Can we do better? Oral contraceptives.
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- Опубліковано 29 чер 2024
- "The reproductive processes are among the most complicated and delicate found in the animal world, and there are numerous stages at which it should be possible to interfere simply and effectively with the sequence of events without harm to either partner."
So, why is the pill only for women right now and will ever see that change?? Well, the development of the birth control pill was a defining moment in human history. It allowed women to control their reproductive health and have greater control over their lives. The pill, as we know it today, is a hormonal oral contraceptive that prevents ovulation and pregnancy. But the history of birth control is long and complex, rooted in cultural, social, and political issues and the serendipitous nature of scientific research with the availability of new chemical substances. Somewhat conveniently, the last two books I’ve read have covered the history of biological research revolving around sex and hormones, and a book about the discovery and commercialisation of the Pill. In fact, the opening quote i used was taken this book i recently read called “Sex, Science and Society” by A.S.Parkes. The other book is “This Man’s Pill” by Carl Djerassi.
So, by blending these books with my extra reading and humour, together we’ll go from the history to the present to some thoughts on the future of how reproductive control can be most effectively managed - can we do better? and see current work looking for a Pill for men? These features a conversation with CEO of YourChoice Therpeutics, Akash Bakshi.
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Timestamps:
Intro - 00:00
Origin of The Pill - 00:30
Male contraceptives - 06:00
Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed. - Наука та технологія
This video took me a long long long time to make, purely as I spent some much time (and still do) thinking out this topic. It also to me still seems like a controversial/taboo topic so am willing to hear other thoughts and experiences! And of course, hope you enjoy it!!
One thing I've realized about contraception and many other things that ended up revolutionizing human health and lifestyle is that they always seem controversial at first. So very, very sad that Mr. Haeberlandt ended up taking his own life; his contributions were massive and he should have gotten the praise he deserved. Very much looking forward to the development of a male contraceptive!
This was very interesting. Eleanor is the BOMB; she Blows It Up Everytime. Big Ups and Respect.
You are an amazing influencer in this field. I hope you continue to explore curiosities beyond aging research. I learn a lot from you about what I should be and do. Your intellectual openness reminds me of the importance of neural plasticity. きみは最高の先生😊
So I think the big questions would be…
does the male pill have life-extending and health benefits like castration has been shown to have?
Are the effects reversible?
How quickly can it take effect and how quickly can it be reversed?
Does it have an effect on libido?
If it does, that would limit its usefulness, although I could still see a place for it.
Does it have any influence on the expression of male traits like muscularity or aggressiveness or hairy-ness, etc?
If it does, that could restrict (or expand) its usefulness.
I’m thinking about some of these questions, because even though it isn’t a hormone, and isn’t acting on a hormone receptor, it might still interact with the body’s hormonal state.
I know I would proceed with caution, but a lot could be learned, and it could be useful, even if the outcome isn’t what is hoped/planned.
Good luck on this research!
This topic is absolutely fascinating. The creation of new contraceptives, that are more effective, safer, and cheaper could be very beneficial to many people. I am especially hopeful for the creation of male bodied contraceptives.
they are more successful in creating infertility pills or anti-erectile pills, antidepressants among them. Who funds pssd solution, ah?
wow!! eleanor is my ideal person to be. i wanna be like u seriously. i will work harder on learning!! keep going
I just recently read an article about the role of retinol in stem cell differentiation in hair follicles. Apparently the stem cells can be either hair follicle stem cells or skin stem cells, and they can de-differentiate to switch roles as needed, but it is dependent on retinol level, and presumably a retinol (aka vitamin A) receptor.
If this is also involved in the pathway for spermatogenesis, then vitamin A probably has a role in a lot of stem cell differentiation.
It was also involved in cancer cell development (not surprising due to its relationship with stem cell differentiation).
But it seems like there is a whole lot left to learn in this area. It would be very interesting if research into this male pill also leads to better understanding of these stem cell processes throughout the body.