Current med school student. That means I have had to learn this concept over 10 different times over the years. AND FINALLY! I found an amazing explanation and i clearly understand it. Thank you so much.
thank you so much for posting this. i am in crna school, and they lecturer was explaining pKa with the assumption that we had a strong understanding of chem - for me that was 10 plus years ago. you put things into plain english for me. i also appreciate your practice of equanimity as you teach.
It makes so much sense when you explain it what the hell.. It has taken me months to understand this and I could've just watched this vid to begin with
Elvina Handini Can you explain,why most of the drugs are weak acid or weak base? In the video I found that it is because small change is required to shift between ionized or non ionized form But I don't understand how?
Most drugs are weak electrolytes, may be weak acids or weak bases. In water, this weak electrolyte will be ionized into its ionic form. For weak acids, a high pH (base atmosphere) will increase its ionization and reduce its nonionic form. In contrast to weak bases, a low pH (acidic atmosphere) that will increase its ionization and reduce its nonion. Only nonionic forms have fat solubility, so only the nonionic and ionic forms are in equilibrium, then after the nonion form is absorbed
Drugs that are weak acids will easily penetrate the cell membrane in the acidic atmosphere. Because in an acidic atmosphere, the drug is relatively unionized or the ionic form is small enough to penetrate the cell membrane more easily. strong acids or strong bases will be easily ionized which is cannot be penetrated to the cell membrane.
Quick question. In the example with aspirin, when it's either in the acidic (HCl) or basic solution (NaOH), does it COMPLETELY dissociate into its respective lipid/water soluble form since aspirin is a weak acid??...or is it more so that in an acidic environment aspirin is MOSTLY lipid soluble while in a basic environment aspirin is MOSTLY water soluble?
GREAT QUESTION! I googled it and came across this. www.ausetute.com.au/aspirin.html They show complete dissociation. But your question is not only outside of my clinical knowledge base, it is outside of the point I want to make. Most drugs are weak acids or weak bases because change in pH change their water solubility. This is an essential concept for drugs that cannot be mixed in the IV lines. So running a drug through a piggyback running normal saline as the maintenance solution can cause that drug to come out of solution and form particulates if it is incompatible with the pH of the maintenance solution. Major med error issue in some hospitals. Hope this helps. Thanks for the great question!
Suppose you have a closed system like the beaker shown in this video, with a finite amount of plain water , you measure ph and it comes at 6.5, and then you add say 1 gram of powdered HCL and it completely dissociates , it gets the pH of the water to an acid 4, then you add 500 mg of Aspirin (pKa is 3.49) what will happen is Aspirin will slowly dissociate (slowly because the pka is very near the current total solution ph which is 4) until the pH reaches more/less 3.49, then at this moment roughly 50% - 50% of the aspirin will be in the uncharged : ionic (charged) form and right here it will stop dissociating. how much of the aspirin will dissociate? 90% ? 10% it depends how much quantity of it you added , if 500mg was enough to donate enough aditional protons to the already acid solution then ir will stop right there, if not, it will keep dissociating until it reaches the thermodynamic equilibrium constant and will stop dissociating and keep at 50% - 50% no matter how much more aspirin you add it will not lower the pH more. thats what pka means.
Sir y does that substance release the proton instead of releasing electron.. since electron in the Valence is easier to remove than the proton in the nucleus...@0.10 min
#Pharmapedia Thank you for this amaizing explaination. I am confused about quinolones, how do they have good absorption from gastrointestinal tract despite that they have a carboxyl group at position 3 and amine group at position 7 which will make them ionized in acidic as well as basic fluids ?
Well, let's take this assidic solution, similar to the asssid in our stomachs. Let's put an ASSSSspirin in. This proton wants to come off the aspirin. BUT IT CAN'T. WHY? because of proton mass AACCtion! ...watever u r having, i need it XDDD
![Lp. Сердце Вселенной #60 РОЖДЕНИЕ ЛОЛОЛОШКИ [Финал] • Майнкрафт](http://i.ytimg.com/vi/YoR0pAV9FVQ/mqdefault.jpg)
My search for understanding pka ph concept ends here...thnks
+11111
Current med school student. That means I have had to learn this concept over 10 different times over the years. AND FINALLY! I found an amazing explanation and i clearly understand it. Thank you so much.
I really need to hug you man, I can’t believe pka is just so simple, my doctors couldn’t get this straight up my head for weeeeeks
thank you so much for posting this. i am in crna school, and they lecturer was explaining pKa with the assumption that we had a strong understanding of chem - for me that was 10 plus years ago. you put things into plain english for me. i also appreciate your practice of equanimity as you teach.
Thank you! Had to actually google equanimity :) My main youtube page is PHRM203. Pharmapedia is a format experiment.
the fact that i now understand this in 10 minutes whilst my prof has been trying to explain it to me multiple times the last 3 weeks… THANK YOU
This man explained in less than 10 min what my professors couldn't do in 2 hours.
I am an old fan of this man (I like his videos on pharmacology)
I like his face: He's like - 'Take it easy, man'
This guy is amazing, he genuinely cares about teaching the material
Trueeeee
Omg finally I understand this concept. Thank u sooo much
Looking beautiful 😍
Wow you must be a genius
Where’s Woody, Taylor, and Kyle?
loved it. A whole day of class...could have watched this 9min video...
I am very grateful to your way of explaining to the basic understanding
By far the best presentation I have seen on this, thanks!
It makes so much sense when you explain it what the hell.. It has taken me months to understand this and I could've just watched this vid to begin with
Very good video, just one error at 1:47: HCl is _not_ a white powder, it's a gas above −85.05 °C (−121.09 °F; 188.10 K).
I understood this concept after 5 years of my graduation here
thanks Dr
Impressive !!Cleared my confusion :) Thnks a ton and stay blessed :')
After hours of trying to understand pka, my clarity is actualized.
Thank you so much. You’re such a blessing
Hallelujah! Thank you so much!
Best video...thanks sir...great...no words to explain ur teaching clarity
Classic Taylor
Thanks for these simple definition, I had problems with these elements, but now I understand that, again thanks a lot
This is my second time I saw this video and it's excellent ❤❤
very nice , i'm a pharmD 2nd yr student and this guy shouldve taught in my courses...
Very good explanation sir
Thank you so much for sharing your video!
Great explanation and a great tutor!
omg your videos saved my life many times :') thankyou so much
Elvina Handini Can you explain,why most of the drugs are weak acid or weak base?
In the video I found that it is because small change is required to shift between ionized or non ionized form
But I don't understand how?
Most drugs are weak electrolytes, may be weak acids or weak bases. In water, this weak electrolyte will be ionized into its ionic form. For weak acids, a high pH (base atmosphere) will increase its ionization and reduce its nonionic form. In contrast to weak bases, a low pH (acidic atmosphere) that will increase its ionization and reduce its nonion. Only nonionic forms have fat solubility, so only the nonionic and ionic forms are in equilibrium, then after the nonion form is absorbed
Elvina Handini,so,they are weak acid or bases,but why are they not strong acid or base?what is the benefit of that?
Drugs that are weak acids will easily penetrate the cell membrane in the acidic atmosphere. Because in an acidic atmosphere, the drug is relatively unionized or the ionic form is small enough to penetrate the cell membrane more easily. strong acids or strong bases will be easily ionized which is cannot be penetrated to the cell membrane.
@@elvinahandini645 thank you ❤️
Very clear explanation. Thank you Sir!
i am confused about protonated and unprotonated form🤔
this was very clear ! thanks
This guy is the best!
The 33 dislikes are 33 Professors that couldn't explain it any better.
Thank you so much for explaining it in the best way possible!!
excelente explicação. Aprendi mais por aqui do que assistindo em muitos outros vídeos. Grata!
Thank you sir...so easily explained
Great teaching, thank you so much.
Finally understood it.... Thanks Alot!
Kyle really thinks he’s some kind of pharmacist now just because he took little acid.
This is a really good video. Thank you, Sir! 💓
I understand the concept now... thank you so much
William can you explain why so many drugs are weak acid or base,not strong?
Quick question. In the example with aspirin, when it's either in the acidic (HCl) or basic solution (NaOH), does it COMPLETELY dissociate into its respective lipid/water soluble form since aspirin is a weak acid??...or is it more so that in an acidic environment aspirin is MOSTLY lipid soluble while in a basic environment aspirin is MOSTLY water soluble?
GREAT QUESTION! I googled it and came across this.
www.ausetute.com.au/aspirin.html
They show complete dissociation. But your question is not only outside of my clinical knowledge base, it is outside of the point I want to make. Most drugs are weak acids or weak bases because change in pH change their water solubility. This is an essential concept for drugs that cannot be mixed in the IV lines. So running a drug through a piggyback running normal saline as the maintenance solution can cause that drug to come out of solution and form particulates if it is incompatible with the pH of the maintenance solution. Major med error issue in some hospitals. Hope this helps. Thanks for the great question!
Suppose you have a closed system like the beaker shown in this video, with a finite amount of plain water , you measure ph and it comes at 6.5, and then you add say 1 gram of powdered HCL and it completely dissociates , it gets the pH of the water to an acid 4, then you add 500 mg of Aspirin (pKa is 3.49) what will happen is Aspirin will slowly dissociate (slowly because the pka is very near the current total solution ph which is 4) until the pH reaches more/less 3.49, then at this moment roughly 50% - 50% of the aspirin will be in the uncharged : ionic (charged) form and right here it will stop dissociating. how much of the aspirin will dissociate? 90% ? 10% it depends how much quantity of it you added , if 500mg was enough to donate enough aditional protons to the already acid solution then ir will stop right there, if not, it will keep dissociating until it reaches the thermodynamic equilibrium constant and will stop dissociating and keep at 50% - 50% no matter how much more aspirin you add it will not lower the pH more. thats what pka means.
Thank you very much
awesome vi. subscribed, thanks!
Thank you man ❤
Will the same case be applied to phenol?..just like for aspirin?
Humm, this is "basically " (haha) acid-base equilibrium.
thanks to u i understood the concept
Thanks for the video.❤️❤️
This helps a ton, thank you.
God bless you
Oh god finally i understand thank u sir 🙏🙏🙏
Thanks a lot completely clear
Thank you
Sir y does that substance release the proton instead of releasing electron.. since electron in the Valence is easier to remove than the proton in the nucleus...@0.10 min
Jeevidha Balasubramaniam h+ ion is considered as proton
Acid base concepts are based on h+ and oh- and not on electron
It really helped.thanks
FAN-tastic.. Thankyou so much
HCl is white powder??
Thank you boss!
So legit. Thanks.
Amazing
It helped me a lot...I couldn't understand this shit from books! Thanks a lot!
From galala University thank u ❤️❤️
Thank you so much!!!
Woody looks really different
Nice
thank you so much ❤️
Amazing video and explains everything very clearly! Thanks
Om gash
Thanks
Love ❤️ u🤧🤧🤧🤧🤧🤧
Thanks 🙏🏻 ❤️❤️
thank you
You’re going to get me thru school
amazing
such an intelligent guy👍
RSK
thank you!!!!
thank you for make so easy
HCl is at atmospheric conditions a colourless gas. Painfull to eyes.
I love u man
thanks
#Pharmapedia
Thank you for this amaizing explaination.
I am confused about quinolones, how do they have good absorption from gastrointestinal tract despite that they have a carboxyl group at position 3 and amine group at position 7 which will make them ionized in acidic as well as basic fluids ?
"Hydrogen chloride is a white powder" - WTF?
0:22 That's Based.
Thanks!!
Thank you sir it's was really helpful
Well, let's take this assidic solution, similar to the asssid in our stomachs.
Let's put an ASSSSspirin in.
This proton wants to come off the aspirin. BUT IT CAN'T. WHY?
because of proton mass AACCtion! ...watever u r having, i need it XDDD
Thanks
I completeeeelyyy understand nowww
💪👌
vielen dank
Nice lecture. My personal favourite Pharmacology channel is: Dr. Junaid Asghar. Have a look at this topic there and thank me later.
Thank you very much
Amazing
Thanks