Demystifying the endocannabinoid system. | Ruth Ross | TEDxMississauga
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- Опубліковано 29 вер 2024
- Dr. Ruth Ross describes what happens in the brain when introduced to tetrahydrocannabinol (THC), one of the primary ingredients in cannabis. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at www.ted.com/tedx
You know you're high at home watching this. We both know.
Sorry but I’m not, I quit a month ago because I developed cannabis hyperemesis syndrome, lost 20 pounds and I almost died from organ failure due to vomiting 8 times a day
Half right. I'm outside hehe.
@@SolidSiren proud of you!!
@@zaneaustin22 omg! What is that??
@@flowstate9716 yeah isn’t that crazy, CHS for short. Look it up. It was the worst pain I’ve ever felt in my life, it had something to do with the stomach and an excess build Up of cannabis there.. the only think that sort of helped was pressing something hot to my stomach actually. It cleared up after I quit smoking and I’m fine now but those months were so bad looking back
almost no actual information was presented here. it is all still mostly unknown. this certainly did not demystify anything at all.
I mean, it's a 20 minutes presentation on a somewhat complicated part of our bodies, there's not much you're gonna learn besides the highlights. You can try to read their papers if you want, but they're usually tough to read if you're not versed in the subject matter as they're directed towards other experts.
Of course this Ted talk goes into THC and weed, rather than the Scottish woman immune to fear, anxiety and pain.
I feel like the reason weed is so controversial is because THC messes up your brain and has harmful effects, while cbd has amazing effects. I know so many people that smoke high THC weed and their iq dropped noticeably just talking to them over the years.
I've met people who after consuming THC became quite aware on the verge of Genius ... they started to research more open minded like the things available to research when in that State of mind ..
@@mcozy333 placebo lol.
@@Submersed24 Lipids / Terpenes .. real life compounds that metabolize ... an entire science to explain = Endocannabinoid system / Cannabinoid sciences / lipid signaling ... the compounds of interest in cannabis are the glandular resins ( phytocananbinoids) .. those cannabis plant only created molecules are terpenophenolic , meroterpinoid , essential fatty acyls . THC is a neuroprotective plant metabolite ... it metabolizes as a neurotransmitter in the brain and protects the neuronal , mylein sheath and much more .... you caqn learn all of what is possible via researching the sciences .. not American NIDA smoke harm research that is only allowed in America ... the research is outsourced to other countries and America is paying for a lot of it
"The endocannabinoid system responds to singing and dancing." This makes me wonder about ancient cultures, Native Americans, and their harmony with plants and nature. Methinks humans need more connection to the plant world to live a happy and fulfilling life!
the better you feel the more endocanabinoids are metabolized to keep good feelings flowing... th ecannabinoids are bliss compound that determine how we feel via constant modulatory cellular maintenance of intracellular signalling of them
Of course we grew in tandem in this biosphere we must respect the powers of photosynthesis. How many plants carry the terpine profile cannabis does??? Amazing plant
Its why RSO does work ..Cured my brother's prostate cancer
@@Jiggs2u2 Hey, wow and which strain do you use for RSO? help please. thanks. Indoor or Outdoor?
Doestheuniversehaveanedge?, I've been singing and whistling a lot lately, hummm, wonder if it is the pot?
I can say with confidence after 7 years of smoking that when I go without weed I DO INDEED become more irritable, easily stressed, less positive and just overall don’t feel very good until I give my body time to upregulate my receptors again.
Dude, this lady isn’t “bashing weed” or saying its bad she is simply clarifying the potential negatives along with the positives by allowing the viewers to see the WHOLE picture on cannabis use, short term AND long term. “FDA brain washer” not even close bro 😂😂😂 those people run wild for sure but this lady just spitting facts. 🤷🏽♂️
I’ve been using cannabis off and on since i was 15. 36 now. Never had an issue when stopping, never had an issue to stop, and never experienced any negative side effects. Memory is great, 3.6 GPA in high school 3.4 in college. I’m rarely sick, especially when i’m using cannabis. Most people won’t experience negative side effects. Remember, cannabis is the second most used drug behind caffeine.
Chris Nicassio Just because one person doesn’t does not account or justify the fact that alot of others do indeed experience negative effects coming off of it.
@@lethalhazard2285 Indeed. Cannabis use disorder is treated frequently in the U.S.
Most people won’t experience this. Less people will experience withdrawal from cannabis than caffeine.
@@DontCancelMeBro I've been drinking coffee since I was 18 and I don't get withdrawal symptoms. Never had issues stopping coffee. GPA 3.98 in college. Terrible in highschool. Must be that coffee made my whole life Better.
I may or may not have experienced some cognitive dissonance while viewing this presentation.
The power of the endocannabinoid system and how it relates to all relevant health systems is amazing. We have to convince medical schools to teach this system to the doctors of the future. It’s the reason why I created a whole education video series around CBD. Just make sure you do your homework and know what to look for in a high quality and safe product. Great talk.
I swear to God I have no incentive, but I use Genesis Pure Botanicals and I've tried about 10 other options and even run a test kit, and their product is the best quality by FAR. I hope this saves someone getting ripped off.
Where can I find your videos and what are they called?
@@JBorg-fb3un lel
🗣No money in a cure tho 😅
I smoke 2 1/2oz a month and can eat 100mg and no high effect. Also it’s all really super duper high quality marijuana. Yay!!🥴💨
She lost me at the 9:30 mark. "For CBD we still have a lot of questions about how it works." So, I guess were just going to dismiss the 20+ years of studies done by the Israeli doctors that discovered the ECS...ok then!
almost all research thus far has been THC research and most of that was NIDA smoke harm research that denies any positive attributes, like phytocannabinoids supporting our cellular homeostasis or preventing oxidative insults... the Gov made this patent = #6630507... and then what ?
@@mcozy333 not true. Take a look at Prof. Raphael Mechoular. Hes the Israeli scientist that discovered the endocannabinoid system and grandfathered CBD research 30+ years ago. Just because the US holds a patent doesn't mean the rest of the world isn't researching.
The US does not hold a patent anymore. It used to, but that patent expired.
@@skinnybuddha74 the patent actually expired today, so at this point, you are correct.
Yes!
As a medical student, I could only dream of having a professor explain medical conceps in such an understandable way
It says nothing about the quality of information...
if only endocananbinoid system were taught in medical schools .........................
You know what? I am going tobmake that my job.
Re: Dependence and a down regulation of the endocannabinoid system. I use cannabis to regulate my emotions and deal with stress. For 42 years, I didn’t need to do this. When I turned 43, my underlying depression became impossible to manage on my own without meds. SSRI’s didn’t work for me. I didn’t like how numb they made me. Cannabis puts me right back on track though. Could it be that age, stress, or genetics makes some people’s endocanniboid system malfunction? And in this case wouldn’t cannabis be seen as a reasonable solution? Like any other medication? And it’s not synthetic?
The endocannabinoids get depleted and cannabis consumption restores the system, from what little I know, and God knows best 😉
@@ItsBenRoyboy lol
.
Which ssri’s did you try that made you numb?
It’s hard to say, but it can at least be said that the endocanebanoid system helps to make more solid neural pathways in the brain of important memories and helps to fizzle out one’s no longer needed. This paired with therapy could be extremely beneficial to those who have been struggling with anxiety and depression for sure. I do look forward to further research in the field.
Ive experienced the same except im 16, mindful use of cannabis seems reap so many benefits especially for physically painful diseases and in our cases depression from deep rooted trauma as seen in ptsd
It has worked miracles for my uncles who, 3, have MS. Myself for addiction to opiates, clean over six years now, and more importantly attacking the root issue, ptsd. It’s helped me with my issues when needed as well. now, it is amazing to see the positive view by the population, which is long over due. I cannot believe we are finally seeing the gov appreciate their citizens wish, hopefully legitimate. Now If only they would finish the idea of removing it from S1.
Big pharma, the alcohol and tobacco industry will always be opposed to the cheaper and more effective alternative that is cannabis.
Its all about profit to the governments and mega corps. Morals and affordable medicine are somewhere at the bottom of their list of priorities.
2018 farm bill was a great thing Trump did. Will Biden continue on it and make thc legal federally.
Otherwise CBD and delta 8 THC would still be illegal right now if not for that 2018 farm bill.
@@larrytate1657 trump didn’t have anything to do with that but sign it. It’s been in the works for years. My local gov felt the need to use it to continue allowing big ag, who are terrible people in small towns, destroy our lands here. Literally and fiscally. We had a multi million lawsuit about to hit from our law firm to the big ag here, they secretly went into that farmers bill and changed, for georgia, the statute of limitations by half in which someone can sue a farming op. For every good there is a bad. But I think most can agree to include almost all farmers, the farmers right to farm is allowing big ag to ruin and finally kill small to medium farming practices. But what it did for delta 8 is great. As I use it every day.
Good job! Same here almost 3 yrs! If it wasn't for God, 2 wks of subs & weed, i wouldn't be here.
Good concise talk. I am not pot user but strong supporter of decriminalization and appreciate good unbiased information... knowledge is power.
What a disappointing lecture. 17 minutes to tell us that endocannabinoids regulate stress. Is that the summation of your PhD? A very condescending lecture. Nothing has been demystified. ‘Regulate’ tell us nothing about the molecular mechanism behind how it works. A lock and key analogy tell us nothing. Was her PhD the term ‘lock and key’ repeated thousands of times? Tell us something! I find it extremely condescending when scientists keep any info that is remotely scientific from us because they think we can’t handle it. All it achieves is an overly simplistic explanation that answers nothing.
phytocannabinoids bio-mimic endocannabinoids - non selectively... we form endocannabinoids from the cell' bi-layer where the essential fatty acids from the diet are stored . phytocannabinoids are termed free flow/ free form cannabinoids already structured to signal as full formed cannabinoids so no need to displace phosphatydilcholine / Sterine from the bi-layer when exogenous plant cannabinoids are in circulation ... plant cannabinoids are anti oxidant compounds taking the same exact pathways in our cells that omega three fatty acids take ... this seems to explain way more and I've not even touched or scratched the surface of endocannaqbinoid system knowledge here
For just over 20 years I had been taking Paxil and Klonopin daily so I could function dealing with C-PTSD for about 3 years I was on Oxycontin for arthritis pain. One of my doctor visits I was asked if I would be willing to give cannabis a try, I did not think it would help all that much I have smoked it many times before. I studied it got my card and now I do not use any prescriptions, just cannabis and it is doing me wonders. Losing the side effects alone from prescriptions was fantastic. With that said I found this talk very interesting but if a person is living in a constant state of fight, fight, or flight (used fight twice on purpose) would THC be the perfect key? Not only did she dismiss CBD she did not mention all the other cannabinoids and terpenes, cannabis is far from being all about THC and CBD but people are stuck there.
I totally agree been taking xanax 4 20 years and tapering and cannabis has really helped. Big Pharma just wants you to get addicted.
@@sirgucci452 420 years, damn Ann talk about getting high.
Indeed they found a new compound called CBG and another which I don’t remember but it’s CBsomething and found out CBG is pretty good at fighting insomnia and pain
Write it down, re-read it then burn the paper. 🔥 Also, download Tetris and play away.
Yep she still a pharma schill .. period .
Here's your data: in America, for instance, tens of millions of people have been consuming THC on a regular basis since the mid-1960's. This group is certainly large enough to draw scientific conclusions from. Such as, there isn't a single negative health effect that can be identified within this group that doesn't exist in the whole population. There's been no increase in schizophrenia as a percentage of population. Cancer, diabetes, stroke and heart disease are in no way elevated in this group. Conversely, we know for a fact that tobacco, fast food, soft drinks and Republicans actually kill people on a regular basis, all in their own way. With tobacco, our response has finally reached a proportional level. With fast food, soft drinks and Republicans, we are firmly in denial. The attack on marijuana began back during the Depression. A decade later, Congress held a hearing on marijuana, wherein a doctor from the AMA testified that he could see no harmful effect from using marijuana. Rather, it made people calmer. One of the Congressman replied "doctor, if you don't have anything to say to help us, why don't you just go home?" That's America. We make up our mind about something and the persecution begins. So, while this video was interesting, Dr. Ross' conclusion that more data is needed, simply ignores the overwhelming data that exists.
You're right and no she's not wrong they do need more data to prove all the pros have cons because they haven't found any cons yet only pros. So they are doing everything they can to disprove it but hey get your opioids anytime from your doctor in the meantime, you know the side effects it's nothing new. So bottom line, try marijuana and be the first out of millions to acquire a horrible side effect from the weed not your actions while on the weed or keep taking opioids and be among the thousands that die from it, your choice.
Only thing more deadly than cigarettes in the US are the Clintons
@@crashhappy7296 - Uninformed nonsense. Stop reading fake right wing news.
There are no official numbers about what you are writing here, I guess...
@@MyOnlineBusinessExperience - There
How can you keep talking on endocannabinoid system without talking about ANANDAMIDE..
Lots of emotion and very little science in the commentary. The problem is the assumption or belief that an auto-regulating system (the endocannabinoid system is an auto regulating system that is part of a much larger auto regulating system called our entire body) can be used to fix problems. It can only be used if it is out of balance and the thing(s) you add specifically put it back into balance - otherwise you make the imbalance worse. It requires precision because counter-regulation means not enough or too much of something even if it is the right thing is as bad as or worse than the wrong thing. This system tells our brain where to make connections when it is developing and that happens a lot before we are born, for our first 5 years,and during puberty and out into our 20s. If you mess up the chemical balance or signalling connections end up malfunctioning or in the wrong places. These wiring problems are the genesis of mental health problems including schizophrenia. We know physical and mental stresses increase risks because they upset the balance. THC upsets the balance because it can't act like our own cannabinoid signallers because it can do different things at the same switch, sticks to it too long and sticks around too long (our own cannabinoids are "on demand") and gets in the way of our own signals trying to regulate themselves. The Big Pharma is a straw man argument. Our human physiology is designed to survive but it is imperfect. Illness is an imbalance of a signalling system because when signalling works it fixes itself. If we are going to take over that job with cannabinoids, or any other chemical regardless of its source, we need to understand it a lot better than we do, and recognize just because something affects a system doesn't mean it is always good.
There is also plenty of evidence of harm. Even those who choose not to believe it cannot show evidence of safety because it has not been systematically measured in the broad population. It doesn't mean we can't find a way to use things that work on this system effectively and safely but we are still far from that understanding and design and testing of any manipulation of the cannabinoid system. This basic understanding of pharmacology started thousands of years ago with systematic assessments and measurement and refinement and purification and isolation og the ingredient that was the key to the balance. What is happening with cannabis is a dangerous shortcut with our population as the phase one study.
our cells contain way way more than just cb1 and cb2... there are at least 300 cannabinoid receptors capable of metabolically signalling a multitude of fatty acid type compounds... ECS is non selective because it is based off diet somewhat ( PUFAS/ HUFAs) and can be activated , modulated by a variety of biological ligands that we as upright beings come in contact with via consumption or diet...
the references to cannabis being helpful ETC is usually noted when the person had failed to receive treatment from mainstream sources and cannabis is last resort... so many people being treated for the good and helping their lipid metabolism by supplementing with exogenous phytocannabinoids.
Edit- a work around for mainstream info on cannabinoids = pro resolving lipid mediators
scientists to pompous to identify with cannabinoids becasue of relation to cannabis plant... well, they know what a resolving mediator is and cannabinoids are that
another thing too = endocannabinoid system is the buffer to the fats we eat... it literally buffers via signalling the fatty acids in our diets and creates signalling toggle switches with those fatty acids... ECS is non selective because of that and will signal any lipid compound with correct mass and formula... we have predicted there are around 300 cannabinoid receptors per cell not just the two we have found so far...
What you smokin bro ?
Conclusion: Weed bad, pharma good, need more money for pharma to make bad weed good.
more research needed ! the cannabis is the most researched plant by millions of miles ... most of that research is biased NIDA smoke harm research that completely ignores cannabinoid sciences or endocananbinoid metabolism and phytocannabinod effects as a cannabimimetic . NIDA outsources the actual biochemistry to Israel where they are developing treatments and such and have the most knowledge of endocananbinoid system
But she would have dinner and a bottle of wine or a few beers without a second thought. Why is alcohol which has no medicinal value and is processed and causes illness and deaths be allowed but we are denied cannabis which saves lives? This is twisted. Money money money. Money matters more than lives. Money rules.
EspressoYourself some US states have made it possible to possess and use recreationally making it far easier for more users to have access in a medical sense as much as a recreational sense. Still a pain if you don’t plan on moving though.
Money spare one the necessity of having to get change in potatoes when buying a chicken. Standard of exchange. Your teachers never used that term? No surprise. Teachers rarely discuss how much they're paid to babysit.
Alcohol has been used to extract medicine from plants (including cannabis)for thousands of years. People are responsible for abusing all substances.... including cannabis
EspressoYourself, Alcohol is legal and kills people, Weed is still illegal in the governments eye's but does not kill you, go figure?
@@harrygearhart4520 It's legal in Canada
God made it for us....apes aren't your ancestors
She did a great explanation on the endocannabinoid system but when she talked about cannabis THC i felt like she wasn't as confident as before
I felt that too
Perhaps she needed another joint...
She nows she had no proof for what she says about THC
Also, she said there are many unknowns about cbd...what?!? There is just as much research on cbd as the. This wasn’t as informative as I thought it would be.
Because in a few cases there with THC, she wasn't telling the scientifically/evidence based information, but rather speaking on assumptions and opinion. For example schizophrenia - there is zero evidence it increases one's chance of having it, but rather bringing forth an episode from an "existing schizophrenic" is correlated, not caused.
The runners high is thought to be due to annandemide in recent times which is a endogenously produced cannabinoid. So runners are stoners teehee
Anandamide is our bliss compound created to keep us happy healthy and other things LOOL .... it is N arachidonoylethanolamine ( AEA) . the Amine of Ethanol ... this is the high
@@mcozy333 cheers for the info
The fact that there’s 420 dislikes on this. Well played stoners, well played. 😂
There is 6000 years of research
Stop trying to monetise Gods gift 70 years ago it was legal and used throughout the world.
you can produce it yourself with meditaion and breathing. no need to consume it. its like creatin, if you tske it from outside the body will stop producing it. just do Wim Hof method
@@danieldias859 thank you for sharing this, had heard of the iceman before but never realized he was wim hof, love his personality and advices and hope to one day be able to regulate my own endocannabinoid system from within for good health and wellbeing-know a friend who did it
@@danieldias859 ther is no way to produce cannabis metabolites via breathing or meditation ... you will create similar lipid metabolites but not exactly like cannabis ingestion ... just saying
She TOTALLY left out the Terpenes and Flavonoids that are important in the "entourage effect"....her lecture is woefully incomplete at best. Grade D
Pretty disappointing if I'm honest. This is just the typical UK government 'yes man' doctor scared to death of going against the government's unjust policy against cannabis.
That was sad. I kept yelling “Terpenes people! Terpenes!” More propaganda.
'This talk is actually not about the effects of cannabis but about the isolated effects of THC. Her views here about the effects of THC on the endocannabinoid system may be very interesting to the pharmaceutical industry, but to those of us wanting to understand the effect of THC when you use the plant naturally it is almost irrelevant'
@@johnf.hebert1409 THC is a terpene - a monoterpene
THIS IS NOT A LECTURE ABOUT CANNABIS! Your comment is totally wrong. Re-read the title of the video. It’s a discussion about the EC system within the human body. It’s meant to demystify this misunderstood system in our body!!!!! As the title clearly states. And in the last few minutes she mentions THC. THIS IS NOT an in-depth video about cannabis. So when you call this short 18 minute TED talk “woefully incomplete at best” you are dead wrong.
Cbd oil helps me. That's all I care about.
CBD is one phytocannabinoid out of 147... cannabis is much more than CBD
@@mcozy333 ok
Problem with this Ted Talk - she was dishing out negatives about THC. Then with CBD or the other cannabinoids m she's like 'nah not relevant'.
June Kirri it’s helped my whole family with a variety of issues. We’ll continue using it.
Same. Makes me much more positive and stable.
Cannabis has been used for thousands of years (probably 10.000+ even) and the only ones complaining about it are the ones that ISN`T using it.. what´s up with that ey ;/? Also, what you call "dependence" I call "preference", as in; "I prefer to feel free enough to choose to take a delicious (imo) health-supplement if I feel like it, aslong as it doesn´t harm anyone."
The levels of stress people experience overwhelms the endocannabinoid system. That's why we have so much inflammation and stress-related diseases. Why don't doctors talk this negatively about Xanax, or Valium, or Klonopin, or any of the drugs prescribed for depression and anxiety? I've known several people whose lives were totally disrupted by these drugs.
Betsarama Xanax helps with my C-PTSD. Marijuana is illegal, so if not Xanax, then what?
Phoebe Lablonde Thank you so much! You just made my day. Unfortunately, the ungodly stress (good ole’ boy judge let ex husband walk for abusing our kids) has led to inflammation so high that it started shutting my organs down.
My dr at Mayo mentioned marijuana reducing the stress and inflammation, but I live in Texas. As it is now, he gave me less than 2 years.
At least I have a good excuse for not going to the gym. 😉
Brandy Moore legalize!!
Medicine is a monopoly. All members scientists or practitioners are brainwashed by the monopoly.
@@RiaSwiftHealing maybe even more so - American Medicine ... there, fixed that for you
I was looking forward to a great talk but Im disappointed, I am not interested in THC but in CBD ... but ok...another scientist telling us things that many have observed already ...
Cannabis has been around for years and used in this country for hundreds of years. This sounded more like a Pharmaceutical talk for drugs not the plant and its well founded medicinal benefits. Granted research is scant here in the US but we have been funding Israel for years and they have tons of research on cannabis benefits as well as Spain!
007jjb the title is the endocannabinoid system. Not the great uses of the plant
I think you might be missing the point of the talk.
@@TheClarkchern we identified ECS because of cannabis... canabis creating the phytocanabinoiods provided a structural platform for us to metabolically follow, trace and identify,... we came up with ECS... an entire physiological system in man
So what’s the alternative pharmacy drugs. I’ll stick with cannibus
up to 50% of prescribed drugs are made to target humans G protein-couple receptors . phytocannabinoids in " the cannabis" are biologically active in the G protein receptors. so, cannabis competes with 50% of meds, or cannabis is active where 50% of meds are
There is no need for any drug.
@@Amy623 every cell in your body is a powerhouse of drugs ( biochemical signals)... just examine the biological goings on in every cell in your body... you can start via examining the endocannabinoid system ( where cannabis metabolism occurs)
Amra Nuric i mean there kinda is, without pain relievers or medicines (drugs) many people would die
@CG Jung there are also up to 300 cannabinoid receptors while we have only really researched two ( cb1 / cb2) and speculated @ a third .... G protein-coupled receptors are in the 7 trans membrane super family of receptors, the largest grouping of cellular receptors in our bodies ... each depolarized Gi protein touches interior of cell 7 times before finalizing that signal with DAGL / FAAH ... a lot of the metabolic expression of cannabis also has to do with increasing / decreasing Epoxides and fatty acid binding proteins and TRPV1 .... basically activating the mechanisms that functionally drive the enzyme production that biodegrades lipids into signals ( biochemicals) ....
endocannabinoid has been a study for a long time, and there is a good reason why people are now becoming interested in it. There is a lot of good benefits on using it.
There should be research into why cannabis is helping me with physical therapy.
THC replaces anandamide and disturbs it's natural production. Anandamide seems rather important for managing mental illnesses. Which is why it makes Schizophrenia worse. Cannabidiol almost has opposite effect. And is all around a good guy molecule.
Also exercising on THC is probably a good idea and easier than you might think. It would like having a runner's high before you run.
I use a puff or too before any exercise. I works.
THC does not replace anandamide. Anandamide is not even regularly produced, it can only happen when the body needs it. The cannabinoids also naturally down regulate, and if there was excess THC in the body it will not oversaturate the receptors but eliminate itself via plasma. THC cannot damage the mind as people say to put it. Regarding anxiety and more, depending on the dose and mindset is what affects it. The feelings people said about feeling unreal, depersonalization, and just blissed out from general living, is mentioned in Eastern philosophy and quantum physics. They make it clear, that this reality is only as real as it's perceiver.
Big pharma wants to create long term customers. These substances may threaten their bottom line hence the suppression
Is this a descendant of Anslinger trying to clear the family name?
Was going to down vote because this was nothing new and not the best presentation, BUT the down votes are exactly 420 so let's keep them that way
Wow, so disappointing to see a TedTalk with a guest that is giving BAD information. I have to wonder who is paying for her "research"....
The hardest task for a TED- speaker is to separate the real valuable facts and knowledge, from the manipulated information and fake news... If you watch this one carefully, you will realize what I'm talking about...
what do you think was manipulated/fake?
@CG Jung It's the money from the industries that play the rules. The scientists are good but have no power to change the law.
@CG Jung I don't think, I know. As said, scientists are not the people to blame, but the industry behind.
She did okay slowly breaking down the bare basics of how the body and endocannabinoid system works, but should have left everything about the actually cannabis plant out, considering she doesn’t actually know anything relevant, useful, or credible, and basically just did the classic play it safe card of saying it could be dangerous or it could not be, we don’t know, we don’t have enough data. That’s fine, but leave it at that if your gonna speak on things you don’t actually know about, instead of saying “it could be dangerous and you shouldn’t do it because we don’t actually know”. Seems like she researched endocannabinoid systems in the body, and did not conduct research or study credible data on cannabis use or effects, and therefor really should have only spoken about what she actually studied.
until cannabis is not being prohibited most people will state stuff such as that ... beware, caution etc.... just so they do not look like they support the plant or something
Thats why we smoke the whole flower and not try to isolate thc
Is she trying to say that it is luck that thc binds to the endocannabinoid receptors?.. I honestly was pretty disappointed with this woman’s presentation. All it is was surface level facts, nothing exploring health benefits nor gave an actual reason for why we have so many cannabinoid receptors.
THC biomimics anandamide which is an endocannabinoid ... there is no coincidence ther @ all or luck whatever LOL.... Anandamide is created from pre cursor phospholipids in the cell membrane ( arachidonate system / arachidonic acid cascade) ... it is depolarization induced messaging dictated by cells' needs as determined via homeostasis response ( maintaining presence in the Void) ..
Why THC is non toxic ETC = THC and all of the plant cannabinoids while xpressing in man are non selective ... they will not force a cb pathway ETC... unless the cell requires that @ the moment of xpression ... if THC is not needed per cell THC will go to waste elimination. Edit - what we have found - THC as a meroterpinoid acts as an essential fatty acyl
She said cannabis is not the reason we have an ECS. But I don’t believe in coincidences lol
Thats so pharma industries can make synthetic analogs and profit. Drabinol is a synthetic analog of a cannabinoid yet one is legal and one isnt.
It's all about the government being involved in every aspect of your life.
9:05 , THC is not actually in cannabis plant. THC is an oxidized / decarboxylated form of THC-a ( carbon active THC/ acidic form ) which exists on living cannabis plant as glandular resin located in the trichome of the flowering cannabis plant. when the plant completely matures into fruition, it dies and dries and the carboxylic acids then melt away from the molecule exposing the active forms of the compounds ( Hi Grazing nature !) ... that exposed compound molecule form is the active version of the compound ( THC) .
Doesn't the chemical reaction of burning hence smoking this plant also cause this reaction? Or does it just amplify the transformation of what is already there?
@@luissoto1491 to exist in a viscous environment ( living plant) the phytocannabinoids contain an enzyme shield consisting of a carboxylic acid, known as carbon active cannabinoids / acidic form cannabinoids. Heat/ time / oxidation will remove that carboxyl grouping from the carbon structure of the molecule thereby making it a compound molecule... the molecular structure then compounds in upon itself making it more biologically active so in that way it is an amplified version of what is already there.
an example of the size / increase / decrease... THCa ( tetrahydrocannabinolic acid ) is 347 g/mol... decarboxylated THC ( tetrahydrocannabinol) is 314.14 g / mol.....
lipophillic / terpenophillic compounds in the C18 - C22 carbon range that are 100 to 500 nano moles in size will be biologically active, capable of passing blood brain barrier , causing a confirmation of change ( bio-activity)...
Edit - new research is showing carbon active phytocannabinoids to have psycho-activity as well... the acidic forms in amn/woman act as Reverse Agonist agents not directly binding to cannabinoid receptors but increasing Epoxides and Amides in the endocananbinoid system that biodegrade poly unsaturated fatty acids into endocannabinoids... I've got a ton of research I could present , not sure where you are in all this but let me know
@@mcozy333 Still very interesting to learn about terpenes !
Y
@@traaavistraaavis8348 Y the short sentence structure ?
This talk is actually not about the effects of cannabis but about the isolated effects of THC. Her views here about the effects of THC on the endocannabinoid system may be very interesting to the pharmaceutical industry, but to those of us wanting to understand the effect of THC when You use the plant naturally it is almost irrelevant.
I agree 100%
Correct...
Very true
im regulating my receptors now
To me marijuana makes me feel bad but that's cuz of medications I already take but to some people it does help them
Scottish against cannabis , what about the toxin called alcohol? She says we need to see the effects of thc but thc is being used studied for centuries , and many things you said not correct
Worried about Pot Safety!? Do they still show the ancient movie, 'Reefer Madness' on this channel too? Eesh!! 9:36 / 17:35
She needs to try cannabis before her next presentation.
B4 people in the cannabis community listen to people like this they first should ask:
1. who/what agency authorized this woman to study cannabis
2. Has this woman ever used cannabis before?
3. What is her agenda?
A major problem I gave is the use of the term medical cannabis. There is no such thing. It is a term that has been manufactured by the state and is a soft form of propaganda. The purpose being to disscredited the safety of non licensedl/home grown trees.
And then of course she said "WE" need to study it more. Why? Has it killed anyone? Since the answer is no, then she should have said that she WANTS to study it more. The way she left it is a tad too REEFER MADNESS 2019 for me.
Don't be duped fam.
NIDA has been studying it for so long... more studies are needed LOL. if they have not found a harm yet still insist on harms = WTF?
How sad to have so much excellent information about the ECS and so little understanding of cannabis and it’s compounds. Probability? Are we serious woman? More propaganda. Learn about terpenes already.
Terpenes vary from cultivar to cultivar. And they can be found in many plants. Such as Rosemary, Lavender and Lemon Balm. And they do have subtle effects on mood.
But nothing major.
phytocannabinoids ( THC/ CBD ) are terpenes too... they are monoterpenes
Thanks for this clear breakdown of the ECS. Would love to hear the talk re: CBD that you said would be an entire other talk. The information out there is extremely confusing and limited re: how CBD actually interacts with our ECS. In turn, there is a lot of misinformation being shared everywhere by all kinds of publishers and companies.
Now I can finally explain the psychoactive reaction! It's basically just you timing and dosing it wrongly! As a healthy person it can lead to wonderfull things but in case something is wrong the overcharging can pinpoint the problems which then have to be resolved with a perfect combo of THC and CBD. If only the pharma industry would have never stopped the researches early 1900's many of my family members would be still alive. Thanks for your work Dr. Ruth Ross you saved so many people and hopefully make them aware of the pharmaceutical scam THEY are trying to pull through the last 100 years 🙏🙏🙏🙏
cannabis tends to make up for a lack of essential fatty acids we do not consume ... the phytocannabinoids act as EFAs with more bio-activity. anandamide and 1-ag require EFAS to build up enough lipids to make and form them ... exogenous cannabinoids supplement that process
oops - 2-AG , a arachidonoylglycerol , not really 1-ag lke my other post ... that guy was wrong LOL
Interesting in that she postulates that Cannabis affects the endocannabinoid system by chance, saying it is a question of probability only.
I'm not so sure.
our ECS is sustained on essential fatty acids we consume in diet... with a lack of EFAs our endocannabinoid tone decreases and less signalling metabolites occur ( cannabinoids)... here is th epathways... EFAS via eicosanoids / prostaglandins / leukotrienes metabolize into PUFAs. oxygenated / phosphorylated PUFAs are endocannabionoids . our cell' phospholilipid bi-layer cleaves off those lipids in order to form them into signalling cannabinoids ( pro resolving mediators) . C-18 to C-22 lipophilic compounds in the 100 to 500g/mol range will be used fr signalling purposes in ECS...
Sea Squirt was the first vertebrae to synthesize cannabinoids and form an endocannabinoid system... 5 billion years ago
Yeah that's where she lost me.
That's not what she said though. She said because we have a large amount of receptors that each fit with certain molecular shapes, chances are that similarly shaped molecules (e.g. THC) can fit into the receptors also. And because a cannabis plant has many cannabinoids, chances are some of them fit into our cannabinoid receptors, which they do (again, e.g. THC).
She isn't saying that it is random that cannabis affects us, she just explains how it can be that outside molecules work in our bodies.
As opposed to...?
Cannabis cures❣️
Sounds like an agenda 🤔
Jackeline Molina it sure does. Rubbish talk half truths.
What agenda are you referring to?
@@TimmyJimmyJack she focuses only on thc
, don't know how she's allowed to talk so biased rubbish
I thought she was pretty fair overall. I've been a daily user for the last 22 years, and although I'm so much more healthy than if I'd been a daily alcohol user for the last 22 years, most of what she said regarding thc rang true with me. It makes sense that your body compensates for over-stimulation. It's why you feel sad for a few days/weeks after hitting the mdma. And it's why I lose my appetite when I stop vaping weed. I don't even feel like she vilified thc tbh. Although my main objection was the repeated use of the word "unsafe". Alcohol is unsafe, not cannabis. Cannabis is just not as "natural" as some people make out; your body would rather be without a daily dose of it, in my experience. And that was pretty much what she said, in a nutshell.
She wraps it up with we need more data for research, yeah right, she means money to keep her job.
She isn't a very good speaker. There are a bunch of other videos and doctors who can explain it better.
If it’s working, stop complaining and start celebrating. Seriously!
Felt like she was walking a fine line and did not want to be seen as endorsing cannabis. I get it but didn't really get much out of this talk.
Dan Heil me neither the reason is the pressure of government funded research from years back people are still studying separated compounds from the plant remember no plant grows with just thc ever!! Nobody smokes or eats thc the reason is scientists want to patten which they almost did with sativex and Marinol study the dam plant and stop manipulating and dismantling its chemical composition and then calling it bad
No she was not. She was batting for synthetic drugs to be used to enhance ECS. Look carefully at the last slide.
Total narc
This video reminds me that a medical dispensary recently opened less than 2 blocks from my house and I have no medical card and no buds... :(
After stopping smoking weed I feel like this actually makes a lot of sense for me in particular
Dogbert, I agree. For me it's necessary to stop. But I can't hahahahahahhhhahah
Like I quit smoking 2 years ago, mentally i was complete wreck. Here I am still putting this mess all together, and its finally starting to make sense.
It is very interesting to hear this..., but I live in Europe and here THC is not allowed. So we have very good Quality from CBD and this is so helpful for People, without intoxicant or psychological change...! For me would not possible to become healthy without it! I love it!
Genesis 1:29
1599 Geneva Bible
29 And God said, Behold, I have given unto you [a]every herb bearing seed, which is upon all the earth, and every tree, wherein is the fruit of a tree bearing seed: that shall be to you for meat.
Footnotes
Genesis 1:29 God’s great liberality to man, taketh away all excuse of his ingratitude.
I have used Weedborn CBD products and have healed without any problems. Now my whole family is healthy.
Budtenders typically don't even study terp profile which could lead to people having allergic reactions. The fundamental ignorance surrounding cannabis is astounding.
She’s missing the point just like the government funded research has all this time. Researching single compound the plant does not come with just thc and we should not use just thc
That is like saying you can only study natural philosophy not physics or biology
Or like saying humans would breathe better if we extracted the hydrogen and discarded the pesky psycho active oxygen...
Especially if we were fish dum de dum
Douglas Ross not at all. He is quite right, in almost every chemical activity there is a catalyst and an active component which performs the function. The catalyst opens the door, the active ingredient goes in and does the job. With just the catalyst used you have an open door and nothing to go in. And leaving an open door could be dangerous too
@@traaavistraaavis8348 totally
Thank you for the value of your time I wish people could see more truth in cannabis can treat cancer related illnesses.
Anyone who uses any kind of cannabis please come forward and help with this research! Simple!
Cannabis > Opiods
Sorry about your sponsor's profit margin doesn't matter.
The powers-that-be always try to steer you away from thc, just like this talk. I'm not buying into her speech.
Thus is unbiased scientific data 😂
If you didn't know her amazing accomplishments she would gladly go over them with you.
I liked the initial explanation of the endocannabinoid but when she was talking about using Cannabis it seemed like her presentation was more skewed to present the drawbacks and downside of Cannabis. She only briefly said that it may help with some symptoms and then quickly added that it may relieve some symptoms in the short term but make them worse in the long run and followed that by saying that scientists are developing medicines to target the endocannabinoid system. Hmmm... pharmaceutical companies can make lots of money off of medications.
real plants are no good , only ingest man made formulas that mimic real plants or real cre4ations = synthetic living on the Grid!
Did I just get this, weed makes part of my brain system stop working? Doesn't that makes one dumber? I quit weed!
Yea it all fits so nicely with the theory that plants grow in the same dirt god grew U.S. from funny how that’s is though considering how many people don’t believe
When I stopped taking an SSRI, it threw me into the worst depression, because my natural serotonin production had been horribly down regulated. Nicotine has a similar effect in how powerfully it down regulates serotonin. That's why people struggle to such a degree quitting smoking. Nicotine is very addictive. Quitting SSRIs was a nightmare that ended in a hospital emergency room. THC doesn't do anything like that. It doesn't down regulate to the same extent in most people; so it's not considered very addictive. It's my personal belief that I have never produced enough endocanabanoids. Microdoses of medical marijuana have helped me tremendously over a long period of time. Moreover I skip days with no ill effects.
Such excellent explanation, but leaving the topic on a negative note I though. Little emphasis on the benefits. Great overall
I have heard very good reviews about Weedborn CBD products.
I been exercising massively for last 6 months. I had a operation and almost lost my left hand. They said it depends on my health. After 6 months of it I have so much energy people think I'm on drugs. I think it's the endocannabinoid system.
I don't get it, are we all supposed to smoke more weed?
more like grow your won cannabis and juice non criminalized cannabis flowers anytime we want with no chance of going to jail
@@mcozy333 Yes. We should be able to grow our own and extract our own oil for our own benefit. It's a plant. Where do they get off telling us it's illegal and only M.D.'s(medical dieties) can properly prescribe it? They're insane.
Who paid this woman to lie like this 😂😂😂😂😂😂
this nostalgia @ this old school comment board where the censorship has not ruined everyones posts and opinions is great ! new school youtube is nothing but censorship all of a sudden
I know nobody wants to hear this, but she's right. One of my friends used to smoke a lot for a long time. He told me about how he never learned healthy mechanisms for dealing with stress, and how it's even affected him physically.
100% impossible to become physically dependent on THC. Mentally addicted yes, much the same as one can become addicted to water or air.
What? You need water and air to survive
Simple fact, you can become mentally dependent upon anything above and beyond the basic needs for survival, much like some people become addicted to eating. No particular foods, just to be eating.
@@GrampsPlace.ChrisGrisolia Ok but you need to drink water and breathe to survive. And there are varying degrees of dependence potential
Yes, the same as you need to eat to survive. I never inferred there wasn’t varying degrees of dependence.
I started using Weedborn CBD five months ago. It is the best option for me.
Is it a separate body system like digestive system and neurological
system?
The serotonin down-regulation by SSRI antidepressants results in a range of symptoms on discontinuation much more dramatic than THC discontinuation.
THC too is a tri-cyclic Terpene ....... THC effects 5HT1 and other NADA/NMDA receptors ... THC bio-mimics Anandamide quite well so our bodies recognize it in that way
I use (ok am addicted to) snuff tobacco (no longer smoke, use cannabis & alcohol) & I think tobacco must have some kind similar cannabinoidic effect, though milder? It's effect flutters between calmness and anxiety, depending like she says on what's going on, i.e. time, situation etc. I think smoking is similar also. Hoping to quit snuff soon so my system will have to become normalised. I expect it will be difficult.
Well, Dont we have enough time by know to know it’s not harmfull in the long run? I thought it was. No death’s for at least 2000 thousand years. Thats not enough?
I am a duffus, a social failure. I am not allowed to know these things. Yet, I am a HUMAN SUPER-COMPUTER.
I studied these things for fun.
Amphetamine is just Adrenaline without the trioxide
am i the only one or were all just waiting to hear about the cannabis 🤣🤣
I was hoping she'd play the Tele Guitar over in the corner so folks would sing and dance. Oh well.....
Its only in the last hundred years we have moved away from hemp fed to our meat animals.
I believe cannabis IS the reason we have receptors for it. Thousands of years in the making. I bet the people from areas where it was first used, have the most brain receptors for CBD?
Also, would people from the opium areas have more natural opioid receptors? Now in almost 2022 I think CBD may be said to be safer when we see what THC overdoses can do to us?,
Now we have THC 8, 10 , THC A CBG on and on. A friend has non-hogkins lymphoma and uses CBG
THC is one decarboxylated phytocannabinoid ... there are 150 carbon active noids in cannabis
I gave cbd a long try... It did nothing for nothing at all
I am Like # 420
2:00 Flight, flight or freeze response.
I was hitting my bowl as I watched this 😆😆😆
Dancing… I knew you were gonna say that! :)