- 00:00:00 💊 Introduction and Background - Discussion on low dose oral minoxidil's safety and initial concerns. - Overview of minoxidil's use for alopecia and hair loss. - Introduction to minoxidil sulfate and its formulation variations. - 00:02:22 📚 Study on Safety and Concerns - Examination of a study on oral minoxidil and safety concerns. - Discussion of side effects like pericardial effusion at varying doses. - Highlighting the need for thorough patient monitoring. - 00:05:36 🔬 Effects and Case Reports - Detailed look into the idiosyncratic effects of oral minoxidil. - Presentation of studies and case reports linking minoxidil to serious side effects. - Mention of potential genetic factors affecting side effects. - 00:08:35 📊 Analysis of a Comprehensive Study - Review of 144-patient study indicating side effects' dose independence. - Questioning of the study's methodology and exclusion criteria. - 00:12:46 🧬 Genetic Factors and Enzyme Activity - Discussion on the role of genetics and the sulfo transferase enzyme in side effects. - Explanation of minoxidil sulfate's function and its enzymatic conversion. - 00:16:52 🧪 Mechanism Behind Side Effects - Insight into the biological mechanism of minoxidil sulfate in vasodilation. - Detail on potassium channel activity and its effects on blood pressure and fluid retention. - 00:22:13 ⚠ Conclusion and Cautions - Final thoughts on the complexity and unpredictability of oral minoxidil's safety profile. - Emphasis on the need for further research and careful consideration in patient use. - 00:24:23 🧬 Genetic Factors in Drug Metabolism - Differences in patient response to oral minoxidil may be due to genetic factors affecting drug metabolism. - Variation in the ability to convert minoxidil to its active form affects side effect severity. - 00:28:12 📝 Case Report on Serious Side Effects - Discussion on a case of pericardial effusion linked to oral minoxidil noted in a medical paper. - Highlights risks related to the drug’s action on potassium channels, drawing parallels with a genetic condition. - 00:32:06 💊 Sublingual Minoxidil as an Alternative - Sublingual administration of minoxidil could offer hair growth with lower systemic side effects. - Study results indicate improved hair density with mild side effects using sublingual minoxidil. - 00:38:44 📊 Comparison of Administration Methods - Discusses systemic absorption differences between oral and topical minoxidil. - A graph illustrates how oral minoxidil leads to higher blood concentration peaks than topical application. - 00:44:12 ⚠ Precautions When Using Oral Minoxidil - Recommendations for safely using oral minoxidil, emphasizing monitoring heart health. - Suggests splitting doses to reduce systemic side effects and regularly checking blood pressure. - 00:45:10 💧 Topical vs. Oral Minoxidil - Pros and cons of oral vs. topical minoxidil, including convenience and side effect profiles. - Explores alternatives to common topical formulas to mitigate side effects like scalp dryness and irritation. - 00:46:31 📊 Study Comparison of Minoxidil Forms - Discusses a clinical trial comparing oral and topical minoxidil for male androgenetic alopecia. - Both treatments showed similar improvements in hair density. - Oral minoxidil was more effective on the vertex, with noted side effects. - 00:49:44 🧬 Enzyme Activity in Minoxidil Response - Explains the role of sulforotransferase enzyme activity in minoxidil effectiveness. - Highlights a study on enzyme genetic variants affecting response to oral minoxidil. - Discusses the potential of pairing topical minoxidil with retinoids to enhance efficacy. - 00:52:43 🔬 Retinoids' Role in Enhancing Hair Growth - Retinoids may improve minoxidil efficacy through increased enzyme activity. - Discusses studies showing retinoids enhance hair growth when paired with minoxidil. - Higher retinoid concentrations potentially boost effectiveness. - 00:55:01 💊 Concentration Effects of Minoxidil - Reviews whether higher concentrations of minoxidil provide additional benefits. - Higher concentrations may improve results in certain cases but can cause side effects. - Solubility issues limit the efficacy of concentrations above 7.5%. - 00:57:32 ❤ Safety Recommendations for Oral Minoxidil - Emphasizes the importance of heart monitoring when on oral minoxidil. - Recommends heart checks every three months during the first year of treatment. - Frequency of checks should be adjusted after dose changes.
great video man! I have been on oral minoxidil for close to 2 years now, everything good so far, this was very helpful. Thx for everything you do for this community.
Very much appreciate how much in-depth videos you create; this is truly what youtube is for. Please keep doing this and stay as intellectually honest as you have so far. Thank you
Video is fire brother. As a layman , oral Minoxidil and its safety is confusing given how much mixed signals I see online and real life. My derm is pushing me oral min saying he has not seen any side effects in his patients but evidence from studies seems to be clear that it is not as safe as doctors purport. Ngl makes me lose faith in dermatologists tbh
Tested 2.5 mg. Palpitations and constant headaches so I stopped. When you are using a drug known to mess with the cardiovascular system, these are very bad signs. Im not messing around with that
I just went to my derm and she put me on oral minoxidil. She told me to start with 0.0625 mg and tirate up to 1.5 the second month and 2.5 by the third month so my body can get used to it.
New hair Just finished watching, great stuff man. This helps me out a lot in deciding whether to even consider oral minoxidil when I eventually do introduce a growth stimulant following a year+ of dut monotherapy. Thanks for the research and info!
Been waiting for you to cover this topic for a while, can’t wait to watch. Thanks for dropping this! Happy new year! You’ve mentioned previously you no longer use minoxidil at all, right?
people say oral min is cheaper but IDK because you might have to buy blood pressure monitor, spend time visiting doctors, maybe buy dieretics to help with water retention etc....
Got consistent chest pain and heart palpitations at night on just 1.25mg/day for a few days. Stopped after a week, side effects went away; tried again a few weeks later, and the same chest discomfort and palpitations returned within a few days again. That was more than enough to show me it isn’t safe. Some of you may get away with it for some time, but in my opinion it isn’t worth it. Oral minoxidil is meant to be a cardiovascular medication and it has the potential to negatively affect your heart at any time, even if you’re not experiencing symptoms. It’s not worth it in my view. Stick to topical.
I don't think you mentioned this in the video (correct me if I'm wrong), but I believe there's also an issue with the specific minoxidil formulations used in some studies. From what I've seen, there have been reports of compounded solutions being overdosed with the active ingredient-sometimes by as much as 100 times. This could potentially explain the discrepancies in reported side effects. Ideally I think the studies we should focus on are those using the Loniten brand, as it is commercially produced by Pfizer. I'm not aware if any of the studies state which kind of Minoxidil is researched (compounded or marketed). But I see a great benefit in indicating which "brand" was used when reporting serious side effects. Great video!
@Kyle_Bu Sorry if my English isn’t perfect (I'm not a native speaker). What I meant is that in these studies, especially those reporting severe side effects, it’s unclear whether the oral minoxidil used is the marketed Loniten brand or a pharmacy-compounded tablet. I think knowing the origin of the drug is important, as there's been cases of the compounded tablet having a dose of the active ingredient higher than "advertised". Being Pfizer's product the most common way people take the drug, or at least it's the standard, it makes sense to me to report adverse effects when using this specific product. In any case, I'm not as well informed as you are in the matter so your feedback in this "theory" is well appreciated.
With all respect base on my own research and talking to few doctors they never ever recommend to use oral minoxidil as it's not entirely designed to use as oral . I know been used for heart and blood pressure but that totally different story which has nothing to do with hairloss . As always thank you for your time
Yeah it's very odd. I'm certain the sides would have been higher if they did! Why else discontinue the drug? When it's your heart, then you can't play around. This is a huge issue in the literature
New hair 🎉 Hello Thanks for the video. I tried one year of topical minoxidil on my scalp and no hair growth... On my beard it worked very good. Weird that it doesn't work on my scalp. 2 years ago I started with 1mg oral minoxidil but no effect. I increased it to 2,5mg then 5mg. I did several KMG and everything is good. But I didn't notice any effect on my hair (or very few, I had one shedding) and am still using it since then. For some months I noticed that my hands are more hairy but now disappeared. Maybe because I changed my compound pharmacy (the new one is cheaper). I'm wondering if I should go with sublingual oral minoxidil. But I'm taking pills and not sublingual tablets. So I have to open the pill and put the powder under the tongue or I have to ask for specific sublingual tablets ? Thank
Thanks for the support. I would check with a doctor but usually the regular min pills could work. But there are specialized sublingual pills that have a lower dose (0.25-0.45) . So it's moreso the dose being what is controlled in sublingual pills vs their normal variants.
People are lazy man. I’d rather just spend 30 seconds applying the topical at night instead of worrying about all this shit with oral. Not to mention body hair growth
you are a man, who cares if you have more body hair lmao. And it is not just about lazyness, correct application of topical minoxidil through the scalp and efficient conversion to minoxidil sulfate are very good arguments in favor of oral minoxidil.
@ I mean I’m a topical responder. Also I had insane amounts of body hair even at like 13 years old. When I was 18 I finally got it lazered off which reduced it like 70%. It was my first major insecurity before hairloss. So no I don’t wanna risk it again. I’m still hairy now but to a normal level which I’m comfortable with
The point is comparison dosage between topical and oral. Based on my test, 2ml topical at 5% + melatonin, caffein, tretinoin and cetirizine +once microneedling a week before application is clearly superior to 5 mg oral with less body hair oncrease
Been on 2.5mg oral minoxodil for 15 months. Never had any side efects, body doesnt feel any different because of it, never been to doctor to check heart. Guess im good
I started OM at 1.25mg just 4 days ago and have had a weird heavier chest feeling the whole time - almost like I hear and notice my heart more. It's also made it harder to fall asleep cos of that feeling. These side effects happened on the first day taking the pill! I'm stopping now after seeing this. Thank you!
This happened to me for about a month and then went away. This is common with many anti hypertensive medications, not just oral minoxidil. The director of my nursing school is a very experienced cardiologist and told me oral minoxidil is safe and great medication to be on.
Same thing happened to me. Turned out that it was a link of anxiety my brain made every time I took the pill… probably from being on Reddit too long. I would essentially have a mini panic attack every time I would take the pill and every time I would wake up in the morning and I always thought that it was a side effect caused by the pill, technically it was. But not from the active ingredient. Once I fixed my anxiety this went away.
Sources: Abdulhai, F., Parizher, G., Zmaili, M., Saraswati, U., Majeed, Z., Majid, M., Syed, A. B., Scheetz, S., Fernandez, A., & Klein, A. L. (2024). Minoxidil-Related pericarditis. JACC Case Reports, 29(19), 102599. doi.org/10.1016/j.jaccas.2024.102599 Adapalene (Synonyms: CD271). (2014, May 31). MedChemExpress. Retrieved December 30, 2024, from www.medchemexpress.com/adapalene.html Bazzano, G. S., Terezakis, N., & Galen, W. (1986). Topical tretinoin for hair growth promotion. Journal of the American Academy of Dermatology, 15(4), 880-893. doi.org/10.1016/s0190-9622(86)80024-x Buhl, A. E., Waldon, D. J., Baker, C. A., & Johnson, G. A. (1990). Minoxidil Sulfate Is the Active Metabolite that Stimulates Hair Follicles. Journal of Investigative Dermatology, 95(5), 553-557. doi.org/10.1111/1523-1747.ep12504905 Chitalia, J., Dhurat, R., Goren, A., McCoy, J., Kovacevic, M., Situm, M., Naccarato, T., & Lotti, T. (2018). Characterization of follicular minoxidil sulfotransferase activity in a cohort of pattern hair loss patients from the Indian Subcontinent. Dermatologic Therapy, 31(6), e12688. doi.org/10.1111/dth.12688 Dlova, N. C., Jacobs, T., & Singh, S. (2022). Pericardial, pleural effusion and anasarca: A rare complication of low-dose oral minoxidil for hair loss. JAAD Case Reports, 28, 94-96. doi.org/10.1016/j.jdcr.2022.07.044 Friedman, E. S., Friedman, P. M., Cohen, D. E., & Washenik, K. (2002). Allergic contact dermatitis to topical minoxidil solution: Etiology and treatment. Journal of the American Academy of Dermatology, 46(2), 309-312. doi.org/10.1067/mjd.2002.119104 Johnson, G. A., Baker, C. A., & Knight, K. A. (1992). Minoxidil sulfotransferase, a marker of human keratinocyte differentiation. Journal of Investigative Dermatology, 98(5), 730-733. doi.org/10.1111/1523-1747.ep12499930 KwRx. (2024, April 18). Oral Minoxidil fails against Topical Minoxidil in New Study? [Video]. UA-cam. ua-cam.com/video/wTri5Q9HyHM/v-deo.html Lachgar, N., Charveron, N., Gall, N., & Bonafe, N. (1998). Minoxidil upregulates the expression of vascular endothelial growth factor in human hair dermal papilla cells. British Journal of Dermatology, 138(3), 407-411. doi.org/10.1046/j.1365-2133.1998.02115.x Mechanisms in Medicine. (2012, November 5). Renin angiotensin Aldosterone system [Video]. UA-cam. ua-cam.com/video/bY6IWVgFCrQ/v-deo.html Penha, M. A., Miot, H. A., Kasprzak, M., & Ramos, P. M. (2024). Oral Minoxidil vs Topical Minoxidil for Male Androgenetic Alopecia. JAMA Dermatology, 160(6), 600. doi.org/10.1001/jamadermatol.2024.0284 Pietrauszka, K., & Bergler-Czop, B. (2020). Sulfotransferase SULT1A1 activity in hair follicle, a prognostic marker of response to the minoxidil treatment in patients with androgenetic alopecia: a review. Advances in Dermatology and Allergology, 39(3), 472-478. doi.org/10.5114/ada.2020.99947 Roberts, J., Desai, N., McCoy, J., & Goren, A. (2014). Sulfotransferase activity in plucked hair follicles predicts response to topical minoxidil in the treatment of female androgenetic alopecia. Dermatologic Therapy, 27(4), 252-254. doi.org/10.1111/dth.12130 Sánchez-Díaz, M., López-Delgado, D., Montero-Vílchez, T., Salvador-Rodríguez, L., Molina-Leyva, A., Tercedor-Sánchez, J., & Arias-Santiago, S. (2021). Systemic minoxidil accidental exposure in a paediatric population: A case series study of cutaneous and systemic side effects. Journal of Clinical Medicine, 10(18), 4257. doi.org/10.3390/jcm10184257 Sharma, A., Goren, A., Dhurat, R., Agrawal, S., Sinclair, R., Trüeb, R. M., Vañó‐Galván, S., Chen, G., Tan, Y., Kovacevic, M., Situm, M., & McCoy, J. (2019). Tretinoin enhances minoxidil response in androgenetic alopecia patients by upregulating follicular sulfotransferase enzymes. Dermatologic Therapy, 32(3). doi.org/10.1111/dth.12915 Shin, H. S., Won, C. H., Lee, S. H., Kwon, O. S., Kim, K. H., & Eun, H. C. (2007). Efficacy of 5% Minoxidil versus Combined 5% Minoxidil and 0.01% Tretinoin for Male Pattern Hair Loss. American Journal of Clinical Dermatology, 8(5), 285-290. doi.org/10.2165/00128071-200708050-00003 Singh, S., Patil, A., Kianfar, N., Waśkiel-Burnat, A., Rudnicka, L., Sinclair, R., & Goldust, M. (2022). Does topical minoxidil at concentrations higher than 5% provide additional clinical benefit? Clinical and Experimental Dermatology, 47(11), 1951-1955. doi.org/10.1111/ced.15338 Trüeb, R. M., Caballero-Uribe, N., Luu, N. C., & Dmitriev, A. (2022). Serious complication of low-dose oral minoxidil for hair loss. JAAD Case Reports, 30, 97-98. doi.org/10.1016/j.jdcr.2022.09.035
- 00:00:00 💊 Introduction and Background
- Discussion on low dose oral minoxidil's safety and initial concerns.
- Overview of minoxidil's use for alopecia and hair loss.
- Introduction to minoxidil sulfate and its formulation variations.
- 00:02:22 📚 Study on Safety and Concerns
- Examination of a study on oral minoxidil and safety concerns.
- Discussion of side effects like pericardial effusion at varying doses.
- Highlighting the need for thorough patient monitoring.
- 00:05:36 🔬 Effects and Case Reports
- Detailed look into the idiosyncratic effects of oral minoxidil.
- Presentation of studies and case reports linking minoxidil to serious side effects.
- Mention of potential genetic factors affecting side effects.
- 00:08:35 📊 Analysis of a Comprehensive Study
- Review of 144-patient study indicating side effects' dose independence.
- Questioning of the study's methodology and exclusion criteria.
- 00:12:46 🧬 Genetic Factors and Enzyme Activity
- Discussion on the role of genetics and the sulfo transferase enzyme in side effects.
- Explanation of minoxidil sulfate's function and its enzymatic conversion.
- 00:16:52 🧪 Mechanism Behind Side Effects
- Insight into the biological mechanism of minoxidil sulfate in vasodilation.
- Detail on potassium channel activity and its effects on blood pressure and fluid retention.
- 00:22:13 ⚠ Conclusion and Cautions
- Final thoughts on the complexity and unpredictability of oral minoxidil's safety profile.
- Emphasis on the need for further research and careful consideration in patient use.
- 00:24:23 🧬 Genetic Factors in Drug Metabolism
- Differences in patient response to oral minoxidil may be due to genetic factors affecting drug metabolism.
- Variation in the ability to convert minoxidil to its active form affects side effect severity.
- 00:28:12 📝 Case Report on Serious Side Effects
- Discussion on a case of pericardial effusion linked to oral minoxidil noted in a medical paper.
- Highlights risks related to the drug’s action on potassium channels, drawing parallels with a genetic condition.
- 00:32:06 💊 Sublingual Minoxidil as an Alternative
- Sublingual administration of minoxidil could offer hair growth with lower systemic side effects.
- Study results indicate improved hair density with mild side effects using sublingual minoxidil.
- 00:38:44 📊 Comparison of Administration Methods
- Discusses systemic absorption differences between oral and topical minoxidil.
- A graph illustrates how oral minoxidil leads to higher blood concentration peaks than topical application.
- 00:44:12 ⚠ Precautions When Using Oral Minoxidil
- Recommendations for safely using oral minoxidil, emphasizing monitoring heart health.
- Suggests splitting doses to reduce systemic side effects and regularly checking blood pressure.
- 00:45:10 💧 Topical vs. Oral Minoxidil
- Pros and cons of oral vs. topical minoxidil, including convenience and side effect profiles.
- Explores alternatives to common topical formulas to mitigate side effects like scalp dryness and irritation.
- 00:46:31 📊 Study Comparison of Minoxidil Forms
- Discusses a clinical trial comparing oral and topical minoxidil for male androgenetic alopecia.
- Both treatments showed similar improvements in hair density.
- Oral minoxidil was more effective on the vertex, with noted side effects.
- 00:49:44 🧬 Enzyme Activity in Minoxidil Response
- Explains the role of sulforotransferase enzyme activity in minoxidil effectiveness.
- Highlights a study on enzyme genetic variants affecting response to oral minoxidil.
- Discusses the potential of pairing topical minoxidil with retinoids to enhance efficacy.
- 00:52:43 🔬 Retinoids' Role in Enhancing Hair Growth
- Retinoids may improve minoxidil efficacy through increased enzyme activity.
- Discusses studies showing retinoids enhance hair growth when paired with minoxidil.
- Higher retinoid concentrations potentially boost effectiveness.
- 00:55:01 💊 Concentration Effects of Minoxidil
- Reviews whether higher concentrations of minoxidil provide additional benefits.
- Higher concentrations may improve results in certain cases but can cause side effects.
- Solubility issues limit the efficacy of concentrations above 7.5%.
- 00:57:32 ❤ Safety Recommendations for Oral Minoxidil
- Emphasizes the importance of heart monitoring when on oral minoxidil.
- Recommends heart checks every three months during the first year of treatment.
- Frequency of checks should be adjusted after dose changes.
great video man! I have been on oral minoxidil for close to 2 years now, everything good so far, this was very helpful. Thx for everything you do for this community.
@@jakesimpson8952 thanks for the support!
dosage? and how much regrowth?
@@paulhong1242 2.5 for a yr, 3mg for 8 months, just started with 5mg recently. yes good regrowth!
Your channel like a gem.
@@nicepicbro3425 thanks!
Very much appreciate how much in-depth videos you create; this is truly what youtube is for. Please keep doing this and stay as intellectually honest as you have so far. Thank you
More to come!
Video is fire brother. As a layman , oral Minoxidil and its safety is confusing given how much mixed signals I see online and real life. My derm is pushing me oral min saying he has not seen any side effects in his patients but evidence from studies seems to be clear that it is not as safe as doctors purport. Ngl makes me lose faith in dermatologists tbh
Tested 2.5 mg. Palpitations and constant headaches so I stopped. When you are using a drug known to mess with the cardiovascular system, these are very bad signs. Im not messing around with that
Do you narrate your own videos? The voice is amazing.
Yup I do. Thanks!
Amazing video bro. Best hair loss channel fr
Thank you so much
I take 1.25mgs at night. Apply topical during the day. Take breaks from oral on weekends. Haven't noticed anything side effect wise.
When you say get your heart checked, what are you referring to exactly?
Like what kind of test or exam should be done?
@@tonj02 bro I mentioned it in the video more than once... 💀
cant wait!
I just went to my derm and she put me on oral minoxidil. She told me to start with 0.0625 mg and tirate up to 1.5 the second month and 2.5 by the third month so my body can get used to it.
Good luck!
New hair
Just finished watching, great stuff man. This helps me out a lot in deciding whether to even consider oral minoxidil when I eventually do introduce a growth stimulant following a year+ of dut monotherapy. Thanks for the research and info!
Thanks for commenting. Wishing you the best, keep us updated throughout the year!
Been waiting for you to cover this topic for a while, can’t wait to watch. Thanks for dropping this! Happy new year!
You’ve mentioned previously you no longer use minoxidil at all, right?
Thanks, and yes.
Happy New Year!
people say oral min is cheaper but IDK because you might have to buy blood pressure monitor, spend time visiting doctors, maybe buy dieretics to help with water retention etc....
Good point!!
you are reaching there, and you should definitely spend time at your doctor regardless if you take oral minoxidil or not.
In Germany oral ist super expensiv
You are rocking it bro!!!!!
You are covering everything. 😅😅😊😊
Thank you so much 😀
Got consistent chest pain and heart palpitations at night on just 1.25mg/day for a few days. Stopped after a week, side effects went away; tried again a few weeks later, and the same chest discomfort and palpitations returned within a few days again. That was more than enough to show me it isn’t safe. Some of you may get away with it for some time, but in my opinion it isn’t worth it. Oral minoxidil is meant to be a cardiovascular medication and it has the potential to negatively affect your heart at any time, even if you’re not experiencing symptoms. It’s not worth it in my view. Stick to topical.
Did you visit the doc for a heart check up?
I don't think you mentioned this in the video (correct me if I'm wrong), but I believe there's also an issue with the specific minoxidil formulations used in some studies. From what I've seen, there have been reports of compounded solutions being overdosed with the active ingredient-sometimes by as much as 100 times. This could potentially explain the discrepancies in reported side effects. Ideally I think the studies we should focus on are those using the Loniten brand, as it is commercially produced by Pfizer.
I'm not aware if any of the studies state which kind of Minoxidil is researched (compounded or marketed). But I see a great benefit in indicating which "brand" was used when reporting serious side effects.
Great video!
Compounded solutions or oral formulations? Side effects are more common with oral minoxidil than topical.
@Kyle_Bu Sorry if my English isn’t perfect (I'm not a native speaker). What I meant is that in these studies, especially those reporting severe side effects, it’s unclear whether the oral minoxidil used is the marketed Loniten brand or a pharmacy-compounded tablet.
I think knowing the origin of the drug is important, as there's been cases of the compounded tablet having a dose of the active ingredient higher than "advertised". Being Pfizer's product the most common way people take the drug, or at least it's the standard, it makes sense to me to report adverse effects when using this specific product.
In any case, I'm not as well informed as you are in the matter so your feedback in this "theory" is well appreciated.
Does Sulfotransferase SULT1A1 levels effect how you react to oral minoxidil? I know it affects whether you respond to topical minoxidil or not.
Please use the timestamps dude. I talked about this.
In italy someone said that the standard oral work without but the sublingual work with it
With all respect base on my own research and talking to few doctors they never ever recommend to use oral minoxidil as it's not entirely designed to use as oral . I know been used for heart and blood pressure but that totally different story which has nothing to do with hairloss . As always thank you for your time
I don't think we're in disagreement here
I got side effects after a few weeks .
Very shady not to include data from users who quit before the 3 month mark.
Yeah it's very odd. I'm certain the sides would have been higher if they did! Why else discontinue the drug?
When it's your heart, then you can't play around. This is a huge issue in the literature
New hair 🎉
Hello
Thanks for the video.
I tried one year of topical minoxidil on my scalp and no hair growth...
On my beard it worked very good. Weird that it doesn't work on my scalp.
2 years ago I started with 1mg oral minoxidil but no effect. I increased it to 2,5mg then 5mg. I did several KMG and everything is good.
But I didn't notice any effect on my hair (or very few, I had one shedding) and am still using it since then.
For some months I noticed that my hands are more hairy but now disappeared. Maybe because I changed my compound pharmacy (the new one is cheaper).
I'm wondering if I should go with sublingual oral minoxidil.
But I'm taking pills and not sublingual tablets. So I have to open the pill and put the powder under the tongue or I have to ask for specific sublingual tablets ?
Thank
Thanks for the support. I would check with a doctor but usually the regular min pills could work. But there are specialized sublingual pills that have a lower dose (0.25-0.45) . So it's moreso the dose being what is controlled in sublingual pills vs their normal variants.
@Kyle_Bu when I said pill 💊 I wanted to say capsule.
So I will try to open it and put the powder under my tongue
@nicolaslorenzo78 I wouldn't. Maybe the capsule helps for a controlled delivery? Just be careful and talk to a doctor of course.
@@Kyle_Bu what I have is exactly this Emoji 💊 lol
I can open it and take the powder
What's your view on accelerated skin aging due to om
I don't know if it's real or not
Not real.
@@Kyle_Bu okay thx! I saw some people making that claim on Reddit, so I've been unsure about whether I should get on it
People are lazy man. I’d rather just spend 30 seconds applying the topical at night instead of worrying about all this shit with oral.
Not to mention body hair growth
you are a man, who cares if you have more body hair lmao. And it is not just about lazyness, correct application of topical minoxidil through the scalp and efficient conversion to minoxidil sulfate are very good arguments in favor of oral minoxidil.
@ I mean I’m a topical responder.
Also I had insane amounts of body hair even at like 13 years old.
When I was 18 I finally got it lazered off which reduced it like 70%. It was my first major insecurity before hairloss.
So no I don’t wanna risk it again. I’m still hairy now but to a normal level which I’m comfortable with
The point is comparison dosage between topical and oral.
Based on my test, 2ml topical at 5% + melatonin, caffein, tretinoin and cetirizine +once microneedling a week before application is clearly superior to 5 mg oral with less body hair oncrease
Idk about "clearly superior". For you perhaps. You're one person
some of us want the eye lash growth though, not sure how to get that without taking oral min
@@bennybenny7382Just bath in min bro
tbh oral minoxidil seems like it has such mild sides that theres no reason why you shouldnt take it unless u respond badly.
Yup
Been on 2.5mg oral minoxodil for 15 months. Never had any side efects, body doesnt feel any different because of it, never been to doctor to check heart. Guess im good
You should get your heart checked out to be suee you're gine
Anymore vids on Dutasteride coming out by any chance?
@@thesaucegroup1877 probably one on fertility and then that's it. No more.
Then maaaybe a bigger video debunking PFS where I mention dutasteride.
Is there any evidence that oral is better than topical? Seems like a big risk for something that is not demonstrably better.
There's some conflict in the literature. It's probably better in terms of compliance. Especially ease of use
20m vs
new hair!
but the real tell is are you going take it?
I don't
@@Kyle_Bu because of the risks or keeping some powder dry?
currently watching you fin->dut transition video. Just discovered this great channel!
I started OM at 1.25mg just 4 days ago and have had a weird heavier chest feeling the whole time - almost like I hear and notice my heart more. It's also made it harder to fall asleep cos of that feeling. These side effects happened on the first day taking the pill! I'm stopping now after seeing this. Thank you!
No problem. Be safe!
This happened to me for about a month and then went away. This is common with many anti hypertensive medications, not just oral minoxidil. The director of my nursing school is a very experienced cardiologist and told me oral minoxidil is safe and great medication to be on.
Same thing happened to me. Turned out that it was a link of anxiety my brain made every time I took the pill… probably from being on Reddit too long.
I would essentially have a mini panic attack every time I would take the pill and every time I would wake up in the morning and I always thought that it was a side effect caused by the pill, technically it was. But not from the active ingredient. Once I fixed my anxiety this went away.
New hair.
Sources:
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