I’m loving your videos. I’m a Medical Laboratory Scientist who works in a hospital lab and an instructor for immunohematology. I want to point out to you that there are many other surface antigens on the red cells other than The A and B antigens (ex: C,c,E,e,Kell,FyA,FyB, JkA,JkB etc) that also contribute to someone’s red cell genotype and phenotype. If exposed to the antigens they lack for these other antigen systems, patients can develop antibodies which can be dangerous for future transfusions and pregnancies. So while O is the universal donor that’s only half the story. If a patient has any clinically unexpected antibodies to these other red cell antigens they must be matched for those as well and A, B and Rh. Even though we teach entire courses for immunhematology and transfusion medicine that can’t be covered here it might be worth mentioning briefly that there are other antigens that exist on red cells and other antibodies certain patients may have that complicate transfusion.
I wish you were my doctor...a hell of a teacher..what a special gift you have. Not even the doctors explain the severity of the mixed blood and the affect between mother and fetus. My hat off to you.👏
I wish I had enough money to support you, I will remember this channel after I graduate in Med School! Thank you so much for sharing free knowledge! Metatron bless you!!
Only thing at 3:00, the Rh antibody is not naturally occurring like the A and B antibodies, so Rh antibodies only forms after the exposure to Rh positive blood.
No! that's incorrect the Rh- negative is Recessive Both my parents are Rh+ positive I am Rh O- negative Pureblood Man No Rhesus Macaque Monkey D Antigen the Rh=Rhesus Factor and both A and B are Added Sugars I know B is Glucose and A sounds like NutraSweet but it's not and the Rh- negative Woman rejects the Rh + positive human fetus like in Genisis 3:15
I don’t really comment on UA-cam videos, but I have to give it to you.. you’re literally the best! You’re a life saver!!! Keeping me sane through medschool. Thank you for all that you do🙏🏼❤️
I used to hate school and had no idea what the teachers were talking about until I met your videos . I watched most of your videos and I’m glad to say that I’ve been getting As because of you. Thank you soooooo much. You’re a Godsent
The way of teaching is awsome, keep it up and bring more videos like this so that Medical students will have a good onset in their topic.........thanks for this wonderful class ❤
Awesome video. I was struggling with this and didn’t think it would be something that I ever needed to worry about again. Now it has come back to haunt me as I prep for the MCAT. This video helped me understand it better now.
Your lectures are really really really helpful. You discuss everything that comes in the exam as well as in our real life practical. You are great dude👍👌 I have learned many things from you. And you give this all knowledge and your experience for free. Everybody who wants to become healthcare professional should watch your lectures. 👍 highly recommended
I will suggest to my med school mates so we can give a percentile of our tuition as support to you Ninja Nerd. Keep up the good work. From Benue State, Nigeria 🇳🇬
Important note: When considering blood transfusions, it is important to distinguish between red blood cells (RBCs) and plasma. Plasma transfusions contain antibodies. If whole blood (or plasma) is being transfused from an O type donor, it can only be donated to O type recipients because O type individuals have anti-A and anti-B antibodies in their plasma. In most blood transfusions, only the red blood cells are transfused, which is why O type is considered the universal donor for red blood cells. O type red blood cells lack A and B antigens, making them safe for all recipients. Similarly, plasma from an AB individual lacks anti-A and anti-B antibodies. Therefore, it can be donated to recipients of all blood types, making AB individuals the universal plasma donors. :)
Very good lecture for beginner Medical Laboratory Science majors. I would also recommend Blood Bank guy for more in-depth discussions in blood banking, especially about other blood groups. There are a lot more surface antigens that MLS majors need to know. But Ninja Nerd's lectures have been so useful for me when I was a student (just graduated a few months ago).
Hi Zach, (not a Doc) just a seasoned organic chemist enjoying your lectures and learning. I was scratching my head trying to understand how Type A blood can be donated to Type AB recipients when Type A has Type B antibodies until I understood that Type B antibody is in the plasma and so a donation A > AB is limited to the RBC fraction. Reading a little more, I realized there may be a multiplicity of situations where blood exchanges can take place by separating plasma from the RBC fraction in such cases where the offending antibody can be separated out prior to the exchange. Obviously, if the antibody is insitu in the recipient you can't unload the corresponding antigen. Cheers!
@goscience, you are absolutely right, and I think it must really be emphasized that all that is said in this video applies when only red blood cells are donated. For instance, when plasma is donated, all of this is reversed. In view of this, I think it could be more appropriate to look at who can receive from who, not who can give to who. Also, emphasizing that AB0 antibodies are IgM's, and Rh antibodies are IgG's is also important in order to understand why an Rh neg mother does not have the antibodies during the first pregnancy (unless she received an Rh pos RBC transfusion earlier). I am putting down all this in acknowledgement of the fact that the system of blood types is way more complex, and I am far closer to a student's level than to an expert's. I appreciate all comments which help in getting a better understanding of this topic. My great big thanks go to dr Murphy for all the great tutorials.
Wow i literally watched so many videos trying to grasp this and your video has helped me so much just to visually see what you are explaining helps. Thank you for you time and patience. I really appreciate it !!!! 🎉❤
Laughed how you mention that babies usually not born with the opposite blood type of their mother. My first two girls have that.. but do LOVE your video..keep it going
Along with A and B antigens, there is another antigen known as the Rh factor which can be present or absent on the red blood cells' surface. In general, Rh-negative blood can be donated to Rh-negative patients only, whereas both Rh-positive and Rh-negative blood can be donated to Rh-positive patients.
Hi! You don’t make antibodies to the Rh antigen until you’re exposed to Rh+ cells through pregnancy or transfusion. If the mother is Rh+ the Rh antigen is seen as “self”. She won’t make Rh antibody because she would then destroy her own antigens/RBCs. If Mom’s Rh- there is potential for the father, thus the child, to be Rh+ and then her body will make Rh antibodies if she’s exposed to the baby’s Rh+ cells. Rhogam is given based on the mothers Rh- status as a preventative regardless of dad and baby’s Rh type. If Dad and baby are negative Mom won’t be sensitized to make antibodies anyway. If Mom were to make an antibody it would happen around 28 weeks, so Moms receive the shot at 28 weeks and after perinatal procedures or delivery when there is potential for fetal maternal hemorrhage (blood mixing). Also want to clarify what RhoGAM does. It’s not an antibody to an antibody. The purpose of it is to fool Mom’s immune system. The anti-G/anti-Rh/Rhogam coats any fetal cells that enter in the mother’s circulation that are Rh+ so she doesn’t “see” them and make her own antibody against them.
I have an important question, Firstly, I really thank you for your clear and easy explaining . Talking about mismatching of baby& mother RH , You said the mother's blood form RH antibody against the second baby's blood which is RH+ ,supposing that the mother's blood is RH- , the question is why would her blood form RH antibodies ,is not it supposed to be formed since her birth ?? Accordingly ,why is not the first baby attacked ?? I need an answer please
Hey according to my lecture slides from class; Antibody production is induced only when an Rh+ RBC enters the blood stream!!! So originally there are no rh antibodies. That’s the difference between the ABO system and the Rh system.
Also the first immune response is igM So it can’t cross the placenta that’s why nothing happens to the first baby but the second immune response is igG which CAN cross the placenta and that’s why the second baby is affected
you are a blessing to med students. thank you for existing, NINJA NERDS
Ikr
hey ,nice name!
I’m loving your videos. I’m a Medical Laboratory Scientist who works in a hospital lab and an instructor for immunohematology. I want to point out to you that there are many other surface antigens on the red cells other than The A and B antigens (ex: C,c,E,e,Kell,FyA,FyB, JkA,JkB etc) that also contribute to someone’s red cell genotype and phenotype. If exposed to the antigens they lack for these other antigen systems, patients can develop antibodies which can be dangerous for future transfusions and pregnancies. So while O is the universal donor that’s only half the story. If a patient has any clinically unexpected antibodies to these other red cell antigens they must be matched for those as well and A, B and Rh. Even though we teach entire courses for immunhematology and transfusion medicine that can’t be covered here it might be worth mentioning briefly that there are other antigens that exist on red cells and other antibodies certain patients may have that complicate transfusion.
Thanks!
Thank you. Is what you explained the same word "Alloimmunity" ?
Love this. Thanks.
Correct. There are 31 Other Regulators
Very insightful
I wish you were my doctor...a hell of a teacher..what a special gift you have. Not even the doctors explain the severity of the mixed blood and the affect between mother and fetus. My hat off to you.👏
Thank you, Ninja Nerd, for posting this fantastic video. You are a gift to this generation!!!👏👏👏
A born teacher... Thanks a million!
Thanks sir❤❤❤
So great! I was so confused by this during class, but now that I have watched this, I understand it perfectly! Thank you, Sir!
+Tiffany Selrick I'm so glad we were able to help!!!!
Thankyou sir for saving my med career 😭😭
I wish I had enough money to support you, I will remember this channel after I graduate in Med School! Thank you so much for sharing free knowledge! Metatron bless you!!
did you graduate!
@@shahdaltiary what sort of question is that??😁
You are simply amazing and your videos should be schools requisites. Thank you for everything that you do for all of us students.
You simplified the blood type lecture in a very simple and easy-to-understand manner. By the way, I enjoy listening to all your lectures.
I had never understood this topic before, but after your explanation it made me absolutely clear. Very well explained. Thanks a lot.
Only thing at 3:00, the Rh antibody is not naturally occurring like the A and B antibodies, so Rh antibodies only forms after the exposure to Rh positive blood.
Yes I am confused
Yesss I m so confused after that
No! that's incorrect the Rh- negative is Recessive Both my parents are Rh+ positive I am Rh O- negative Pureblood Man No Rhesus Macaque Monkey D Antigen the Rh=Rhesus Factor and both A and B are Added Sugars I know B is Glucose and A sounds like NutraSweet but it's not and the Rh- negative Woman rejects the Rh + positive human fetus like in Genisis 3:15
You are one of the best things that happen in this world. THANK YOU!
I don’t really comment on UA-cam videos, but I have to give it to you.. you’re literally the best! You’re a life saver!!! Keeping me sane through medschool. Thank you for all that you do🙏🏼❤️
I used to hate school and had no idea what the teachers were talking about until I met your videos . I watched most of your videos and I’m glad to say that I’ve been getting As because of you. Thank you soooooo much. You’re a Godsent
The way of teaching is awsome, keep it up and bring more videos like this so that
Medical students will have a good onset in their topic.........thanks for this wonderful class ❤
8 dislikes are my faculty teachers
SPECIFICALLY SCIENCE TEACHERS
Lol
😂
Hahahaha🤣
😂😂😂😂😂
Awesome video. I was struggling with this and didn’t think it would be something that I ever needed to worry about again. Now it has come back to haunt me as I prep for the MCAT. This video helped me understand it better now.
pretty ridiculous to learn that pre med school, we are just learning it right now and im in the 3rd semester
Your lectures are really really really helpful. You discuss everything that comes in the exam as well as in our real life practical. You are great dude👍👌 I have learned many things from you. And you give this all knowledge and your experience for free. Everybody who wants to become healthcare professional should watch your lectures. 👍 highly recommended
So simple and very effortless to understand.
Thank u for making it so simple,clear and comprehensive.
Much love and respect
I will suggest to my med school mates so we can give a percentile of our tuition as support to you Ninja Nerd. Keep up the good work. From Benue State, Nigeria 🇳🇬
Important note:
When considering blood transfusions, it is important to distinguish between red blood cells (RBCs) and plasma. Plasma transfusions contain antibodies. If whole blood (or plasma) is being transfused from an O type donor, it can only be donated to O type recipients because O type individuals have anti-A and anti-B antibodies in their plasma.
In most blood transfusions, only the red blood cells are transfused, which is why O type is considered the universal donor for red blood cells. O type red blood cells lack A and B antigens, making them safe for all recipients.
Similarly, plasma from an AB individual lacks anti-A and anti-B antibodies. Therefore, it can be donated to recipients of all blood types, making AB individuals the universal plasma donors.
:)
Thank you from the bottom of my heart !!! i had to understand for the mother/foetus mismatched and YOU EXPLAINED IT SO WELL !!! God bless you
Please explain it for me
no need to go through the lecture 'cause the legend cover more than the objectives ask for!
Normally, intelligent individuals are not worried about pretty hair, muscles, fancy vehicles, cool outfits. And this guy here is one of them.
Hahha but he's still cool
You're teaching in a professional way
Very good lecture for beginner Medical Laboratory Science majors. I would also recommend Blood Bank guy for more in-depth discussions in blood banking, especially about other blood groups. There are a lot more surface antigens that MLS majors need to know. But Ninja Nerd's lectures have been so useful for me when I was a student (just graduated a few months ago).
you are a true blessing to a whole lot of us out there, thank you very much what you do.
We need more people like him🔥😭😭
You are one of the genius person on earth. Respect !!!
Hi Zach, (not a Doc) just a seasoned organic chemist enjoying your lectures and learning. I was scratching my head trying to understand how Type A blood can be donated to Type AB recipients when Type A has Type B antibodies until I understood that Type B antibody is in the plasma and so a donation A > AB is limited to the RBC fraction. Reading a little more, I realized there may be a multiplicity of situations where blood exchanges can take place by separating plasma from the RBC fraction in such cases where the offending antibody can be separated out prior to the exchange. Obviously, if the antibody is insitu in the recipient you can't unload the corresponding antigen. Cheers!
@goscience, you are absolutely right, and I think it must really be emphasized that all that is said in this video applies when only red blood cells are donated. For instance, when plasma is donated, all of this is reversed. In view of this, I think it could be more appropriate to look at who can receive from who, not who can give to who. Also, emphasizing that AB0 antibodies are IgM's, and Rh antibodies are IgG's is also important in order to understand why an Rh neg mother does not have the antibodies during the first pregnancy (unless she received an Rh pos RBC transfusion earlier). I am putting down all this in acknowledgement of the fact that the system of blood types is way more complex, and I am far closer to a student's level than to an expert's. I appreciate all comments which help in getting a better understanding of this topic. My great big thanks go to dr Murphy for all the great tutorials.
You are my favorite human being right now!
you are the best !! you answered to my question in the first 40 seconds of your video :) best teacher ever
i wish all the teachers in college teach like you
I highly enjoyed this video. Very easy to visualize and understand after this. Thank you!
Wow i literally watched so many videos trying to grasp this and your video has helped me so much just to visually see what you are explaining helps. Thank you for you time and patience. I really appreciate it !!!! 🎉❤
This guy is too good 😮.
Glad to watch you videos
Most of the people that commented 7 years ago were in the med school, I think they are all doctors now with help of Ninja nerd!
YOU'RE THE BEST. THANK YOU FOR HELPING ALL OF US!
You are the best doctor in the world
ваши объяснения-предел мечтаний))) thanks for your work
Hands down best review and practice. I finally understand now, thanks😭👍🏽
Hi
I am so thankful to have come across your videos for my anatomy and physiology class. I have shared your videos in our group discussions as well.
Your students must be very lucky to have a professor like you. My professor sucks with big 'S'.
Quando eu me formar em medicina, toda a minha dedicatória será para o ninja nerd. Não seria NADA sem esse canal!!!
Thankyou so so much Sir , your life is blessing to us . We love you so much!
Once a ninja nerd🤓, forever a ninja nerd ❤️😘
Good thing you have that Beanie on. Really drives home the concepts
Definitely sharing this lesson in class tomorrow 👏🏼🙌🏼
i hated physiology ,
ninja nerd made me love it ....... thanks!!!!!!!!!
Top notch explanation! Bravo!
Cute Nerd! Thanks for helping me with my A&P class 😊
Thank you for helping us, your lectures made study easy!
Saying that you’re awesome doesn’t sound good enough. You’re my favorite person right now..BLESSINGS xBLESSINGS.
Thank you sir! I've learned a lot 🥰
Love all your videos and it helps tremendously
Your doing a great job. Your lesson's are the best and easy to understand. am grateful and i appreciate you, remain bless.
Laughed how you mention that babies usually not born with the opposite blood type of their mother. My first two girls have that.. but do LOVE your video..keep it going
Amazing lecture, thank you love! 💟
Nobody taught it this awesome!!!!
Thanks Nerd... You make my presentation one of the best.. I hope to meet you one day
Amazing lecturer
Love your videos, all helped me learn better!
Thanks for videos.
Grear work... ❤️ ❤️ ❤️.... Very learning and informative lectures... Love
Thank you so much! Your lectures are best!
You’re carrying me through anesthesia school, my friend.
Along with A and B antigens, there is another antigen known as the Rh factor which can be present or absent on the red blood cells' surface. In general, Rh-negative blood can be donated to Rh-negative patients only, whereas both Rh-positive and Rh-negative blood can be donated to Rh-positive patients.
that's brilliant thank you so much for making things so limpid.
Amazing lecture!!! Thank you So much for this effort👏👍👍👍
+Indu R you are very welcome!!! thank you so much for your kind words I'm so happy that we were able to help!
Hi! You don’t make antibodies to the Rh antigen until you’re exposed to Rh+ cells through pregnancy or transfusion. If the mother is Rh+ the Rh antigen is seen as “self”. She won’t make Rh antibody because she would then destroy her own antigens/RBCs. If Mom’s Rh- there is potential for the father, thus the child, to be Rh+ and then her body will make Rh antibodies if she’s exposed to the baby’s Rh+ cells. Rhogam is given based on the mothers Rh- status as a preventative regardless of dad and baby’s Rh type. If Dad and baby are negative Mom won’t be sensitized to make antibodies anyway. If Mom were to make an antibody it would happen around 28 weeks, so Moms receive the shot at 28 weeks and after perinatal procedures or delivery when there is potential for fetal maternal hemorrhage (blood mixing). Also want to clarify what RhoGAM does. It’s not an antibody to an antibody. The purpose of it is to fool Mom’s immune system. The anti-G/anti-Rh/Rhogam coats any fetal cells that enter in the mother’s circulation that are Rh+ so she doesn’t “see” them and make her own antibody against them.
Thank you for this video, Sir! I understand perfectly by this video!
U r the best teacher keep it up
wow you are truly a blessing, thank you.
well i passed blood because of this man thanks
THANK YOU SO SOOOO MUCH
YOU SAVED MY LIFE!!!!
Best teacher❤️❤️❤️❤️
Thank you so much Dr Zack!
Brilliant explanations!
I have an important question,
Firstly, I really thank you for your clear and easy explaining .
Talking about mismatching of baby& mother RH ,
You said the mother's blood form RH antibody against the second baby's blood which is RH+ ,supposing that the mother's blood is RH- , the question is why would her blood form RH antibodies ,is not it supposed to be formed since her birth ?? Accordingly ,why is not the first baby attacked ??
I need an answer please
Hey according to my lecture slides from class; Antibody production is induced only when an Rh+ RBC enters the blood stream!!! So originally there are no rh antibodies. That’s the difference between the ABO system and the Rh system.
Also the first immune response is igM So it can’t cross the placenta that’s why nothing happens to the first baby but the second immune response is igG which CAN cross the placenta and that’s why the second baby is affected
Finally I understood it. Thank you so much
AYEEEEEEEE YOU UNDERSTOOD IT, CAN I HAVE 5 BUCKS
This helped me a lot. Thank you so much.
You are really amazing
This cleared all my confusions
Thankyou
the best video ever
thanks🍓🍓🍓🍓
I have only one thing to say : Thanks a lot !
Lol watching this video 3 years later Buh I still enjoyed and understood every bit of it
Thank u so much such....such a amazing lecture..thank u...👍🙏🙏🙏🙏...
As usual next level 😊
Thanks so much that helped me a lot 🙏
Thank you very much for a very good explanation.
Thank u so much,u saved me from reading and not understanding,😘😘😭😁
you are blessing for everyone
شرح جميل وبسيط وكافي
استفدت كثيرا شكرا 🤍🔥
You have done a lot to medical world.
I love the way you teach! This saves me a lott!
May ninja crush! I'm here again... Blood bank exam is coming soooooon....
So, nose bleed and headache before exam!
Thanks so much this was really helpful and well explained
The way u use to explain it is very very good
Thank you for teaching me❤
thank you so much! I understand blood types now!
I am so grateful + U made it easy 💜