenia but Sometimes it feels like you push a lot of people to do medical keto when it can be very unsafe for the individual. Many of us down have a great support system to watch out for us while coming off medication. Keto can be life threatening to some individuals with health conditions. It’s very risky for someone with diabetes (especially type 1) to go on a keto diet bc of cutting out all sugar and can result in low blood sugar or hypoglycemia. You have a great platform and a huge audience and I wouldn’t steer people the wrong way or influence them that medical keto is a “miracle” diet to help schizophrenia just like you’re saying that everyone is saying Cobenfy is a “miracle” drug but you very disagree. Saying this all with no hate, just concern.
Lauren has schizoaffective disorder. She has always been anti drugs as part of her illness means that she has delusions about people poisoning her medication. She has discussed this in the past. I fear her new obsession with medical keto has some root in her already existing delusions about medication. With this diet, she’s able to convince herself and her husband that she’s actually not delusional but just using a different therapy. The reality is that if medical keto could treat schizophrenia, everyone with it would be cured. The reality is people like Lauren are very prone to believing their delusions and of convincing others that what they believe is true. I hope for her sake that she doesn’t end up alone and on the street like so many other people with her condition that refuse to medicate themselves properly.
@ Yeah wow, I completely forgot that was one of her delusions. I remember her talking about it in a video. Now this all makes more sense. She really sweet and has a great platform to help others with schizophrenia/ schizoaffective disorder and also to help others to understand the disorder, It’s sad that she’s somewhat influencing others to try keto or that keto heals the disorder when there’s many people on medication and managing their symptoms. Others could also fall into that same delusional and go off their medication when they are doing well. I know she seems to have a wonderful husband and hopefully her support system will notice any increasing symptoms. Schizophrenia/schizoaffective disorder is a hard disorder to live with.
@@NormaJean951 "The reality is that if medical keto could treat schizophrenia, everyone with it would be cured." It is not as simple as you think. Schizophrenia is a complex disease. Genetics, epigenetics, the microbiome and environmental factors are different in every person living with schizophrenia. There is evidence from preclinical trials that medical keto modulates the microbiome, reduces inflammation and oxidative stress, increase ATP production in impaired mitochondria, stimulates production of new mitochondria etc.. A ketogenic diet even influences gene expression by activating genes involved in mitochondrial function, cell protection, and anti-inflammatory processes, largely through mechanisms like HDAC inhibition and DNA methylation changes. Due to these many factors, each person will respond to a ketogenic diet differently and at a different pace.
@@NormaJean951 If you are interested in the science behind medical keto, you should listen to "Bipolarcast Episode 18: Dr Dominic D'Agostino" on UA-cam by Iain Campbell who recently published in Nature Magazine. The paper might also give you some interesting information for your clinical work: "The metabolic overdrive hypothesis: hyperglycolysis and glutaminolysis in bipolar mania"
This seems a strange dodge. Instead of providing an honest video update about how it is really going after stopping meds, you are giving a "scientific critique" of a drug you don't have credentials to do credibly. It also strikes me as weirdly verbose, like a script prepared with help from a sponsor with an agenda. Plus...I wonder why all this energy being poured into critiquing a "press release" rather than an original source if we are such a scientific whiz. The drug is being used in this video as evil foil as a fresh peg to hawk keto irresponsibly.
I can understand both sides of it. I think it needs to have more transparency when it comes to the specifics of the studies and not being overly motivated if those numbers are not aligning. But I can also see the excitement towards triggering new parts of the brain in these medications as there are different classes of medications. I know when it comes to ADHD it has been incredibly difficult to find a good stimulant because I am a cardiac patient and can’t have my blood pressure or heart rate high but having hype on something that maybe a healthy diet and exercise or staying consistent in is the same alternative. We do need to be careful in clinical studies.
I'm really glad keto worked so well for you and i also totally get that medications can be really tricky and not always that effective however medication is still the safest option for most people with this disease. Not just because its the most tried and true but also because its the most sustainable. Simply put, the keto diet is simply not sustainable for many people. While i think its amazing that your channel is mainly about keto and how effective it can be for schizophrenia and how well it worked for you i think it's important that you don't present a cure-all argument for keto or kind of have a negative outlook on meds... i know you say you don't but its the vibe you give off a lot of the time and as you remember from when you were dependent on meds, it can be really dangerous for someone with this disease to go off their medication.
I don't understand how keto isn't sustainable if it is working for someone suffering with schizophrenia... I mean, the idea that you could CHANGE YOUR ENTIRE life by changing the way you eat... isn't that incredible motivating? Would the carb cravings be so great that someone would literally choose a lifetime of dangerous meds with significant side effects just so they could eat donuts and spaghetti? I can't understand your comment. A little bit of self-discipline vs. a lifetime of psych meds...
anti psychoistics coem with black box warnings for cancer and diabetes. Im not sure how you think increased risk of those diseases is the "safest for disease"
Loved this video it nicely helps inform everyone from those who can't or don't want to do keto right through to those doing keto. Felt like some of your old videos with the new more expresionate you. Well done. Worth also noting metabolic mind did a video on drug interactions and covered cobenfy and said keto had some potentially interesting interactions with the two halves of the drug that potentially were not good but it was too early to really know yet
I’m not able to do 20 GM of carbohydrates only in a day with being a cardiac patient but I am trying to figure out how to stay in ketosis and still receive all the medical benefits that I know it has. And yes we should be focusing on underlying issues and not symptoms management.
Cherry picking EMERGENT-5 is quite shocking especially when you try to compare its PANSS score to thinks like clozapine, for example you even showed that EMERGENT-2 had a -21.2 PANSS reduction! AND EMERGENT-3 had a -20.6 reduction, very comparable to the clozapine figure you showed of a -22. Also really EMERGENT-5 was done in mild illness with *stable symptoms* which likely tells us that Cobenfy unsurprisingly shows biggest effect in unstable symptoms and moderate-to-severe schizophrenia
Thank you, I agree with you that we should have also included a comparison of Clozapine’s baseline PANSS reduction compared to the Cobenfy baseline PANNS reductions in both Emergent-2 and Emergent-3, as well as Emergent-5 in order to give the best comparison possible. It probably is worth pointing out though, that in the Emergent-2 and Emergent-3 trials, the duration of both trials were relatively short (5-weeks), and even the placebo had fairly impressive reduction in PANSS scores, perhaps implying that the Cobenfy results were amplified by this placebo effect. This is why we also highlighted comparing the difference in PANSS score reduction between Cobenfy and placebo and between second-gen antipsychotics and placebo. (We were talking about Emergent-2 for this comparison so we did not just cherry pick Emergent-5 for our analysis.) If we had really wanted to cherry pick data we could have compared the baseline reduction of placebo in Emergent-3 (-12.2), to the baseline reduction of Cobenfy in Emergent-5 (-5.5). Based on Emergent-2 and 3, it’s clear that Cobenfy is more meaningfully effective than placebo. However, it also points demonstrates how powerful the placebo effect can be.
@@LivingWellAfterSchizophrenia Hypochondriasis and ruminations play a big role in one's mental well being. Anxiety that comes from uncertainty of future is another one. No wonder placebo can have such effect. People who took placebo had already different mental state. More optimistic. Valis is a 1981 novel written by Philip K. Dick. It's semi autobiography. You can read about cancer and its remission in one of his friends. Any time his female friend was expecting cancer it would happen. And with a mood swing there was a remission. Those are just his claims, but autosuggestion is a powerful tool indeed. And NLP itself pops up in psychiatry textbooks.
@@LivingWellAfterSchizophrenia High placebo response rates in schizophrenia clinical trials are nothing new and nothing specific to the Cobenfy trials at all. Placebo is real and powerful, and it's WHY we include a placebo arm in these trials! To show that they are doing something more than placebo, and that's exactly what Cobenfy demonstrated.
the linking of the "placebo affect" and schizophrenia really does inform the "naturopathic medicine" industry as being a threat to those with the disorder as being predatory actors.
Thank you for a very interesting video. I haven't seen your videos in a while and was blown away that you feel so much better with this keto - thing. I don't know anything about it but now I might research. I am a schizophrenic and my medication is being changed at the moment, and now will probably ask my doctor about this Cobenfy. Hadn't heard about it before and you are right, a different mechanism is exciting. My symptoms are in control with a very small amount of medication and am wondering if this could help me in any way. I've always been prone to all the side effects that medications have. Maybe a different profile could help. We will see. But thank you for the video.
Keto has been shown to more than double cardiovascular risk. This channel is not honest. There ARE side effects of keto and NOT everyone benefits. I remember a video where you essentially responded to people saying they tried keto and it didn't help that they weren't doing it right, and that's the reason, vs accepting it may in fact not have a 100% success rate..... I get you're excited. But you need to be responsible.
@@paklenim9989 - I don't think @deschroma is arguing that fact. I think they are just pointing out that Lauren has unfairly presented the medical ketogenic diet as not having any negative health effects, when it might. I say might, because not everyone does keto responsibly, and poor nutrition might account for some of the poor health outcomes, versus the idea of keto in and of itself.
I think you have to remember that Lauren is very sick. No one should be using her as a reliable resource to treat mental illness. She has always had delusions about her medication being poison. This is just an extension of that.
Thanks Lauren. I love that you are always prepared ask the difficult/ controversial questions. Think that is needed especially in the Mental Health world 🌎🙏x
I would of tried cobenfy, I don't know 100% what my antipsychotic is doing to me, weight gain yes, what else who knows, I'm 6 months into keto for my schizophrenia, you helped push me there. Yea I'm getting better by the week. My first psychosis 25 years ago, and it reoccurred more times than I can count. I was completely nuts looking back. I still think in the well worn paths, the same triggers trigger. But it feels like the days coming where like someone clinically depressed realizes there not depressed anymore and they smile. I have little wins like that often. If you read this Lauren I'll put this emoji here 😉 with keto and schizophrenia, for some, there's revelations around every bend 🙂 and relief.
Thanks for the in-depth breakdown of COBENFY and its potential as a new treatment option for schizophrenia! I think it’s exciting to see the development of medications with novel mechanisms, but I wanted to share a few thoughts about some of the data comparisons in the video that might need a bit more context. For example, when comparing COBENFY’s 5.5-point PANSS reduction in EMERGENT-5 to the 22-point reduction often seen with clozapine, it’s worth noting that these studies involved different patient populations and baseline symptom severities. Clozapine is usually prescribed for treatment-resistant cases, so those patients often have more room for symptom improvement. Do you think this difference in baselines might impact the perceived efficacy gap between the two? Another point I found interesting was the high satisfaction rate in EMERGENT-5 (93% willing to recommend it, 78% willing to continue) despite the modest efficacy (30% saw at least a 30% reduction). I wonder if factors like COBENFY’s side effect profile or even a more subjective quality-of-life improvement might explain why so many patients were satisfied despite lower symptom reduction? It would be great to explore what’s driving that patient satisfaction. Also, just a thought-it might help viewers to add the note about your expertise earlier in the video, especially for those who might assume there’s a research or clinical background behind the analysis. If you worked with anyone to interpret the data, a quick mention could also add useful context for viewers. Finally, with the differences between EMERGENT-4 (69% efficacy in patients with more acute symptoms) and EMERGENT-5 (30% in a stable population), it seems like COBENFY might show more potential in acute exacerbations. I’d love to hear your thoughts on whether it might be best suited for those who don’t respond well to current meds during more symptomatic periods rather than as a blanket treatment for all schizophrenia cases. Thanks again for shedding light on COBENFY! I think discussions like these help us look at the full picture and consider where this new treatment might fit best.
You were unable to obtain a master's degree, but yet you are juggling the facts and figures of medical studies in detail as if you were a specialist, presenting the latest outcome of your medical research - I get very weird vibes from that, to say the least ...
It will be the same as with Valdoxan for depression. Works for some corner cases, but in a hospital setting, they will use anti-dopaminergic drugs anyways, as those are tried and true. Muscarinic receptors indirectly regulate dopaminergic pathways. Same with Valdoxan. Melatonin indirectly regulates mood. Works for some, but in general it is not going to be a wonder drug. At this time its marketing. All marketing. Real life will determine actual efficacy.
@@Heilungfreiheit there is not enough data to say if the one is better than the second in terms of PANSS. But so far Cobenfy has completely different side effects picture from the rest of antipsychotics.
Well done! I didn't know I needed this but have heard of/been curious about KARXT for years. This got into the nitty gritty which I wouldn't want to do and it's really insightful, Lauren! lots of good graphics and charts, not what I'm into 👋👋Thank you!!! I'm still hoping for keto to be my main line of treatment in addition to metabolic therapies, but I like how you mentioned cobenfy could be for acute situations. I don't have a good med lined up as once I'm off olanzapine, I don't want to go back. And yes, how can we make medical keto covered by insurance? SO needed!!!
@@user-xr9db2zw7y Hello! I've done keto for about 11 months now, and it took two months to notice any benefit, and no new benefits until 2-3 months after the first benefit. I am doing great when I'm stable, as in going slower in my reduction with olanzapine. In the beginning I went quicker and well withdrawal can be awful I learned and it made me get sick easily due to a lot of insomnia. I am good currently, but I do have possibly some mild migraines so not sure what's going on b/c keto should help with that, unless I'm eating something that's bothering me. Or hormones rebalancing while lowering olanzapine. Soooo many factors could be at play so patience is key. I hope this helps
@@user-xr9db2zw7y yes! I thought I responded but I can't see it. Thanks for askinng! I've been on keto for 11 months now, started tapering olanzapine two months in. I noticed one benefit of keto after doing it for 2 months - I'd say it's been a long journey of slow progress, things get in the way like lots of withdrawal even though I taper slowly. I believe I will notice more keto benefits over time when I'm on less olanzapine. I have noticed my new benefits too but I have to taper olanzapine really slowly and once I am stable at a lower dose, I feel good, but patience is key!!! I hope this helps :)
After every video you say 'I'm not anti medication'. Yet in every video lately you criticise medication and bring up keto again. It's great something worked for you, but the majority of people are gonna stick to conventional treatments. If you really weren't anti medication you wouldn't have to keep saying it
@@PhoenixFeathers @sebastian-so1hb this is an unfair assesment of her intentions. Critical analysis of any medication is important. All reputable doctors do a review of the drug study data when they decide what to prescribe. And patients should be able to do research to properly advocate for themselves as well.
@@mgray999 it's not up to me to decide what's 'acceptable'. It's up to each individual who needs to weigh the risks and consider their own health. For many people mental health conditions can make life unbareable and some side effects are worth an improved quality of life. Also you're acting like keto or any metabolic intervention has no risks....
@@Propa_jo and they should advocate for themselves and understand the potential risk and BENEFITS of any medical intervention. However, just because you've decided that a treatment isn't appropriate for you, doesn't mean you get to go on the internet and criticise everyone else for trying to take care of their own health in a way that they feel is appropriate.
I got skitzophenia when I was about 21, and I still got *ALL* my wisdom teeth. I take olanzapine 5 -20mg depending on environmental energy from people. I like keto diet.
If nothing else, hopefully this leads other pharmeceutical companies to try and make schizo drugs that use novel mechanisms of action, rather than just slightly tweaking what already exists.
i think they would recommend it to people since their previous experiences on antipsychotics have much more intense symptoms so ofc the efficacy wasn’t there for some but i think their point in recommendation is it being a tolerable med
I just recently started this medication and let me tell you it is…different. Now I have tried literally every antipsychotic there is, so this drug looked promising for me. The first morning I took it it felt like I was really drunk. I was stumbling around and had the strangest sensation in my head BUT the voices were not there. Idk it does feel really strange. Anyways I also noticed that my movement disorder has improved and now I can say I think they’re almost gone. I’ve also lost 12 pounds. If you can try this medication do it!
Do you know if any of the studies have broken down the results into the positive and negative symptom scales? Maybe even though overall efficacy isn't that different to other antipsychotics, if it has a better effect on negative symptoms, then that could explain why most people who tried it want to keep taking it? It's just a hypothesis but I think an interesting one to explore
The idea of targeting acetylcholine is as old as antipsychotics and goes right back to chlorpromazine. Most of the interest came not from chlorpromazine but the observation that chronic cases of schizophrenia and manic depression seemed to benefit from smoking and the patients themselves could not be separated from their cigarettes. Of course these are muscarinic and not nicotinic receptors in this case. Part of the benefit of smoking may have been in reduction of side effects and a reduction in the amount of antipsychotic.
i am very afraid about medications and other interventions... because I had to use adult diapers because of medication once... allergies to medication and had a severe headache with another one and another time I was sleeping too much like 1% of people have that and I did. It is nice that there is scientists trying to help and doctors also and everyone has their own reactions but still everything is a risk we never know... of course, drugs can help but is not everything I feel like when I changed my lifestyle I improved so much. It is sum of of intervention meds in the begining, spirituality, diet, and meaning/beliefs.
So what do you hope to achieve from all the 23 so far comments that have been from a place of not being nice. What would you like from Lauren so you can move on.
@@amandasmith6342You counted? My issue is: accountability. This channel isn’t accountable to anyone. What if there’s a relapse and because keto “cured” the illness, the relapse is covered up? The channel isn’t a reliable/ safe source for people w/ mental illness. Thanks!
I think it’s important to mention that if you’re on this new two component medication that if you decide to do keto while on it , it will affect the efficiency of the medication. It lowers the component that helps with symptoms by 30% and the other component that helps with side effects by 70%. So, idk is this new medication worth it. You will kinda be stuck on it for the rest of your life.
hi iam 16 years old i have never in my life have gone to a psychiatrist to check my symptoms out .But i have hallucination most of the time in night time some random shadow figures pop up in front of my eyes which are identical to human figure every figure i see scares the shit out of me and also i always take a night shower before sleeping i hear my mum or my dad or any relatable persons voice screaming or calling my name. I also see some random object in the day time today i saw a peach or a plum on my work desk. SHOULD I JUST GET A APPOINTMENT PLEASE TELL ME ANYONE.
definitely tell your parents what you're experiencing and have them make an appointment with a psychiatrist or get your primary care doctor refer you to one. You're going to be okay, but you do need help
You are ONE person who believes keto works for them. That’s great. But why make this into a ketovangelical channel? Why not just live your life? Why the need to push this as THE cure? Is it money? 💰 For you to be believably unbiased you’d have to give us the info on who pays you for your influencing. Now I strongly suspect some organisation is filling your pockets nicely.
With over 300k subscribed and millions of views on their "popular videos" along with merchandise and sign up fees ...who needs monetary collaboration? They're making some good cash flow! Rather the Metobolic Minds need them (her and husband, this is a joint effort, I wonder if he's in video production?)
I've noticed that a lot of "professional vlogs" aka money makers, all include these cut and paste hype visuals. All of them. It's like watching the news. And the most of them are repeated content, over and over again, before they get to the point. The business of vlogging and the visual stimulation that goes with it to hook people in (always the ads) it's a form of click baiting. Every click is a penny earned. And on this topic? Wow. I see it as a form of exploiting mental illness for profit, the easy cheesy way.youtube channel vlogs.
If they have 300 subscribed (I think she mentioned that detail at the metabolic mind meeting) at $5 month ... just that alone equals $1500 a month, every month. And you know how all those "little subscriptions" keep paying on auto pay and people don't unsubscribe. Lol they have made "talking about schizophrenia" into a very substantial income.
@@Candace-u6lI agree completely - however why then change the name of the channel to exclude the click-bait term schizophrenia? Now it’s ‘just’ ~ Lauren Kennedy, and she’s cured herself with keto ~ kind of thing. How long is that going to interest her followers, many of whom subscribed because of earlier more relatable content?
Maybe for legal reasons, pertaining to their business name? Liability? Claiming insanity lol personally may legally keep you out of the liability circle@@PhoenixFeathers
Lauren what it often boils down to is drug companies making money, there is no profit in medical Keto for drug companies!! Sad but my guess is likely true. Medical Keto may not work for everyone so yes new drugs are needed.
Not knowing anything about what mental health services are available in India to know what drugs or therapies are offered I would suggest the ketogenic diet check out Dr Chris Palmers book Brain Energy or Dr Georgia Ede book change your diet change your mind. Aim to lower carbs and achieve ketones ideally above 1.5mmol/ltr of blood. This is what Lauren has been doing to amazing effect. I hope these books are available to you in India
get your brother on antipsychotic medication and stable before considering keto. the right medicine can help him live a normal life again much faster and then you can consider keto down the line once he's doing well
@@shainassights6237 my wife spent 8.5 years find the "right" combination of antidepressants, antipsychotics and mood stabilisers and certainly wasn't living a normal life on them. Yes reduced suicidality and marginally less psychosis but blunting, brain fog, weight gain, dysfunction, tremors, polydipsia and skin conditions when not good side effects. 3 days into measured ketosis and we could see huge potential, 8 months on and the change is incredible not only in her but her drug combinations and there side effects. Mood stabilisers halved below therapeutic dose and still lowering. Antipsychotic dropped by a third and will continue once the other has gone. I expect this persons brother has tried everything India has to offer except keto so I know what I would try
@ because by the end of the review she heavily promototes keto diet for a ‘cure’ and therefore has an agenda. Its the same thing as seeing who sponsors a trial in research. If you know a thing or two about science you Will also see that she is heavily biased. I studied research!
I bet if you actually tried it, you would actually like it and maybe know what you're talking about. Being a carnivore didn't fix you and it's not going to fix us. Of course you don't like it. Just as you were figuring out your Keto, something that actually helped came out.
She is severely mentally ill. Let’s not be too hard on her. She truly isn’t capable of understanding she’s wrong. I blame her husband a lot more. He is of sound mind and not only going along with all of this but also exposing his children to her illness despite the many psychotic episodes. I feel the most for that baby. Why would you have a baby knowing you are this sick?
Whether you like it or not future therapies that treat the root cause of schizophrenia will be about metabolic health. There is so much evidence in preclinical data. Watch "Can the Keto Diet Help Bipolar Disorder & Schizophrenia?" by Dr. Tracey Marks, who explains the most important points.
Clozapine could cause major side effects and other health issues and extreme tiredness, so karxt/cobenfy might be a option to try, and so would medical diet Keto.
No, Cobenfy acts on muscarinic receptors of the cholinergic system. Xanomeline addresses the antipsychotic symptoms as an M1/M4 muscarinic receptor agonist.
@OfficialRogue whereas every other medication on the shelf is a muscarinic receptor antagonist, this one is an agonist like mescaline lol what could go wrong?
@@doramc3155 Mescaline is a serotonergic psychedelic, which mainly works as a nonselective serotonin receptor agonist. Mescaline is not a muscarinic receptor agonist, so the two are completely different.
Hi Lauren, thanks for the informative video!! Being from Australia, I actually haven't heard of Cobenfy. But it's really interesting to hear their findings. I wonder what the combined effect of a dopamine affecting antipsychotic and this cholinergic one would be like?
Hiya Lauren, sending some love your way, there's a lot of kinda shitty comments on here and they seem to go a bit beyond just concerned criticism. Hope you are doin okay with it all. Much love
every time they come up with some "new treatment," I sigh. I've tried newer antipsychotics, and they did horrible things to me and my body. The perphenazine has been tried and neither of us are dead.
Meanwhile, metabolic therapy has not done half of this. Look, I am really happy for you but you often talk about Keto as a game changer like as "they" talk about Cobenfy.
Except that medical keto has already been tried. If it was effective we wouldn’t have any more people suffering from schizophrenia. The reality is that this diet doesn’t work for everyone. We don’t even know if it actually works for Lauren. She has severe mental illness and she believes a lot of things that aren’t true.
I fast forwarded through much of her presentation and listened for about 2 minutes total...she made some good points...basically, results are not in...
I think unfortunately the results are in - Bristol Myers Squibb shared the results of their two latest 52 week trials (what I talk about in this video) that give a fairly decent picture of efficacy. What hasn't been done yet, are studies directly comparing Cobenfy to other antipsychotics - which of course would be helpful.
SchizoKitzo was faster than you, Lauren. ;P Yet yours is more in depth. Plus, let's not forget that FDA approved mRNA as well. I recommend Dr Campbell's channel, where he goes through medical papers considering this topic. Dr Raszek from Merogenomics uploaded recently a video about depression. He's another positive freak, when it comes to "how it works". PS. Are you planning a colab with Stephen by any chance? PS. S. It's 78% from 82% that started the trial. Which is 63,96% ;) That's how you play with numbers. They are good at selling stuff.
Hey Lauren can you tell everyone what medicine you are taking for your schizoaffective disorder. That is if you are willing to. On my channel I talk about the medicine I am on with Schizoaffective Disorder thanks. Have a great day.
overhyped. It gets the conversation going in science and psychiatry for better treatments. this condition has been being studied for 300+ years and these people have been abandoned and mistreated. It is a symbolic drug that opens the door to better treatments.
schizophrenia is one of the worst diseases. and they just never find out about the etiological mechanisms behind it. its sad. almost everywhere else there is more progress. its just horrible
Honestly, probably not. I was stable on the antipsychotic I took previously and so would probably use that if I ever need medication in an acute episode again. Reminder though, that medications affect everyone differently anyway. (But also, 30% of people getting a 30% reduction in symptoms doesn't sound particularly enticing to me).
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imagine all of the naturophatic practices that would instantly vanish overnight if there actually was a _"miracle drug"_ for the disorder.
Lauren Kennedy West you are bipolar, you will fall like everyone else... I'm waiting calmly, I also have bipolarity, you will see how nice it is to be without medication..
Sorry Lauren for don't believe in the truth and correct think. Now I can understand.
Hi Lauren,
I wanted to add my voice to this discussion and point out a few potential issues with your analysis from the most recent video.
For the emergent-5 trial, I think you might have interpreted the data in an incorrect way. These are people with a lower PANSS baseline who were already stabilized on their medications. If I read it right its that 30% of people experienced 30%, or higher further reduction of symtpoms from their already less symptomatic, more stable baseline. This is very different than 30% of people experienced 30% reduction in symtpoms overall. To compare it to the systematic review is wrong because that's a very specific set of circumstances that I don't believe were replicated in the systematic review. Also that 10% is still statistically significant. This is amplified in my mind because even if there was a 0% reduction from baseline for all participants and cobenfy just kept them stable at the level they were already at, cobenfy carries so much less risk to overall health than many current antipsychotics. I'd rather my tummy hurt than have lifelong struggles with diabetes, metabolic syndrome, or tardive dyskenesia.
I also think its worth noting that many people in the community have tried keto and experienced a 0% reduction in symtpoms or active worsening of symtpoms as compared to long term medication use and stabilization. I think its incorrect to compare these two treatments without data similar to the PANSS baseline data from the other antipsychotic studies.
I myself will be trying cobenfy in the winter of this year so I'll let you know how it goes! I hope this message doesn't come off as mean in any way, I dont intend that at all, I just wanted to provide my perspective on the issue and encourage furthur discussion in the community
This is the kind of feedback I was looking for in the comments. I’ve learned that interpreting clinical studies and trials is tricky, and as a layperson there are many, many pitfalls. I’d love to see someone in the field do a critical review of the data, or even just a response to Lauren’s analysis.
Been following the channel for a couple years, always glad to hear from Lauren. ❤️
@@shainassights6237 great analysis!
Hi Shaina,
I appreciate you sharing your insights. I think something that’s missing from this picture is a better understanding about when and how baseline was measured.
I don’t think the full trial study information is publicly available yet. However, clinicaltrials.gov does show what the inclusion criteria were (clinicaltrials.gov/study/NCT04820309?term=emergent-5&rank=1). One of the criteria is that “Subject is willing and able, in the opinion of the investigator, to discontinue all antipsychotic medications prior to baseline visit.”. Another inclusion criteria is “Subjects taking a long-acting injectable antipsychotic could not have received a dose of medication for at least 12 weeks (24 weeks for paliperidone palmitate) before Day 0”. Is day zero the day they took baseline? What this could be establishing is that patients may have been required to have been off their medication long enough for it to clear their system BEFORE a baseline was taken (it makes sense to me that baseline would be taken on day zero). (Side anecdote: Lauren was on a monthly (4-week) injectable for Abilify. Often symptoms were so bad by week 3 she needed an emergency injection.)
This is a bit of a tough situation to balance, especially around ethics. On the one hand researchers probably don’t want to have participants entering the study in a psychotic state or in withdrawal because they’ve had to go off medication. On the other hand in terms of being able to properly assess baseline, they would obviously need to be off medication - my guess is this is why they selected people who didn’t have as severe acute symptoms as the previous trials. I think based on the inclusion criteria, at least around discontinuing LAIs, that for those people baseline assessment would be closer to essentially being unmedicated. And so the statistic of 30% of people seeing at least a 30% reduction in symptoms would be valid (not an additional 30% improvement from their already stable situation on medication).
Now when it comes to comparing Cobenfy to the systematic reviews. I believe what you’re talking about is our comparison of placebo in the systematic review (30% of the population with at least a 20% reduction) compared to Emergent-5 (30% of the population with at least a 30% reduction)? I agree that 10% is still statistically significant. But again, I don’t believe that baseline for Emergent-5 was measured with people currently stable and on their medication.
Appreciate your perspective of preferring the Cobenfy side effects over other antipsychotics if they end up having the same efficacy in symptom reduction for you. The point we were trying to make is that it doesn’t seem like it’s more effective at symptom reduction than currently available antipsychotics, which is why we cautioned against switching to it if people are stable on their current medications. We’re trying to address the narrative that has been building in the community that this drug is more effective at addressing symptoms. We do also mention though that it is an individual choice around which side effects are more tolerable for each individual. I’m not sure it’s fair to chalk Cobenfy’s side effects up to a “sore tummy” when nearly 1 out of 5 people had to discontinue during the trial. My guess is these people were dealing with more than a tummy ache.
Regarding the efficacy of medical keto this study is interesting: pubmed.ncbi.nlm.nih.gov/35873236/
The study shows an average reduction of PANSS of -42.1. I don’t think it’s totally fair to compare this to Cobenfy (If we did it would be blowing Cobenfy away. To be honest though our personal experience with keto has blown anti-psychotics away!). This medical keto study wasn’t a large study, and it was people with various persistent mental illness (only 10 people with schizoaffective disorder). Still, I think studies like this are evidence informing conversation about how effective the medical keto diet can be. (Also, of note in the study was: “Significant improvements were also observed in metabolic health measures including weight, blood pressure, blood glucose, and triglycerides.” - I think this really speaks to the connection of improved mental health, with improved metabolic health).
I’m interested to hear about your experience with Cobenfy (as hearing real world experience is valuable), and truly do wish for you the improvements you’re hoping for.
Thank you again for sharing your thoughts here,
Lauren & Rob
@@LivingWellAfterSchizophrenia
Lauren and Rob,
As someone who works in mental health, I can tell you that from my experience, medical keto has caused horrible issues in the patients that tried it. I would love nothing more than to have this work. If medical keto could actually treat schizophrenia, the mental health community would be absolutely willing to use it. We watch so many patients struggle with schizophrenia and it’s horrendous and heartbreaking. Most of us would love nothing more than to have a safe and effective treatment. It’s what some of us want more than anything in the world. I have mourned people I love before their death because of schizophrenia. This idea you perpetuate that medical keto is a wonder cure makes me truly sick. You are selling people a fantasy that isn’t true. Your own doctors think you’re wrong and find you difficult to work with. It is so so scary to watch you continue on this path when I already know where it’s going to end.
The study that you cite as evidence of PANSS reduction by keto was a retrospective study. The authors write”Neither the treating psychiatrist responsible for assessing outcomes nor the patients themselves were blinded to the intervention, therefore there is a risk that impressions of clinical progress may have been biased. While patients may have benefited simply from having been hospitalized,..” Waiting for a well done study. I am very glad Keto works for you!
I'd rather get the take of a MD or psychiatrist on this subject.
Psychiatry has been infiltrated to profit big pharma. Meds are needed for some people, but a lot of research which provides a foundation for the decisions that psychiatrists make is funded by pharmaceutical companies interested more in profits than seeing people well. Many good psychiatrists have much to say about this - Bessel van der Kolk, Daniel Amen, and James Davies to name a few. In most cases, psychiatrists are given 15 minute windows of time to formulate their decisions for their clients when realistically they need hours. How do I know this doesn't work? My brother self-admitted to a mental health facility before being cleared to leave by a psychiatrist the very next day, he passed an hour after being released. Very few psychiatrists currently endorse metabolic therapies because there is less research in this area. Why is there less research? Big pharma has no incentive to sponsor research they can make little money from. They don't care about the people, yet they have such a heavy hand in what psychiatrists believe and how they treat people.
As opposed to someone who actually has or had schizophrenia and found something that worked for her . Makes sense .
@@michaelblankenau6598 🤣
I’ve found drs. Sometimes have never heard of many things we’ve shared. Moms don’t take the night or day off. Thanks for sharing.
Her own experience with the drug? I'm all ears! A close read of a press release on drug study results? That's better from a MD PhD
I understand your opinion on cobenfy and antispsychotics since you have had so drastic improvements on keto. I follow every video of yours and hope that this is a long lasting improvment with hopfully no symptoms coming back. 🙏
In treatment resistant schizophrenia, this client has had to be on clozapine for many years. The side effects are barely tolerable. So for side effects alone, this is a game changer. Side effects are key component when discussing schizophrenic medications.
Thank you Lauren for all this interesting info and your channel over all. ❤
The trial papers are available to read. You can find them easily. Idk why you asked questions based on the press release and didn't even attempt to answer the questions.
Because that doesn’t fit her narrative. Lauren is hell bent on refusing medication because she has a delusion specific to believing medication is poisoned. This is just an extension of that delusion for her. She has found a way to claim she doesn’t need the medication because of this diet. She probably truly believes this because Lauren is a very sick woman. I think we need to be compassionate while also reminding people that Lauren is not someone that can be trusted because her mind is not well and her reality is not always aligned with the real world.
Hi Lauren,
I think you need to consider something. You may not be the correct person to discuss what other people should be doing to treat their mental health.
I realize you think medical keto is some life changing revolution. I know you want more than anything to just be normal and have a fully functioning brain. I get it. I struggled for decades to help a loved one deal with his paranoid schizophrenia diagnosis and I have seen first hand how devastating the disease is. He also had a period where he was convinced that his illness was controlled with a keto diet.
Unfortunately, just like everything else we tried, this eventually failed. He refused to try traditional medication again even after it was clear that he needed to give up on the medical keto route .
I feel like you are not recognizing your own limitations when you come on UA-cam and tout your new medical cure. I used to watch you because I trusted that you were honest and measured in the way you discussed your illness. Lately, what I have noticed more than anything is you disregarding medical opinions and making decisions that have the potential to ruin your life. I felt this when you chose to have a baby but I feel it even more so now.
You coming on here and trying to knock on a medication that you clearly don’t understand is troubling. You clearly don’t even understand how to interpret the data which isn’t your fault. You’re not a medical researcher. I feel your mental illness comes with a lot of delusions of grandeur. You may be over estimating your ability to decide your treatment as well as your ability to speak on these treatments with others. I don’t blame you at all. I understand the magnitude of what you’re dealing with mentally. I just hope you are truly doing the right thing here.
Miscalculating what the proper treatment is could have deadly repercussions for you. More so than those with milder mental health issues. I sincerely hope this diet works for you. I also hope that when you realize this isn’t the miracle you wanted it to be, that you are open to trying other avenues.
@@NormaJean951 Yes I agree with you 100% ever since she started Keto diet, she has really changed and I know one of her delusions is that she’s being poisoned by her medication. She has a big platform and she seems to push this keto diet on people that seemingly cures schizophrenia and to turn away from medication.
It’s not good to fuel your own delusions onto others who suffer with other delusions as well.
I just hope things get better.
It is legitimate to criticize the content of this video. However, this should be done with objectivity and respect. Regarding grandiosity, I can’t help but notice that it is you who is thoughtlessly crossing several boundaries here.
@@Susanne-qp8vj I don’t think you’re doing well. I’m not going to continue discussing anything with you because what you say is not based in reality. Good luck. I hope you get your illness under control.
@@Susanne-qp8vj We aren’t being mean and rude towards Lauren. We are concerned about her and the content that she is pushing out to the mental health community. It can be very dangerous to some people who suffer from delusions to push out their own delusions and beliefs that this keto diet is a cure for schizophrenia/schizoaffective disorder
@@jsokalski123 It's not a delusion; she's been asymptomatic for about a year. She's made these changes in her life under the guidance of accredited medical professionals. In addition, Rob seems pretty sharp, and I seriously doubt he would allow someone who'd been actively delusional for a year to care for the children. I also don't think he would allow Lauren to endanger her well-being. You seem like a condescending prick.
Thank you for making this video! I have been doing medical keto for a little over 3 months now with promising results. After hearing about cobenfy and all the positive opinions on it I started to question whether i should keep going with medical keto or just take this new medication. It even made me start to question my future career as a metabolic therapy dietitian! But after hearing you dissect the results of the trials I am no longer thinking of this drug as the wonder drug it has been hyped up to be. My resolve for continuing medical keto is strong and I will keep keto-ing on!(:
Can you @ me when you’ve completely or are almost off your current anti-psychotic med so i can know how it turned out for you. I agree if you are willing & health wise able to do medical keto (with proper dr supervision), that is a better option to do vs trying cobenfy.
@lexisjones8109
I feel like it'd be better to go to a scientist or doctor for this kind of information if it's really informing your medical decisions and career choice!
Ive been following this drug release for past 2-3 years. Cobenfy seems like exciting stuff but I am even more excited about emraclidine which works with same mechanics and might have a lot better side effect profile + its taken only once day. I Definetly think its a step to the right direction.
Can you tell us more about emraclidine? That's the first I've heard
@@doramc3155 google it bro its on phase 3 trials atm
@@doramc3155 on 3rd phase trial and if all goes well it will come in 2 years
emraclidine failed huge. sad sad sad.
@ ohh that sucks..
No one thinks Cobenfy is a miracle treatment, but it is so wonderful that it DOES have comparable efficacy to other antipsychotic studies with a totally different mechanism of action which could mean people who never improved on existing mechanisms of action could find massive results with Cobenfy. Likewise if people prefer certain side effects.
You continue to downplay this importance and try to act like you temper that in this video but you in fact do not. To the people reading this -- if prior antipsychotics did not work for you or you don't like their side effect profiles of weight gain, this could be a great option to talk to your psychiatrist about. 18% of people yes had side effects, which is consistent with other antipsychotics sadly. Don't let her fear monger you.
Lauren's approach is a sober one. Many people unfortunately will jump on new medication like on last train from hell. People need to be well informed, not amazed that FDA approved it. FDA approved mRNA as well. Current data shows that there are "turbo cancers". You can check it on Dr Campbell's channel, where he delves into medical papers. Were people well infromed about the jabs?
I understand that jjjjrrrr11111 seems to disagree with the approach with which the great Lauren Kennedy West explains her point of view on this particular drug. Pretty sure no one who is watching this video is being forced to watch it or is in a distressing enough situation where they feel like she’s fear mongering them either. Please keep the comments to a grade that actually helps your fellow man and just say you disagree and move on.
She’s totally biased with her stupid medical keto agenda
I do not share your sentiment at all. I felt no fear-mongering or "downplaying" of the importance of the drug from her, simply a pragmatic and as objective as possible way to convey her interpretation of these findings... if anything I think she agrees with you that it can benefit a lot of people who have not yet found success with other treatments.
Also, you said "no one thinks Cobenfy is a miracle treatment", but it's literally what many of the headlines and media conveyed, with other exaggerated phrases like "best of class" and "game changing" literally heard in the snippets she put in the beginning of the video.
But yeah I think it's more you projecting that onto her, than her actually doing any fear-mongering 🤷
She is very very sick. She has schizoaffective disorder. Not only that but she’s completely off treatment. Her current delusions about metabolic therapies are just part of her illness. I can’t blame her because by the very nature of her disease, she’s not in her right mind. She is spouting very dangerous stuff but she is not to blame here. The woman has been actively psychotic and delusional in the past few months. No one should be listening to her opinions on how to treat mental illness. We should make sure people understand how very ill she is before they listen to anything she says.
Keep going Lauren, there are more answers than medications.
I used to enjoy your channel, but nowadays it all turned into praising ketogenic diet and defending it. And now bashing other options I guess. I've never been in your shoes, but psychological illnesses are especially harder to accept. Many people don't want treatment or therapy. I honestly am not sure if your content helps people, or just confuses them about their medication. I don't think I want to follow along anymore, have a good one.
Agree. She is not qualified to speak on this topic and it very much reads like she is pushing keto diet and discouraging the use of medication management. Scary and dangerous for those who are following her advice.
While I understand your constant referral to the open-label numbers of EMERGENT-5, the 30% reduction of PANSS scores < 80 is still pretty significant. I agree that the most “game changing” part of Cobenfy is the receptor pathway. Not necessarily that it’s more effective, but that it’s just as effective as 2nd gen APD. Would be very interested to see if/when there is a comparative study done between the 2nd gen APDs and Cobenfy.
i agree with all your points but to me i’m happy because the side effects arent insane i often see horror stories with permanent tardive dyskinesia + horrible weight and metabolism issues with common antipsychotics so i think to me it’s moreso just the step in the right direction and better side effects in general for the average person on AS who deal with already bad side effects
it’s also important for me to mention is suffered from very fleeting tardive dyskinesia and metabolic issues + immense weight gain in just the couple months i was first introduced to AS
I actually was apart of a clinical trial for this drug and had bad side effects of my joints being tight. It worked like any other medication for me, not completely getting rid of symptoms. But now I've started Medical Keto, thanks to you Lauren, and that has been a huge game changer. Life keeps getting sweeter and sweeter.
Thanks for your input. It’s important to know
Congratulations! My meds gave me joint pain too. All better with medical keto.
@ how long did it take you to get better from eating keto?
Can you share what you eat and how much etc please? Thanks
@@caitlinhoey841 that's amazing! I'm so glad Medical Keto has helped you so much 💞
@@user-xr9db2zw7y hi I would recommend doing this with a specialist because it can be dangerous otherwise. Medical Keto is very powerful.
It’s hard to stay strong and to think it will get better! The meds aren’t really working for me and I don’t know how everything will be in the future for me.But the psychiatrists in my area seem all to prescribe the same. There is no growing and real interest from their sides. The wards are here like prisons and dangerous. When there would be a med who could free me from this hell. Of course I would be happy and grateful to take it! So many times I was off meds and I wasn’t function at all ..a pure mess. Of course you feel better when you eat better( only you know what it is for you) But in my opinion only a change of diet…will not cure you. I tried so many ways of eating. God bless all who suffer❤ and much love
I don't have schizophrenia but I'm watching those kind a video to understand and somehow to help them. Thank you for explain this new medication and schizophrenia level or score.
The thing that gets me is the disconnect in the accusation of potentially giving people false hope about Keto because it might not help everyone, and the percentage of people that weren't helped by cobensy
I think a lot of us have issue with this keto thing because a lot of people who need to be medicated have tried to use this diet as an excuse to refuse treatment and there have been some really horrific results due to this.
@@NormaJean951 Every experience, also yours, is anecdotal and so you should also acknowledge different experiences. There are as well people who are resistant to medical treatments and might profit immensely of the information provided on this channel. Maybe many of the people that you think need to be medicated (I don't like this language - they might need to take medicine) might as well stabilize on a ketogenic diet without medication. There are several clinical trials on the way and more will follow and there will soon be more evidence on which patient groups profit most of a ketogenic diet.
@@Susanne-qp8vj actually, my experience is not anecdotal. I work in mental health. I have worked with hundreds of patients with different types of schizophrenia. A lot of them are now dead. The issue here is that Lauren is not the first person to come up with this “cure”. Plenty of other people have tried this with different levels of efficacy. There are doctors and researchers that have already studied this. This is not something new. This is not something that hasn’t been tried. Lauren is extremely sick. She could end up dead if this situation doesn’t work out well.
This woman has been hospitalized in the very recent past and she comes off her medications against medical advice. Her husband is not holding her accountable. This is not safe and all of you cheering her on will feel really guilty when you realize that schizoaffective disorder is so dangerous and deadly that no one escapes it.
Wow, 1850 a month. Good point on the medical keto thing. Unfortunately it seems like if there is no profit to be made from the keto approach, even if it looks to be the most efficacious, less research will go into it because it would be hard for pharma to harness the keto diet to make money. If they really cared about peoples health, they would spend money in both directions and disregard the losses. Love your journey Lauren!
Medical keto has already been tried by companies in the United States. Billions have been made selling foods marketed towards health. I don’t think treating the schizophrenic community is something anyone would ignore if it was effective. Lauren is severely mentally ill and she has no education on this topic. Basing your opinions on this topic on someone who is claiming a diet cured her extremely severe mental illness is not a good way to approach life. I don’t doubt that she believes what she is saying. The issue is she also believes people are poisoning her food. She believes a lot of things that are not true. Just like everyone else with her disorder. That doesn’t mean these things are true. This is also a woman who chose to have children despite knowing she has a 50% chance of passing her illness on to her child. She’s not exactly a beacon of great life choices.
People in a clozapine group I am in are excited about this new drug. My son as been doing so well on clozapine for the last 5 years, I would never want to chance him becoming unstable to try a new drug when ot took him being on 13 different Antipsychotics before clozapine to get him were he is.
He did well pn Keto but at 24 it was hard to keep him on it. I wish she had your dedication and insight.
Clozapine works
I, too, am having a hard time convincing my 24 year old son to do keto. He is on Clozapine as well.
@@romaurer don't do anything stupid, clozapine is the best i have schizophrenia I am takeing clozapine i am fine enjoying life think about relapse?
My son is taking clozapine which saved his life! Now almost 3 years on CLZ and quite stable he is trying keto but his ketones levels vary a lot.... I will never risk his life to reduce meds unless he is experiencing potentiation. Even though he is not "there" I consider a win, he is losing weight and experiencing more mental clarity, energy (in his words).
I embarked on this two, and my eczema flares are subsided and lost weight
@@Gondimgondim831 be carefull
Thank you for the informative video about Cobenfy. But I feel ever since you started doing medical keto, it seems like you are very against all psychiatric drugs. I know so many people struggle to find the right medication or combination and for some people they are just med resistant but I wouldn’t be anti medication. It’s great that medical keto has improved your symptoms of schizophrenia but Sometimes it feels like you push a lot of people to do medical keto when it can be very unsafe for the individual. Many of us down have a great support system to watch out for us while coming off medication. Keto can be life threatening to some individuals with health conditions. It’s very risky for someone with diabetes (especially type 1) to go on a keto diet bc of cutting out all sugar and can result in low blood sugar or hypoglycemia. You have a great platform and a huge audience and I wouldn’t steer people the wrong way or influence them that medical keto is a “miracle” diet to help schizophrenia just like you’re saying that everyone is saying Cobenfy is a “miracle” drug but you very disagree. Saying this all with no hate, just concern.
Lauren has schizoaffective disorder. She has always been anti drugs as part of her illness means that she has delusions about people poisoning her medication. She has discussed this in the past. I fear her new obsession with medical keto has some root in her already existing delusions about medication. With this diet, she’s able to convince herself and her husband that she’s actually not delusional but just using a different therapy. The reality is that if medical keto could treat schizophrenia, everyone with it would be cured. The reality is people like Lauren are very prone to believing their delusions and of convincing others that what they believe is true. I hope for her sake that she doesn’t end up alone and on the street like so many other people with her condition that refuse to medicate themselves properly.
@ Yeah wow, I completely forgot that was one of her delusions. I remember her talking about it in a video. Now this all makes more sense. She really sweet and has a great platform to help others with schizophrenia/ schizoaffective disorder and also to help others to understand the disorder, It’s sad that she’s somewhat influencing others to try keto or that keto heals the disorder when there’s many people on medication and managing their symptoms. Others could also fall into that same delusional and go off their medication when they are doing well.
I know she seems to have a wonderful husband and hopefully her support system will notice any increasing symptoms.
Schizophrenia/schizoaffective disorder is a hard disorder to live with.
@@NormaJean951 "The reality is that if medical keto could treat schizophrenia, everyone with it would be cured." It is not as simple as you think. Schizophrenia is a complex disease. Genetics, epigenetics, the microbiome and environmental factors are different in every person living with schizophrenia. There is evidence from preclinical trials that medical keto modulates the microbiome, reduces inflammation and oxidative stress, increase ATP production in impaired mitochondria, stimulates production of new mitochondria etc.. A ketogenic diet even influences gene expression by activating genes involved in mitochondrial function, cell protection, and anti-inflammatory processes, largely through mechanisms like HDAC inhibition and DNA methylation changes. Due to these many factors, each person will respond to a ketogenic diet differently and at a different pace.
@@NormaJean951 If you are interested in the science behind medical keto, you should listen to "Bipolarcast Episode 18: Dr Dominic D'Agostino" on UA-cam by Iain Campbell who recently published in Nature Magazine. The paper might also give you some interesting information for your clinical work: "The metabolic overdrive hypothesis: hyperglycolysis and glutaminolysis in bipolar mania"
This seems a strange dodge. Instead of providing an honest video update about how it is really going after stopping meds, you are giving a "scientific critique" of a drug you don't have credentials to do credibly. It also strikes me as weirdly verbose, like a script prepared with help from a sponsor with an agenda.
Plus...I wonder why all this energy being poured into critiquing a "press release" rather than an original source if we are such a scientific whiz.
The drug is being used in this video as evil foil as a fresh peg to hawk keto irresponsibly.
Yes, this video could have been made weeks ago.
@PhoenixFeathers .A hostage video vibe!
I can understand both sides of it. I think it needs to have more transparency when it comes to the specifics of the studies and not being overly motivated if those numbers are not aligning. But I can also see the excitement towards triggering new parts of the brain in these medications as there are different classes of medications. I know when it comes to ADHD it has been incredibly difficult to find a good stimulant because I am a cardiac patient and can’t have my blood pressure or heart rate high but having hype on something that maybe a healthy diet and exercise or staying consistent in is the same alternative. We do need to be careful in clinical studies.
I'm really glad keto worked so well for you and i also totally get that medications can be really tricky and not always that effective however medication is still the safest option for most people with this disease. Not just because its the most tried and true but also because its the most sustainable. Simply put, the keto diet is simply not sustainable for many people. While i think its amazing that your channel is mainly about keto and how effective it can be for schizophrenia and how well it worked for you i think it's important that you don't present a cure-all argument for keto or kind of have a negative outlook on meds... i know you say you don't but its the vibe you give off a lot of the time and as you remember from when you were dependent on meds, it can be really dangerous for someone with this disease to go off their medication.
I don't understand how keto isn't sustainable if it is working for someone suffering with schizophrenia... I mean, the idea that you could CHANGE YOUR ENTIRE life by changing the way you eat... isn't that incredible motivating? Would the carb cravings be so great that someone would literally choose a lifetime of dangerous meds with significant side effects just so they could eat donuts and spaghetti? I can't understand your comment. A little bit of self-discipline vs. a lifetime of psych meds...
anti psychoistics coem with black box warnings for cancer and diabetes. Im not sure how you think increased risk of those diseases is the "safest for disease"
Loved this video it nicely helps inform everyone from those who can't or don't want to do keto right through to those doing keto. Felt like some of your old videos with the new more expresionate you. Well done.
Worth also noting metabolic mind did a video on drug interactions and covered cobenfy and said keto had some potentially interesting interactions with the two halves of the drug that potentially were not good but it was too early to really know yet
I’m not able to do 20 GM of carbohydrates only in a day with being a cardiac patient but I am trying to figure out how to stay in ketosis and still receive all the medical benefits that I know it has. And yes we should be focusing on underlying issues and not symptoms management.
Cherry picking EMERGENT-5 is quite shocking especially when you try to compare its PANSS score to thinks like clozapine, for example you even showed that EMERGENT-2 had a -21.2 PANSS reduction! AND EMERGENT-3 had a -20.6 reduction, very comparable to the clozapine figure you showed of a -22.
Also really EMERGENT-5 was done in mild illness with *stable symptoms* which likely tells us that Cobenfy unsurprisingly shows biggest effect in unstable symptoms and moderate-to-severe schizophrenia
Thank you, I agree with you that we should have also included a comparison of Clozapine’s baseline PANSS reduction compared to the Cobenfy baseline PANNS reductions in both Emergent-2 and Emergent-3, as well as Emergent-5 in order to give the best comparison possible. It probably is worth pointing out though, that in the Emergent-2 and Emergent-3 trials, the duration of both trials were relatively short (5-weeks), and even the placebo had fairly impressive reduction in PANSS scores, perhaps implying that the Cobenfy results were amplified by this placebo effect. This is why we also highlighted comparing the difference in PANSS score reduction between Cobenfy and placebo and between second-gen antipsychotics and placebo. (We were talking about Emergent-2 for this comparison so we did not just cherry pick Emergent-5 for our analysis.)
If we had really wanted to cherry pick data we could have compared the baseline reduction of placebo in Emergent-3 (-12.2), to the baseline reduction of Cobenfy in Emergent-5 (-5.5). Based on Emergent-2 and 3, it’s clear that Cobenfy is more meaningfully effective than placebo. However, it also points demonstrates how powerful the placebo effect can be.
@@LivingWellAfterSchizophrenia Hypochondriasis and ruminations play a big role in one's mental well being. Anxiety that comes from uncertainty of future is another one. No wonder placebo can have such effect. People who took placebo had already different mental state. More optimistic. Valis is a 1981 novel written by Philip K. Dick. It's semi autobiography. You can read about cancer and its remission in one of his friends. Any time his female friend was expecting cancer it would happen. And with a mood swing there was a remission. Those are just his claims, but autosuggestion is a powerful tool indeed. And NLP itself pops up in psychiatry textbooks.
@@LivingWellAfterSchizophrenia High placebo response rates in schizophrenia clinical trials are nothing new and nothing specific to the Cobenfy trials at all. Placebo is real and powerful, and it's WHY we include a placebo arm in these trials! To show that they are doing something more than placebo, and that's exactly what Cobenfy demonstrated.
Thank you for reporting this info.
the linking of the "placebo affect" and schizophrenia really does inform the "naturopathic medicine" industry as being a threat to those with the disorder as being predatory actors.
Thank you for a very interesting video. I haven't seen your videos in a while and was blown away that you feel so much better with this keto - thing. I don't know anything about it but now I might research. I am a schizophrenic and my medication is being changed at the moment, and now will probably ask my doctor about this Cobenfy. Hadn't heard about it before and you are right, a different mechanism is exciting. My symptoms are in control with a very small amount of medication and am wondering if this could help me in any way. I've always been prone to all the side effects that medications have. Maybe a different profile could help. We will see. But thank you for the video.
Keto has been shown to more than double cardiovascular risk.
This channel is not honest.
There ARE side effects of keto and NOT everyone benefits. I remember a video where you essentially responded to people saying they tried keto and it didn't help that they weren't doing it right, and that's the reason, vs accepting it may in fact not have a 100% success rate.....
I get you're excited. But you need to be responsible.
I think I'll have another steak
All diets have risk
And i think that keto diet have much smaller risk than taking 10 tablets od medication per day
@@paklenim9989 - I don't think @deschroma is arguing that fact. I think they are just pointing out that Lauren has unfairly presented the medical ketogenic diet as not having any negative health effects, when it might. I say might, because not everyone does keto responsibly, and poor nutrition might account for some of the poor health outcomes, versus the idea of keto in and of itself.
I think you have to remember that Lauren is very sick. No one should be using her as a reliable resource to treat mental illness. She has always had delusions about her medication being poison. This is just an extension of that.
Thanks Lauren. I love that you are always prepared ask the difficult/ controversial questions. Think that is needed especially in the Mental Health world 🌎🙏x
I would of tried cobenfy, I don't know 100% what my antipsychotic is doing to me, weight gain yes, what else who knows, I'm 6 months into keto for my schizophrenia, you helped push me there. Yea I'm getting better by the week. My first psychosis 25 years ago, and it reoccurred more times than I can count. I was completely nuts looking back. I still think in the well worn paths, the same triggers trigger. But it feels like the days coming where like someone clinically depressed realizes there not depressed anymore and they smile. I have little wins like that often. If you read this Lauren I'll put this emoji here 😉 with keto and schizophrenia, for some, there's revelations around every bend 🙂 and relief.
Thanks for the in-depth breakdown of COBENFY and its potential as a new treatment option for schizophrenia! I think it’s exciting to see the development of medications with novel mechanisms, but I wanted to share a few thoughts about some of the data comparisons in the video that might need a bit more context.
For example, when comparing COBENFY’s 5.5-point PANSS reduction in EMERGENT-5 to the 22-point reduction often seen with clozapine, it’s worth noting that these studies involved different patient populations and baseline symptom severities. Clozapine is usually prescribed for treatment-resistant cases, so those patients often have more room for symptom improvement. Do you think this difference in baselines might impact the perceived efficacy gap between the two?
Another point I found interesting was the high satisfaction rate in EMERGENT-5 (93% willing to recommend it, 78% willing to continue) despite the modest efficacy (30% saw at least a 30% reduction). I wonder if factors like COBENFY’s side effect profile or even a more subjective quality-of-life improvement might explain why so many patients were satisfied despite lower symptom reduction? It would be great to explore what’s driving that patient satisfaction.
Also, just a thought-it might help viewers to add the note about your expertise earlier in the video, especially for those who might assume there’s a research or clinical background behind the analysis. If you worked with anyone to interpret the data, a quick mention could also add useful context for viewers.
Finally, with the differences between EMERGENT-4 (69% efficacy in patients with more acute symptoms) and EMERGENT-5 (30% in a stable population), it seems like COBENFY might show more potential in acute exacerbations. I’d love to hear your thoughts on whether it might be best suited for those who don’t respond well to current meds during more symptomatic periods rather than as a blanket treatment for all schizophrenia cases.
Thanks again for shedding light on COBENFY! I think discussions like these help us look at the full picture and consider where this new treatment might fit best.
Thanks for pointing out the inconsistency of the results and the hype.
You said it right!
Best to listen to your doctor about the illness, it's a rare disease.
You were unable to obtain a master's degree, but yet you are juggling the facts and figures of medical studies in detail as if you were a specialist, presenting the latest outcome of your medical research - I get very weird vibes from that, to say the least ...
@@a.mie.533 true
It will be the same as with Valdoxan for depression. Works for some corner cases, but in a hospital setting, they will use anti-dopaminergic drugs anyways, as those are tried and true. Muscarinic receptors indirectly regulate dopaminergic pathways. Same with Valdoxan. Melatonin indirectly regulates mood. Works for some, but in general it is not going to be a wonder drug. At this time its marketing. All marketing. Real life will determine actual efficacy.
This was very helpful. Thank you! I’ve been stable on medication for over twenty years but was wondering about this drug.
at 13:06 Cobenfy shows -21.2 in total PANSS score which is comparable to Clozapine -22.0 on the PANSS
But why is cobenfy worser then clozapine?,
@@Heilungfreiheit there is not enough data to say if the one is better than the second in terms of PANSS. But so far Cobenfy has completely different side effects picture from the rest of antipsychotics.
Well done! I didn't know I needed this but have heard of/been curious about KARXT for years. This got into the nitty gritty which I wouldn't want to do and it's really insightful, Lauren! lots of good graphics and charts, not what I'm into 👋👋Thank you!!! I'm still hoping for keto to be my main line of treatment in addition to metabolic therapies, but I like how you mentioned cobenfy could be for acute situations. I don't have a good med lined up as once I'm off olanzapine, I don't want to go back. And yes, how can we make medical keto covered by insurance? SO needed!!!
Have you tried reducing olanzapine? Are you getting any good results Doing keto? Thanks
@@user-xr9db2zw7y Hello! I've done keto for about 11 months now, and it took two months to notice any benefit, and no new benefits until 2-3 months after the first benefit. I am doing great when I'm stable, as in going slower in my reduction with olanzapine. In the beginning I went quicker and well withdrawal can be awful I learned and it made me get sick easily due to a lot of insomnia. I am good currently, but I do have possibly some mild migraines so not sure what's going on b/c keto should help with that, unless I'm eating something that's bothering me. Or hormones rebalancing while lowering olanzapine. Soooo many factors could be at play so patience is key. I hope this helps
@@user-xr9db2zw7y yes! I thought I responded but I can't see it. Thanks for askinng! I've been on keto for 11 months now, started tapering olanzapine two months in. I noticed one benefit of keto after doing it for 2 months - I'd say it's been a long journey of slow progress, things get in the way like lots of withdrawal even though I taper slowly. I believe I will notice more keto benefits over time when I'm on less olanzapine. I have noticed my new benefits too but I have to taper olanzapine really slowly and once I am stable at a lower dose, I feel good, but patience is key!!! I hope this helps :)
After every video you say 'I'm not anti medication'. Yet in every video lately you criticise medication and bring up keto again. It's great something worked for you, but the majority of people are gonna stick to conventional treatments. If you really weren't anti medication you wouldn't have to keep saying it
She’s not a mental health advocate anymore. She’s a keto advocate. She’s not a true ally anymore. This is just a business.
@@PhoenixFeathers @sebastian-so1hb this is an unfair assesment of her intentions. Critical analysis of any medication is important. All reputable doctors do a review of the drug study data when they decide what to prescribe. And patients should be able to do research to properly advocate for themselves as well.
So you're pro side effects: fatty liver, tardive dysconesia, weight gain, apathy, depression.
Many people experience these and it is acceptable?
@@mgray999 it's not up to me to decide what's 'acceptable'. It's up to each individual who needs to weigh the risks and consider their own health. For many people mental health conditions can make life unbareable and some side effects are worth an improved quality of life. Also you're acting like keto or any metabolic intervention has no risks....
@@Propa_jo and they should advocate for themselves and understand the potential risk and BENEFITS of any medical intervention. However, just because you've decided that a treatment isn't appropriate for you, doesn't mean you get to go on the internet and criticise everyone else for trying to take care of their own health in a way that they feel is appropriate.
I got skitzophenia when I was about 21, and I still got *ALL* my wisdom teeth. I take olanzapine 5 -20mg depending on environmental energy from people. I like keto diet.
I love when you do deep dive video in papers and research and such! Making it more digestible to public. Please do more!!
If nothing else, hopefully this leads other pharmeceutical companies to try and make schizo drugs that use novel mechanisms of action, rather than just slightly tweaking what already exists.
i think they would recommend it to people since their previous experiences on antipsychotics have much more intense symptoms so ofc the efficacy wasn’t there for some but i think their point in recommendation is it being a tolerable med
Brilliant work. Great Communicator. TY
I just recently started this medication and let me tell you it is…different. Now I have tried literally every antipsychotic there is, so this drug looked promising for me. The first morning I took it it felt like I was really drunk. I was stumbling around and had the strangest sensation in my head BUT the voices were not there. Idk it does feel really strange. Anyways I also noticed that my movement disorder has improved and now I can say I think they’re almost gone. I’ve also lost 12 pounds. If you can try this medication do it!
Do you know if any of the studies have broken down the results into the positive and negative symptom scales? Maybe even though overall efficacy isn't that different to other antipsychotics, if it has a better effect on negative symptoms, then that could explain why most people who tried it want to keep taking it? It's just a hypothesis but I think an interesting one to explore
It's effin expensive! Cost is 1600/1800 a month? GEEEEEEEZZZ!
Brand name is always more expensive, especially until they age until generics are available.
thank you ❤
You are extraordinary
My understanding is that Caplyta works on Glutamine pathways, so that's another exciting new pathway?
Can it be added to other antipsychotic meds or do you need to pick one or the other?
She is not qualified to tell if one can take it with other meds
Do you have to have schizophrenia to diagnose someone with it?
No, not at all.
Metabolic therapies also have very equivocal evidence of benefit.
The idea of targeting acetylcholine is as old as antipsychotics and goes right back to chlorpromazine. Most of the interest came not from chlorpromazine but the observation that chronic cases of schizophrenia and manic depression seemed to benefit from smoking and the patients themselves could not be separated from their cigarettes. Of course these are muscarinic and not nicotinic receptors in this case. Part of the benefit of smoking may have been in reduction of side effects and a reduction in the amount of antipsychotic.
i am very afraid about medications and other interventions... because I had to use adult diapers because of medication once... allergies to medication and had a severe headache with another one and another time I was sleeping too much like 1% of people have that and I did. It is nice that there is scientists trying to help and doctors also and everyone has their own reactions but still everything is a risk we never know... of course, drugs can help but is not everything I feel like when I changed my lifestyle I improved so much. It is sum of of intervention meds in the begining, spirituality, diet, and meaning/beliefs.
You’re not a mental health advocate. You’re a keto advocate. It’s different.
So what do you hope to achieve from all the 23 so far comments that have been from a place of not being nice. What would you like from Lauren so you can move on.
@@amandasmith6342You counted? My issue is: accountability. This channel isn’t accountable to anyone. What if there’s a relapse and because keto “cured” the illness, the relapse is covered up? The channel isn’t a reliable/ safe source for people w/ mental illness. Thanks!
Lauren would like to know what's medical keto
Hey Lauren wanted to kindly know is this new medicine available in Africa specifically uganda.
it is not. sadly. us is always first. i hope you will receive it.
Makes sense
I think it’s important to mention that if you’re on this new two component medication that if you decide to do keto while on it , it will affect the efficiency of the medication. It lowers the component that helps with symptoms by 30% and the other component that helps with side effects by 70%. So, idk is this new medication worth it. You will kinda be stuck on it for the rest of your life.
I'm schizophrenic, and so am I.
Its good that you, as biggest channel about schizophrenia and mental ilnessess, showing keto and diets as possible alternative treatment.
hi iam 16 years old i have never in my life have gone to a psychiatrist to check my symptoms out .But i have hallucination most of the time in night time some random shadow figures pop up in front of my eyes which are identical to human figure every figure i see scares the shit out of me and also i always take a night shower before sleeping i hear my mum or my dad or any relatable persons voice screaming or calling my name. I also see some random object in the day time today i saw a peach or a plum on my work desk. SHOULD I JUST GET A APPOINTMENT PLEASE TELL ME ANYONE.
Hi, I work in mental health. You absolutely need to make an appointment. Are you using any drugs at the moment? Please get in touch see someone asap.
definitely tell your parents what you're experiencing and have them make an appointment with a psychiatrist or get your primary care doctor refer you to one. You're going to be okay, but you do need help
As a mental health provider, absolutely yes see a psychiatrist/psych NP
You are ONE person who believes keto works for them. That’s great. But why make this into a ketovangelical channel? Why not just live your life? Why the need to push this as THE cure? Is it money? 💰 For you to be believably unbiased you’d have to give us the info on who pays you for your influencing. Now I strongly suspect some organisation is filling your pockets nicely.
With over 300k subscribed and millions of views on their "popular videos" along with merchandise and sign up fees ...who needs monetary collaboration? They're making some good cash flow! Rather the Metobolic Minds need them (her and husband, this is a joint effort, I wonder if he's in video production?)
I've noticed that a lot of "professional vlogs" aka money makers, all include these cut and paste hype visuals. All of them. It's like watching the news. And the most of them are repeated content, over and over again, before they get to the point. The business of vlogging and the visual stimulation that goes with it to hook people in (always the ads) it's a form of click baiting. Every click is a penny earned. And on this topic? Wow. I see it as a form of exploiting mental illness for profit, the easy cheesy way.youtube channel vlogs.
If they have 300 subscribed (I think she mentioned that detail at the metabolic mind meeting) at $5 month ... just that alone equals $1500 a month, every month. And you know how all those "little subscriptions" keep paying on auto pay and people don't unsubscribe. Lol they have made "talking about schizophrenia" into a very substantial income.
@@Candace-u6lI agree completely - however why then change the name of the channel to exclude the click-bait term schizophrenia? Now it’s ‘just’ ~ Lauren Kennedy, and she’s cured herself with keto ~ kind of thing. How long is that going to interest her followers, many of whom subscribed because of earlier more relatable content?
Maybe for legal reasons, pertaining to their business name? Liability? Claiming insanity lol personally may legally keep you out of the liability circle@@PhoenixFeathers
Lauren what it often boils down to is drug companies making money, there is no profit in medical Keto for drug companies!! Sad but my guess is likely true. Medical Keto may not work for everyone so yes new drugs are needed.
🛎️ 🛎️ 🛎️
weren't the phenothiazines anti-cholinergic
Enjoyed this. 😊
Hi my brother is suffering from schizophrenia for 10 years. As of now no improvement. Can he live normal life like us? I’m from india
keto genic diet. look and find info on it. However in india you dont eat meat products?
Not knowing anything about what mental health services are available in India to know what drugs or therapies are offered I would suggest the ketogenic diet check out Dr Chris Palmers book Brain Energy or Dr Georgia Ede book change your diet change your mind. Aim to lower carbs and achieve ketones ideally above 1.5mmol/ltr of blood. This is what Lauren has been doing to amazing effect. I hope these books are available to you in India
get your brother on antipsychotic medication and stable before considering keto. the right medicine can help him live a normal life again much faster and then you can consider keto down the line once he's doing well
@@shainassights6237 my wife spent 8.5 years find the "right" combination of antidepressants, antipsychotics and mood stabilisers and certainly wasn't living a normal life on them. Yes reduced suicidality and marginally less psychosis but blunting, brain fog, weight gain, dysfunction, tremors, polydipsia and skin conditions when not good side effects. 3 days into measured ketosis and we could see huge potential, 8 months on and the change is incredible not only in her but her drug combinations and there side effects. Mood stabilisers halved below therapeutic dose and still lowering. Antipsychotic dropped by a third and will continue once the other has gone. I expect this persons brother has tried everything India has to offer except keto so I know what I would try
@@jeanpaultongeren125 India eats meat, tandoori yum yum. Keto is not a high protein diet anyway and can be done as a vegetarian too.
More vlogs please
Youre biased with your medical keto!
@ thats not the point. She’s highly biased
@ because by the end of the review she heavily promototes keto diet for a ‘cure’ and therefore has an agenda. Its the same thing as seeing who sponsors a trial in research. If you know a thing or two about science you Will also see that she is heavily biased. I studied research!
Good luck with your meds!!
@@theangriestoftabbies Im doing perfectly fine on Them
Succes comes with haters
I bet if you actually tried it, you would actually like it and maybe know what you're talking about. Being a carnivore didn't fix you and it's not going to fix us. Of course you don't like it. Just as you were figuring out your Keto, something that actually helped came out.
She is severely mentally ill. Let’s not be too hard on her. She truly isn’t capable of understanding she’s wrong. I blame her husband a lot more. He is of sound mind and not only going along with all of this but also exposing his children to her illness despite the many psychotic episodes. I feel the most for that baby. Why would you have a baby knowing you are this sick?
Whether you like it or not future therapies that treat the root cause of schizophrenia will be about metabolic health. There is so much evidence in preclinical data. Watch "Can the Keto Diet Help Bipolar Disorder & Schizophrenia?" by Dr. Tracey Marks, who explains the most important points.
I would be hard pressed to try it because clozapine is already extremely effective.
The issue is Clozapine's tolerability.
Clozapine could cause major side effects and other health issues and extreme tiredness, so karxt/cobenfy might be a option to try, and so would medical diet Keto.
Clozapine is great! The issue is FDA's Clozapine REMS and the outdated views of this 30yrs+ medication.
Are you being sponsored by a metabolic company, Lauren?
Placebo wins
Is this another dopamine antagonist?
No, Cobenfy acts on muscarinic receptors of the cholinergic system. Xanomeline addresses the antipsychotic symptoms as an M1/M4 muscarinic receptor agonist.
@OfficialRogue whereas every other medication on the shelf is a muscarinic receptor antagonist, this one is an agonist like mescaline lol what could go wrong?
@@doramc3155 Mescaline is a serotonergic psychedelic, which mainly works as a nonselective serotonin receptor agonist. Mescaline is not a muscarinic receptor agonist, so the two are completely different.
I think we gonna find out soon who bought Lauren out 🎉🎉🎉
😂😂😂
Hi Lauren, thanks for the informative video!! Being from Australia, I actually haven't heard of Cobenfy. But it's really interesting to hear their findings. I wonder what the combined effect of a dopamine affecting antipsychotic and this cholinergic one would be like?
Hiya Lauren, sending some love your way, there's a lot of kinda shitty comments on here and they seem to go a bit beyond just concerned criticism. Hope you are doin okay with it all. Much love
Working with Nature can help heal Schizophrenia
Well, if that was the case, we wouldn't need medication now, would we?
Maybe you are telling the truth to the people.
every time they come up with some "new treatment," I sigh. I've tried newer antipsychotics, and they did horrible things to me and my body. The perphenazine has been tried and neither of us are dead.
Meanwhile, metabolic therapy has not done half of this. Look, I am really happy for you but you often talk about Keto as a game changer like as "they" talk about Cobenfy.
...How can you have diarrhea AND constipation???
Hahaha Keto comes out and there like " quick send out a new schizo miracle drug we've been working on!"
Except that medical keto has already been tried. If it was effective we wouldn’t have any more people suffering from schizophrenia. The reality is that this diet doesn’t work for everyone. We don’t even know if it actually works for Lauren. She has severe mental illness and she believes a lot of things that aren’t true.
I fast forwarded through much of her presentation and listened for about 2 minutes total...she made some good points...basically, results are not in...
I think unfortunately the results are in - Bristol Myers Squibb shared the results of their two latest 52 week trials (what I talk about in this video) that give a fairly decent picture of efficacy. What hasn't been done yet, are studies directly comparing Cobenfy to other antipsychotics - which of course would be helpful.
Theyre just cashing in on the side effect relief...
Sounds like a lot of jarken
jargon, dear, jargon!
As long as it isn't zyprexa😱😈😶
SchizoKitzo was faster than you, Lauren. ;P Yet yours is more in depth. Plus, let's not forget that FDA approved mRNA as well. I recommend Dr Campbell's channel, where he goes through medical papers considering this topic. Dr Raszek from Merogenomics uploaded recently a video about depression. He's another positive freak, when it comes to "how it works". PS. Are you planning a colab with Stephen by any chance? PS. S. It's 78% from 82% that started the trial. Which is 63,96% ;) That's how you play with numbers. They are good at selling stuff.
Hey Lauren can you tell everyone what medicine you are taking for your schizoaffective disorder. That is if you are willing to. On my channel I talk about the medicine I am on with Schizoaffective Disorder thanks. Have a great day.
overhyped. It gets the conversation going in science and psychiatry for better treatments. this condition has been being studied for 300+ years and these people have been abandoned and mistreated. It is a symbolic drug that opens the door to better treatments.
schizophrenia is one of the worst diseases. and they just never find out about the etiological mechanisms behind it. its sad. almost everywhere else there is more progress. its just horrible
@@maxaffe3195 it is mitochondrial. Science continues to think they can solve these things by popping pills
are u ever gonna try it and let us know how it affects you?
I doubt it. She found her miracle cure.
Honestly, probably not. I was stable on the antipsychotic I took previously and so would probably use that if I ever need medication in an acute episode again. Reminder though, that medications affect everyone differently anyway. (But also, 30% of people getting a 30% reduction in symptoms doesn't sound particularly enticing to me).
@@LivingWellAfterSchizophrenia what medication did u find most helpful for schizophrenia if its ok to ask
Why not share which meds you were taking
PANNS is a subjective tool