【Mustard Gas for Cancer?】Cyclophosphamide, Pharmacology Made Easy【Anti-Cancer Drug Pharmacology】

Join Dr. Chat Perche, MD, PhD, for a high-speed study session.
This video is designed so that by the time you finish watching, you'll have perfectly memorized the frequently asked exam topics.
By the end of this video, you'll have perfectly memorized aboutCyclophosphamide.
Step into the realm of cyclophosphamide in this video, specially crafted for students on their arduous journey towards success.
Learn about its uses in treating various cancers and autoimmune diseases, its mechanism of action, and how it can cause side effects like hemorrhagic cystitis.
You are not alone - this video stands as a testament to your unwavering courage and unwavering resolve.
#cyclophosphamide #pharmacology #cancertreatment
【Notes】
▹This video was created based on data as of February 2024, with the purpose of supporting medical students in their exam preparations.
▹Please note that thanks to the tireless efforts of researchers worldwide, this data is updated daily. ▹Unauthorized reproduction is prohibited.
【Contents】
00:00 The Key points
00:25 It was produced as potential chemical warfare weapons.
00:58 The Mechanism of Action of Cyclophosphamide
02:30 A final confirmation
02:35 Cell cycle and Cyclophosphamide
03:02 The Mechanism of Action of cyclophosphamide
03:21 Side Effects of Cyclophosphamide
03:45 SIADH and Cyclophosphamide
【Reference and figure】 I express my gratitude and respect for your wonderful achievements.
1. Facts about Nitrogen Mustards. CDC centers for Disease Control and Prevention.
emergency.cdc.gov/agent/nitro...
2. Chemotherapy: From the Trenches of Warfare A Weapon to Fight Cancer.
Yale School of Medicine/Yale Center for Clinical Investigation (YCCI)
medicine.yale.edu/ycci/clinic...
3. Rajesh K. Singh, Sahil Kumar, D.N. Prasad, T.R. Bhardwaj, Therapeutic journery of nitrogen mustard as alkylating anticancer agents: Historic to future perspectives, European Journal of Medicinal Chemistry, Volume 151, 2018, Pages 401-433,
ISSN 0223-5234,
doi.org/10.1016/j.ejmech.2018....
(www.sciencedirect.com/science...)
4. trichlormethine, Trimustine, Tris-N-lost, Agent HN3 HN-3, YiKrazuul, Wikipedia.
5. Bone marrow, NIH National cancer institute, www.cancer.gov/publications/d...
6. Human Lymphocyte, Dr. Triche. National Cancer Institute, Sep 20 1976, AV-7609-4358, NIH Visual online. visualsonline.cancer.gov
7. Leukemia. Cleveland Clinic.
my.clevelandclinic.org/health...
5.Ogino MH, Tadi P. Cyclophosphamide. [Updated 2023 Jul 3]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: www.ncbi.nlm.nih.gov/books/NB...
6. Emadi, A., Jones, R. & Brodsky, R. Cyclophosphamide and cancer: golden anniversary. Nat Rev Clin Oncol 6, 638-647 (2009). doi.org/10.1038/nrclinonc.200...
7. Leif Oxburgh,, Chapter Nine - Growth control of the kidney, Editor(s): Thomas Gridley, Leif Oxburgh, Current Topics in Developmental Biology, Academic Press, Volume 148, 2022, Pages 237-263, SSN 0070-2153, ISBN 9780128171318, doi.org/10.1016/bs.ctdb.2021.....
8. Anthony W. Norman, Helen L. Henry, Chapter 4 - Posterior Pituitary Hormones, Editor(s): Anthony W. Norman, Helen L. Henry, Hormones (Third Edition), Academic Press, 2015, Pages 81-88, ISBN 9780123694447, doi.org/10.1016/B978-0-08-091.... (www.sciencedirect.com/science...)
9. Dang S, Zhang S, Zhao J, Li X, Li W. The syndrome of inappropriate antidiuretic hormone associated with nasal and paranasal malignant tumors. Eur Arch Otorhinolaryngol. 2024 Jan 2.
doi: 10.1007/s00405-023-08347-5. Epub ahead of print. PMID: 38163817.
10. Fiordoliva I, Meletani T, Baleani MG et al (2017) Managing hyponatremia in lung cancer: latest evidence and clinical implications. Ther Adv Med Oncol 9(11):711-719. doi.org/10.1177/1758834017736210
11. Moses AM, Miller M. Drug-induced dilutional hyponatremia. N Engl J Med. 1974 Dec 5;291(23):1234-9. doi: 10.1056/NEJM197412052912307. PMID: 4607502.
12. Baker M, Markman M, Niu J. Cyclophosphamide-induced severe acute hyponatremic encephalopathy in patients with breast cancer: report of two cases. Case Rep Oncol. 2014 Jul 31;7(2):550-4. doi: 10.1159/000365832. PMID: 25232325; PMCID: PMC4164106.
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