p53: Guardian of the Genome

The tumour-suppressing protein called p53, also known as the guardian of the genome, protects our cells from cellular damage. Under cellular stress, p53 jumps into action, regulating gene expression to control DNA repair, cell division and cell death.
But, p53 malfunction is associated with a vast array of difficult to treat cancers, and these can arise either from mutations in the TP53 gene, or through an overabundance of a regulatory protein that keeps p53 inactive. Unfortunately, there are no catch-all drugs to tackle these types of cancer, but several combination therapies are undergoing research, offering hope for the future.
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[@NSXTypeRGTRLM]

While in medical school we had a security guard that would always give us a hard time even when we had our IDs on us. We lovingly called her p53.

[@lConfusedCatl]

So you are the cancer? 😅

[@charvyr]

I really liked the creative take on such a complex topic. Am thrilled how innovatively some of this protein's mechanisms are presented in here! Doesn't cover the whole story but anyone interested in learning the very basic might find it useful. As someone who submitted their thesis on p53, this was actually refreshing to watch.

[@esk7290]

Any where we could read your thesis if you don't mind? Is it published

[@charvyr]

@@esk7290 No it's not published anywhere, ' was simply a dissertation thesis. I guess you could go through articles on p53 and cancer on PubMed. Review articles or chapters of the book "Molecular Biology of the Cell" by Bruce Alberts could be really helpful.

[@raceostler533]

Do you know any ways to in general enhance / assist mutated tp53 genes?

[@dehaya10]

By far the best medical animation I've ever watched. Thanks to those who contributed. The adventure of understanding p53 continues...

[@Electroblade360]

I Really Liked The Idea Where The P53 Gene And The Cancer Fighting Super Duo Are Superheroes, Nice Touch

[@jentwa97]

I'm defending my PhD in Molecular Biology next month... well done!

[@rylaczero3740]

Didn't hear a word. I was focused on the animation. Nice job.

[@august.282]

No way this video is BEYOND 😂❤ thank you so much

[@hatibmuhamad585]

Wow! the best science communication of the year so far

[@bhargavikulkarni6322]

Amazingly visualized! Great work!

[@elizabethelson1124]

Thanks for simplyfying the topic in this way...and making it understandable 🙏😊

[@taariqparker2788]

This is the most exciting/well explained video I've ever watched

[@yurineri2227]

YOW, the random sakuga at the fight scene at the end goes crazy tough 2:50 🗣🔥🔥🗣💯

[@negartoorany]

it was really good! great job! please do more of these videos

[@Alara106]

Great video

[@TheSheekeyScienceShow]

This is the protein i study :D

[@user-bp8yg3ko1r]

Nice art style, very well explained!

[@paulaz.flaquer9570]

Great animation!

[@lisadigangi2310]

how would the drug selinexor work in regards to maintenence therapy for endometrial cancer? I'm trying to learn more for my mom who is in treatment for the disease now. We are beginning the selinexor clinical trial soon. I like to understand things so I can have questions ready for the dr. Thanks everyone. :)

[@holydiver588]

Awesome video!

[@klausseestern5153]

Better than marvel

[@armandoperezgutierrez1382]

Good video

[@user-tf9zh2jh6w]

Miracle video

[@shahirkhan6344]

Great way of representation!

[@mufaddalmanaquib8496]

Lovely

[@amadiohfixed1300]

I admire to be like p53

[@Chris-pi2lm]

Intro goes hard asf

[@hudaqasim4012]

What a superhero 🤩

[@flaminmongrel6955]

this reminds me of the presentation in the first Jurassic park movie

[@sooooooooDark]

fun fact: genistein (from soy) apigenin (from parsley) and oroxylin A (from bBaikal skullcap) increase p53 expression
the more u know

[@KarenMwelwa]

Wow❤

[@ahmedelbery2249]

give me a hug

Excellent animation. Thank you so much. Greetings from Bimac research group at Universidad del Cauca, Colombia.

[@bigfootpegrande]

Amen

[@DrMSSR_tips_tricks]

Super 🎉🎉🎉🎉

[@jorgmethfessel5774]

after the robot i stopped listening, of course i watched the video till the end :D

[@ShadyForest]

I thought this was about the PS3 when I first read the title...

[@Graag08]

Is it Apo-ptosis? Or a-pop-tosis?

[@isabelmacdonald3602]

Apo-ptosis. Pronounced "Apotosis"

[@AmruMagdy]

الله

[@tbird81]

The silly animation doesn't really explain anything. There's a better video on P53 on the "But Why?" Channel.

[@charvyr]

Well it's more of a basic take on the complex topic to let any lay person grasp the idea. Btw watched the video you mentioned, it is definitely more informative but would have a limited audience.

[@bingeltube]

Too cartoonish! Did not like it! Perhaps, nice for teenagers!

[@shubhambarik202]

Great video

[@KarenMwelwa]

Wow❤

[@KarenMwelwa]

Wow❤