I am a recently retired male NP, and my wife is near retirement from her career as an OR RN. Our oldest daughter, an elementary school principal, developed triple -ve invasive ductal CA two years ago. She had surgery, chemo, and radiation therapy. She is back to work and doing well. As a NP I diagnosed several women with breast CA, as well as cervical disease. I continue to research literature about triple -ve disease, and are encouraged by health care colleagues who share their personal experience with breast CA. Your expertise and personal experience is so important to share with patients and families who are going through this process. I will follow your progress and look forward to learning more about this disease. You have my best regards and respect for your work. Take care and know that there are many who will benefit from your journey. Take good care of yourself.
@ChrisDWXX I'm so sorry to hear that about your mom, I thought the worst when we initially got the news but did my best to stay strong for her and have been doing all I can to be strong for my mom and encourage her as well so thank you for the reply, my mom is actually doing very well, she went through and finished her chemo which was pretty rough but then had to wait a few weeks for her immune system to strengthen afterwards for her surgery and that's what we're waiting on now but I do pray and hope the best for your mom!! 🙏🏾🙏🏾🙏🏾
@RocStone thank you so much for your kind reply I wish you the best as well. It's interesting to hear from someone else in a similar position. When she was first told it's breast cancer everyone said oh u will be fine it's very highly treatable. Now we know it's triple negative so I looked into it and I was not surprised but concerned. My mother doesn't know what I have read about it. I'm just still hoping it's highly treatable and the majority of people come through this ok ??
@@ChrisDWXX You're most definitely welcome, I would like to believe anyone who loves their parent would do the same and you are wise to not panic but instead gather information and research it's a hard pill to swallow when you find out but I, as I'm sure you are doing the same, have just tried to be strong for my mom remembering what she has gone through raising us, there was no question on what I and my siblings had to do and that is do our best, care and love our mother no matter how difficult it may be so I know that you can get through it because it's scary and discouraging but it's not a death sentence so my advice to you is continue to be diligent in your research and always do your best to be strong for your mom 🙏🏾
It's nearly three years since I was diagnosed with TNBC. My treatment plan was chemotherapy, lumpectomy, radiation therapy and carboplatin. My tumour turned out to be chemo resistant so my chemo was stopped and I was rushed in for a mastectomy. Thankfully it was localised. I continued with the rest of my treatment plan. I also had two reconstructive surgeries and need to have one more as the result was not satisfactory. I am a recently subscriber and so happy I came across your channel, your information is invaluable thank you.
@DrLizORiordan how would one know if their cancer is resistant to the chemo? I wasn't diagnosed triple negative until after the cancer was removed. Why should I now receive chemo for something that may not exist, and may be chemo resistant.
@@ASH-T786 After my first round of chemo, I had an examination and a scan, my tumour had nearly doubled in size. Oncology decided to proceed with my 2nd course but it was still increasing. I could feel and see the changes it was happening so fast. Therefore I was told my tumour wasn't responding to chemo (chemo resistant). The 2nd course was stopped immediately and I had a mastectomy.
@@wendaoosterbroek1162 I am completely horrified on your part. 😢 I wish the very best for you. I have Triple negative BC as well but mine is responding to chemo.
I was diagnosed with tnbc in June 2020 , I’d just turned 50 . I had lumpectomy , followed by 4 rounds of chemo - docetaxel and cyclophosphamide…. Then a month of radiotherapy, including 4 boosters at the end of. Such a scary type of breast cancer . Thank you for such an interesting video , wishing you good health
I had TNBC I was diagnosed at age 48 in Dec 2022, I had 2 tumours a 1cm tumour and the big daddy a 12cm Tumour, I started treatment consisting of Carboplatin, Paclitaxel and pembrolizumab in Feb 2023 all 3 at once was 1 cycle and a cycle would be every 3 weeks, the weeks in between that I would just have Paclitaxel. Despite some hurdles along the way including emergency surgery for a perforated bowel, 2 weeks later after restarting treatment by the end of May I received the news that I had a Positive Clinical Response. The 1cm tumour had completely disappeared and the 12cm tumour had shrunk to less than a centimetre. I had a mastectomy in July 2023 with a tissue expander, and a year later yesterday in fact I had the second stage of my surgery, and I'm currently recovering at home as I type, I had the expander exchanged for an implant and in my opposite breast I had a reduction. Im just praying that after I recover I can finally get my life back and I certainly wont take a second minute for granted ever again.
my Oncologist discontinued my pembro after having severe allergies-rashes.. until then, my tumor shrink.. but by the time my onco changed my regimen, my tumor continues to grow, and i'm worried..
@@lalalaflor5280 I can only imagine how worried and frustrated you must feel right now. But please remember that you're not alone in this-so many of us have faced setbacks during treatment, and I want you to know that progress isn't always a straight line. Your body has already shown that it can respond, and with your oncologist adjusting your treatment, there's still hope for more progress. Stay strong and focus on each step forward, no matter how small. Take care of yourself, lean on your support system, and never lose sight of the fight within you. You’ve come this far, and that says so much about your strength. Sending you love and positive energy. 💕
Thank you Dr. I was first diagnosed with Her2 positive, when through all the treatment, surgery, docitaxel, EC and then phesgo (herceptin injections). I thought I was ok and starting to live my life but then a few months later discovered a lump under my collar major bone, it was triple negative, PD1 negative, had lumpectomy, they could remove all the tumour as was near blood vessels. I had chemo, carboplatin and paclitaxel. On pet ct, it showed I was responding well, then another follow up, it showed I had progression. My world shattered there, my oncologist recommended trodelvy as my cancer was in chest wall, axilla. I didn’t want any more chemo so hubby and I decided on radiotherapy. Oncologist mentioned that radiotherapy will not get rid of the cancer. I didn’t care as I wanted to have a family holiday. I did radiotherapy. I had ct snd showed stable, had a pet ct after a month and it showed complete metabolic response. I was so shocked. Oncologist said it’s good news. You are NEAD. I now have a scan end of October, I am nervous but keeping positive. I am not sure if my fasting helped. Sorry for the long comments.
Good luck I am currently having chemo for her2 positive breast cancer 4/6 done Hate the side effects with passion 😢😢 icing on top picked covid from my last chemo session
Thank you. I had adenoid cystic carcinoma of breast with a local recurrance 20 years later which was excised from reconstructed breast. Triple neg. Diagnosed at 36 now in my 60s
Thank you for taking the time to share these important information for us whoa are diagnosed with breast cancer. It’s a scary, overwhelming, and filled with emotions. Equipped with the necessary information makes it less scary.
I have learned a lot about breast cancer thanks to your videos and my wife's oncologist. Now I can understand and help my wife more and also share the information with more women than I know Thank you. I always have you in my prayers. You are making the Difference in our lives!
Thank you Dr I would be really grateful for an in-depth video for Inflammatory Breast Cancer please. I am HER2 and Er positive I had Neo-adjuvant chemo Carboplatin and Docetaxel and Phesgo injections but only had a partial response. Had masectomy and radiotherapy and now I have just started Kadcyla as high risk of it coming back
Thank you so much for your video. I have TNBC in my right breast and weak ER+ in my left 20% ER+. Dr advised I was being treated as if both were TNBC. I have been using ovestin cream, with my left being weak ER+? Is this ok? 6:01 PS writing this from my hospital bed following bilateral mastectomy yesterday and feeling great.
I have triple negative breast cancer stage 3 I already did the taxol and carb and keytruda. It didn’t shrink made it softer now there changing to red devil and coxyonan
Your cancer sounds like mine in that it didn't shrink but made it "less avid" according to my breast MRI after completing the carbo/taxol/keytruda. I also just started A/C/keytruda and I'm hoping for a complete pathological response, and I hope the same for you💝. I am 67 and stage 2.
Hi Dr Liz, I have TNBC treated three years ago, I have just found a large lump in the same breast as the primary. I was wondering if I would be able to get Keytruda as I also have MS. Thanks for all your work. Yvonne.
Have a relative that hasn't been diagnosed, but got the strange raw , open sore rash under the breast . I recommended coconut oil and the rash quickly healed and disappeared. She has had flare ups over the years and same treatment and disappears in 2 to 3 days. We had never heard of TNBC , but I imagine if she had gone for medical help it may have ended with invasive intervention.
So, I have been diagnosed with TNBC but did not receive the diagnosis until after lumpectomy and lymphnode surgery. Biopsy acquired 4 samples and at that time was reported as weak er+, pr-, her2-. After surgery it was reclassified as triple negative. So, I did not have neoadjuvant chemo. Tumor was 6mm, nodes negative, clear margins. If all cancer is gone and never traveled to lymph nodes, why do I need chemo?
I would be so grateful if you could help me with the following question. I have just finished 8 rounds of chemotherapy for triple negative breast cancer. My oncologist and surgeon have said that I dont qualify for Olaparib due to my tumour being smaller than 2cm. I am BRAC2. I am so scared about reoccurrence. Even though my cancer was considered small, would I still benefit from taking Olaparib? Would this help reduce my chances of reoccurrence? I am 31 with 2 young babies and petrified, now my treatment has ended.
Hello and thank you for your clear explanation! It's really helpful. If I may, I have the Ki67 of 90% and did not CPR after the chemo treatment. Got about 3mm lump of cancer cells left over in my left breast. From your experience, is there a big chance of having a metastasis soon enough? I'm 43. Thank you in advance. Warm greetings from Poland. Basia 😊
Thank you for posting this. I haven’t through red devil and then taxol. There is still something there on the MRI and I have surgery this week. I am stage IB but my KI 67 score is 70-80%. I am reading that I still have a high chance of recurrence even if I experience pCR, is that true? I am scared, appreciate any information you can share.
6 cycles of chemo finished. docetaxel and carboplatin last MARCH 15 by the way i am triple negative breast cancer frozen surgery done. last june 2024 tumor markers are negative thank God. at present no meds at all from my ONCO. what are my chances to full recovery? thanks
Thank you so much your videos are very good! I hope you are feeling ok now ? I am TNBC had 14 months treatment 6 months chemo x2 surgeries and then 6 months oral chemo ( as the IV chemo only shrunk my breast tumour by a third) and during this time 12 months of IV Keytruda ( Penbro ), and 3 weeks of radiation !- my first surgery showed 2 dots had spread into my sentinel nodes so they re operated again and did an axillary clearance which was clear but of course that was the worst op to recover from - can you do a pod cast on that - the risk of Lymphodema, cording, aching arm due to nerves being cut ? I also only had a lumpectomy as BRCA gene negative but scared maybe I should have had a double mastectomy ? Guess I could still ?
Thank you so much for this - I’ve completed my active treatment for TNBC a year ago & am now on zoledronic acid for 3 years. My question regards my daughter & 2 granddaughters as I’m 69 years old& therefore wasn’t given the Brach gene test. As I don’t fit the first 2 criteria for TNBC does this mean my daughter & granddaughters should be tested/monitored? My daughter is 42 & granddaughters 12 & 10. Many thanks
Hello dr. My sister has stage 4 tnbc and it has spread to her skin. This is the 3rd video ive commenting on of yours looking for help. It is spreading like wildfire and shes doing taxol and immunotherapy..
❤❤❤ Faith !! Believe and RECEIVE it, which allows the body to release the Healing hormones in addition to the nutrients and treatments. 2nd round of Chemo for me for Triple Negative Breast Cancer, things are looking up. Keep yourself in the most Positive space as possible, voiding out the horrible, negative background noises of folks's negative energy. There are even some family members that we may have to love from a distance while we are trying to heal. Forgive the harm that some folks may have brought against us the best we can, so that the negative energy is not blocking our healing. My deepest sincere wishes and prayers 🙏 for all that are battling this Horrible, Demonic disease.
Thank you for sharing and being so encouraging❤️ I was diagnosed recently and I am opting to not share this news with some family only a handful of people know because sadly enough not everyone will care. With God and my son by my side I know I will get through this in Jesus Name🙏 Wishing you a speedy and full recovery! Blessings🙌
my tumor continues to grow. Im on my 4th cylce. my regimen are docetaxel and cyclophosphamide. Y does it still continues to grow even while im on chemo Doc?
And I am only 48 I was diagnosed at 47 4 months after my biopsy nonone got hold of me till 4 months after. So I never knew I had it for 4 months and it was 1.1 com grew in that matter of 3cm
Thanks for your videos about breast cancer - very useful. I was diagnosed with TNBC this year. You don't mention in your video the Keynote 522 protocol which I believe should be used for TNBC - which fortunately for me includes Immunotherapy from the beginning of treatment, having been cleared by NICE late last year? I have completed the chemotherapy regime and because it (and immuno) were so effective only needed a lumpectomy and 3 lymph nodes removing, so avoided mastectomy or even double mastectomy. Hoping to get PCR when results come back. Radiotherapy to follow. Don't know my BRCA status as it seems the service is very behind - my appointment is late October, this all started in February!!! If there is something there it may require further surgery. From my readings there is also something called Capecitabine which many people are prescribed if there is any residual cancer cells? I'm not sure if your video needs to be updated to include these 2 things? (Keynote 522 and Cape) Many thanks for your calm and informative videos.
Hi Dr thank You for Your information I have been treated TNBC in India now I m undergoing immunotherapy only I m an Indian citizen now I to come to UK under dependant Visa tier am I eligible for Immunotherapy under NHS and is there availability of injection and can I get it on time ie 21 day cycle
Hello doc its good to learn more about tnbc from your vedeos. I was also diagnosed just recently from tnbc DCIS grade 2 and may i know more about ki67 labelling index as it was mention in my biopsy report it was high=87%
What type of cancer did you suffer from? My sister has triple 3 negative cancer. My mum, who is over 80, does not have cancer. How likely will I develop cancer as we have same parents?
We can't tell that from looking at them under the microscope I'm afraid, There's no real way of knowing whether anyone's TNBC is fast or slow growing in the beginning
Was first diagnosed in 2019 at 25years old. Had chemo, lumpectomy,reduction and radiation on my right breast. Recently was diagnosed with the same on the left. The tumor is growing to quickly, currently having chemo and pembro(2 doses so far)...the tumor is growing still,skin is changing and tumor is soft around the skin...battling the thought of mastectomy before finishing chemo as I fear the lump will burst. What is your opinion on my next step?
I've heard that, after TNBC, if you have two years "cancer free" it is recommended you take HRT....Liz, what is your take on this? Hope you are feeling ok in yourself whilst helping the rest of us xx
Breast cancer tends to come back in the first 2-3 years or 10-20 years later. Although TNBC doesn't have ER receptors so HRT should be safe, if it does come back it can mutate to develop ER receptors so there's a risk that HRT could stimulate mutated cancer cells to grow
My mother was told today she has thos type of cancer. I looked into it and was quite alarmed. She doesnt know what i have read nor will i tell her. Thats upto the doctors. Its still very highly treatable isnt it?? Majority of folk come through ok???
I read in a “ Living with triple negative breast cancer” book that it said “avoid coffee as can increase reoccurrence risk only for TNBC but not hormone positive cancers” is this correct should I have decaffeinated coffee / teas ?
Thanks a lot Dr. O Riordan. This was a detailed description of management of Tripple negative test cancer with BRCA 2 receptor positive 0please clarify: 1) is Neo Adjuvant chemo therapy before breast cancer surgery beneficial? And does it work by debunking the tumor and h hence making surgery easier? 2) Which chemotherapeutic agents are generally chosen for neoadjuvant chemotherapy in tripple receptor negative breast cancer. 3) In a patient with BRCA 2 receptor and tripple receptor negative would mastectomy be a better option than breast preserving lumpectomy? 4) in a patient with tripple negative and BRCA 2 positive - is bilateral prophylactic mastectomy an advisable approach to prevent a recurrence? .
I'd be really grateful for an in-depth DCIS video, especially re high grade, extensive DCIS. How common is it? What happens if an invasive element is found? What are the risks? I have 140 mm micro calcifications with DCIS. It's in every milk duct. I have been trying to get some clarity on what might happen if an invasive element IS found. I've not come across anyone with anywhere near as much as me. I've been told the likelihood of an invasive element being found is low, but I think it's higher than I've been led to believe...I'm also starting to think my personal situation is uncommon. I'm 44 by the way.
Hi. I''ll add those questions to the things I cover when I do DCIS. The larger the area of DCIS, the more likely it is that there will be a small invasive element, as we know DCIS does become invasive breast cancer if it's not treated. But we cannot give personal odds of you having cancer with DCIS
@DrLizORiordan I understand that, but the local clinic has been saying it's UNLIKELY I'll have an invasive section. They've also told me off for watching UA-cam videos! However, I've had to fill in the gaps myself. They are reluctant to discuss hypothetical scenarios, but being autistic means I don't cope well with unknowns. Now that I know there is a very real possibility of ongoing treatment, I can mentally prepare myself. It's a case of hoping for the best but preparing for the worse. BTW all the best with your treatment.
I diagnosed triple negative breast cancer patients 3 m ago my chemo is complete I take medicine my question is you just tell me after chemo n medicine you tell me my survivel time my pet scan is clear
BRCA1 positive here. Diagnosed at 40 with a 2.9cm tumour. Margins were clear. Negative nodes. Had PCR after lumpectomy followed by radiotherapy and double mastectomy with reconstruction. Did try Olaparib last year however my bloods were always down and it made me quite poorly. Is it worth trying Olaparib again a year later? Many thanks
1:43 More clarification needed here. Since Triple Neg 'also' doesn't have the Her2 receptor, how did Triple Neg 'get discovered at the same time Her 2 was~? Or do you mean that any 'left over' type cancer (one that does not even respond to Her 2 receptor drugs) is considered Triple Negative? I do understand the part about the receptors. I simply do not understand how 'it didn't exist' until the "trials were over". Do you mean, labs and doctors were simply unaware of it as a distinguishable cancer?
I am a recently retired male NP, and my wife is near retirement from her career as an OR RN. Our oldest daughter, an elementary school principal, developed triple -ve invasive ductal CA two years ago. She had surgery, chemo, and radiation therapy. She is back to work and doing well. As a NP I diagnosed several women with breast CA, as well as cervical disease. I continue to research literature about triple -ve disease, and are encouraged by health care colleagues who share their personal experience with breast CA. Your expertise and personal experience is so important to share with patients and families who are going through this process. I will follow your progress and look forward to learning more about this disease. You have my best regards and respect for your work. Take care and know that there are many who will benefit from your journey. Take good care of yourself.
My mother was just diagnosed with Triple Negative and we're praying and trying to stay strong, thank you for the information.
How's your mum got on. I hope it has gone well. My mother was told this today
@ChrisDWXX I'm so sorry to hear that about your mom, I thought the worst when we initially got the news but did my best to stay strong for her and have been doing all I can to be strong for my mom and encourage her as well so thank you for the reply, my mom is actually doing very well, she went through and finished her chemo which was pretty rough but then had to wait a few weeks for her immune system to strengthen afterwards for her surgery and that's what we're waiting on now but I do pray and hope the best for your mom!! 🙏🏾🙏🏾🙏🏾
@RocStone thank you so much for your kind reply I wish you the best as well. It's interesting to hear from someone else in a similar position.
When she was first told it's breast cancer everyone said oh u will be fine it's very highly treatable.
Now we know it's triple negative so I looked into it and I was not surprised but concerned.
My mother doesn't know what I have read about it.
I'm just still hoping it's highly treatable and the majority of people come through this ok ??
@@RocStone your mom is lucky to have your support as well bless her. Not everyone does have much support ❤️
@@ChrisDWXX You're most definitely welcome, I would like to believe anyone who loves their parent would do the same and you are wise to not panic but instead gather information and research it's a hard pill to swallow when you find out but I, as I'm sure you are doing the same, have just tried to be strong for my mom remembering what she has gone through raising us, there was no question on what I and my siblings had to do and that is do our best, care and love our mother no matter how difficult it may be so I know that you can get through it because it's scary and discouraging but it's not a death sentence so my advice to you is continue to be diligent in your research and always do your best to be strong for your mom 🙏🏾
It's nearly three years since I was diagnosed with TNBC. My treatment plan was chemotherapy, lumpectomy, radiation therapy and carboplatin. My tumour turned out to be chemo resistant so my chemo was stopped and I was rushed in for a mastectomy. Thankfully it was localised. I continued with the rest of my treatment plan. I also had two reconstructive surgeries and need to have one more as the result was not satisfactory. I am a recently subscriber and so happy I came across your channel, your information is invaluable thank you.
Thank you for sharing this with us. I'm glad that you've found my videos useful x
@DrLizORiordan how would one know if their cancer is resistant to the chemo? I wasn't diagnosed triple negative until after the cancer was removed. Why should I now receive chemo for something that may not exist, and may be chemo resistant.
If you don't mind me asking how did you know your tumour was chemo resistant
Can we ask our oncologist to do scan while doing chemo sessions?
@@ASH-T786 After my first round of chemo, I had an examination and a scan, my tumour had nearly doubled in size. Oncology decided to proceed with my 2nd course but it was still increasing. I could feel and see the changes it was happening so fast. Therefore I was told my tumour wasn't responding to chemo (chemo resistant). The 2nd course was stopped immediately and I had a mastectomy.
@@wendaoosterbroek1162 I am completely horrified on your part. 😢 I wish the very best for you. I have Triple negative BC as well but mine is responding to chemo.
I was diagnosed with tnbc in June 2020 , I’d just turned 50 .
I had lumpectomy , followed by 4 rounds of chemo - docetaxel and cyclophosphamide…. Then a month of radiotherapy, including 4 boosters at the end of.
Such a scary type of breast cancer .
Thank you for such an interesting video , wishing you good health
How are you doing now. I hope all is going well. My mother was told this today. I'm hopeful it will be ok ...
How are you now?
I had TNBC I was diagnosed at age 48 in Dec 2022, I had 2 tumours a 1cm tumour and the big daddy a 12cm Tumour, I started treatment consisting of Carboplatin, Paclitaxel and pembrolizumab in Feb 2023 all 3 at once was 1 cycle and a cycle would be every 3 weeks, the weeks in between that I would just have Paclitaxel. Despite some hurdles along the way including emergency surgery for a perforated bowel, 2 weeks later after restarting treatment by the end of May I received the news that I had a Positive Clinical Response. The 1cm tumour had completely disappeared and the 12cm tumour had shrunk to less than a centimetre. I had a mastectomy in July 2023 with a tissue expander, and a year later yesterday in fact I had the second stage of my surgery, and I'm currently recovering at home as I type, I had the expander exchanged for an implant and in my opposite breast I had a reduction. Im just praying that after I recover I can finally get my life back and I certainly wont take a second minute for granted ever again.
my Oncologist discontinued my pembro after having severe allergies-rashes.. until then, my tumor shrink.. but by the time my onco changed my regimen, my tumor continues to grow, and i'm worried..
@@lalalaflor5280 I can only imagine how worried and frustrated you must feel right now. But please remember that you're not alone in this-so many of us have faced setbacks during treatment, and I want you to know that progress isn't always a straight line. Your body has already shown that it can respond, and with your oncologist adjusting your treatment, there's still hope for more progress.
Stay strong and focus on each step forward, no matter how small. Take care of yourself, lean on your support system, and never lose sight of the fight within you. You’ve come this far, and that says so much about your strength. Sending you love and positive energy. 💕
Amazing news!
😢❤@@lalalaflor5280
Thank you Dr. I was first diagnosed with Her2 positive, when through all the treatment, surgery, docitaxel, EC and then phesgo (herceptin injections). I thought I was ok and starting to live my life but then a few months later discovered a lump under my collar major bone, it was triple negative, PD1 negative, had lumpectomy, they could remove all the tumour as was near blood vessels. I had chemo, carboplatin and paclitaxel. On pet ct, it showed I was responding well, then another follow up, it showed I had progression. My world shattered there, my oncologist recommended trodelvy as my cancer was in chest wall, axilla. I didn’t want any more chemo so hubby and I decided on radiotherapy. Oncologist mentioned that radiotherapy will not get rid of the cancer. I didn’t care as I wanted to have a family holiday. I did radiotherapy. I had ct snd showed stable, had a pet ct after a month and it showed complete metabolic response. I was so shocked. Oncologist said it’s good news. You are NEAD. I now have a scan end of October, I am nervous but keeping positive. I am not sure if my fasting helped. Sorry for the long comments.
Thank you for sharing this with me. I'll keep my fingers crossed for you x
Could you please explain to me NED and NEAD. Does this mean I still have cancer cells but they are dormant as I am NEAD. Thank you.
Good luck
I am currently having chemo for her2 positive breast cancer 4/6 done
Hate the side effects with passion 😢😢 icing on top picked covid from my last chemo session
I know it’s not easy but you are nearly there. All the best.
@@saraquiney3887❤
Thank you. I had adenoid cystic carcinoma of breast with a local recurrance 20 years later which was excised from reconstructed breast. Triple neg. Diagnosed at 36 now in my 60s
What was your symptoms?
Thank you! I learn so much from you and am becoming a better RN because of you.
You are so welcome!
Thank you for taking the time to share these important information for us whoa are diagnosed with breast cancer. It’s a scary, overwhelming, and filled with emotions. Equipped with the necessary information makes it less scary.
I have learned a lot about breast cancer thanks to your videos and my wife's oncologist. Now I can understand and help my wife more and also share the information with more women than I know Thank you. I always have you in my prayers. You are making the Difference in our lives!
Thank you so much for your lovely message. I'm glad I can help
Same here I learnt so much from you Dr Liz thank you
Always praying for your good health
This is incredible content Dr Liz.
thanks
Thank you for so vividly explaning TNBC. One of the few times IHC paves the way to the right treatment options.
Sincere thanks …. Take good care of yourself as well 🙏😊
Thank you! You too!
I had tnbc August 23
All chemos and surgury.
Achieved PCR
20 rounds of radiotherapy.
Taken off immunotherapy due to ill effects
Thank you Dr
I would be really grateful for an in-depth video for Inflammatory Breast Cancer please.
I am HER2 and Er positive
I had Neo-adjuvant chemo Carboplatin and Docetaxel and Phesgo injections but only had a partial response.
Had masectomy and radiotherapy and now I have just started Kadcyla as high risk of it coming back
I. I've done a short talking about IBC and I've got a video coming in the next couple of months.
Thank you so much for your video. I have TNBC in my right breast and weak ER+ in my left 20% ER+. Dr advised I was being treated as if both were TNBC. I have been using ovestin cream, with my left being weak ER+? Is this ok? 6:01 PS writing this from my hospital bed following bilateral mastectomy yesterday and feeling great.
Great to hear you're feeling good after your surgery. I can't give personal medical advice about HRT I'm afraid
I have triple negative breast cancer stage 3 I already did the taxol and carb and keytruda. It didn’t shrink made it softer now there changing to red devil and coxyonan
Your cancer sounds like mine in that it didn't shrink but made it "less avid" according to my breast MRI after completing the carbo/taxol/keytruda. I also just started A/C/keytruda and I'm hoping for a complete pathological response, and I hope the same for you💝. I am 67 and stage 2.
I have been diagnosed with triple negative breast cancer this week.
I am so scared.
Hi Kim, I too was just diagnosed with TNBC. I meet with the Oncologist next week and I’m scared as well. We can do this!!
I’ve also just been diagnosed with triple negative breast cancer last week. We can do this! ❤
Hello doctor, what is the use of achieving PCR after neoadjuvant chemo? And if we achieve will it reduce the reoccurrence for grade 2 and stage 2 tnbc
If you get a PCR then trials have shown your risk of getting a recurrence in the future is much smaller than someone who didn't get a PCR
Hi Dr Liz, I have TNBC treated three years ago, I have just found a large lump in the same breast as the primary. I was wondering if I would be able to get Keytruda as I also have MS. Thanks for all your work. Yvonne.
Thank you.
You're welcome!
Is it safe to use ovestin cream vaginally after being treated for TNBC please ? My GP said it was safe but I want to be sure ?
Yes it is
Have a relative that hasn't been diagnosed, but got the strange raw , open sore rash under the breast . I recommended coconut oil and the rash quickly healed and disappeared.
She has had flare ups over the years and same treatment and disappears in 2 to 3 days.
We had never heard of TNBC , but I imagine if she had gone for medical help it may have ended with invasive intervention.
5 yrs ago my wife was diagnosed with er/pr positive breast CA. Now had recurrence to tnbc. How is that possible?
So, I have been diagnosed with TNBC but did not receive the diagnosis until after lumpectomy and lymphnode surgery. Biopsy acquired 4 samples and at that time was reported as weak er+, pr-, her2-. After surgery it was reclassified as triple negative. So, I did not have neoadjuvant chemo. Tumor was 6mm, nodes negative, clear margins. If all cancer is gone and never traveled to lymph nodes, why do I need chemo?
Hi I have a similar situation as you and wonder the same thing. I’ve only done one round of chemo.
I would be so grateful if you could help me with the following question. I have just finished 8 rounds of chemotherapy for triple negative breast cancer. My oncologist and surgeon have said that I dont qualify for Olaparib due to my tumour being smaller than 2cm. I am BRAC2. I am so scared about reoccurrence. Even though my cancer was considered small, would I still benefit from taking Olaparib? Would this help reduce my chances of reoccurrence? I am 31 with 2 young babies and petrified, now my treatment has ended.
Did you say that tamoxifen just wont work im takeing it and struggling not going to take it if i dont have too
Hello and thank you for your clear explanation! It's really helpful.
If I may, I have the Ki67 of 90% and did not CPR after the chemo treatment. Got about 3mm lump of cancer cells left over in my left breast. From your experience, is there a big chance of having a metastasis soon enough? I'm 43.
Thank you in advance.
Warm greetings from Poland.
Basia 😊
Thank you for posting this. I haven’t through red devil and then taxol. There is still something there on the MRI and I have surgery this week. I am stage IB but my KI 67 score is 70-80%. I am reading that I still have a high chance of recurrence even if I experience pCR, is that true? I am scared, appreciate any information you can share.
6 cycles of chemo finished. docetaxel and carboplatin last MARCH 15 by the way i am triple negative breast cancer frozen surgery done. last june 2024 tumor markers are negative thank God. at present no meds at all from my ONCO. what are my chances to full recovery? thanks
Thank you so much your videos are very good! I hope you are feeling ok now ? I am TNBC had 14 months treatment 6 months chemo x2 surgeries and then 6 months oral chemo ( as the IV chemo only shrunk my breast tumour by a third) and during this time 12 months of IV Keytruda ( Penbro ), and 3 weeks of radiation !- my first surgery showed 2 dots had spread into my sentinel nodes so they re operated again and did an axillary clearance which was clear but of course that was the worst op to recover from - can you do a pod cast on that - the risk of Lymphodema, cording, aching arm due to nerves being cut ?
I also only had a lumpectomy as BRCA gene negative but scared maybe I should have had a double mastectomy ? Guess I could still ?
Thank you so much for this - I’ve completed my active treatment for TNBC a year ago & am now on zoledronic acid for 3 years. My question regards my daughter & 2 granddaughters as I’m 69 years old& therefore wasn’t given the Brach gene test. As I don’t fit the first 2 criteria for TNBC does this mean my daughter & granddaughters should be tested/monitored? My daughter is 42 & granddaughters 12 & 10.
Many thanks
If HER2 absent in TNBC then chalcone3 bind with which protein for antiproliferative activity
Hello dr. My sister has stage 4 tnbc and it has spread to her skin. This is the 3rd video ive commenting on of yours looking for help. It is spreading like wildfire and shes doing taxol and immunotherapy..
I was just diagnosed. Most terrifying word in the English language: malignant.
Sending you a hug x
🙏🙏 praying for you
We know what you are going though 4 months ago I was diagnosed the emotions still feels like the day I was told I have it
❤❤❤ Faith !! Believe and RECEIVE it, which allows the body to release the Healing hormones in addition to the nutrients and treatments.
2nd round of Chemo for me for Triple Negative Breast Cancer, things are looking up. Keep yourself in the most Positive space as possible, voiding out the horrible, negative background noises of folks's negative energy. There are even some family members that we may have to love from a distance while we are trying to heal.
Forgive the harm that some folks may have brought against us the best we can, so that the negative energy is not blocking our healing.
My deepest sincere wishes and prayers 🙏 for all that are battling this Horrible, Demonic disease.
Thank you for sharing and being so encouraging❤️ I was diagnosed recently and I am opting to not share this news with some family only a handful of people know because sadly enough not everyone will care. With God and my son by my side I know I will get through this in Jesus Name🙏 Wishing you a speedy and full recovery! Blessings🙌
Hi Liz, thanks for your informative videos. Please can you do another one on triple positive breast Ca? X
i'll add it to my list
@@DrLizORiordan Thank you so much❤️
my tumor continues to grow. Im on my 4th cylce. my regimen are docetaxel and cyclophosphamide. Y does it still continues to grow even while im on chemo Doc?
And I am only 48 I was diagnosed at 47 4 months after my biopsy nonone got hold of me till 4 months after. So I never knew I had it for 4 months and it was 1.1 com grew in that matter of 3cm
Is it possible to have both ER+ Her2_ AND Triple Negative breast cancer at the same time?
Thanks for your videos about breast cancer - very useful. I was diagnosed with TNBC this year. You don't mention in your video the Keynote 522 protocol which I believe should be used for TNBC - which fortunately for me includes Immunotherapy from the beginning of treatment, having been cleared by NICE late last year?
I have completed the chemotherapy regime and because it (and immuno) were so effective only needed a lumpectomy and 3 lymph nodes removing, so avoided mastectomy or even double mastectomy.
Hoping to get PCR when results come back. Radiotherapy to follow.
Don't know my BRCA status as it seems the service is very behind - my appointment is late October, this all started in February!!! If there is something there it may require further surgery.
From my readings there is also something called Capecitabine which many people are prescribed if there is any residual cancer cells?
I'm not sure if your video needs to be updated to include these 2 things? (Keynote 522 and Cape)
Many thanks for your calm and informative videos.
How are you now?
@@Ammanakairuchi7 All good thank you - clear of cancer. Just feel about 10 years older in terms of aches and pains
Hi Dr thank You for Your information
I have been treated TNBC in India now I m undergoing immunotherapy only
I m an Indian citizen now I to come to UK under dependant Visa tier am I eligible for Immunotherapy under NHS and is there availability of injection and can I get it on time ie 21 day cycle
Hello doc its good to learn more about tnbc from your vedeos. I was also diagnosed just recently from tnbc DCIS grade 2 and may i know more about ki67 labelling index as it was mention in my biopsy report it was high=87%
High Ki67 means that your cancer cells are growing more quickly and it's being used in some places to decide whether to give chemo
What type of cancer did you suffer from? My sister has triple 3 negative cancer. My mum, who is over 80, does not have cancer. How likely will I develop cancer as we have same parents?
How do I know if I have the Braca mutation and does this mean my daughter and granddaughter are at risk?
You need to get your saliva tested for the different things genetically linking you and family members who've had cancer.
Can i know the differenent type of TNBC which are slow growing and in which way they are differnt Doctor
We can't tell that from looking at them under the microscope I'm afraid, There's no real way of knowing whether anyone's TNBC is fast or slow growing in the beginning
Was first diagnosed in 2019 at 25years old. Had chemo, lumpectomy,reduction and radiation on my right breast. Recently was diagnosed with the same on the left. The tumor is growing to quickly, currently having chemo and pembro(2 doses so far)...the tumor is growing still,skin is changing and tumor is soft around the skin...battling the thought of mastectomy before finishing chemo as I fear the lump will burst. What is your opinion on my next step?
Your oncologist may decide to halt chemo so you can have surgery and then go back on it again
Diagnosed TNBC W/Ki67=60%, grade 3 but the imaging didn’t provide enough to know stage? Is this common?
Stage is a combination of nodal invovlement, tumour size and receptors so imaging alone can't tell you that
I've heard that, after TNBC, if you have two years "cancer free" it is recommended you take HRT....Liz, what is your take on this? Hope you are feeling ok in yourself whilst helping the rest of us xx
Breast cancer tends to come back in the first 2-3 years or 10-20 years later. Although TNBC doesn't have ER receptors so HRT should be safe, if it does come back it can mutate to develop ER receptors so there's a risk that HRT could stimulate mutated cancer cells to grow
My mother was told today she has thos type of cancer. I looked into it and was quite alarmed. She doesnt know what i have read nor will i tell her. Thats upto the doctors. Its still very highly treatable isnt it??
Majority of folk come through ok???
Mam triple N brustcancer ki67=75% what is this and how to treat
My beautiful niece was only 34 when she died of tnb
Make also a vid on ER+ PR+ Her2- case thanks be well truly Dr. Liz 🌎🩺💖🙏
Great suggestion!
@@DrLizORiordan 💖💖💖🌹🤗
I read in a “ Living with triple negative breast cancer” book that it said “avoid coffee as can increase reoccurrence risk only for TNBC but not hormone positive cancers” is this correct should I have decaffeinated coffee / teas ?
I’m not aware of any research proving that
Thanks a lot Dr. O Riordan. This was a detailed description of management of Tripple negative test cancer with BRCA 2 receptor positive
0please clarify:
1) is Neo Adjuvant chemo therapy before breast cancer surgery beneficial? And does it work by debunking the tumor and h hence making surgery easier?
2) Which chemotherapeutic agents are generally chosen for neoadjuvant chemotherapy in tripple receptor negative breast cancer.
3) In a patient with BRCA 2 receptor and tripple receptor negative would mastectomy be a better option than breast preserving lumpectomy?
4) in a patient with tripple negative and BRCA 2 positive - is bilateral prophylactic mastectomy an advisable approach to prevent a recurrence? .
I'd be really grateful for an in-depth DCIS video, especially re high grade, extensive DCIS. How common is it? What happens if an invasive element is found? What are the risks? I have 140 mm micro calcifications with DCIS. It's in every milk duct. I have been trying to get some clarity on what might happen if an invasive element IS found. I've not come across anyone with anywhere near as much as me. I've been told the likelihood of an invasive element being found is low, but I think it's higher than I've been led to believe...I'm also starting to think my personal situation is uncommon. I'm 44 by the way.
Hi. I''ll add those questions to the things I cover when I do DCIS. The larger the area of DCIS, the more likely it is that there will be a small invasive element, as we know DCIS does become invasive breast cancer if it's not treated. But we cannot give personal odds of you having cancer with DCIS
@DrLizORiordan I understand that, but the local clinic has been saying it's UNLIKELY I'll have an invasive section. They've also told me off for watching UA-cam videos! However, I've had to fill in the gaps myself. They are reluctant to discuss hypothetical scenarios, but being autistic means I don't cope well with unknowns. Now that I know there is a very real possibility of ongoing treatment, I can mentally prepare myself. It's a case of hoping for the best but preparing for the worse. BTW all the best with your treatment.
I diagnosed triple negative breast cancer patients 3 m ago my chemo is complete I take medicine my question is you just tell me after chemo n medicine you tell me my survivel time my pet scan is clear
Very helpful. Yes, TNBC is very scary.
BRCA1 positive here. Diagnosed at 40 with a 2.9cm tumour. Margins were clear. Negative nodes. Had PCR after lumpectomy followed by radiotherapy and double mastectomy with reconstruction. Did try Olaparib last year however my bloods were always down and it made me quite poorly. Is it worth trying Olaparib again a year later? Many thanks
1:43 More clarification needed here. Since Triple Neg 'also' doesn't have the Her2 receptor, how did Triple Neg 'get discovered at the same time Her 2 was~? Or do you mean that any 'left over' type cancer (one that does not even respond to Her 2 receptor drugs) is considered Triple Negative? I do understand the part about the receptors. I simply do not understand how 'it didn't exist' until the "trials were over". Do you mean, labs and doctors were simply unaware of it as a distinguishable cancer?
Oh, I'm so sick of being an anomaly. My ER+/HER neg lobular cell carcinoma has devolved and is now triple negative (my skull metastasis was excised)
Oh I’m so so sorry.