Introduction to Cancer Biology (Part 1): Abnormal Signal Transduction

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  • Опубліковано 25 жов 2012
  • This animation is the first part of the series "An Introduction to Cancer Biology", and explains the mechanism of abnormal signal transduction resulting in uncontrolled cell proliferation. This animation also provides an overview of the potential targets of anticancer therapies.
    REFERENCES:
    1. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000 Jan 7;100(1):57-70.
    2. Herbst RS. Review of epidermal growth factor receptor biology. Int J Radiat Oncol Biol Phys. 2004;59(2 Suppl):21-6.
    3. Gerharz CD, Ramp U, Reinecke P, et al. Analysis of growth factor-dependent signalling in human epithelioid sarcoma cell lines. Clues to the role of autocrine, juxtacrine and paracrine interactions in epithelioid sarcoma. Eur J Cancer. 2000 Jun;36(9):1171-9.
    4. Potapova O, Fakhrai H, Mercola D. Growth factor PDGF-B/v-sis confers a tumorigenic phenotype to human tumor cells bearing PDGF receptors but not to cells devoid of receptors: evidence for an autocrine, but not a paracrine, mechanism. Int J Cancer. 1996 May 29;66(5):669-77.
    5. Andl CD, Mizushima T, Nakagawa H, et al. Epidermal growth factor receptor mediates increased cell proliferation, migration, and aggregation in esophageal keratinocytes in vitro and in vivo. J Biol Chem. 2003 Jan 17;278(3):1824-30.
    6. Di Fiore PP, Pierce JH, Kraus MH, Segatto O, King CR, Aaronson SA. erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells. Science. 1987 Jul 10;237(4811):178-82.
    7. Batra SK, Castelino-Prabhu S, Wikstrand CJ, et al. Epidermal growth factor ligand-independent, unregulated, cell-transforming potential of a naturally occurring human mutant EGFRvIII gene. Cell Growth Differ. 1995 Oct;6(10):1251-9.
    8. Egeblad M, Mortensen OH, Jaattela M. Truncated ErbB2 receptor enhances ErbB1 signaling and induces reversible, ERK-independent loss of epithelial morphology. Int J Cancer. 2001 Oct 15;94(2):185-91.
    9. Lage A, Crombet T, González G. Targeting epidermal growth factor receptor signaling: early results and future trends in oncology. Ann Med. 2003; 35(5):327-36.
    10. Adjei AA, Hidalgo M. Intracellular signal transduction pathway proteins as targets for cancer therapy. J Clin Oncol. 2005 Aug 10;23(23):5386-403.
    11. Beeram M, Patnaik A, Rowinsky EK. Raf: a strategic target for therapeutic development against cancer. J Clin Oncol. 2005 Sep 20;23(27):6771-90.
    12. Schmelzle T, Hall MN. TOR, a central controller of cell growth. Cell. 2000 Oct 13;103(2):253-62.
    13. Yarden Y, Sliwkowski MX. Untangling the ErbB signalling network. Nat Rev Mol Cell Biol. 2001 Feb;2(2):127-37.
    14. Igney FH, Krammer PH. Death and anti-death: tumour resistance to apoptosis. Nat Rev Cancer. 2002 Apr; 2(4):277-88.
    15. Delhalle S, Duvoix A, Schnekenburger M, Morceau F, Dicato M, Diederich M. An introduction to the molecular mechanisms of apoptosis. Ann N Y Acad Sci. 2003 Dec;1010:1-8.
    16. Veiby OP, Read MA. Chemoresistance: impact of nuclear factor (NF)-kappaB inhibition by small interfering RNA. Clin Cancer Res. 2004 May 15;10(10):3333-41.
    17. Foo P. Metastasis: The journey of mobile cancer cells. Harvard Science Review. Spring 2002;30-2.
    18. Hicklin DJ, Ellis LM. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol. 2005 Feb 10;23(5):1011-27.
    19. Ellis LM. Epidermal growth factor receptor in tumor angiogenesis. Hematol Oncol Clin North Am. 2004 Oct; 18(5):1007-21.
    20. Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus Irinotecan, Fluorouracil, and Leucovorin for Metastatic Colorectal Cancer. N Engl J Med. 2004 Jun 3;350(23):2335-42.
    21. Motzer RJ, Michaelson MD, Redman BG, et al. Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J Clin Oncol. 2006 Jan 1;24(1):16-24.

КОМЕНТАРІ • 64

  • @markmcnulty2164
    @markmcnulty2164 4 роки тому +110

    Ah yes of course, I understood everything.
    *rewinding intensifies*

  • @westfield90
    @westfield90 5 років тому +11

    Very good video. It demonstrates how many moving parts are involved in cancer and why most drugs fail to control it. We just do not know enough of the incredible complexity involved in cancer development

  • @AhmedMD
    @AhmedMD 8 років тому +16

    This was just a great video !!! thanks for editing, producing and thanks for people on sharing!

  • @osamaomar5681
    @osamaomar5681 9 років тому +5

    this is just EPIC and extremely awesome , i really can`t tell how i loved that series . excellent work INDEED

  • @petrunjelaa
    @petrunjelaa 9 років тому +27

    pretty dope series about the cancer mechanism! trully enjoyed it.

  • @IsabelRodriguez-nv2ue
    @IsabelRodriguez-nv2ue 3 роки тому +7

    Amazing high quality video!!! Thanks so very much for creating it!

  • @flames1000000
    @flames1000000 11 років тому +5

    I found this video extremely helpful, it has provided a basis about signaling within a cell.
    I would recommend this video to someone wanting to brush up on intracellular signaling.

  • @joshuabrucetaylor9897
    @joshuabrucetaylor9897 10 років тому +5

    Excellent video! Now THIS is a good way to learn. Keep up the good work :)

  • @smenila
    @smenila 10 років тому +2

    Thanks a lot! Excellent video!

  • @embroidery1415
    @embroidery1415 7 років тому +3

    extremely instructive...thank you

  • @akalharpreet
    @akalharpreet 7 років тому +1

    ultimate and outstanding video.

  • @carolinegronnier6888
    @carolinegronnier6888 4 роки тому +3

    Thank you for this amazing and very pratical vidéo.

  • @nehasharma7013
    @nehasharma7013 6 років тому +4

    Very good explanation

  • @souravssg4906
    @souravssg4906 6 років тому +3

    Awesome explanation :-)

  • @bondstreet2300
    @bondstreet2300 11 років тому +3

    Great video

  • @user-eq8mc2hi3y
    @user-eq8mc2hi3y 3 роки тому

    Thank you for a great video

  • @khanhnguyenvan3001
    @khanhnguyenvan3001 9 років тому +1

    thank you so much

  • @ksomkiart
    @ksomkiart 10 років тому +2

    thank you

  • @Chalermdate
    @Chalermdate 11 років тому +3

    Thanks! uploader

  • @julianrg
    @julianrg 5 місяців тому

    Very good! I was able to learn more

  • @eglalreda5552
    @eglalreda5552 7 років тому +1

    great !!!

  • @sportscook
    @sportscook 9 років тому +2

    superv explaination :)

  • @michelangelocaravaggio5018
    @michelangelocaravaggio5018 4 роки тому

    very very very well explanation

  • @drsondhi
    @drsondhi 11 років тому +2

    Fabulous

  • @99lavanya
    @99lavanya 11 років тому +2

    thank u soo much.......

  • @gjzztrrettmmggrrertzhgyena4950
    @gjzztrrettmmggrrertzhgyena4950 4 роки тому +1

    Yes Yes Yes Sir💖💖💖 GooooooD 💚💚

  • @idarmistorres3156
    @idarmistorres3156 10 років тому +1

    super nice video!!

  • @ildarkabirov
    @ildarkabirov 10 років тому +4

    thank u

  • @Uveps
    @Uveps 11 років тому +2

    great vid

  • @iceprince710
    @iceprince710 9 років тому +1

    Great.

  • @victor3431
    @victor3431 5 років тому

    Great!

  • @akp398
    @akp398 6 років тому +2

    Nice video, it explains how the body can heal itself if we give them good balanced nutrition.

  • @alirezatopu8681
    @alirezatopu8681 10 років тому +2

    nice one

  • @archa1624
    @archa1624 8 років тому +3

    Where can I find transduction pathways associated directly with gene expression and regulation?

  • @tonydehn1419
    @tonydehn1419 7 років тому +1

    awsome

  • @andrewdjburke
    @andrewdjburke 6 років тому +10

    Transforming Growth Factor Alpha, Not Tumor Growth Factor Alpha. Tumor Growth Factor Beta, Transforming Growth Factor Alpha.

  • @frax6962
    @frax6962 4 роки тому +1

    Can someone please suggest some good introduction textbooks about general cancer biology?

  • @charlestsebesta7812
    @charlestsebesta7812 7 років тому +1

    Interesting

  • @myme4ever
    @myme4ever 5 років тому +1

    The animation is excellent and the explanation are clear but very unstructured. It was hard to take notes while watching

  • @MichaelHarrisIreland
    @MichaelHarrisIreland 7 років тому

    Seems to me like a promotional video of how well they are doing. Which is fine even if it's not true. But not fine if, "not true", holds up some other research which is.

  • @sadiasanawar6869
    @sadiasanawar6869 5 років тому +1

    The animation is way too good.

  • @gianlucadantonio7924
    @gianlucadantonio7924 8 років тому +1

    umm --the video says that overexpression of Growth factor receptors causes ligand independent firing - id look over that one more time
    Its more likely structural mutations to the tyrosine kinase receptor cause ligand-independant activation while overexpression, on the other hand, causes hyper proliferation in basal levels of growth factor

    • @geovannig8849
      @geovannig8849 8 років тому +2

      When the receptors are over expressed, the Monomers of receptor tyrosin kinases will interact with each other due to the abundance of the receptors on the plasma membrane.
      Thus, the overexpression of the receptor will lead to the activation of these receptors by each other by means of transphosphorylation(biochemically speaking-biologically speaking autophosphorylation), giving the cell an oncogenic power.making the cell mitotically active irresepective of the ligand presence. (ligand independent firing).

  • @indiranegari3389
    @indiranegari3389 6 років тому

    can anyone let me know, what does he say in the 50th minutes? solid .... molecules,
    thank you

    • @leylaakh1467
      @leylaakh1467 6 років тому

      "...extracellular matrix components, or cell adhesion molecules."

  • @singaporethomasgiam5608
    @singaporethomasgiam5608 10 років тому

    Introduction to Cancer Biology (Part 1): Abnormal Signal Transduction

  • @yessiperez6662
    @yessiperez6662 8 років тому +12

    I hope someone finds a cure some day

    • @Rickyrab
      @Rickyrab 8 років тому

      +Yessi Perez ... or at least a way to tame and regulate cancers. Sometimes a mass of fast-replicating cells can come in handy, but we would still need a way to tell them when and where to stop or slow down, and tell them not to metastasize.

    • @username-usernamov
      @username-usernamov 6 років тому

      Trinitrophenylnitramine just stop eating anything

  • @ahmedsalem7975
    @ahmedsalem7975 9 років тому

    nice

  • @ext1013
    @ext1013 5 років тому

    trying to wait until they mention mitochandia....when????

  • @davdarksun
    @davdarksun 10 років тому

    Because they hav seen better ones..which are much more clear..

  • @adelgado6557
    @adelgado6557 7 років тому +98

    When your lecturer is useless... go to youtube >,

  • @sphinxishta6861
    @sphinxishta6861 2 роки тому +2

    Cell antenna

  • @user-ei5dn4qr2q
    @user-ei5dn4qr2q 6 років тому

    Want arabic translation please

  • @smartbien-etrebusiness6412
    @smartbien-etrebusiness6412 3 роки тому +1

    Solution :
    *Dr Otto Heinrich Warburg* German MD physiologist and biochemist, Nobel Prize for Physiology or Medicine in 1931:
    *>*

  • @safkumar
    @safkumar 11 років тому +2

    thank you

  • @binghamhawn3974
    @binghamhawn3974 6 років тому +1

    Very good explanation

  • @MaheshKondapuram
    @MaheshKondapuram 11 років тому +2

    thank u