Ionization | General pharmacology

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🔹 Ionization, PKa of drugs, effect on PH on drug pharmacokinetics,
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👨‍⚕️ Who am I:
My name's Dr Apurva Popat, a medical graduate from India. I have scored 261 on USMLE Step 1 Examination. Check regularly to know about my USMLE journey! I have been teaching medical sciences since my 1st year of medical school. You can expect Productivity tips, Medical concepts, Motivational videos, Latest medical trends and medical tutoring videos from my channel.
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[@user-hj7qu9kt2r]

Just want to say thank you ❤for easier and informative video Dr 😊

[@mansoor1308]

Thankyou so much, i benefited alot from this precise video lecture & the questions in the end were cherry on top. I am an anesthesia PG.

[@cyrenefaithonda360]

Thank you so much for doing this Dr. Apurva. This was 4 years ago but it helped me a lot in reviewing concepts in medicine for my boards in less time and in an easier way.

[@Chantal_o]

I love this video. Thank you so much you just saved me from failing my upcoming tests ❤️❤️❤️❤️❤️

[@MUHAMMADABDULLAH-zj6qs]

Well explained sir 👌

[@ninachanel9]

THANK YOU!! this helped so much!

[@satyendrasahani4814]

Very informative video. Thank you 💞 bro

[@sadiamaqsood4307]

No doubt very well explained.

[@areejfatima1739]

Thank you sir...I finally understood concept of ionization....

[@ghaziaraheem4177]

Excellent! A Million thanx

[@MrArjun936]

This was the best explanation, finally able to clear this concept. Thank you sir.

[@savemeows]

thanks doctor very informative. was reading kaplan pharma, and looked for ionized non ionized so confusing in kaplan... u made it simple..and also love the morphine part..now i know why addistc hate lemon juice!!! cuz it washes it out!!

[@abcs6755]

simply extra suberbbb sir salute to You

[@Arhzaa]

best explanation ive found so far

[@rongerduniya1535]

Well done !
Love From BD🇧🇩🇧🇩

[@ActuallyCurious1402]

Thank youuu thank you finallly thank you

[@erickmuthomi1942]

Thank you so much

[@opporeno2387]

This is wonderful. Great 👍

[@funkdaddy5641]

thank you dr apurva i now understand the concept of ionisation and unionisation of drugs

[@ApurvaPopat]

😀😀😀⚕️⚕️⚕️

[@zubairsadiq5565]

I have a question....I already know the concept and mechanism of this....but one question keeps on irritating me and confusing me...
When we are alkalinizing urine with sodium bicarbonate, bicarbonate is trapping aspirin in tubules (refering to ion trapping process) and so aspirin is excreted....but my question is why sodium bicarbonate is not neutralising aspirin IN BLOOD when both are already present in blood? Why it has to work in urine specifically??

[@vaishnaviramakrishna265]

Thank you so much! That was very understandable and helpful video!

[@shafio2]

you have made it really easy. Thank you

[@jeevidhabalasubramaniam2341]

Got a very good idea bro...just keep rocking.. very neat, clear simple explanation

[@anae.garcia9289]

Thank you so much, this has been the best explanation I have found on this concept!

[@muhetahir7804]

Thanks so much for sharing this education thanks 👍

[@lilywhite8123]

Thank you very much
I finally understand the concept of ionization
Cheers for the good work

[@petroszekarias7045]

Very nice presented and very helpful❤

[@heerkshah]

Really good video. Very helpful and easy to understand.

[@chegobego7930]

THANK YOIOOU

[@rouaalharby2987]

Thx

[@erinsinclair8407]

thank you very much for thus video! i was really struggling to understand this topic but you made it so clear! Huge help!

[@onyxgan9923]

Great job.. Impressive 😁

[@udunnati]

Very well explained

[@leximassey7931]

thank you for simplifying! so helpful =)

[@thabisonyawo500]

thanks alot man this helped a lot with my pharmacokinetics section

[@goatsk]

Thank you please upload more videos on ADME Of drugs

[@pankajtomar1348]

In 1st question how the ionisation will not affect with changes in ph.though ph and pka both are dependent on each other?
Plz explain

[@sathvikreddy1441]

If ph changes by 1 unit then ionization changes by 10 units...

[@perlaelbomba]

This video was so helpful!! Thanks a lot!!

[@kirsten9729]

THANK. YOU. SO. MUCH.

[@dharmendrakewat8336]

Sir well explained I liked please make more and more videos

[@Gaayathrie.ponakala]

Change of 1 scale in ph leads to 10 fold change in ionization

[@Gaayathrie.ponakala]

Then how option 2 is true

[@saadiaaden8965]

Honestly this was fantastic ❤️❤️❤️

[@solid648]

Awesome video, helped a lot.

[@teaganbatis7103]

This was so helpful thank you so much

[@harshalrahangdale968]

Thanku u ...... it's a very helpful vedio

[@ApurvaPopat]

🎉🎉😀

[@nhienhoang7761]

why is the phenobarbitone with pKa of 7.2 is weak acid ?

[@somahiwa5416]

why most the drug weak acid and weak baise? can you explain for me please

[@cattymed4419]

Thanks

[@bobothefool3037]

Thank you so so much for posting this! I really needed help understanding this subject for my vet med classes.

[@mahnoorsajid4063]

Need more videos

[@tharukshihansika5736]

Thankyou so much for this explanation!!! Helped me alot!!! 😊💜

[@pratibhagupta8816]

Sir, amphetamine basic drug h to stomach me inonised ho jaegi to ye to souble hoye to ye BBB (lipid) Ko cross kese kr leta h 😵😵

[@ApurvaPopat]

The absorption doesnt only depend on whether the drug is basic or acidic. It depends on many other factors as well, gut lining, particle size route of administration etc. Just it may augment in the process of absorption.

[@karthiktron]

Thanks for the explanation...is ionization and unionization will affect the therapeutic efficacy.. need clarity on this ..can any one plz

[@ainasultan7641]

i cant see your video properly, its too dark i hope next time you can fix this anyways i understand a bit thanks still

[@nourhansalah3615]

I didnt understand the last question... Term of hs... Any clarification plz?

[@ApurvaPopat]

Term hs means "hora somni" meaning, the medication should be taken at bedtime.

[@somnathchanda1250]

listen at 1.5 speed

[@saudalqahtani6148]

Thank you so much