Paraneoplastic Syndromes - Cancers - Neoplasia (Tumors) - Pathology Series

Paraneoplastic Syndromes - Cancers - Neoplasia - Pathology Series.
Paraneoplastic syndromes (cancer-associated symptoms and signs) include nephrotic syndrome, superficial migratory thrombophlebitis (Trosseau syndrome), increase secretion of erythropoietin (EPO) which causes erythrocytosis (polycythemia), increased secretion of parathyroid hormone-related peptide (PTHrP) which causes elevated serum calcium (hypercalcemia), antidiuretic hormone (ADH) elevation causing SIADH with hyponatremia (low serum sodium concentration) causing mental status abnormalities, elevated ACTH (causing Cushing syndrome and hyperglycemia), Lambert-Eaton myasthenic syndrome (LEMS).
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[@Callmetheblackout]

00:27 🩺 Neoplastic syndromes occur alongside cancer and present as a set of synchronized manifestations.
06:00 🩸 Renal cell carcinoma can cause blood in urine (hematuria), and anatomical correlations can lead to left-sided varicocele due to metastasis to the left renal vein.
11:38 📈 Paraneoplastic syndrome associated with renal cell carcinoma includes inappropriate secretion of erythropoietin leading to absolute polycythemia.
12:45 💊 Renal cell carcinoma can secrete parathyroid hormone-related peptide causing hypercalcemia and liver enzymes, mimicking liver function, due to the kidney's metabolic activities.
16:34 💡 Small cell lung cancer can secrete various hormones causing Cushing's syndrome, SIADH leading to hyponatremia, and paraneoplastic hypertrophic osteoarthropathy.
19:04 🦠 Pancreatic cancer may lead to paraneoplastic syndromes such as migratory thrombophlebitis and nonbacterial thrombotic endocarditis.
20:43 🌟 Lésar sign, characterized by sudden eruption of multiple seborrheic keratoses, can be indicative of underlying gastrointestinal malignancies like stomach or colon cancer.
21:51 💡 Various paraneoplastic syndromes exist, aiding in the diagnosis of cancer before other methods.
22:16 🩸 Paraneoplastic syndromes include migratory thrombosis (Trousseau syndrome), Sister Mary Joseph nodule, acanthosis nigricans, and more, which can serve as clues to underlying malignancies.
23:38 🧬 Pre-neoplastic syndrome precedes the development of cancer and may warrant further exploration in a separate video.

[@spiggs2182]

Acantho means spine or thorn. It derives from the skin's spinous/prickle layer.

[@humairaemma3701]

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[@MedicosisPerfectionalis]

Thank you so much!
Welcome back!

[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

Thank you!

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Great video

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hi medicosis ..would I list videos according to systems think would be helpful on searching

[@MedicosisPerfectionalis]

I have a separate playlist for each system: (e.g. cardiology, nephrology, neurology, endocrinology, immunology, gastroenterology,…etc).

[@waelfadlallah8939]

It's worth noting that paraneoplastic signs are not a common finding for malignancy suspicion since they occur as little as 40% in all cancer patients. So, only the presence of tumor with damage to its surrounding displays the first sign of malignancy

[@ragaeeramzy7432]

Very nice❤

[@MedicosisPerfectionalis]

Many many thanks!

[@Mohamedyassin08]

Other cancer secrete high EPO is hepatocellular carcinoma

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