Breakdown - we need a Good Energy Metabolism = Thyroid & Insulin balance for proper energy system. Glutamate > (Mg & ATP) = Glutamine Glutamine > (B6) = GABA GABA to function - by electrolytes (salt, potassium) No crazy diet methods And mindfulness meditation
Yeah I dunno, he started with saying glucose is needed to make GABA, but then advocates keto later. It's good to know components, but don't lose sight of forest from the trees.
Keto is the worse thing you can do if you're trying to increase GABA. You're dramactly decreasing glucose, raising stress hormones (cortisol helps with gluconeogensis). Going very low carb reduces T3 dramactily. Horrible idea. Only thing good about Keto is the short term weight loss benefits and it keeps you away from junk food and helps with satiety.
@@RobertLongM Check out the research and work of Dr. Ray Peat. He goes into detail why Keto is so dangerous. Why leads to insulin resistance the longer you do it which is funny because most think it helps insulin resistance. Chris Masterjohn actually agrees with many of the things in Ray Peat's model. Cheers & stay healthy!
Or if your Receptors are downregulated - then it won’t matter how much GABA is there. I guess then we need BDNF / NGF nootropics OMG! That makes sense “glucose” which is why Alcohol is like liquid Benzo!
Correct me if I’m wrong, I eat all the necessary foods mentioned in the video, but my unstable insulin jeopardizes the making of Gaba, if I take a Gaba supplement, will my Gaba get to a normal level despite the insulin issue? Are there side effects if I stop taking the Gaba supplement? Thanks
there is a supplement that has all of this in it except "meditation" of course, it's called "MOOD" by "NOW", but I've been told that GABA supplements cannot cross the brain blood barrier (BBB)
Thank you! I’m currently going through Benzo Withdrawal which are horrifically painful. The benzodiazepine I had taken down-regulated my Gaba receptors so my body and mind are in fight or flight all the time- it is exhausting to say the least. This helps me. It can take many months for these Gaba receptors to heal.
Pretty confusing...This is how it works naturally: fasting (Omad) and carnivore.fasting releases Gaba production and carnivore -diet combined makes it a perfect match.I feel everyday Gaba -euphoria and its awesome! Very calm and relaxed still I can burst into action rapidly if needed.Highly focused through a day.Natural high🎉
Is it - to your knowledge - possible, that the GABA metabolism is impaired in the fetus through the intake of Benzodiazepines during pregnancy? Do you have any idea how to support in that situation in a now adult person affected?
Thanks for sharing your research and insights. When I supplement with glutamine (for gut healing) I notice no neurological effects while supplementing (physically there are some effects.) But upon ceasing supplementation, about 24 hours later, terrible effects develop that tick most of the boxes for low GABA (anxiety, muscle twitches, unpleasant ideation, sweating [at night], excessive thirst and urination). Most of the worst symptoms occur at night, beginning at bedtime. It is dose dependent; the higher the dose I have been taking, the longer it takes to normalize after cessation. Could it really be low GABA, or something else I am overlooking? (BTW, many of my symptoms also fit high serotonin). Thanks again!
First, she said we had to get her blood sugar up and then you said keto diet was good for GABA. I thought you would have to cut out carbs wouldn’t that lower your blood sugar?
Glutamate sensitivity likely means you're not shunting enough down the GABA pathway so the glutamate concentration rises to neurotoxic levels. A B6 deficiency is likely the culprit.
Well, respectfully, that is not really correct. Keto means low exogenous glucose intake but the liver still keeps blood suger stable from gluconeogenesis. I am on a very low carb diet and my blood suger is super stable according to my CGM. I also cured my type 2 diabetes in 4 weeks going strict keto. By week four I was insulin sensitive again as shown by a bolus test with carbs. I got an Immediate glucose spike, then a drop and 2 to 3 hours later a flatline , normal glucose level. Chris is exactly right. Keto diets balance glutamate toxicity and raise gaba. They even lower the need for Benzos and reduce seizures in people detoxing from alcohol. Part of that is the ketones replace alcohol ( or acetate, a ketone body produced from alcohol) as a brain fuel. The other part is keto diets are usually rich in animal foods and high in nutrients including glutamine and b vits.
@@chrismasterjohn you said fat should be lowered if a diet is deficient in veggies and fruits to prevent potassium deficiency, but you ended the video by saying ketogenic diet might be the best diet for increasing Gaba
Health is an emotional state, just like peace. When your mind is threatened by what you perceive to be an enemy then it cannot heal. Nurture yourself. A pill, food, or person will never be able to give you what you need except yourself.
What you say is partially true but we all very and I've done all the practices that didn't involve supplements. Now that I use supplements, I've been able to cut most of hose practices substantially and still achieve a healthy State of Mind. Supplementing with magnesium alone cut my minimum required yoga time to not have scoliosis symptoms down to 20% of the yoga that I used to have to do. Most people have micronutrient deficiencies. Some people have much greater symptoms from these deficiencies and deficiencies vary from person to person.
Wow this really turned on a light for me. I was wondering why gaba positive modulator supplements (skullcap, magnolia, etc) were making me more sedated on keto.
Don Duchane advocated 5/2 days per week ketogenic diet for bodybuilders. 2 days of carbohydrates ( recomposition ) feels good for GABA. Ketogenic diet , CONTINUOUS is very harmful , and very Depressive.
This seems to explain why taking GABA directly makes matters worse for me. Even the smallest of doses knocks me on my butt, but does little to help with sleep and leaves me with an AM hangover.
It sounds like the most important thing is to fix the insulin and stabilize it as well as fixing any thyroid issue and perhaps inflammation too? That way, all the vitamins, etc. would do their jobs? Thank you😊
Simple question and I want a yes or no answer Damn it .does Gaba make one sleepy? Does it cause depression or make depression worse? Yes or no Simple question
Why focus on increasing glutamate when you can easily supplement glutamine and be one step closer to gaba synthesis? Glutamine itself can be converted into glutamate if glutamate is low. I use glutamine as a pre and post workout supplement to decrease stress on the central nervous system. Works very well. I suppose because of increasing gaba. Not to mention the effect of reducing sugar cravings.
I was talking about the *normal route of synthesis.* Glutamine is a *minor* way of generating GABA. The brain burns through 120 grams of glucose a day, most of which has the potential to generate glutamate, which is the overwhelming precursor to GABA under all conditions.
@@chrismasterjohn Thanks for your answer! I am a bit confused though, since the Brain uses glucose primarily as an energy source, would not only a surplus of it be available for gaba synthesis? From my personal experience glutamine does significantly reduce the initial impact of weight training to failure on the cns while dextrose, even in much higher amounts, does not. I suspected gaba synthesis to be the reason but maybe there is another mechanism? (or placebo, but the effect has been very reliable for me)
Did you noticed how he said this all requires good thyroid and insulin status?? Keto reduces T3 dramactily, really messes with your thyroid & actually makes you insulin resistant in the long run. Only do keto for a very short time if you need to do for some major health reason.
Very informative and easily understandable. Good job!
Breakdown - we need a Good Energy Metabolism = Thyroid & Insulin balance for proper energy system.
Glutamate > (Mg & ATP) = Glutamine
Glutamine > (B6) = GABA
GABA to function - by electrolytes (salt, potassium)
No crazy diet methods
And mindfulness meditation
Yeah I dunno, he started with saying glucose is needed to make GABA, but then advocates keto later. It's good to know components, but don't lose sight of forest from the trees.
Keto is the worse thing you can do if you're trying to increase GABA. You're dramactly decreasing glucose, raising stress hormones (cortisol helps with gluconeogensis). Going very low carb reduces T3 dramactily. Horrible idea. Only thing good about Keto is the short term weight loss benefits and it keeps you away from junk food and helps with satiety.
@@rbaddict2947 amen to that...
I was a wreck doing keto..
I wrote that a year ago... I was off the wall.
I deleted thst Keto line
@@RobertLongM Check out the research and work of Dr. Ray Peat. He goes into detail why Keto is so dangerous. Why leads to insulin resistance the longer you do it which is funny because most think it helps insulin resistance. Chris Masterjohn actually agrees with many of the things in Ray Peat's model. Cheers & stay healthy!
@@rbaddict2947 keto has been shown to upregulate gaba receptors in brain
Or if your Receptors are downregulated - then it won’t matter how much GABA is there. I guess then we need BDNF / NGF nootropics
OMG! That makes sense “glucose” which is why Alcohol is like liquid Benzo!
Alcohol is a liquid benzo because they're both gaba A agonists lol
Why keto diet increases GABA?
Thank you, great info.
What about taking Desiccated liver capsules?
Good question
Did you ever find an answer?
Correct me if I’m wrong, I eat all the necessary foods mentioned in the video, but my unstable insulin jeopardizes the making of Gaba, if I take a Gaba supplement, will my Gaba get to a normal level despite the insulin issue? Are there side effects if I stop taking the Gaba supplement? Thanks
To increase gaba- take all together
Taurine
Glycine
Glutamine
Gaba
Ashwagandha
Vit b6
Magnesium
Valerian root
Meditation
Yoga
there is a supplement that has all of this in it except "meditation" of course, it's called "MOOD" by "NOW", but I've been told that GABA supplements cannot cross the brain blood barrier (BBB)
Shirt is fire! Where did you get it?
Beef heart? Beef kidney? Or what animals?
not all is supplements, wrong you have to cut certaim habits
Will alpha wave stimulation help to heal damaged GABA receptors?
I don't know.
@@chrismasterjohn Thank you for replying.
I didn't think it would at all but seems to be helping me
Yoga nidra
Is this anything like how Gabapentin works?
Even better.
if people only knew the solution to every problem is to eat the intestines of some exotic animal.
Thank you! I’m currently going through Benzo Withdrawal which are horrifically painful. The benzodiazepine I had taken down-regulated my Gaba receptors so my body and mind are in fight or flight all the time- it is exhausting to say the least. This helps me. It can take many months for these Gaba receptors to heal.
Hows it going
Bifidobacteria makes gaba
complicated and seeming contradictory info
What seems to contradict?
Imagine trying to figure out every reason we should eat liver.. l love your approach to nutrition... Getting your vitamins
Nutritional yeast has glutamic acid in it, which may increase glutamate, something to be aware of for people who have glutamate sensitivity.
You could offset increased glutamate with increased B6
Deadly water hemlock kills by destroying one's GABA. Maypop is an edible plant that is high in GABA.
Pretty confusing...This is how it works naturally: fasting (Omad) and carnivore.fasting releases Gaba production and carnivore -diet combined makes it a perfect match.I feel everyday Gaba -euphoria and its awesome! Very calm and relaxed still I can burst into action rapidly if needed.Highly focused through a day.Natural high🎉
GLP-1 stimulates pancreatic GABA production and GLP-1 production is stimulated by consumption of Omega 3 FAs.
Is it - to your knowledge - possible, that the GABA metabolism is impaired in the fetus through the intake of Benzodiazepines during pregnancy? Do you have any idea how to support in that situation in a now adult person affected?
Thanks for sharing your research and insights. When I supplement with glutamine (for gut healing) I notice no neurological effects while supplementing (physically there are some effects.) But upon ceasing supplementation, about 24 hours later, terrible effects develop that tick most of the boxes for low GABA (anxiety, muscle twitches, unpleasant ideation, sweating [at night], excessive thirst and urination). Most of the worst symptoms occur at night, beginning at bedtime. It is dose dependent; the higher the dose I have been taking, the longer it takes to normalize after cessation. Could it really be low GABA, or something else I am overlooking? (BTW, many of my symptoms also fit high serotonin). Thanks again!
First, she said we had to get her blood sugar up and then you said keto diet was good for GABA. I thought you would have to cut out carbs wouldn’t that lower your blood sugar?
Adept delivery.
Greatly appreciated.
Is glutamate sensitivity a myth? I mean almost all foods we eat has glutamic acid its unavoidable.
Glutamate sensitivity likely means you're not shunting enough down the GABA pathway so the glutamate concentration rises to neurotoxic levels. A B6 deficiency is likely the culprit.
You just gave me another reason to carry on eating loads of Roquefort cheese... very high in glutamate! 👍
why would people say to use keto diet to get GABA? keto means low or no carbs which means no glucose formation then how can melatonin be produced?
Well, respectfully, that is not really correct. Keto means low exogenous glucose intake but the liver still keeps blood suger stable from gluconeogenesis. I am on a very low carb diet and my blood suger is super stable according to my CGM. I also cured my type 2 diabetes in 4 weeks going strict keto. By week four I was insulin sensitive again as shown by a bolus test with carbs. I got an Immediate glucose spike, then a drop and 2 to 3 hours later a flatline , normal glucose level. Chris is exactly right. Keto diets balance glutamate toxicity and raise gaba. They even lower the need for Benzos and reduce seizures in people detoxing from alcohol. Part of that is the ketones replace alcohol ( or acetate, a ketone body produced from alcohol) as a brain fuel. The other part is keto diets are usually rich in animal foods and high in nutrients including glutamine and b vits.
Ketosis( not a fan) has a dramatic effect on gabba, ask any epileptic. This is downstream of course.
Why not a fan?
Is lipoic acid you mention the same as alpha lipoic acid?
Yes
Confused, you said low fat and then said the keto diet helps....
This video is four years old. What did I say about low fat?
@@chrismasterjohn you said fat should be lowered if a diet is deficient in veggies and fruits to prevent potassium deficiency, but you ended the video by saying ketogenic diet might be the best diet for increasing Gaba
Would eating raw beef liver provide you with even higher amounts of the B vitamins you mention and other nutrients? Thank you.
What if you take straight glutamine supplement?
Health is an emotional state, just like peace. When your mind is threatened by what you perceive to be an enemy then it cannot heal. Nurture yourself. A pill, food, or person will never be able to give you what you need except yourself.
keep living, this is easier said than done.
What you say is partially true but we all very and I've done all the practices that didn't involve supplements. Now that I use supplements, I've been able to cut most of hose practices substantially and still achieve a healthy State of Mind. Supplementing with magnesium alone cut my minimum required yoga time to not have scoliosis symptoms down to 20% of the yoga that I used to have to do. Most people have micronutrient deficiencies. Some people have much greater symptoms from these deficiencies and deficiencies vary from person to person.
Wow this really turned on a light for me. I was wondering why gaba positive modulator supplements (skullcap, magnolia, etc) were making me more sedated on keto.
Don Duchane advocated 5/2 days per week ketogenic diet for bodybuilders. 2 days of carbohydrates ( recomposition ) feels good for GABA.
Ketogenic diet , CONTINUOUS is very harmful , and very Depressive.
I'm sensative to Glutamate! MSG makes me sleepy
This seems to explain why taking GABA directly makes matters worse for me. Even the smallest of doses knocks me on my butt, but does little to help with sleep and leaves me with an AM hangover.
What about supplementing with l-glutamine for more gaba???
I took but make me allergy good luck
What do we do if our body makes the excitatory neurotransmitters instead of gaba, when increasing glutamate?
Anything mentioned in my gaba series can help with glutamate and gaba balance. Keto diet can shift toward gaba.
@@chrismasterjohn oh ok. Good. I’ll go through the videos. Thank you kindly
Hey, Chris, wear whatever you feel comfortable. You're sexy, gorgeous, intelligent. You're attractive irrespective of the outfits.
This anti fat thing is silly
LOL. I don't have any receptors, so I can make all the GABA in the world but it will do not good.
A lot of vitamins are fat soluble,low fat diet doesn’t work.
I sure do love me some gaba now. yes sir.
i dont know whats going on with me and doctors dont know
Turn to jesus when doctors cannot help you.watch Andrew wommack. Go to awmi.net
It sounds like the most important thing is to fix the insulin and stabilize it as well as fixing any thyroid issue and perhaps inflammation too? That way, all the vitamins, etc. would do their jobs? Thank you😊
Why are you focused specifically on insulin? You’re worried the nutrients won’t get into your cells?
One of the best videos of yours I've seen. Broad range of actionable factors and why. Thanks.
Simple question and I want a yes or no answer
Damn it
.does Gaba make one sleepy?
Does it cause depression or make depression worse?
Yes or no
Simple question
Yes GABA supplement makes you sleepy. No it does not and will not increase your depression.
What does liver taste like? I'm scared
Wait, what does lipoic acid do for Gaba levels?
What about bee pollen???
Liver no go for those who've iron overload
My serum iron and ferritin didn't change eating 2lb red meat/day and 1lb liver/week.
Vegemite.
Why focus on increasing glutamate when you can easily supplement glutamine and be one step closer to gaba synthesis? Glutamine itself can be converted into glutamate if glutamate is low. I use glutamine as a pre and post workout supplement to decrease stress on the central nervous system. Works very well. I suppose because of increasing gaba. Not to mention the effect of reducing sugar cravings.
I was talking about the *normal route of synthesis.* Glutamine is a *minor* way of generating GABA. The brain burns through 120 grams of glucose a day, most of which has the potential to generate glutamate, which is the overwhelming precursor to GABA under all conditions.
@@chrismasterjohn Thanks for your answer! I am a bit confused though, since the Brain uses glucose primarily as an energy source, would not only a surplus of it be available for gaba synthesis? From my personal experience glutamine does significantly reduce the initial impact of weight training to failure on the cns while dextrose, even in much higher amounts, does not. I suspected gaba synthesis to be the reason but maybe there is another mechanism? (or placebo, but the effect has been very reliable for me)
Very good! Thank you!
Keto ftw again
Did you noticed how he said this all requires good thyroid and insulin status?? Keto reduces T3 dramactily, really messes with your thyroid & actually makes you insulin resistant in the long run. Only do keto for a very short time if you need to do for some major health reason.
@@rbaddict2947 %100
ketogenic is the worst diet for Gaba- learned the hard way