Why do people get cancer, how it spreads, and how to prevent it? | Sendurai Mani | TEDxProvidence
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- Опубліковано 31 сер 2023
- After heart disease, cancer remains the second most common cause of death in the US. Only around 5% of cancers are hereditary, and the remaining 95% are sporadic, contributed by environmental factors and lifestyle. Among these cancers, carcinomas account for over 80%, which develop in epithelial cells. Epithelial cells are attached to one another; therefore, when cancer starts in these cells, they are also attached to one another, confined to the local environment, and develop a benign tumor. At some point, when cancer progresses, the cancer cells activate a latent embryonic program known as epithelial-mesenchymal transition, gain stem cell properties, and start to behave like cells in an embryo. These cancer cells with stem cell properties are resistant to most therapies. They move around the body and develop metastasis. Advancements in sequencing, imaging, and precision oncology allow us to characterize these detrimental cells spatially and temporally at a single-cell level to find a cure for cancer. Sendurai A. Mani is a tenured Professor in the Department of Pathology and Laboratory Medicine and Dean’s Endowed Chair for Translational Oncology. He is also the Associate Director for Translational Oncology at Legorreta Cancer Center and Director of the Cancer Stem Cell Center at Brown University. After completing his Ph.D. at the Indian Institute of Science, Bangalore, India, Dr. Mani joined the Weinberg laboratory at the Whitehead Institute/MIT as a postdoctoral fellow. Dr. Mani and his colleagues at MIT demonstrated that the activation of latent embryonic epithelial-mesenchymal transition (EMT) promotes metastasis. In addition, Dr. Mani was the first to show that the activation of EMT provides stem cell properties to cancer cells. This highly cited finding provided insights into the presence of plasticity within the tumor and how cancer cells survive in the circulation and develop metastasis similar to the tissue of origin at the distant site. Dr. Mani received several prestigious awards, including the V-Scholar and American Cancer Society Research Scholar awards and Dean's Endowed Chair for Translational Oncology at Brown University. He is an elected member of the scientific research honor society Sigma Xi and an elected fellow of the American Association for the Advancement of Sciences (AAAS). This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at www.ted.com/tedx
Resentment, mountains of deep anger and inability to speak yor buried emotions causes cancer.. i deeply feel it even though it hasnt been fully proved yet. But i know....my dad held grudges against random.neighbours and ex colleagues from 40 years ago. If he ever had a slight difference of opinion with anyone, he never spoke to him again and had bursts of anger for decades. He died of carcinoma of bile duct in a very bad situation, after all his organs were removed and he was left at 35 kgs.. even on this deathbed, he was angry at his nephew and was cursing him. I feel so constricted even typing this...he gave me a lot of doscomfort and stiff neck from all those painful memories.i wish he has found his peace.
Important topic and work you, God bless you all in Providence
You are in the list of favorites
I love how you described the body as a community! This was such a powerful talk, my friend!
Thank you, Tara!
Yes, that's all you got out of it. Community. Rest was palaver.
Mr you give hope to a generation
You are amazing. So inspiring
Some incredible information in this one, I don't know how you remembered it all!
GREAT STORY TELLING
Love the anecdotel storytelling here, one of the best TEDx Talk I've heard of late !
Thanks so much for sharing!
Research is lucky to have you, I read about you in an article recently too
One of the most clear, articulate, positive, powerful speakers i have seen
Thank you!
Appreciate💕 both you and your Shares Thank you
Your weekend shares are honestly my favorite. I look forward to them
Thanks lovely Videos!!
Happy to note the positive developments in Cancer Research.
One of the longest cancer survivors in the UK, delivers a triple award-winning book of inspiration. Me and My Shadow - memoirs of a cancer survivor, described as one of the most inspirational books of 2023.
Wow one of my favorite
Excellent talk Mandeep
Looked at your website too Mani, inspirational work you do!
Such Wonderful
Such Amazing
4:00 Three types of cancer
7:55 Cancer is an age related disease
9:55 Poor diet/habits
13:15 Future looking bright
Thank you for sharing.
Breathtaking
Absolutely amazing many thanks for you work and superb presentation
Thank you, @popotv9385!
absolutely stunning video Wow
Fantastic,your video just keep getting better & better All my favorites
Excellent,your video just keep getting better & better All my favorites
Beautifully delivered, such stage presence Dr Rai.
Although the title of your video say "how to prevent it" you did not say how to prevent cancer. What is the point of giving us an overload of medical information, when we cannot even manage to see a doctor these days. What can we as patients do with that information? We need consciencious doctors who seriously care about their patients health.
He told u numb nuts - get early diagnosis to cure it
Jeez it’ll be done way to go before they invent brain cell corrections
Dr. Jason Fung wrote The Cancer Code.
For everyone interested in all the un-answered questions left by this speaker.
he said don't stress, take time to enjoy life. don't smoke, don't drink alcohol, don't eat junk food, stay away from pollution, be respectful of your microbiome. he told what to do and what not to do but you didn't listen.
He said how to prevent cancer around the 10 minute mark were you even listening
Sounds like you are looking for a pill ?
One of Thee Best!
Your explanation of the difference between DNA and genes 5:10 is amazing.
Woow thanks for Sharing 🙏
Awesome talk, Mani.
Thank you, John!
Pleasant video
This looks incredible!!! ❤
The Values Compass- I love this , thank you fort sharing, enlightened !
💯Exceptionally amazing Videos
Value led leadership at its finest in this wonderful talk
Fantastic talk! Congrats!
Thank you!
Thank you for inspiring me to better ❤️😍😍
awesome I think Im crying Its that engaging
Outstanding talk, Mani. Thank you.
Thank you, John!
This is Fascinating
Thank you!
So empowering, thank you
what is empowering for us though? He didnt talk about what WE can do besides sending them more money and volunteering for clinical trials. We don't have power here.
Oh My God! Your video is really Enormous Graceful Frame
Superb!
Shade, gradient, idea, colour fantastic m8
great ! thanks !
I learned a lot! Thank you
I just want to name this Videos.."stunning"
I LOVE THIS
No words, only emotions
Very elegant💎💎💎
Many of us are here for the same reason so therefore, i recommend that you look at the work of Dr Thomas Seyfried and how his Boston university clinic is tackling cancer using a metabolic approach. While cancer continues to be treated as a genetic disease, we will never get on top of it. It also goes without saying that standard of care (chemotherapy and radiation) is going to do us in anyway.
Dr Thomas is the best at cancer he changed my life for the better.
Very Wonderful ❤️
Marvelous⏺
your Snapshots really awesome, i like it, looking forward for you next Snapshots, keep it up!
I know two people successfully on immunotherapy for melanoma. Both were given six months and both are fine and one is over three years on, the other about two years one. Absolutely brilliant for them and their families but it was very expensive.
Both must have been in early stages, and both would have been fine without establishment immunotherapy or chemo. Find better doctors.
Omg wow! That's incredible💓 I appreciate your Videos
Energetic
❤🌹 God bless you 🙏🙏
It's fascinating not just cool!
wonderful🌹
Thank you Sir for sharing wonderful information. If we see the causes of cancer and try to get rid of those factors with help from inside family or outside help. And very important point is to be happy and be respectful towards everyone. Always use good words, all the time our cells are getting the signal of love and hate from us. If love is more, for others too then no cancer. This is what I could understand. Harmony in our cells and bacteria will promote healthy body.
Please make treatme t for chronic diseases cheaper. Our right to live shouldnt depend on how much money one has. 😢
Wow👌 Awesome!✌💪☝👏👏👏👏 Very different
Super🎯amazing mate
Loved it
Thank you!
Amazing 🔥🔥🔥
Superb❤️
Thank you, Mani, for making complex ideas in simple terms for everyone to understand.
Thank you!
Amazing🔥
Very attractive❇
Deserves more views More people need to know
Thank you!
This one is awsm❤❤
for all people of peace and love
I Love this video
fabulous😍😍😍
your so Sweet😍 Thank you so much
Super talk.....sendurai mani ... by Prasad Madurai
Thank you, Prasad!
I love your posts so much
So excited For This Supercool Videos
This one is awsm😘😘
great🔥🔥
Very cool🎉
You are a Star👏
Top Notch 🌷
exceptional😍💞
One Of The Best Talks in Recent Times 🔥🔥
Thank you, @Manishceo!
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Sir is it you in the lecture. Nice to see it. Thank you ❤
OH! I like this one
you are so Special thank you for this Videos
Very attractive👏 🤝 👍
Oh wow! That's Fabulous💋 I love your Video
Divine😍
awesome! Have considered Master Class
Cool!
My role model ❤
Silence is golden indeed !!!!!!!!!!!!!!!!!!
Why you say silence? I want to know