02:20 Quarantine and isolation 02:48 CDC accounts for survivor immunity 03:35 Outcomes before and after Omicron 09:12 Infectious viral load in Delta vs Omicron infections 15:17 PCR vs rapid antigen test 22:54 Booster interval to 5 months 23:23 Cross-reactive memory T cells 26:09 Risk factors for severe outcomes in vaccinated 27:50 Vaccine effectiveness vs MIS C 29:41 Cross-reactive T cells to Omicron from vaccines 34:47 anti virals and monoclonals 38:06 Rivaroxiban for thromboprophylaxis 43:53 Email Questions Audio Timestamps by Jolene. Thanks
I was listening to a NPR RADIO show with Colin broadcast from the Hartford CT studio and heard Briana from TWIV was on the phone with this talk show host. Colin made a nice recommendation to the audience that TWIV is a worthwhile show to listen to. Nice to hear.
I think this update is especially good. I like when Vincent and Daniel talk to each other a bit at least. Daniel is speaking better than ever imho. :-) It's very useful information.
Thank you. Please keep reminding us, it helps me. Going to have to listen to this a few times, so much here. Looking forward to that twiv. Also you have helped me to help a few other people that don’t listen to you.
It's s pleasure watching you two together! You both have good chemistry together and a great sense of humor. And so much valuable information! Thank you again!!
Sirens in the background. Dr. Griffiin says, " I hope that's just some criminal activity." 2022 in a nutshell right there! My sincere gratitude for all the good information you guys provide, these conversations between Daniel and Vincent are priceless!
Dear professor Vincent, I studied virology two years ago from your channel when COVID occurred, this year we have a course on virology. Thank you for making such awesome lectures. I have one less course to worry about studying from scratch
I like everything they do including that the music, which isn't charming, makes me jump. It's just so wonderful getting to know these boffins and getting the good stuff, even when I cannot understand it (and I have a medical degree) that somehow I like it that they are not slick in all departments.
The outro has been consistently way too loud in these clinical updates - I hope Vincent notices this message. I can't justify bothering him over the email for this reason, yet I consider it every week after watching one of these :)
Yeah...volume normalization is often overlooked in production. It would be useful to extend that to the intro and outro. It is common to set a standard volume level for all videos, and the most attentive pay attention to the volumes on similar videos.
Why? The +1000000dB for the outro music makes a good 0dB average 😵💫 The intro doesn't bother me, I'm always right next to the equipment and turn it down temporarily. The sudden outro though. Holy hell that's loud!
Boost the gain Daniel's lav and try different placement of the element. Yes, there's a bunch of bogies to dodge (bow tie, shifting coat & lapels) but move it higher up (as well as gain up that channel)
I think Kari Stefansson's Icelandic data are even better than that lab data. They combined repeat qPCR, genome sequencing and contact tracing data (plus 6 antibody assays), this repeated multiple times for each individual until 60 days after symptoms gone. So they were able to identify all imported SARS-CoV-2 lineages as a baseline (ie from source countries), plus identified nearly 700 mutations that occurred in Iceland community, plus tracked these mutation transmission routes. Because of these mutations, contact tracing, transmission routes & timelines, they were able to estimate how long each person was infectious (better than identifying how long viral samples are viable).
The theme song of this show is really loud and obnoxious. Is there any way to bring the volume down just a bit. I cannot imagine that it is that ear-splittingly loud on purpose, or that I am the only one who has commented on it. Yes, it is attention grabbing, but not in a good way. Otherwise, it is a great show and I have no other complaints. Thank you for your service to the public.
I have been tested twice a week for work for the last year and a half and after aaaaall this time and aaaall the Covid that I have been exposed to, my Wednesday PCR came back positive. I have zero symptoms so far. I saw patients all last week not knowing that I had the presence of some Covid in my nose. They say I can go back to work Wednesday so fingers crossed. I am so grateful for the vaccine. Thanks for another update fellas.
@@jmer9126 Why are you traveling during a pandemic? We traveled all the time before COVID-19 and in Business or First only, w/benefits of special short TSA lane & Lounge privileges so it doesn't get any better (Frequent Flyer miles). My wife worked for 2 international carriers until the mid-2000s. We have flown since late 2019 & won't for the foreseeable future as we don't want to become ill & suffer effects that would make traveling difficult (or die). A big change in lifestyle for now but not the time to roll the dice. Aircraft air circulation is misrepresented as to safety as studies were done under unrealistic conditions & do not include factors such as collective body heat (which rises, interfering with downward motion of cabin air circulation mechanism), interruption of air flow by FAs & pax walking through aisles, tray tables put down, beverage & meal service carts, seat recline, pax putting & retrieving luggage from overhead bins, poor mask wearing by majority of people & discounts that you must transit at least 2 airports, including retrieval of luggage at baggage carousel with exertion. If you're in coach you're inches from others. Even if middle seat is empty-they are only 18 inches wide. Yet many cases of Delta arrived in Business class. The restrooms in airports and on aircraft a nightmare. It doesn't matter that aircraft toilet uses vacuum system. People spend plenty of time in the them so virions accumulate. With testing poor, asymptomatic cases may not be picked up & one test represents only one point in time.
Sound is a bit patchy Vincent since you moved to the new studio. I primarily listen to podcasts so any deterioration in quality is probably more noticeable.
Family friends of ours, 3 adult children in 20s and mom and dad, all 2x vaxxed. Entire family got Covid Dec 20. Just recovering now. Hearing lots of these stories.
Guys, I just recommended your clinical updates to my hairdresser. She’s fully vaxxed, but has been reluctant to get her school-age sons vaccinated. I hope I convinced her, or at least got her to call her son’s’ pediatrician. At least she’s 100% on board with masks & social distancing.
This episode is a game changer. I think this provides incontrovertible, evidence-based numbers that people can use as their entree into the world of the vaccinated. These are numbers that we simply didn't have before, and I think they can help set the course. Unvaccinated, young people... you are our future. Please pay attention to this podcast, and steer your ship away from the iceberg. By the same token, stop inviting other ships to join you on your course. SOS.
Appreciate the update. One correction: Paxlovid is contraindicated with losartan and simvastatin, but not atorvastatin, rosuvastatin, or other statins.
Doesn't make sense for you to be together. I know you are each triple vaccinated but a remote approach would be much safer, especially since Daniel has had direct exposure to Covid positive patients with high viral loads.
What about blood transfusions between the vaccinated and unvaccinated. I am thinking of tainted blood as HIV was transmitted. Could those with the vaccine transmit the spike proteins which cause clots and myocarditis?
In Switzerland every State (Kanton) has a different procedure testing K-12 and upper classes and the procedure depends on duration of days pupils are attending school. An example for one Swiss State in which testing at schools and wearing masks is mandatory for pupils, teachers and other staff: - pupils attending school for 5 days test once a week (saliva pooling test, one class= one pool), pool test result arrives evening same day at school, class teacher gets informed of the result by head of school and has to inform class of result, if the pool result is pos, every pupil has to test till the evening of the next day (electronically book an appointment for a depooling test), pupils attend school while waiting for personal test result (if the school principal or head medical adviser didn't mandate distant learning for the pool), if personal test result is positive, pupil has to isolate and close contact persons have to quarantine (5 days beginning day of showing symptoms resp. pos. result, ends, if day 4 and 5 no symptoms for people in isolation, 5 days for people in quarantine, beginning from last day of contact with positive tested, no quarantine for recovered and vaccinated
This may surprise you guys, but most lay people have NO IDEA what you're talking about when you declare that, "rna copy number is NOT viral load!" Some of the details of these studies just go way over my head, and that's frustrating. (I am a college graduate.) It might be helpful to remember that most of your audience on UA-cam (for the clinical updates, in particular) is outside of your scientific world. I LOVE 💗 these clinical updates so much, and rely on them to counter the gross misinformation of main stream media on COVID-19. Thank you for your time and dedication to all of us. I know you spend countless hours on these presentations. You are greatly appreciated!!!
Analogy: You have an active tiger. He is dangerous and can affect your health. Take a second tiger, put him in a meat grinder. It is an inactivated tiger. It is not dangerous. Sample each tiger. Both show up positive on a PCR test because both have Tiger genetic material.
Wow! One of the best and most useful TWIVs. Only quibble is that it was hard to find references using the keywords given verbally in the discussion. URLs in text would be useful. I know I can find them in PWB, but immediate access would increase utility.
Clinical medicine has always been at the edge (fringe ?) of hard science and research, throughout human history. Opinions and reccomendations about Covid 19 are no different. I love this show but admittedly, I am not a member of the fan club. I have a healthy respect as well as scepticism of research Daniel is trying to translate in to clinical advice.
Sometimes, obviously. But often it is locked in dogmatic 'remedies' - leeches and such, and is the most retrograde and hyper-conservative aspect of science. OK so I am not trying to pick an argument, but I am curious what your differences are with TWIV. I have my own critique - Vince is overly dismissive of concerns about G-o-F and does not explain his sanguine expectation that such research won't derail, and some of the moderators here are overly aggressive in suppressing criticism. But overall this is the most reliable and authoritative high-frequency vlog on covid, all the more so now that John Campbell is being called out on his theory on innoculation procedure. Any thoughts my friend?
@@jdeverhard That's a lot to comment on. I find TWIV and John Campbell well reasoned at all times. However, Daniel trying to translate some preliminary research findings to useful clinical pearls tend to go a bit too far. It is not really his fault. He is trying to make things useful for clinicians. I have no opinion over GOF research because it is not something I have ever seen done in normal research labs.
@@udayaliyanage3776 Daniel Griffin is also a research scientist with both an MD & a PhD and is a Professor of Microbiology at Columbia University School of Medicine. He is the head of Infectious Diseases for the NYC Metro areas largest hospital group. By June of 2020 he'd personally seen over 1700 COVID-19 patients. He is also a Parasitologist & on the Board of Parasites Without Borders. He's spent time treating patients in developing countries and is leaving soon for 2 weeks in Ghana to treat patients there. He's not some local GP who treats the typical problems of suburban Americans. Try getting up to speed about those on whom you're being critical. He'd run circles around you on any discussion of COVID-19.
@@udayaliyanage3776 Shows your ignorance. GOF has been done for decades. It does not require some special lab as many thousands of biology-related experiments use GOF. Most have nothing to do with diseases-as an example, the flavor of many wines are enhanced by tweaking the characteristics of ingredients via GOF. It merely means changing an aspect of a biological entity & used regularly in many fields. How embarrassing for you that you don't know this simple concept that's been used for decades in non-medical as well as medical fields.
We moved from last week's certainty that Omicron was not less severe than Delta, to this week's we don't have the data to say that stance. Things are looking up.
@A Q welp ok … it’s been close to 2 years and I thank God it’s still extremely high. I tested last about 12/13/2021( about)..and again I thank God …maybe just like getting the Measles the antibodies will be for life … I pray🙏🏽🙏🏽🙏🏽🙏🏽.. Question: I know the synthetic antibodies looses it’s efficacy… are they he scientist saying that the natural ones are “ suppose” to loose it’s efficacy? Also, what do you think about being over vaccinated for Covid? I am hearing some scientists expressing concern based on their studies that it will damage the natural immune system.. what say you?
My household and my mom's- all fully vaccinated, except for my youngest. Visited on New Year's Day. Took off mask only for picture taking. Five days later, mom's fully-vaccinated help gets a runny nose- positive. Two days later, my youngest (who never went anywhere else, ever) gets the flu and within two days infects my family including two boosted individuals. So no, I don't believe droplet exposure between fully vaccinated individuals is worth the risk if any of them live with anyone who haven't/ cannot be vaccinated.
Yes, similar experience with some of my relatives. 4 households, all adults vaccinated. One vaccinated adult transmitted SARS-CoV-2 to all the others, including two toddlers. No one wearing masks, big family gathering.
I definitely believe that being fully vaccinated significantly reduces risks of severe illness, but the simple truth is VE against symptomatic infection has significantly reduced from early Israeli results (which was Pfizer 90% VE against all infections, including asymptomatic).
Since Delta was twice as risky as Alpha and Omicron is half as risky as Delta , so we are back to where we were with Alpha? This is like a grade school word problem.
In Iceland they combine qPCR CT values plus antibody assays to estimate whether someone is infectious (border screening, where they don't have histories).
Transmission and human behavior Many people have been very confused that Japan seems to have largely escaped the firestorm of Omicron. There is tremendous confusion about why there is no obvious reason for their near miraculous escape. But no one seems i interested in the fact that there is near universal voluntary masking in Japan…. And, presumably other population driven voluntary mitigation measures.
Thinking on doing my thesis on. Correlation of dosage or ARN and myocarditis or other tight jointions or S1 circulating levels. Zebrafish model? Or mamals inclusions
Thank you doctors. Dr R you are correct behavior effects spread. Post a poll. My guess is most Americans do not think the pandemic is raging. Dr. G i hope people listen to your observation on child deaths- you are a pediatric expert. Great podcast.
A coworker of mine is 22 years old and healthy. She is not vaccinated. She has missed two weeks of work bc of covid. She has felt miserable. She may not end up in the hospital but she is very sick
Vaccination status isn’t the only factor that affects how someone experiences the virus. But these guys are screaming “sellouts” with so much stomping for and focus on the shots. Quoting politicians doesn’t help.
@@jonigarciajg If it was, that’s even worse if vaccination status is the only factor a “scientist” is focusing on, when 90% of covid deaths in the US are among the elderly and obese.
44:20 vaccinated shed less virus - Vincent Racanciello. Ph D cite this time stamp when arguing the point. If anyone has the reference page in 'today's paper' please put in comments. This is a key point in the debate with vaccine sceptics and needs citable sourcing.
Ref: Infectious viral load in unvaccinated and vaccinated patients infected with SARS-CoV-2 WT, Delta and Omicron (preprint, 11 Jan 2022) 'Vaccination was associated with lower infectious titres and faster clearance for Delta, showing that vaccination would also lower transmission risk.'
It strikes me that every other UA-cam channel, specifically Drs., talking about vaccination has to continuously repeat that they are not giving medical (or financial) advice ...
Could you please tell me about 2-5 year olds and why they are not showing a decent immune response after 2, 0.3mcg doses of Phizer? Thanks so much, I so appreciate you guys!
I live in small-town MN where there is a serious disconnect with reality; the majority of people feel like this virus is a joke or a hoax. I have 5 kids who are kindergarten - 12th grade. We've been distance learning since this began and as they've been fully vaccinated, they've returned to school (a no mitigation school, but nonetheless the closest place within 25 miles). Anyhow, my 3 youngest (K-6) are set to return to in person learning in a week. Should I keep my kindergartener home distance learning (which has been incredibly adventageous, at least from a learning standpoint)? My county has very low vaccination rates- far below the national rate. No masks. And the local school boards have chosen to bury their heads in the sand. Our rural clinics and hospitals are "packed". I would absolutely love and appreciate any advice (from anyone).
@ty Ty Thank goodness no, my kids are within normal BMI range, it's hard to get them to eat their veggies but we keep up on supplements (which might be just a waste of $) and have 2 indoor trampolines that work good for exercise in the winter months. I was diagnosed with COPD while in my 30's (not long ago). I'm pretty sure growing up and working on a farm (hog) didn't help any. So I guess I'm higher risk... Could stand to drop a 25 pounds as well, but as far as I know, my kids have no comorbitities other than maybe not eating as much fruits & and vegetables as they ought to (my fault, I'll work on that, you make a great point).
@@jillstruthers If your kid is doing okay remotely a little longer won’t be too bad and once your county is less stressed the school will still be there.
Has anyone looked to see if Omicron persists longer on surfaces? Hand hygiene messaging seriously dropped off when the ventilation message came out, but we weren’t talking about drippy noses and sneezing then. Snot doesn’t evaporate as quickly as spit.
When it comes to ambiguous terms, none are more so than "natural immunity." I suggested early on to use the term "acquired immunity." Regardless, people believe want they want to in this "black and white" country we live in. Wait, I'm not referring to black and white people, see there you have it, ambiguity rears its ugly head. Imprecision in language can be as harmful as imprecision in science, where science is self-correcting given sufficient time; language not so much.
“Evusheld is not for the unvaccinated…I think that’s important”…answer should obviously be if we have enough supply, sure, hopefully we get there…hopefully those who don’t produce antibodies have T cell responses…but, don’t miss a chance to jab them anyway…
Human behavior. That's what responsible. Now government should start to change that horrible behavior which probably helped people to survive before you guys started saying and trying to change people against their will.
@@EvonZundel As Paul Offit quoted on recent children hospitalisation data, 1/3 of hospitalised Covid cases had no underlying conditions. Recently in Australia a 24 yro fit man, double dosed, with no significant underlying conditions, died from COVID. So, would he have died if given 3 doses? Possibly, but the 3rd dose might have been enough to keep him alive, and why die wondering.
02:20 Quarantine and isolation
02:48 CDC accounts for survivor immunity
03:35 Outcomes before and after Omicron
09:12 Infectious viral load in Delta vs Omicron infections
15:17 PCR vs rapid antigen test
22:54 Booster interval to 5 months
23:23 Cross-reactive memory T cells
26:09 Risk factors for severe outcomes in vaccinated
27:50 Vaccine effectiveness vs MIS C
29:41 Cross-reactive T cells to Omicron from vaccines
34:47 anti virals and monoclonals
38:06 Rivaroxiban for thromboprophylaxis
43:53 Email Questions
Audio Timestamps by Jolene. Thanks
Thank you
Thank you!!!!!!
Thank you so much! This is very useful to go over the video again for specifics.
Thank you, Les!!
Awesomeness
My mom and I quote Dr Daniel quite frequently. We love all the twiv updates.
I was listening to a NPR RADIO show with Colin broadcast from the Hartford CT studio and heard Briana from TWIV was on the phone with this talk show host. Colin made a nice recommendation to the audience that TWIV is a worthwhile show to listen to. Nice to hear.
I think this update is especially good. I like when Vincent and Daniel talk to each other a bit at least. Daniel is speaking better than ever imho. :-) It's very useful information.
Thank you. Please keep reminding us, it helps me. Going to have to listen to this a few times, so much here. Looking forward to that twiv. Also you have helped me to help a few other people that don’t listen to you.
It's s pleasure watching you two together! You both have good chemistry together and a great sense of humor. And so much valuable information! Thank you again!!
PLEASE sort out your outro volume. It's insanely loud.
Really outstanding series. Thank you from healthcare professionals everywhere.
Sirens in the background. Dr. Griffiin says, " I hope that's just some criminal activity." 2022 in a nutshell right there!
My sincere gratitude for all the good information you guys provide, these conversations between Daniel and Vincent are priceless!
Dear professor Vincent, I studied virology two years ago from your channel when COVID occurred, this year we have a course on virology. Thank you for making such awesome lectures. I have one less course to worry about studying from scratch
Vincent, the music is just plain too loud. I love your shows, but please, 6dB lower level on the music.... Thanks for all you do!
I like everything they do including that the music, which isn't charming, makes me jump. It's just so wonderful getting to know these boffins and getting the good stuff, even when I cannot understand it (and I have a medical degree) that somehow I like it that they are not slick in all departments.
The outro has been consistently way too loud in these clinical updates - I hope Vincent notices this message. I can't justify bothering him over the email for this reason, yet I consider it every week after watching one of these :)
Yeah...volume normalization is often overlooked in production. It would be useful to extend that to the intro and outro. It is common to set a standard volume level for all videos, and the most attentive pay attention to the volumes on similar videos.
I would suggest bringing up the microphone levels by 40%. If you have VU meters, shoot for the "0dB" mark (or just under the red lines).
Why? The +1000000dB for the outro music makes a good 0dB average 😵💫
The intro doesn't bother me, I'm always right next to the equipment and turn it down temporarily. The sudden outro though. Holy hell that's loud!
Boost the gain Daniel's lav and try different placement of the element. Yes, there's a bunch of bogies to dodge (bow tie, shifting coat & lapels) but move it higher up (as well as gain up that channel)
I think Kari Stefansson's Icelandic data are even better than that lab data. They combined repeat qPCR, genome sequencing and contact tracing data (plus 6 antibody assays), this repeated multiple times for each individual until 60 days after symptoms gone. So they were able to identify all imported SARS-CoV-2 lineages as a baseline (ie from source countries), plus identified nearly 700 mutations that occurred in Iceland community, plus tracked these mutation transmission routes. Because of these mutations, contact tracing, transmission routes & timelines, they were able to estimate how long each person was infectious (better than identifying how long viral samples are viable).
Thanks for the great report. I was asking myself how come Bob Hope knows so much about immunology for a while there.
Great to see the both of you together.
I love the studio. Very good video quality .
The theme song of this show is really loud and obnoxious. Is there any way to bring the volume down just a bit. I cannot imagine that it is that ear-splittingly loud on purpose, or that I am the only one who has commented on it. Yes, it is attention grabbing, but not in a good way. Otherwise, it is a great show and I have no other complaints. Thank you for your service to the public.
I have been tested twice a week for work for the last year and a half and after aaaaall this time and aaaall the Covid that I have been exposed to, my Wednesday PCR came back positive. I have zero symptoms so far. I saw patients all last week not knowing that I had the presence of some Covid in my nose. They say I can go back to work Wednesday so fingers crossed. I am so grateful for the vaccine. Thanks for another update fellas.
Tell us more about the comorbidities associated with severe covid cases.
“PCR tests are overly sensitive”……duh. This has been known for well over a year. It’s nearly criminal to report a PCR test without the CT data.
Especially when getting on an airplane depends on a PCR test
@@jmer9126 Why are you traveling during a pandemic? We traveled all the time before COVID-19 and in Business or First only, w/benefits of special short TSA lane & Lounge privileges so it doesn't get any better (Frequent Flyer miles). My wife worked for 2 international carriers until the mid-2000s. We have flown since late 2019 & won't for the foreseeable future as we don't want to become ill & suffer effects that would make traveling difficult (or die). A big change in lifestyle for now but not the time to roll the dice. Aircraft air circulation is misrepresented as to safety as studies were done under unrealistic conditions & do not include factors such as collective body heat (which rises, interfering with downward motion of cabin air circulation mechanism), interruption of air flow by FAs & pax walking through aisles, tray tables put down, beverage & meal service carts, seat recline, pax putting & retrieving luggage from overhead bins, poor mask wearing by majority of people & discounts that you must transit at least 2 airports, including retrieval of luggage at baggage carousel with exertion. If you're in coach you're inches from others. Even if middle seat is empty-they are only 18 inches wide. Yet many cases of Delta arrived in Business class. The restrooms in airports and on aircraft a nightmare. It doesn't matter that aircraft toilet uses vacuum system. People spend plenty of time in the them so virions accumulate. With testing poor, asymptomatic cases may not be picked up & one test represents only one point in time.
Sound is a bit patchy Vincent since you moved to the new studio. I primarily listen to podcasts so any deterioration in quality is probably more noticeable.
Thank you both!
Family friends of ours, 3 adult children in 20s and mom and dad, all 2x vaxxed. Entire family got Covid Dec 20. Just recovering now. Hearing lots of these stories.
Interesting and worthwhile video.
Guys, I just recommended your clinical updates to my hairdresser. She’s fully vaxxed, but has been reluctant to get her school-age sons vaccinated.
I hope I convinced her, or at least got her to call her son’s’ pediatrician. At least she’s 100% on board with masks & social distancing.
This episode is a game changer. I think this provides incontrovertible, evidence-based numbers that people can use as their entree into the world of the vaccinated. These are numbers that we simply didn't have before, and I think they can help set the course. Unvaccinated, young people... you are our future. Please pay attention to this podcast, and steer your ship away from the iceberg. By the same token, stop inviting other ships to join you on your course. SOS.
Appreciate the update. One correction: Paxlovid is contraindicated with losartan and simvastatin, but not atorvastatin, rosuvastatin, or other statins.
It's recommended to decrease dosage or stop/switch if possible while taking Paxlovid per the clinicians' version.
Another very good episode, watched it twice 🙌
Could you please put on ur shelve books you recommend for the general public
Thank you
Daniel's jacket rustles loudly. Otherwise, great sound and camera work.
Doesn't make sense for you to be together. I know you are each triple vaccinated but a remote approach would be much safer, especially since Daniel has had direct exposure to Covid positive patients with high viral loads.
Excellent! Thank you.
What about blood transfusions between the vaccinated and unvaccinated. I am thinking of tainted blood as HIV was transmitted. Could those with the vaccine transmit the spike proteins which cause clots and myocarditis?
In Switzerland every State (Kanton) has a different procedure testing K-12 and upper classes and the procedure depends on duration of days pupils are attending school.
An example for one Swiss State in which testing at schools and wearing masks is mandatory for pupils, teachers and other staff:
- pupils attending school for 5 days test once a week (saliva pooling test, one class= one pool), pool test result arrives evening same day at school, class teacher gets informed of the result by head of school and has to inform class of result, if the pool result is pos, every pupil has to test till the evening of the next day (electronically book an appointment for a depooling test), pupils attend school while waiting for personal test result (if the school principal or head medical adviser didn't mandate distant learning for the pool), if personal test result is positive, pupil has to isolate and close contact persons have to quarantine (5 days beginning day of showing symptoms resp. pos. result, ends, if day 4 and 5 no symptoms for people in isolation, 5 days for people in quarantine, beginning from last day of contact with positive tested, no quarantine for recovered and vaccinated
This may surprise you guys, but most lay people have NO IDEA what you're talking about when you declare that, "rna copy number is NOT viral load!"
Some of the details of these studies just go way over my head, and that's frustrating. (I am a college graduate.)
It might be helpful to remember that most of your audience on UA-cam (for the clinical updates, in particular) is outside of your scientific world.
I LOVE 💗 these clinical updates so much, and rely on them to counter the gross misinformation of main stream media on COVID-19.
Thank you for your time and dedication to all of us. I know you spend countless hours on these presentations. You are greatly appreciated!!!
Analogy: You have an active tiger. He is dangerous and can affect your health. Take a second tiger, put him in a meat grinder. It is an inactivated tiger. It is not dangerous. Sample each tiger. Both show up positive on a PCR test because both have Tiger genetic material.
Wow! One of the best and most useful TWIVs. Only quibble is that it was hard to find references using the keywords given verbally in the discussion. URLs in text would be useful. I know I can find them in PWB, but immediate access would increase utility.
What were you trying to google? I found everything through the links at the website. Show notes, I think it is called in the description.
Costs of medicines, is rivaroxaban (xarelto) really that expensive in the US? Over here it's 2 to 3 € per daily dose.
Clinical medicine has always been at the edge (fringe ?) of hard science and research, throughout human history. Opinions and reccomendations about Covid 19 are no different. I love this show but admittedly, I am not a member of the fan club. I have a healthy respect as well as scepticism of research Daniel is trying to translate in to clinical advice.
Sometimes, obviously. But often it is locked in dogmatic 'remedies' - leeches and such, and is the most retrograde and hyper-conservative aspect of science. OK so I am not trying to pick an argument, but I am curious what your differences are with TWIV. I have my own critique - Vince is overly dismissive of concerns about G-o-F and does not explain his sanguine expectation that such research won't derail, and some of the moderators here are overly aggressive in suppressing criticism. But overall this is the most reliable and authoritative high-frequency vlog on covid, all the more so now that John Campbell is being called out on his theory on innoculation procedure. Any thoughts my friend?
@@jdeverhard That's a lot to comment on. I find TWIV and John Campbell well reasoned at all times. However, Daniel trying to translate some preliminary research findings to useful clinical pearls tend to go a bit too far. It is not really his fault. He is trying to make things useful for clinicians.
I have no opinion over GOF research because it is not something I have ever seen done in normal research labs.
@@udayaliyanage3776 Daniel Griffin is also a research scientist with both an MD & a PhD and is a Professor of Microbiology at Columbia University School of Medicine. He is the head of Infectious Diseases for the NYC Metro areas largest hospital group. By June of 2020 he'd personally seen over 1700 COVID-19 patients.
He is also a Parasitologist & on the Board of Parasites Without Borders. He's spent time treating patients in developing countries and is leaving soon for 2 weeks in Ghana to treat patients there. He's not some local GP who treats the typical problems of suburban Americans. Try getting up to speed about those on whom you're being critical. He'd run circles around you on any discussion of COVID-19.
@@udayaliyanage3776 Shows your ignorance. GOF has been done for decades. It does not require some special lab as many thousands of biology-related experiments use GOF. Most have nothing to do with diseases-as an example, the flavor of many wines are enhanced by tweaking the characteristics of ingredients via GOF. It merely means changing an aspect of a biological entity & used regularly in many fields. How embarrassing for you that you don't know this simple concept that's been used for decades in non-medical as well as medical fields.
We moved from last week's certainty that Omicron was not less severe than Delta, to this week's we don't have the data to say that stance. Things are looking up.
A cool "co-located" episode!!!
Very useful. Nice to see you guys in the same room. Thank you!
Daniel in the house
Apixoban less GI bleeding in many studies cf Rivoroxiban - perhaps add PPI ?
I am extremely grateful that my antibodies, since I contracted Covid in March 2020, has not waned & remains extremely high 🙏🏽🙏🏽🙏🏽
@A Q welp ok … it’s been close to 2 years and I thank God it’s still extremely high. I tested last about 12/13/2021( about)..and again I thank God …maybe just like getting the Measles the antibodies will be for life … I pray🙏🏽🙏🏽🙏🏽🙏🏽.. Question: I know the synthetic antibodies looses it’s efficacy… are they he scientist saying that the natural ones are “ suppose” to loose it’s efficacy? Also, what do you think about being over vaccinated for Covid? I am hearing some scientists expressing concern based on their studies that it will damage the natural immune system.. what say you?
@A Q lol … ok .. works for me 😝… maybe
@A Q I did remove and tweaked one of my other responses… I was referring to the vaccine being synthetic antibodies
"I'm hoping that was just some criminal activity and not someone dying of covid" is my favorite line of the year
Could you please comment on different between virus variants strains and mutants
Thank you
Vincent often says we’re testing too much Daniel says never miss an opportunity to test ?
Where is the middle ground ?
My household and my mom's- all fully vaccinated, except for my youngest. Visited on New Year's Day. Took off mask only for picture taking. Five days later, mom's fully-vaccinated help gets a runny nose- positive. Two days later, my youngest (who never went anywhere else, ever) gets the flu and within two days infects my family including two boosted individuals. So no, I don't believe droplet exposure between fully vaccinated individuals is worth the risk if any of them live with anyone who haven't/ cannot be vaccinated.
Yes, similar experience with some of my relatives. 4 households, all adults vaccinated. One vaccinated adult transmitted SARS-CoV-2 to all the others, including two toddlers. No one wearing masks, big family gathering.
I definitely believe that being fully vaccinated significantly reduces risks of severe illness, but the simple truth is VE against symptomatic infection has significantly reduced from early Israeli results (which was Pfizer 90% VE against all infections, including asymptomatic).
Would Molnupiravir be more effective as post exposure - maybe takes longer to work .
Use in aged 55 plus ?
Since Delta was twice as risky as Alpha and Omicron is half as risky as Delta , so we are back to where we were with Alpha? This is like a grade school word problem.
plus 2 years later we have vaccines and survivors with immunity
In Iceland they combine qPCR CT values plus antibody assays to estimate whether someone is infectious (border screening, where they don't have histories).
Transmission and human behavior
Many people have been very confused that Japan seems to have largely escaped the firestorm of Omicron. There is tremendous confusion about why there is no obvious reason for their near miraculous escape. But no one seems i interested in the fact that there is near universal voluntary masking in Japan…. And, presumably other population driven voluntary mitigation measures.
Thinking on doing my thesis on. Correlation of dosage or ARN and myocarditis or other tight jointions or S1 circulating levels. Zebrafish model? Or mamals inclusions
Has the deep dive Happened yet?
Infection Viral Titre and Rapid Antigen tests ?
Thank you doctors. Dr R you are correct behavior effects spread. Post a poll. My guess is most Americans do not think the pandemic is raging. Dr. G i hope people listen to your observation on child deaths- you are a pediatric expert. Great podcast.
A coworker of mine is 22 years old and healthy. She is not vaccinated. She has missed two weeks of work bc of covid. She has felt miserable. She may not end up in the hospital but she is very sick
Yup, death is not the only relevant outcome that warrants prevention. I see it around me, young people starting to see the use of the vaccinations.
Vaccination status isn’t the only factor that affects how someone experiences the virus. But these guys are screaming “sellouts” with so much stomping for and focus on the shots. Quoting politicians doesn’t help.
@ty Ty which is why we should take the pandemic seriously
@@ibeeline9431 are you sure it wasn't the politicians quoting the scientists?
@@jonigarciajg If it was, that’s even worse if vaccination status is the only factor a “scientist” is focusing on, when 90% of covid deaths in the US are among the elderly and obese.
Sorry! there is no pill to cure stubbornness and st......ty.
44:20 vaccinated shed less virus - Vincent Racanciello. Ph D cite this time stamp when arguing the point. If anyone has the reference page in 'today's paper' please put in comments. This is a key point in the debate with vaccine sceptics and needs citable sourcing.
Ref: Infectious viral load in unvaccinated and vaccinated patients infected with SARS-CoV-2 WT, Delta and Omicron (preprint, 11 Jan 2022)
'Vaccination was associated with lower infectious titres and faster clearance for Delta, showing that vaccination would also lower transmission risk.'
27:30 Lol! I'm hoping that was just some criminal activity haha
It strikes me that every other UA-cam channel, specifically Drs., talking about vaccination has to continuously repeat that they are not giving medical (or financial) advice ...
Could you please tell me about 2-5 year olds and why they are not showing a decent immune response after 2, 0.3mcg doses of Phizer? Thanks so much, I so appreciate you guys!
The dose is just too small.
I live in small-town MN where there is a serious disconnect with reality; the majority of people feel like this virus is a joke or a hoax. I have 5 kids who are kindergarten - 12th grade. We've been distance learning since this began and as they've been fully vaccinated, they've returned to school (a no mitigation school, but nonetheless the closest place within 25 miles). Anyhow, my 3 youngest (K-6) are set to return to in person learning in a week. Should I keep my kindergartener home distance learning (which has been incredibly adventageous, at least from a learning standpoint)? My county has very low vaccination rates- far below the national rate. No masks. And the local school boards have chosen to bury their heads in the sand. Our rural clinics and hospitals are "packed". I would absolutely love and appreciate any advice (from anyone).
@ty Ty Thank goodness no, my kids are within normal BMI range, it's hard to get them to eat their veggies but we keep up on supplements (which might be just a waste of $) and have 2 indoor trampolines that work good for exercise in the winter months. I was diagnosed with COPD while in my 30's (not long ago). I'm pretty sure growing up and working on a farm (hog) didn't help any. So I guess I'm higher risk... Could stand to drop a 25 pounds as well, but as far as I know, my kids have no comorbitities other than maybe not eating as much fruits & and vegetables as they ought to (my fault, I'll work on that, you make a great point).
@@jillstruthers If your kid is doing okay remotely a little longer won’t be too bad and once your county is less stressed the school will still be there.
Has anyone looked to see if Omicron persists longer on surfaces? Hand hygiene messaging seriously dropped off when the ventilation message came out, but we weren’t talking about drippy noses and sneezing then. Snot doesn’t evaporate as quickly as spit.
When it comes to ambiguous terms, none are more so than "natural immunity." I suggested early on to use the term "acquired immunity." Regardless, people believe want they want to in this "black and white" country we live in. Wait, I'm not referring to black and white people, see there you have it, ambiguity rears its ugly head. Imprecision in language can be as harmful as imprecision in science, where science is self-correcting given sufficient time; language not so much.
Can't you "acquire" immunity from a vaccine? Anyway's I think "natural" is to contrast with "artificial". One is from nature, the other is man-made.
Why can't we just say "immunity from infection" and "immunity from vaccination"? That is unambiguous, as far as I can tell.
It was less volume on my bedroom yourube Blueray device. Remember us deaf buggers
Probably the most important update so far
Double masks for indoors Cloth :Surgical but only for 15 minutes because of breathability and. Po2 levels with pulse oximetry ?
24:40 go team B cells!
I guess in America it’s still about how does Covid affect ME attitude even amongst top virologists.
But that makes sense because everyone is different 😁
@@jpaynter149 welp not sure if that’s 100% predictable but I get your point… agreed 👏🏽👏🏽👏🏽
safe and effective 🤑🤑
“Evusheld is not for the unvaccinated…I think that’s important”…answer should obviously be if we have enough supply, sure, hopefully we get there…hopefully those who don’t produce antibodies have T cell responses…but, don’t miss a chance to jab them anyway…
Why ???
@ty Ty I think he said that because it is untested for that use. It had nothing to do with condemning people.
The sound on this recording is not up to usual standards. A distortion problem.
Human behavior. That's what responsible. Now government should start to change that horrible behavior which probably helped people to survive before you guys started saying and trying to change people against their will.
How can Spike Vaccines produce T cells able to recognise nucleocapsid antigens unless they are duplicates of spike ?
They don't. But there's plenty of t-cell epitopes in the S protein.
👍🏻
More boosters- more t cells?
Funny … scientists are now talking about the dangers of over vaccinations… this is truly a case by case scenario 🤷🏽♀️
I see some excellent spinach-eating going on here. It's so disarming.
We need Boosters, more Boosters
please
Boosters forever and ever?
@@mauriciovillada2028 Only a Booster a day keeps the doctor away.
Not convinced for healthy people.
@@EvonZundel As Paul Offit quoted on recent children hospitalisation data, 1/3 of hospitalised Covid cases had no underlying conditions.
Recently in Australia a 24 yro fit man, double dosed, with no significant underlying conditions, died from COVID.
So, would he have died if given 3 doses? Possibly, but the 3rd dose might have been enough to keep him alive, and why die wondering.
@@kazoz3520 Does that include vitamin D deficiency?