Multiple Myeloma - Malignancy of Plasma Cells - Bone marrow - Hematology & Oncology
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- Опубліковано 31 тра 2024
- Multiple Myeloma - Malignancy of Plasma Cells - Bone marrow - Hematology & Oncology
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►👨🏫💊Antibiotics Lectures: www.medicosisperfectionalis.c... ... Check out my brand new "Electrolytes" course at www.medicosisperfectionalis.c... and use the PROMO code: ELECTROLYTES50 to get a 50% discount. Multiple myeloma is a plasma cell dyscrasia.
Multiple myeloma (MM) is characterized by the overproduction of plasma cells.
Bone marrow fibroblasts, as well as myeloma cells, produce interleukin-6 (IL-6) which stimulates osteoclasts to break down bones, that's why bone pain is the most common symptom in multiple myeloma.
Since osteoblasts were not stimulated:-
1) Nuclear bone scans are useless to diagnose multiple myeloma.
2) Alkaline phosphatase (ALP) will NOT be elevated.
The anemia in multiple myeloma is normocytic normochromic (normal mean corpuscular volume "MCV").
Neurological symptoms include neuropathy as well as radiculopathy.
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I can definitely say this is the best series on hematology in the entire Universe. THANK YOU VERY MUCH. Love from Nepal.❤
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@@MedicosisPerfectionalis can u do a video if someone's cbc w diff and CMP is all normal. ... yet their NRBC is 1 ... normal is 0 so its considered HIGH. your thoughts...? Thanks
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1. Due to hypercalcemia fatigue,weakness including bone pain
2. Infection mostly bacterial
3. Pneumonia ,uti, pharyngities etc
4. Ecoli,staph,step,kleb
5. Ecoli
6. Normal bec no osteoblast activation
7. Due to acidosis anion gap is low
1. Bone pain
2. Bacterial infection
3. Uti and pneumonia
4. Staph, strep, ecoli, klebsiella
5. Ecoli staph?
6. Normal
7. High anion gap?
Thank you so much!!!
I guess normal AG, because it causes RTA (a normal serum AG acidosis).
Anion Gap is decreased.
Anion gap is usually low in multiple myeloma
Thank you for placing this in order.
"In addition to displacement of sodium-containing water from serum by large amounts of non-sodium-containing paraproteins, some paraproteins (eg, IgG in multiple myeloma) can have a net positive charge at physiological pH. This leads to an increase in unmeasured cations and a low anion gap"
the most powerful lecture about multiple myeloma on youtube platform
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I was admitted 4 days ago to the hospital. Diagnosis Multiple Myeloms. Tuesday my bone marrow biopsy test will provide more information. I watched the entire video, will watch every video in your library related. Im am so grateful for your documentation.
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1. Bone fracture
2. renal problems ?
3. bacteria infections as pneumonia
4. staph ; strepto ....
6. ALP = normal
7. anion gap = is decreased
Thank you for your videos, your channel is very helpful !
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My videos are on UA-cam, but the illustrations that are used for them are available on www.patreon.com/medicosis/ organized in pdf forms...I would be happy to give them to you 😊...Thanks!
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I have a question though you said we get proteinaceous tubular casts which may consist of albumin in the cast in urine but then in the bullet point u said glomerular function is nearly normal thus no albuminuria. care to explain?
hi, can you elaborate more why ALP is unaffected in MM?
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) Which of the following cytokines is intermediate in the pathogenesis of MM ? IL6 OR IL1? I HAVE Exam please reply?
Thank You from Iran
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1. Bone pain
2. Infections
3. Bacterial infections ( Staph, E Coli, Klebsiella)
4. Staphylococcus Aureus 🤔
5. UTI - e.coli
6. Increased
The answers are posted in the next video in the series.
@@MedicosisPerfectionalis gotcha
👍👍
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Are lymphocytes elevated in multiple myeloma?
I have a question that why only light chain get excreted not the heavy chain bcozz of bigger size?? Plzz tell
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