I just wanted to say a massive thank you for these videos!! They are so great, perfect speed of speaking ( hate it when they are 100 miles an hour) not over simplified, still containing the correct level of academic understanding, and are so clear and easy to understand. Its so good to be able to draw out what you have to further my understanding of these concrete concepts. Many thanks! Keep up the fab work, will share this around!
This channel is fantastic! I study this in my university course of Pharmacology in Italy but i was in trouble because my university professor doens't explain it well. Now i'm starting to understand him, thank u
Your vids are really helpful for consolidating what I’ve learned in those drug chemistry things , even way better than my uni I would say👍 has got all the key points here in this 5 min length video
I've been waiting for other vids for endocrine hormones control such as reproductive, digestive etc etc. U've been doing really well and tbh way better than my physiology lecturer :P
why am i just knowing about this channel now! I needed it for the last 2 years! T_T I failed anatomy1 and 2 ,physiology1 and 2 , Biochem1 and embryo. because i wasn't having fun taking those lectures with those boring drs T_T. thank u so much!
OK, so if a drug is more protein bound, it will tend to pass more slowly into other compartments. Permeability of barriers also depends on pH of the compartment. Higher binding capacity means less movement into other compartments. I think I get it. Thanks for the overview! Oh, and it looks like you spelled permeability wrong. :-P
would like to hear bout Elimination half time ,elimination half life, context sensitive halftime, time of recovery for iv anaesthetic drugs.kindly let me know once its on you tube.
Does anybody know why the conc. drug in plasma is the only one discussed? Is that a standardized form of measurement for determining the effect of a drug? If so, are there any variables that might be overlooked, such as if a specific patient has abnormal permeability been one compartment and another? e.g. For a drug that's active in the CNF, and the patient has higher permeability between intracellular fluid and extracellular fluid?
I noticed that the units are different (5 L/kg and 3/70 mg/L). Can you just multiply different units like that? I feel like mathematically this is not right. Could someone please clarify?
Although somewhat late... the Vd is = Dose/(Cp * kg). Dose is in mg and Cp is the peak concentration of the drug (mg/L) times the weight of the person (kg). So you have mg/(mg/L)(kg) or mg * L/mg * kg so mg cancels out and Vd is in L/mg units.
***** How did you get 15/10 mg/kg? You just start with 5 x 3/70 = 15/70. For the units, it's L/kg x mg/L, so you just take the "L" out, which leaves you with mg/kg. In the end, we have 15/70 mg/kg, or 15 mg/70 kg, or 15 mg of the drug for a 70 kg person. By the way, these tutorials are amazing! Thank you!
I just wanted to say a massive thank you for these videos!! They are so great, perfect speed of speaking ( hate it when they are 100 miles an hour) not over simplified, still containing the correct level of academic understanding, and are so clear and easy to understand. Its so good to be able to draw out what you have to further my understanding of these concrete concepts. Many thanks! Keep up the fab work, will share this around!
actually its about our intellectual level in student life we never focus and now we already know allot just a litle help inline us again.
@@3mazhar3 AcTuaLLy
@@3mazhar3 wya rn
This channel is fantastic! I study this in my university course of Pharmacology in Italy but i was in trouble because my university professor doens't explain it well. Now i'm starting to understand him, thank u
Currently in pharmacy school, studying for the PCOA, you're doing god's work, good sir
These videos are more helpful to me than any other video aid. Thank you so much for providing these!
Your vids are really helpful for consolidating what I’ve learned in those drug chemistry things , even way better than my uni I would say👍 has got all the key points here in this 5 min length video
Nice job for educating the world! Your job is being appreciated!
All those lectures I wasted attending when I could have just looked At this video
+Joe B I hear that. :(
couldn't wrap my head around this during lectures but in 5mins u helped me understand. tyvm!
Awesome videos by hand written tutorials !!!! Keep up the great work !!
3:53 Volume of Distribution
amazing ,the hand written tutorial really cleared my doubt on pharmacokinetics
Thanks for uploading.... In one word your lectures r awesome.....
I've been waiting for other vids for endocrine hormones control such as reproductive, digestive etc etc. U've been doing really well and tbh way better than my physiology lecturer :P
Sir, this is very helpful short tricks vedio on pharmacokinetics , thankyou sir.
Amaaaaaazing! :) Absolutely love the explanations! :) Got back the hope to pass my test tomorrow!
If u hav not commeted tat day..u would hav got 1 more marks atleast
@@kbsandeepgouda1264 wbu would you have gotten that one mark ?
why am i just knowing about this channel now!
I needed it for the last 2 years! T_T
I failed anatomy1 and 2 ,physiology1 and 2 , Biochem1 and embryo.
because i wasn't having fun taking those lectures with those boring drs T_T.
thank u so much!
Edward X لا جامعة الملك خالد ف أبها
Edward X ما عندي الحين الا مايكرو2 والترم الجاي ان شالله ادخل مستوى7
+Reem Hussain يارب انكم نجحتو !!
Hamood 6642 ابشرك اني نجحت الحمدلله انفكت جميع العقد والنفسية الي اول
والحين مستوى 8 وخلصت البلوك الاول
+Reem Hussain الحمدلله والله يوفقك ، حتى انا صارلي شوية تعثرات والحمدلله عدت ع خير 😭 عقبال التخرج ان شاءالله
Thank you is never enough
Thanks for making understanding easy!
The volume of distribution part was so well described... Far better than Lippincott...👍🏻
Simple but yet so better explained
OK, so if a drug is more protein bound, it will tend to pass more slowly into other compartments. Permeability of barriers also depends on pH of the compartment. Higher binding capacity means less movement into other compartments. I think I get it. Thanks for the overview! Oh, and it looks like you spelled permeability wrong. :-P
wow...... awesome ,,, finally i have understand the compartment model ...... many many thanks for sharing this lecture
oh god u make every thing easy! now I get it!
I'v had no idea in the lecture at collage!
thank you this really helpful i was looking for it since a month ago
Wow, really cleared some questions for me. Vd=dose/conc
I also find your example of 3/70 mg/L very weird however conceptually, something just clicked. Thank you.
Thanks for knowledgeable videos plz describe more ....
Thanks for sharing, It's very useful.
Make life seem simple. Thank you
Thanks very much 🙏
thank u so much ..pls do upload more of these
really nice...... very easy to understand......
Very helpful video...
What size sharpie marker is that at 4:41. I want it
Extra Fine Point Sharpie. Box of 12 for $12.79 at Staples. This is the real takeaway from 4 years of post-secondary. Hope it's going well.
@@muskanty hows it goin w you
THANK YOU FOR POSTING THIS
3:20 spelt *permeability
you mean *spelled...???
would like to hear bout Elimination half time ,elimination half life, context sensitive halftime, time of recovery for iv anaesthetic drugs.kindly let me know once its on you tube.
Highly useful
at 5th yr i got this channel
Very helpful
Soo many thanks ♥️🇮🇶
Good and appreciated
Does anybody know why the conc. drug in plasma is the only one discussed? Is that a standardized form of measurement for determining the effect of a drug? If so, are there any variables that might be overlooked, such as if a specific patient has abnormal permeability been one compartment and another? e.g. For a drug that's active in the CNF, and the patient has higher permeability between intracellular fluid and extracellular fluid?
thank you so much for this
What does it mean 3 by 70th ? Does it indicate that the plasma concentration ( known concentration ) is 3*70 = 210mg /liter ?
Not known concentration...its wt he wanted to achieve...i mean tat amount of concentration
But I didn't understand the calculation part. L/kg and mg/L.
Any how thank you.
Great, very helpful
More plzzzz,,, thanks for this!
Amazing!!!
very educating
can you do the pharmacodynamics???
really nice... thx
definitely!
whats wrong with audio volume...
thanks
just in ex ,
3/70 ×5 =3/14 right ?or not I'm little confused 😑
but, it is very good and helpful tutorials
thank you
just need answer her please .?!
Thank you!
I just find your example 3/70 mg/L very weird.
I noticed that the units are different (5 L/kg and 3/70 mg/L). Can you just multiply different units like that? I feel like mathematically this is not right. Could someone please clarify?
Although somewhat late... the Vd is = Dose/(Cp * kg). Dose is in mg and Cp is the peak concentration of the drug (mg/L) times the weight of the person (kg). So you have mg/(mg/L)(kg) or mg * L/mg * kg so mg cancels out and Vd is in L/mg units.
In this position they managed, with the aid of the patient cab-horse, to drag the vehicle through the narrow part of the passage.
يااااابوي الله يسعدك
Nyc lecture
awesome
great!
the final result in the demonstration of vd is 105mg not 15mg
I got 15mg, how did you get 105mg? Wondering if I did it incorrectly
you're right i made a mistake
***** How did you get 15/10 mg/kg?
You just start with 5 x 3/70 = 15/70. For the units, it's L/kg x mg/L, so you just take the "L" out, which leaves you with mg/kg.
In the end, we have 15/70 mg/kg, or 15 mg/70 kg, or 15 mg of the drug for a 70 kg person.
By the way, these tutorials are amazing! Thank you!
the sound is very low in this one. I can barely understand what you are saying :(
Thanks for the tutorials!!
nice
Hello sir video , Good
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How does one find the VD of a drug? In the video he already knows the VD of morphine is 5L/kg bw
assuming the drug facts are already given
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