When I was 19, I was given nitrous oxide to remove my wisdom teeth. At 36 I got an Epstein Barr virus and later diagnosed with Lupus and given Methotrexate. It wrecked my life and relationships because people thought I was just being lazy. I didn’t find out till 2 years ago that I had MTHFR. It feels nice to be validated, so thank you.
Yes, I've had to grapple with these same feelings. I was especially harsh on myself about having chronic fatigue. I thought other people just handled life better or I was lazy. But eventually I realized, no, THIS kind of fatigue is not normal. I didn't take a nap every day for fun; I hated it. And chronic pain. Standing at the counter chopping veggies shouldn't be painful. But it was my normal for so long, I didn't realize how bad it was. When I realized, I was finally able to give myself some grace and begin healing. Turns out I was autistic all this time too. I really DID get a harder lot than others, but for some reason people don't like to think that others may actually have it harder than them. So they're a jerk and call you lazy instead. It's some sort of personal insecurity.
I'm sorry you went through that awful experience and gaslighting. I have MTHFR also and I understand how fatigued you can be without supplementation and the right diet. Hugs!
Nitrous oxide is like a vampire, it robs yr brain and then the rest of yr body of b12 Left untreated, causes devastating consequences Yr issue is not mthfr, its from b12 deficiency
It definitely seems like there are 2 extremes... Doctors who think it's useless and people online who attribute EVERY issue they've ever had with it. I appreciate your reasonable teaching on it.
this stuff is TMI for most people and they obsess about markers they don't really understand. I've been on groups where that is the only way they identify themselves, through these biomarkers. I've done great healing for myself and clients without this level of biochemical obsession
@elizabethheyenga9277 There's PLENTY of really basic podcasts if this is too complex. I'm absolutely SO tired of the super simple, basic podcasts. Find what works for you.
Wow! Just found out my son has 2 copies of 667. 4 years ago he had nitrous oxide gas for the first time for just a few minutes to prep him for an MRI. Thankfully, he ended up fighting (very unlike him) to take it off so I had them stop. We were in the ER later that night because he couldn’t walk, felt numb, stomach tightness and vomiting. He kept screaming for me to call 911. The ER did nothing. They said it was a “stomach bug”. He had these episodes off and on where he couldn’t stand for a week and nothing was ever done. We were told it was anxiety. He also has autism and ADHD. He is now 15 and still says he has not been the same since. I just ordered your book Dirty Genes. I am praying for the answers that I have searched for for so long.
I have mthfr double homozygous . I found out after I had 2 brain strokes and they couldnt figure out why. I was so sick, I developed an auto immune disease and was so so sick I could not walk. 5 years later at 54... I changed my diet..no dairy, no gluten and started suppliments full complex bs, d3 omegas & mthf ... I am now hiking in the woods again and exploring beautiful places. It was a life changer for me !! Im proof you can change your health with epigenetics :) ❤
🎯 Key Takeaways for quick navigation: 00:40 *🧬 Having the MTHFR variant doesn't guarantee specific health conditions but makes you more vulnerable due to reduced methyl folate production.* 01:39 *💡 Supplementing with methylfolate, dietary changes, and avoiding substances like folic acid can support MTHFR enzyme function.* 03:28 *🚫 Some medical organizations discredit testing for MTHFR, but awareness of vulnerability allows for proactive measures.* 05:31 *⚠️ Individuals with MTHFR variants should avoid medications like methotrexate and laughing gas due to potential adverse effects on B12 and folate.* 07:34 *🌟 Knowing your MTHFR status enables better health choices and awareness of potential risks and interventions.* Made with HARPA AI
Should we take vitamin b12 with methylfolate? I'm trying to help my daughter. I just ordered vitamin b12 and methylfolate but I'm not sure if the b12 is the correct vitamin to take with it?
Lots of mental health issues are being linked to diet - low carb/keto type diets seem to have very good results with treating mental health, including adhd.
So glad to have found you. I just ordered both Dirty Genes and The Histamine Workbook. Thank you so much for helping those of us who are just everyday people be able to take action and manage our health.
I did real well until I had some severe trauma after childhood trauma and a bad marriage. I was dx'd in 2014 677t++ and did great working with a genomicist with a nutrition professor who has MTHFR. Recent trauma really taught me and now having Stratagene and Dirty genes I am coming back. I am highly sensitive/vulnerable and am finally really getting the need for boundaries.
I got addicted to nitrous oxide for a couple months last fall. Definitely worsened the neuropathy I was already experiencing as a result of my MTHFR mutation. I lose balance everyday and cannot sleep on my side without my limbs going numb or eat any carbs or processed sugar without the neuropathy worsening. Never thought nitrous oxide contributed to this until I heard another woman share in a nitrous recovery group about how her abuse of the drug wreaked havoc on her body bc she had a genetic mutation. It’s validating to hear this from a Dr.
DMT and having very low ferritin caused me to have neuropathy instantly. It did go away mostly but I have to take iron supplements and if I eat too much sugar I feel it in my toes.
I was given laughing gas at the dentist when I was much younger. I just remember immediately feeling trapped inside my body and paralyzed. I had no control over my body. I told them to immediately stop and turn it off!! I never knew it could be related to MTHFR!! I thought I just couldn't mentally handle it.
WOAH, I panicked when given laughing gas as a kid!! I thought I was just too anxious and my fight-or-flight was activated when my brain recognized my reasoning capacity wasn't all there.... But I attacked the doctor and actually have no memory of it, which is totally uncharacteristic!! I've never blacked out from anything, heavy drinking, even anaesthesia I woke up totally conscious and remember things from that moment. But that is the ONE time that someone else had to tell me what actually happened.
Having a few previous surgeries I always vomited after anesthesia for couple of days afterwards. I have Dirty Genes and I found out so many things about the MTHFR double mutation which I am ", blessed" to have.
@tanyawieczorek6603 just let the Anesthesiologist know that I am very sensitive to anesthesia. Pseudocholinesterase deficiency is a abnormally prolonged drug effects.
I appreciate Dr. Lynch’s simple explanation. I have also listed to Dr. William Walsh who authored “Nutrient Power”, he goes into great detail with Methylation, along with epidemics, Copper overload, zinc, etc. Dr. Walsh has protocol which he has trained over 1000 psychiatrists around the world. He has over 1 million blood samples from psychiatric patients. Give him a listen- he goes really deep, with 30 years experience in this 🙏👍
Two of my children have had Stephen's Johnsons reactions to Penicillin. Could this be because of this variant? I have MTHFR from both of my parents. Laughing gas made me vomit almost immediately when I was a child. Do we know of any connection between cartilage issues?
I have a friend whose 5 year old daughter had her tonsils out & they gave her Penicillin as an afterthought…….it killed her! Her dad is a MD and her mom is a RN. So tragic!
There could be variable reasons for a person experiencing anxiety. Giving an answer without knowing a persons history could prove deleterious and ineffective.
just found I have red flagged high homocysteine and fibrinogen activity so need to make a plan. with an LPa of 468nmolar. at 67 with no events so far with a CAC of 167
@DrBenLynch, after watching many of your videos, i took the bloodtest and showed i have the c677. I quit my coffee addiction the next morning. 2 days were horrible with malaise and migraine, but i started taking all B vitamins, and folic acid. and i immediately felt better. Lost 3 lbs of waterretention, and im on my 6th day of no caffee, and i feel so much better. Thank you so much for helping us to become more healthy!!
@@Ephedrenaline Yes i think so. However where im at right now thats imposdible to get( eastern europe for you) but i ordered from dr Ben Lynch's website some.
I have double C677T variant. Would you say that proper supplementation and a balanced diet and lifestyle would bring the reduced function to 100%? Thank you. I appreciate you 😊
I'd phrase that differently. You cannot bring a frayed rope to 100% function. You can use it -but you have to be mindful. If you have 30% function of your MTHFR enzyme, and you do genetically, then with the right lifestyle and food, and periodic supplementation, you're absolutely fine. You can feel 100% with a 30% functional MTHFR enzyme. That's a more accurate way to put it. Check your homocysteine levels. You want them between 6 umol/L to 8 umol/L. Use Homocysteine Nutrients if above 8 umol/L or a multivitamin with methylated folate and B12. www.seekinghealth.com/products/homocysteine-nutrients
I may have RA and am dreading being asked to go on methotrexate. I am already low B12 and homozygous for A1298C. Really nervous to start taking meds 😢. I’m also allergic to cobalt so it’s very hard for me to get my levels up. So annoying.
@@carlavegas887 thank you. I have heard that usually insurance makes you “fail” other meds first (like methotrexate) before letting you start on a biologic(?)
find a doctor to put you on low dose naltrexone. get off all gluten and all cow dairy products. i'd also get on Histamine Digest and take with meals and before bed along with ProBiota HistaminX after dinner. www.seekinghealth.com/collections/histamine-intolerance-supplements
It’s very interesting to see that many auto immune conditions have b12 as a common deficiency but instead of looking at it that perhaps the B12 deficiency ‘caused’ or triggered the auto immune conditions, they say that the condition caused the deficiency. My 23andMe test showed all these predispositions to conditions that are linked to B12 deficiencies!!! I’m hoping that with this knowledge, I can avoid going down the same route as my mum and nan by developing hypothyroidism (got that one unfortunately), then diabetes and then dementia - which are all linked and part of a progressive path. I’m doing everything I can to support my body and have massively changed my diet.
I have MTHFR, one copy of the 677 and I’m supplementing with a methylated vitamin B complex. This last year have had several issues (long covid, leaky gut, Candida, parasites, dysfunctional cortisol) leading to what I suspect is malsorbtion of nutrients. Despite taking vitamins and minerals, suspect that I’m still low. Do people with MTHFR over or under methylate? Can we have malsorbtion issues despite having MTHFR?
MTHFR is not a condition or a medical problem. It's not a set issue. Having a MTHFR variant is like having a key that has a nick in it. It still works but you may have to jiggle it to get it in the ignition. If you work it too hard, or force it, it may become more of an issue. If you're careful with it, it's fine. I recommend reading Dirty Genes. More knowledge is better when it comes to understanding how to handle MTHFR.
I have severe chronic migraine with psychiatric symptoms Taking Magnesium for my migraines led to severe insomnia (contrary to what is expected, to aid sleep). I searched about similar cases and led me to people who have MTHFR. Does it make sense? Should I continue testing for homocysteine or MTHFR?
It appears that Mg is a cofactor to calcium and vitamin D Taking high dose of magnesium at once (300mg) caused the insomnia by certain reactions. Now taking 200mg BID with no insomnia
I would like to add, that when taking B complex plus folate, in the afternoon I would get so tire that I had to take a 15 minute nap, and then I would be excellent......then I was told that it is best to take vitamin B complex at the night..............game changer for me...............any opinions? Also the folate had me irritated a lot of times!!!! some of the pills had to much........i don't take it as often and I fell much better...........has this happen to you, that folate would make you anger, and anxious, short temper, etc?
Everyone is different. Usually I recommend a full spectrum B complex to be taken during the day never at night. Folate definitely can increase irritation, headaches and other issues. I often do not take, or recommend others, to take, the full suggested serving size of any of our multivitamins at seekinghealth.com if they are sensitive. We also have a line for people who are sensitive to methylfolate. This line is called 'MF' which stands for Methyl-Free. We have a Prenatal Essentials MF, Multivitamin One MF, Kids Chewable Multivitamin MF for example. All using folinic acid and hydroxocobalamin instead of the stimulating methylcobalamin and methylfolate.
How would someone address B vitamin levels if they are homozygous C677T and was recently administered laughing gas? (2 months ago). Just supplement with B12? Asking for a friend 😅
Love your knowledge. I had a question though that I can’t seem to get answered by other ways. I did the strategene kit when you were sending those out and now when I try to access my report, it says access denied. I know you don’t do the kits anymore but I am bummed I can not get my report when I need it most.
I have MTHFR A1298C heterozygous and MTRR Ile22Met homozygous mutations, and when I take methylfolate and methylcobalamin, I feel overwhelmed, anxious, and experience insomnia. I’m not sure why this happens.
When I had a full blood count my B12 Levels were raised & I was asked was I having B12 injections for which I replied no So the Drs said that we can redue the test, but as your Folate levels are ok, we arent to concerned...! For which makes me think that B12 isnnt getting in to the cell & is just going round & round:-( I have got a Compromised Immune System due to past work place exposure to toxins, for which I had to have private Toxicology tests to find out what was going on
Great video and information …Would anesthesia or getting a local anesthesia such as something they give you for a routine colonoscopy be dangerous as well?
Is there a list of Ben Lynch approved consultants who can analyse my info and just give me the actionable steps? (I know the strategene report is good for the proactive people, but I’m still too dumb and lazy to know what to do, I just want someone to spoon feed me). Thank you.
you're not dumb :) - you're unfamiliar with biochemistry and genetics. It's new territory. You could absolutely learn it if you had the time and ability to dedicate effort to it. Life's busy. Reach out to my team at seekinghealth.com for a list of health professionals.
I’m interested to see what your view is regarding the autism spectrum. Apparently 90% of people on the spectrum (I have high functioning autism and adhd), have the mthfr mutation. I have the mthfr mutation and I’m wondering if this actually ‘causes’ high functioning autism/adhd? I also think that it’s 100% of people who have high functioning autism/adhd have the mthfr mutation and the other 10% are possibly misdiagnoses - possibly caused by b vitamin deficiencies which then create the symptoms of autism/adhd…..I also wonder if there’s a link between pernicious anemia and the mthfr mutation as I believe I have that - I’m awaiting testing…
So from what I'm understanding the best place to start is by supplementing methyfolate and methylated b12. Is that correct or is there something else we should be looking at as well?
oof - way way less. Start out low and go from there - and ideally use MTHF with Methyl B12 so it works more effectively - www.seekinghealth.com/products/methyl-b12-with-l-methylfolate - start with 1/4 to 1/2 lozenge - this is 800 mcg of MTHF - and it's powerful - start low so you don't regret it.
you should not use nitrous oxide no. You should use CBD or some other thing that reduces your anxiety levels. Nitrous oxide is NOT pain relief. It is designed to reduce anxiety mainly with a minor pain relief component
@@DrBenLynch I dont have anxiety but laughing gas eliminates pain for dental or cosmetic skin procedures. Never had any bad reaction to it and have used it couple times a year for at least 5 years. Am I misunderstanding your comment?
Since mold my mthfr has been more apparent, before mold I was 100% normal. Now if I take individual B's I have the same symptoms as if I'm living in mold I need to find a B complex that works for my body
Maybe a B complex isn't what you need right now. If it's not working, don't force it. Stop it and switch to a glutathione supplement, sauna and use electrolytes.
I have to disagree with the methy forms being best. I am double c677t and do better with your optimal MF vs methylated forms. I feel anxious or upregulated. Folinic is better for me than methylfolate.
familiar but I don't follow his work. I agree with anyone who talks about the importance of the fundamentals of health - but in a healthful, non exaggerated manner.
It gets confusing! Idiopathic PE led to finding out I have homozygous c677T, hyperhomocysteinemia, antiphospholipid. Dirty Genes says for mthfr to eat red meat, eggs, etc.….while sources for the hyperhomocysteinemia diet say no red meat, eggs, etc. These types of dualities keep me confused so I just eat what I feel like my body is wanting and support with supplements if I feel crappy. I am grateful for your supplements and for your teaching!
If one has high homocysteine, the solution is not to stop eating meat. It's to identify how much protein you are eating - and to support methylation. It's not all or nothing. It's a balancing act.
Hmm so what should I do when having MRTHR gene and taking Methotrexate for RA? So far i have replaced the folic acid they want me to take with it with methylfolate. Anything else needed?
I have the same. It's a bad situation in which to be. If your reumatologist is not willing to change your medication, take supplements to support methylation. I personally take active forms of B2, B6, B9, B12, Creatine (cuts methylation requirments in half, as per Dr Lynch), and Magnesium and/or other similar important co-factors. Just be mindful to not take too much, as some of this can give toxicity (B6 if in excess). So blood work also important to monitor. Also for RA, check your Vitamin D status, in general. And suggest you to bring to 60 at least, if lower than that. The 25-H form. Hope this can help.
Is there a place to go to explain the different snips/variants? I know I have MTHFR 1298 AC? I have Ace DD. I have COMT val158met GG. I have MAOA arg297arg TT. NOS -786 TT. DAO his645 CG. GSTM1 DEL. But I dont know if these are the ones with issues. I did 3x4 and gives some detail but wondering if there is a better place to research. Thanks in advance
Guys/Gals...think of how many genetic variants wr must all have, d/t having 30,000 genes! Well be following new "polymorphisms", until the end-of-time. We're speak8ng of just ONE here. Eat well...do the best you can in this short life. Love and live for God...help others...accept Jesus as YOUR Savior - die,...and GO HOME. Heaven shld be our goal.😮
Folinic Acid has been crucial in my severe concussion recovery and beating POTS postural orthostatic tachycardia syndrome. I will need to take it for the rest of my life. It has helped me get a second chance at life. I have the MTHFR gene variant which I was tested for after my brain injury. I do not tolerate methyl folate, methyl trapping.
Got my StrateGene Results yesterday. Relieved that I only have two very important Folate Cycle SNPs. Reduced Methylfolate/B12. Many other cycles far more compromised. I’ll ask your team for a consulting doctor referral. So profoundly grateful for your brilliant work❣️ One curious personal question: Have you taken Dr d’Adamo’s Geno Type testing and are you an Explorer Geno Type? I’m an Explorer Geno Type, that’s why I ask. Folate Cycle SNPs MTHFR A1298C +/+ GG SLC19A1 G80A +/+, TT
Dr Lynch, what a delight! I took the test many years ago. Since then I’m aware how identified I am with my genotype. As I recall, he measures mostly physical features. Like you, Peter is brilliant. I first read his work in a journal called the Townsend Letter back in the mid 90s. It matched so closely with my own health changes that I’ve had unwavering confidence in his work ever since. I suggest that you order the test to see what genotype you are. As I recall there are currently six types. The topic is fascinating!
I'm SO glad to see you back teaching. I'm 66 years old. Stratagene absolutely explained my whole family. And...saved my life! Thank you!
God to hear! What is stratagene?
When I was 19, I was given nitrous oxide to remove my wisdom teeth. At 36 I got an Epstein Barr virus and later diagnosed with Lupus and given Methotrexate. It wrecked my life and relationships because people thought I was just being lazy. I didn’t find out till 2 years ago that I had MTHFR. It feels nice to be validated, so thank you.
Yes, I've had to grapple with these same feelings. I was especially harsh on myself about having chronic fatigue. I thought other people just handled life better or I was lazy. But eventually I realized, no, THIS kind of fatigue is not normal. I didn't take a nap every day for fun; I hated it. And chronic pain. Standing at the counter chopping veggies shouldn't be painful. But it was my normal for so long, I didn't realize how bad it was. When I realized, I was finally able to give myself some grace and begin healing. Turns out I was autistic all this time too. I really DID get a harder lot than others, but for some reason people don't like to think that others may actually have it harder than them. So they're a jerk and call you lazy instead. It's some sort of personal insecurity.
You're not alone ♡
I'm sorry you went through that awful experience and gaslighting. I have MTHFR also and I understand how fatigued you can be without supplementation and the right diet. Hugs!
Nitrous oxide is like a vampire, it robs yr brain and then the rest of yr body of b12
Left untreated, causes devastating consequences
Yr issue is not mthfr, its from b12 deficiency
Carla, what supplements did you start taking and have they helped you?
It definitely seems like there are 2 extremes... Doctors who think it's useless and people online who attribute EVERY issue they've ever had with it. I appreciate your reasonable teaching on it.
great point.
this stuff is TMI for most people and they obsess about markers they don't really understand. I've been on groups where that is the only way they identify themselves, through these biomarkers. I've done great healing for myself and clients without this level of biochemical obsession
@elizabethheyenga9277 There's PLENTY of really basic podcasts if this is too complex. I'm absolutely SO tired of the super simple, basic podcasts. Find what works for you.
Wow! Just found out my son has 2 copies of 667. 4 years ago he had nitrous oxide gas for the first time for just a few minutes to prep him for an MRI. Thankfully, he ended up fighting (very unlike him) to take it off so I had them stop. We were in the ER later that night because he couldn’t walk, felt numb, stomach tightness and vomiting. He kept screaming for me to call 911. The ER did nothing. They said it was a “stomach bug”. He had these episodes off and on where he couldn’t stand for a week and nothing was ever done. We were told it was anxiety. He also has autism and ADHD. He is now 15 and still says he has not been the same since. I just ordered your book Dirty Genes. I am praying for the answers that I have searched for for so long.
OMG this is huge 😮I don’t have enough words to thank you for this dr Lynch, thank you very very much 🙏🙏🙏
I have mthfr double homozygous .
I found out after I had 2 brain strokes and they couldnt figure out why.
I was so sick, I developed an auto immune disease and was so so sick I could not walk.
5 years later at 54... I changed my diet..no dairy, no gluten and started suppliments full complex bs, d3 omegas & mthf ... I am now hiking in the woods again and exploring beautiful places. It was a life changer for me !! Im proof you can change your health with epigenetics :) ❤
awesome :)
This is so encouraging! You've done such an amazing job getting your health back on track! You should be proud of yourself ☺
which warriant do you have? the one with 677 or 1298?
@@hellno9072 I believe the main commenter said they were double (homozygous for both)
Sorry it says compound homozygous
🎯 Key Takeaways for quick navigation:
00:40 *🧬 Having the MTHFR variant doesn't guarantee specific health conditions but makes you more vulnerable due to reduced methyl folate production.*
01:39 *💡 Supplementing with methylfolate, dietary changes, and avoiding substances like folic acid can support MTHFR enzyme function.*
03:28 *🚫 Some medical organizations discredit testing for MTHFR, but awareness of vulnerability allows for proactive measures.*
05:31 *⚠️ Individuals with MTHFR variants should avoid medications like methotrexate and laughing gas due to potential adverse effects on B12 and folate.*
07:34 *🌟 Knowing your MTHFR status enables better health choices and awareness of potential risks and interventions.*
Made with HARPA AI
brilliant ;)
Should we take vitamin b12 with methylfolate? I'm trying to help my daughter. I just ordered vitamin b12 and methylfolate but I'm not sure if the b12 is the correct vitamin to take with it?
@@angelacruz114same question here. B12? 😅
Thank you dr Lynch. Just bought your book & test kit - need your help dissecting this!!
Your guidance and support has been invaluable 🙌🏼 I'm forever grateful! Thanks a million! 😌
You're so welcome!
Lots of mental health issues are being linked to diet - low carb/keto type diets seem to have very good results with treating mental health, including adhd.
They don’t like you doctor but WE LIKE YOU :). God bless you ❤
So glad to have found you. I just ordered both Dirty Genes and The Histamine Workbook. Thank you so much for helping those of us who are just everyday people be able to take action and manage our health.
Ben Lynch is a hero and a warrior! Appreciate your consistent efforts throughout the years
I did real well until I had some severe trauma after childhood trauma and a bad marriage. I was dx'd in 2014 677t++ and did great working with a genomicist with a nutrition professor who has MTHFR. Recent trauma really taught me and now having Stratagene and Dirty genes I am coming back. I am highly sensitive/vulnerable and am finally really getting the need for boundaries.
I got addicted to nitrous oxide for a couple months last fall. Definitely worsened the neuropathy I was already experiencing as a result of my MTHFR mutation. I lose balance everyday and cannot sleep on my side without my limbs going numb or eat any carbs or processed sugar without the neuropathy worsening. Never thought nitrous oxide contributed to this until I heard another woman share in a nitrous recovery group about how her abuse of the drug wreaked havoc on her body bc she had a genetic mutation. It’s validating to hear this from a Dr.
DMT and having very low ferritin caused me to have neuropathy instantly. It did go away mostly but I have to take iron supplements and if I eat too much sugar I feel it in my toes.
Thanks for your HELP‼️
I was given laughing gas at the dentist when I was much younger. I just remember immediately feeling trapped inside my body and paralyzed. I had no control over my body. I told them to immediately stop and turn it off!! I never knew it could be related to MTHFR!! I thought I just couldn't mentally handle it.
WOAH, I panicked when given laughing gas as a kid!! I thought I was just too anxious and my fight-or-flight was activated when my brain recognized my reasoning capacity wasn't all there.... But I attacked the doctor and actually have no memory of it, which is totally uncharacteristic!! I've never blacked out from anything, heavy drinking, even anaesthesia I woke up totally conscious and remember things from that moment. But that is the ONE time that someone else had to tell me what actually happened.
@@Ayverie4 I think we saved our own lives! I’m almost 49 figuring this out.
Having a few previous surgeries I always vomited after anesthesia for couple of days afterwards.
I have Dirty Genes and I found out so many things about the MTHFR double mutation which I am ", blessed" to have.
So if you had to have surgery again in the future, how would you handle it differently?
@tanyawieczorek6603 just let the Anesthesiologist know that I am very sensitive to anesthesia. Pseudocholinesterase deficiency is a abnormally prolonged drug effects.
I appreciate Dr. Lynch’s simple explanation. I have also listed to Dr. William Walsh who authored “Nutrient Power”, he goes into great detail with Methylation, along with epidemics, Copper overload, zinc, etc. Dr. Walsh has protocol which he has trained over 1000 psychiatrists around the world. He has over 1 million blood samples from psychiatric patients. Give him a listen- he goes really deep, with 30 years experience in this 🙏👍
Two of my children have had Stephen's Johnsons reactions to Penicillin. Could this be because of this variant? I have MTHFR from both of my parents. Laughing gas made me vomit almost immediately when I was a child. Do we know of any connection between cartilage issues?
I have a friend whose 5 year old daughter had her tonsils out & they gave her Penicillin as an afterthought…….it killed her! Her dad is a MD and her mom is a RN. So tragic!
Curious about cartlidge as well.
Dr Ben I am having anxiety really bad. I refuse to take meds but need help. Any supplements in Seeking Health store I can buy?
he probably will never answer here... 95$ he wants, at least...
There could be variable reasons for a person experiencing anxiety. Giving an answer without knowing a persons history could prove deleterious and ineffective.
Till you figure out. ..I get relief from L THEANINE. AND AT NIGHT MAGNESIUM CALM.
ALSO TRY LEMON BALM.
❤
@@suzihazlove4979 thank you
@@carlavegas887 thanks
just found I have red flagged high homocysteine and fibrinogen activity so need to make a plan. with an LPa of 468nmolar. at 67 with no events so far with a CAC of 167
@DrBenLynch, after watching many of your videos, i took the bloodtest and showed i have the c677.
I quit my coffee addiction the next morning. 2 days were horrible with malaise and migraine, but i started taking all B vitamins, and folic acid. and i immediately felt better. Lost 3 lbs of waterretention, and im on my 6th day of no caffee, and i feel so much better.
Thank you so much for helping us to become more healthy!!
Wouldn’t taking methylfolate be better than taking folic acid?
@@Ephedrenaline Yes i think so. However where im at right now thats imposdible to get( eastern europe for you) but i ordered from dr Ben Lynch's website some.
I have double C677T variant. Would you say that proper supplementation and a balanced diet and lifestyle would bring the reduced function to 100%? Thank you. I appreciate you 😊
I'd phrase that differently. You cannot bring a frayed rope to 100% function. You can use it -but you have to be mindful. If you have 30% function of your MTHFR enzyme, and you do genetically, then with the right lifestyle and food, and periodic supplementation, you're absolutely fine. You can feel 100% with a 30% functional MTHFR enzyme. That's a more accurate way to put it. Check your homocysteine levels. You want them between 6 umol/L to 8 umol/L. Use Homocysteine Nutrients if above 8 umol/L or a multivitamin with methylated folate and B12. www.seekinghealth.com/products/homocysteine-nutrients
@@DrBenLynch Thank you so much. That makes a lot of sense. 😊
I very much enjoy the vignettes for my longterm memory!
I have both genes the 677 and 1298. I found out in 2015 or so. I also had epstein barr and a whole host of problems. I have no idea how to treat it.
I may have RA and am dreading being asked to go on methotrexate. I am already low B12 and homozygous for A1298C. Really nervous to start taking meds 😢. I’m also allergic to cobalt so it’s very hard for me to get my levels up. So annoying.
Ask your doctors for a Biologic Medicine, that’s should really help your RA, aside from changing your diet.
@@carlavegas887 thank you. I have heard that usually insurance makes you “fail” other meds first (like methotrexate) before letting you start on a biologic(?)
find a doctor to put you on low dose naltrexone. get off all gluten and all cow dairy products. i'd also get on Histamine Digest and take with meals and before bed along with ProBiota HistaminX after dinner. www.seekinghealth.com/collections/histamine-intolerance-supplements
@@natasha09179 did you try those recommendations and did they help you?
I may have commented on this before, but do not the Methylated B Complex work well?
It’s very interesting to see that many auto immune conditions have b12 as a common deficiency but instead of looking at it that perhaps the B12 deficiency ‘caused’ or triggered the auto immune conditions, they say that the condition caused the deficiency. My 23andMe test showed all these predispositions to conditions that are linked to B12 deficiencies!!! I’m hoping that with this knowledge, I can avoid going down the same route as my mum and nan by developing hypothyroidism (got that one unfortunately), then diabetes and then dementia - which are all linked and part of a progressive path. I’m doing everything I can to support my body and have massively changed my diet.
I have MTHFR, one copy of the 677 and I’m supplementing with a methylated vitamin B complex. This last year have had several issues (long covid, leaky gut, Candida, parasites, dysfunctional cortisol) leading to what I suspect is malsorbtion of nutrients. Despite taking vitamins and minerals, suspect that I’m still low. Do people with MTHFR over or under methylate? Can we have malsorbtion issues despite having MTHFR?
MTHFR is not a condition or a medical problem. It's not a set issue. Having a MTHFR variant is like having a key that has a nick in it. It still works but you may have to jiggle it to get it in the ignition. If you work it too hard, or force it, it may become more of an issue. If you're careful with it, it's fine. I recommend reading Dirty Genes. More knowledge is better when it comes to understanding how to handle MTHFR.
@@DrBenLynch thank you from responding! Curious if info about over methylating is in the MTHFR chapter in Dirty Genes?
I have severe chronic migraine with psychiatric symptoms
Taking Magnesium for my migraines led to severe insomnia (contrary to what is expected, to aid sleep).
I searched about similar cases and led me to people who have MTHFR.
Does it make sense? Should I continue testing for homocysteine or MTHFR?
The hypothesis is that high Mg supplementation caused hypermethylation, resulting in insomnia.
It appears that Mg is a cofactor to calcium and vitamin D
Taking high dose of magnesium at once (300mg) caused the insomnia by certain reactions.
Now taking 200mg BID with no insomnia
I would like to add, that when taking B complex plus folate, in the afternoon I would get so tire that I had to take a 15 minute nap, and then I would be excellent......then I was told that it is best to take vitamin B complex at the night..............game changer for me...............any opinions? Also the folate had me irritated a lot of times!!!! some of the pills had to much........i don't take it as often and I fell much better...........has this happen to you, that folate would make you anger, and anxious, short temper, etc?
Everyone is different. Usually I recommend a full spectrum B complex to be taken during the day never at night. Folate definitely can increase irritation, headaches and other issues. I often do not take, or recommend others, to take, the full suggested serving size of any of our multivitamins at seekinghealth.com if they are sensitive. We also have a line for people who are sensitive to methylfolate. This line is called 'MF' which stands for Methyl-Free. We have a Prenatal Essentials MF, Multivitamin One MF, Kids Chewable Multivitamin MF for example. All using folinic acid and hydroxocobalamin instead of the stimulating methylcobalamin and methylfolate.
@@DrBenLynch Thank you for your response, I guess I'm one of those LOL, sensitive to Folate
How would someone address B vitamin levels if they are homozygous C677T and was recently administered laughing gas? (2 months ago). Just supplement with B12? Asking for a friend 😅
Love your knowledge. I had a question though that I can’t seem to get answered by other ways. I did the strategene kit when you were sending those out and now when I try to access my report, it says access denied. I know you don’t do the kits anymore but I am bummed I can not get my report when I need it most.
I have MTHFR A1298C heterozygous and MTRR Ile22Met homozygous mutations, and when I take methylfolate and methylcobalamin, I feel overwhelmed, anxious, and experience insomnia. I’m not sure why this happens.
Then why does Dr Jerry Tennant recommend N02 lozenges to all his patients in his protocol? I’m confused.
Maybe it's the difference between nitrous oxide and nitric oxide. Nitric is the good one
What are the interventions you can do if you have to have surgery and they use Nitric Oxide and you have MTFHR?
I wonder the same thing. Is there a possibility that increasing daily doses of the b12 / lm ethyl folate could help offset?
Did you ever find out the answer?
When I had a full blood count my B12 Levels were raised & I was asked was I having B12 injections for which I replied no So the Drs said that we can redue the test, but as your Folate levels are ok, we arent to concerned...! For which makes me think that B12 isnnt getting in to the cell & is just going round & round:-( I have got a Compromised Immune System due to past work place exposure to toxins, for which I had to have private Toxicology tests to find out what was going on
6:40
methylfolate
and
Methylcobalamin
gives me extreme anxiety
Great video and information …Would anesthesia or getting a local anesthesia such as something they give you for a routine colonoscopy be dangerous as well?
What is best for someone who is vegan and has MTHFR mutation?
Is there a list of Ben Lynch approved consultants who can analyse my info and just give me the actionable steps? (I know the strategene report is good for the proactive people, but I’m still too dumb and lazy to know what to do, I just want someone to spoon feed me). Thank you.
you're not dumb :) - you're unfamiliar with biochemistry and genetics. It's new territory. You could absolutely learn it if you had the time and ability to dedicate effort to it. Life's busy. Reach out to my team at seekinghealth.com for a list of health professionals.
@@DrBenLynch Thanks, Sir. I will do that. Have a good day.
Check out David Delgado Mind-Body Healing. He's a health coach that focuses on people with MTFHR
What about exposure to nitrous working in dentistry? Is that enough to cause issue?
I’m interested to see what your view is regarding the autism spectrum. Apparently 90% of people on the spectrum (I have high functioning autism and adhd), have the mthfr mutation. I have the mthfr mutation and I’m wondering if this actually ‘causes’ high functioning autism/adhd? I also think that it’s 100% of people who have high functioning autism/adhd have the mthfr mutation and the other 10% are possibly misdiagnoses - possibly caused by b vitamin deficiencies which then create the symptoms of autism/adhd…..I also wonder if there’s a link between pernicious anemia and the mthfr mutation as I believe I have that - I’m awaiting testing…
So from what I'm understanding the best place to start is by supplementing methyfolate and methylated b12. Is that correct or is there something else we should be looking at as well?
Should persons with COMT use methylated vitamins?
you advise to use 7.5 mg or more of 5-mthf ?
oof - way way less. Start out low and go from there - and ideally use MTHF with Methyl B12 so it works more effectively - www.seekinghealth.com/products/methyl-b12-with-l-methylfolate - start with 1/4 to 1/2 lozenge - this is 800 mcg of MTHF - and it's powerful - start low so you don't regret it.
How do Redox Signaling Molecules affect this?
So if we have MTHFR some version, we cannot take nitrous oxide for pain relief during minor surgeries??? Or what happens?
you should not use nitrous oxide no. You should use CBD or some other thing that reduces your anxiety levels. Nitrous oxide is NOT pain relief. It is designed to reduce anxiety mainly with a minor pain relief component
@@DrBenLynch I dont have anxiety but laughing gas eliminates pain for dental or cosmetic skin procedures. Never had any bad reaction to it and have used it couple times a year for at least 5 years. Am I misunderstanding your comment?
Since mold my mthfr has been more apparent, before mold I was 100% normal. Now if I take individual B's I have the same symptoms as if I'm living in mold
I need to find a B complex that works for my body
Maybe a B complex isn't what you need right now. If it's not working, don't force it. Stop it and switch to a glutathione supplement, sauna and use electrolytes.
Where can I find the full interview?
I have MTHFR and lipedema…how does this cause lipedema?
I have to disagree with the methy forms being best. I am double c677t and do better with your optimal MF vs methylated forms. I feel anxious or upregulated. Folinic is better for me than methylfolate.
Hospitals are aware of this but feign ignorance cause they don’t wanna get sued n lose
Any thoughts on Dr.Jack Kruse?
familiar but I don't follow his work. I agree with anyone who talks about the importance of the fundamentals of health - but in a healthful, non exaggerated manner.
It gets confusing! Idiopathic PE led to finding out I have homozygous c677T, hyperhomocysteinemia, antiphospholipid. Dirty Genes says for mthfr to eat red meat, eggs, etc.….while sources for the hyperhomocysteinemia diet say no red meat, eggs, etc. These types of dualities keep me confused so I just eat what I feel like my body is wanting and support with supplements if I feel crappy. I am grateful for your supplements and for your teaching!
If one has high homocysteine, the solution is not to stop eating meat. It's to identify how much protein you are eating - and to support methylation. It's not all or nothing. It's a balancing act.
Are vitamin B12 shots considered?
Does Tadalafil cause issues with mthfr
So much information it’s so hard to know what is what 😢
Do not take Montelukast aka Singulair either.
Curious why or how that plays into this?
My son had a terrible reaction to laughing gas from dental office
What happened?
Hmm so what should I do when having MRTHR gene and taking Methotrexate for RA? So far i have replaced the folic acid they want me to take with it with methylfolate. Anything else needed?
I have the same. It's a bad situation in which to be. If your reumatologist is not willing to change your medication, take supplements to support methylation. I personally take active forms of B2, B6, B9, B12, Creatine (cuts methylation requirments in half, as per Dr Lynch), and Magnesium and/or other similar important co-factors. Just be mindful to not take too much, as some of this can give toxicity (B6 if in excess). So blood work also important to monitor. Also for RA, check your Vitamin D status, in general. And suggest you to bring to 60 at least, if lower than that. The 25-H form. Hope this can help.
I guess this is why l-citrulline gave me insomnia.
i love ronald reagan AD
What about nitric oxide?
What if the reason we have this variant is epigenetic... the consequence of a century of ubiquitous lead poisoning, for instance?
it is epigenetic at this point - it's easier to be born with MTHFR now that we have so much pregnancy intervention -
@@DrBenLynchcan you elaborate please?
I have just tried to share this video in France and it is being flagged as going against comunity standards , proof what i said underneath
Is there a place to go to explain the different snips/variants? I know I have MTHFR 1298 AC? I have Ace DD. I have COMT val158met GG. I have MAOA arg297arg TT. NOS -786 TT. DAO his645 CG. GSTM1 DEL. But I dont know if these are the ones with issues. I did 3x4 and gives some detail but wondering if there is a better place to research. Thanks in advance
I have 20% less capacity...1298. I need to change my diet so I can have 2 more healthy bebe!
Why do you need 2 more babies?!
👏👏
Guys/Gals...think of how many genetic variants wr must all have, d/t having 30,000 genes! Well be following new "polymorphisms", until the end-of-time. We're speak8ng of just ONE here.
Eat well...do the best you can in this short life. Love and live for God...help others...accept Jesus as YOUR Savior - die,...and GO HOME. Heaven shld be our goal.😮
Folinic acid, I read somewhere better avoid this one also
yeah - you probably did read that somewhere. The internet is FULL of inaccurate information. Folinic acid is great.
Folinic Acid has been crucial in my severe concussion recovery and beating POTS postural orthostatic tachycardia syndrome. I will need to take it for the rest of my life. It has helped me get a second chance at life. I have the MTHFR gene variant which I was tested for after my brain injury. I do not tolerate methyl folate, methyl trapping.
@@strengthwithinme6795and what are the differences between the two forms?
@@strengthwithinme6795 what happens if you take folate?
Thanks genetics 😒
Got my StrateGene Results yesterday. Relieved that I only have two very important Folate Cycle SNPs. Reduced Methylfolate/B12. Many other cycles far more compromised. I’ll ask your team for a consulting doctor referral. So profoundly grateful for your brilliant work❣️
One curious personal question: Have you taken Dr d’Adamo’s Geno Type testing and are you an Explorer Geno Type? I’m an Explorer Geno Type, that’s why I ask.
Folate Cycle SNPs
MTHFR A1298C +/+ GG
SLC19A1 G80A +/+, TT
I haven't taken Peter's test. That's interesting. What combination of SNPs makes one an explorer genotype? There research on that?
Dr Lynch, what a delight!
I took the test many years ago. Since then I’m aware how identified I am with my genotype. As I recall, he measures mostly physical features. Like you, Peter is brilliant. I first read his work in a journal called the Townsend Letter back in the mid 90s. It matched so closely with my own health changes that I’ve had unwavering confidence in his work ever since. I suggest that you order the test to see what genotype you are. As I recall there are currently six types. The topic is fascinating!