Are there foods that can increase NAD? (Part I)
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- Опубліковано 4 лип 2024
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Many interventions have been reported to increase NAD levels, but dietary components that can impact NAD levels are less discussed. Here, I highlight the ability of two dietary components, apigenin and quercetin to increase NAD, and report the foods that contain these metabolites.
Relatedly, apigenin increases muscle mass and function:
• Apigenin Increases Mus...
Apigenin, quercetin content in foods: www.ars.usda.gov/ARSUserFiles... - Наука та технологія
Dried parsley has been reported to have the maximum quantity of apigenin, at 45,035 μg/g
Isn't the higher amount of apigenin in dried compared to fresh just based weight, with the water taken out of the fresh. I don't know why drying parsley would increase the apigenin.
@@jeffgilligan2004 Yes. Lose the water, get higher apigenin on a weight basis.
I forgot to include this info in the video-fresh parsley has 215.46 mg of apigenin/100 grams of parsley:
www.ars.usda.gov/ARSUserFiles/80400525/Data/Flav/Flav_R03.pdf
I believe dry parsley has even more apigenen concentration than fresh. It is also very cheap. Chamomile is also a good source.
@@andrewj4426 true, but I'm also interested in maximizing nutrient density. Fresh parsley has more nutrition (vitamins, minerals, etc.) than dried when compared by the same amount of grams.
@@conqueragingordietrying1797 I eat both. i also package dry parsely into gelatin pills and take every second day. what do you think is a safe upper limit for apigenin as some cd38 is needed?
@@andrewj4426 Thanks completely unknown-so many variables may impact it, including body weight, liver function, age, etc. You could have your blood NAD+ levels checked to see if your current dose is enough, while looking at other markers to make sure it isn't too much.
Watch your units, I'm sure you meant to say 215.46 milligrams/100g
Thank you for making these, they are very helpful
I prefer life management and food over supplements thanks this is very helpful. Nice the require quantities are not great.
Videos are getting better and better. Keep up the great work!!
Thanks Jack!
@@conqueragingordietrying1797 I really mean it! Keep up the good work and I'm sure the viewership of the channel will continue to grow :)
@@jackharley8564 That's the plan!
Terrific videos here - thanks! I have subscribed…
Excellent research! I agree that it's best to use food sources, but it is difficult for me. Will you be able to convert the graph information at 1:26 in the video to milligrams of apigenin and quercetin supplements for people (like me) who will more likely use supplements? And, do you have any thoughts on the shelf stability of these two supplements?
Amazing video!! Can you please do an update on how much this changed your NAD levels with no other variables changed (as much as possible)?
Thanks @agelessangel. There are many NAD-focused videos in this playlist:
ua-cam.com/video/pj-CSSghDXo/v-deo.html
Good video. What about capers for quercetin? I thought they were the highest natural source by far?
Thanks Open Mind. Capers are a great source of quercetin (173 mg/100g; see www.ars.usda.gov/arsuserfiles/80400525/data/flav/flav_r03-1.pdf), but the taste is terrible for me.
Thanks
How much Quercetin & apegenin optimal doses?
I'm supplementing, eating whole foods is troublesome due to dental issue I'm working on. This stuff really works, do as many different things as u can to increase NAD, Activate all the potential pathways for synthesis and salvage. IMO.
Not for gut bacterial production of SCFAs, which may impact health and longevity.
More videos like this please.
For Nad?
@@conqueragingordietrying1797 Actionable things we can do now.
Two questions that matter:
1) Were the studies the studies you referenced en vitro? Or en vivo?
2) If en vivo, were apigenin and quercetin administered IV or through diet?
Nice, clear, and informative video :)
Just wondering how are these two compounds impacted by heat from cooking? For example, my mums chicken soup recipe has heaaaps of fresh parsley and red onion, but it's simmered together with a whole chicken for about 3 hours.
Thanks! For hesperidin, there was only a 2% loss when cooking at 90C (which is close to simmering temp, 100C) for 4 hours :
pubs.acs.org/doi/10.1021/jf0700529
@@conqueragingordietrying1797 Why do you mention hesperidin? The question was about apigenin and quercetin.
@@NickWestgate It's a flavanone, chemically related to apigenin and quercetin.
@@NickWestgate Exactly like rutin being almost the exact same nutrient as quercetin.
Rutin and hesperidin are probably present together as bioflavonoids in many sources.
It needs fats(oleanolic acid in olive oil) to be bioavailable,correct?I love the wholefood idea but there is no land for farming in my country and the quality of the soil these days are poor in nutrients.
Apigenin is insoluble in water, so including fat when eating foods that contain it would be a good idea.
Hey Mike, Does Quercetin work on it's own or does it have to be combined with Dasatinib? Thanks for the video.
That's beyond my focus, Mike-my focus is on getting it from food. The other issue is, which is more bioavailable, getting it from food, or by itself? There's limited data for that.
I don't think it has to be combined with Dasatinib. It's been shown in multiple studies (do a simple search on scholar) to elicit positive health effects individually. It's also probably one of the most studied polyphenol.
Quercetin is combined with dasatanib for senolytic activity. CD38 inhibition is separate and doesn't need dasatanib.
Quercitin helps the Dasatinib elimanate senolytic cells, however not by itself, at least in the studies I read. We need to find a natural molecule similar to Dasatinib to use with quercitin. I wonder if quercitin can supercharge fasting against senolytic cell activity.
What about wheat grass???
lol i am eating this everyday because i feel like i need it and i didnt know why till now , like my body instructed me to do so
Are the veges need to be fresh when consuming 😅
Brewers yeast and peanuts are good NAD sources? They contain highest amounts of niacin.
black coffee produces the highest amount. I tried not to drink coffee until I read that. Many peanuts -mainly the cheaper ones covered in spices- are either partly rancid (the fats) or can have aflatoxins. Peanut butter is safer (easier to test - buy a major brand), but the high heat to make it probably kills most of the B-vitamins. That's one opinion (mine). Brewer's yeast taste like crap and smells bad, too. Nutritional yeast, however, tastes awesome, but much of it is actually added vitamins and the stuff isn't cheap. Tastes great over greens, though.
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Are these two substances enhancing the homing of CD34+ stem cells into muscles?
I haven't looked into that-is there published evidence that suggests it's true?
Does the dill being used in dill pickle help at all?
Some dill is likely better than none, but the question is, how much would you need to inhibit CD38? That likely varies between people.
Do you make these slides available anywhere?
Only on Patreon!
Can I use dried herbs? 5gr of dried herbs is equivalent to 50gr fresh. I can easy add 10gr of dry herbs to any sauce.
More important than the dried vs fresh debate is blood testing, to see if taking very large doses of apigenin actually improves any aspects of health.
Also, when foods are dried, they lose much of their nutrition. I aim for nutrient density, so fresh is best for me.
I keep hearing dried parsley is better for apigenin absorption.The fresh is going to have better enzymes etc.
@@conqueragingordietrying1797 as I understand it dried parsley has considerably more apegenin than fresh?
@@tristenjames8354 Per gram, but per calorie, it should be close to the same.
@@conqueragingordietrying1797 I'm not sure as the caloric value is pretty much negligible in parsley...I eat 1/3 cup of dry everyday. I add it to a blend of vegetables that I break my fast with everyday. Your videos are very informative nonetheless:-)
Does cooking the onions in a meal destroy the quercetin? So does heat have any effect on Apigenin or Querciten? So do you have to eat them raw?
I haven't looked into that, as I'd bet that cooking won't destroy all of it, and there is still a benefit. If you find any papers for that, can you please post them here?
@@conqueragingordietrying1797I shall if I find anything on that. Also if you find anything, reply on the message so I could see your follow up video or any papers you may have found. This is an extremely important piece of knowledge.
Did you hear about the oxygen pressure chambers they are using in Israel to fix your DNA and reverse the DNA damage? I will post the link in a follow up reply.
Here is one of the video discussing DNA repair ua-cam.com/video/-cuSC11g4fQ/v-deo.html
@@jeffrey8154 I skimmed the video, I didn't see any paper references...
@@conqueragingordietrying1797 This video is on the other subject I mentioned in my reply about cell repair, haven't looked for papers on the cooking issue as of yet.
Think I've read something about apigenin being a MAOI, not sure how strong. Might be an issue.
Even more of a reason to get it from food, rather than a supplement. That's what I do.
@@conqueragingordietrying1797 Can't MAOI's be dangerous? I think its advised not to eat certain foods if you take them because the combination can raise blood pressure to dangerous levels.
@@Torulv It looks like apogenin would have a favorable effect on MAO activity:
"Unregulated MAO activity could be responsible for a number of psychiatric and neurological disorders and their inhibitors, like apigenin, work as antidepressant and antianxiety agents, as well as to treat Alzheimer’s and Parkinson’s disease."
www.ncbi.nlm.nih.gov/pmc/articles/PMC6472148/
I can tell you it's true. Eating parsley is a stimulating mood booster and freshens the alimentary canal!
@@Torulv Nah, that's mostly disproven because it's highly improbable to overdose on tyrosine/tyramine from normal dietary intake.
Dried parsely is much more concentrated.... one teaspoon is enough to get 600 micrograms
Sure, but nutrient density decreases as the food becomes dehydrated. For example, see my post on raisins vs. grapes:
michaellustgarten.com/2014/07/27/grapes-vs-raisins-a-nutritional-analysis/
@@conqueragingordietrying1797 Then why you said sure?
2:31 the food yo want to eat...
I take 2 caps of apigenin and 2 quercetin every day, 1 gram of nmn, sublingual then swallowed.
I definitely have more energy at 55. EVOO, green tea, greens for days. I still eat crap occasionally lol.
Best to take these with greens and fats(yogurt, milk...pizza)
@@stoictraveler1 Pizza with mushrooms, arugula, parsley, kale, red onions, sun dried tomatoes, and sausage with a cauliflower crust ....mmmm
@@PFLEONARDI0906 dam right. Top with evo oil
Mark, I think you could add Resveratrol to this list, also 1g.
Yeah I am there at .5 on resv.
That is what I usually eat :D
How do I test my nad level
I shall encourage the wife to cook more parsley sauce then. Very good
Just inform the wife that Apigenin is heat sensitive and needs to be eaten fresh or cooked lightly.
@@ManageDeMaia dried is the best
Eat lots of tabbouleh!
What is NAD?
a form of niacin. Most minerals and vitamins come in 3 or more forms. Each form works differently and some aren't absorbed well or at all. Some forms are considered better for human health than others. Some minerals, for example, are absorbed by plants better, too, and then we eat those plants...
If Apigenen increases NAD+.. should I not take up apigenin at night?
That assumes that it will instantly increase NAD+. I'd do the experiment, see if it causes you to stay awake for longer or not. For ex., I can't eat cacao too close to bed-yesterday it kept me up for 2 hours past my normal bedtime.
@@conqueragingordietrying1797 well , let's spin the wheel.. bcuz I just took it 30 minutes ago 😄🤙🏽
...btw, I cant wait to see your next video on biological age. I'm testing in a few weeks
@@conqueragingordietrying1797 what is the benefit of cacao?
@@Vakti892 Taste! I'm a big fan of chocolate, and eating it by including the whole cacao bean (which are also fiber-rich!) satisfies my chocolate cravings.
One more reason to vegan. High niacin foods such brewers yeast and peanuts can help produce NAD+, nicotinamide riboside.
There are many roads to optimal health, and it doesn't have to be vegan, or the opposite, carnivore. My global theme is to let the circulating biomarkers drive the dietary choices.
@@conqueragingordietrying1797 So which foods can increase NAD+? Typical animal meats contain harmful substances such as saturated fats, dioxins, antibiotics, hormones, too much protein, purines and lack important antioxidants as well vitamins to slow aging. Not to mention meat industry is incredibly barbaric and contributes a lot to global warming.
@@RynaxAlien Unfortunately eating meat does require killing animals, and hopefully one day we can solve that problem. But not yet. Nothing in biology makes sense except in the light of evolution, and diet is no exception. Humans evolved to eat meat. And if anything we need more protein as we age.
Yeast is not a plant and so technically not vegan. But as I'm carnivore or rather carnivorish, nutritional yeast fits perfectly into my diet or so one could argue. Then again, I used to eat nutritional yeast back when I was a vegetarian. As neither plant nor animal, anyone can include or exclude it in their diet. Of course, one could simplify it all by being an omnivore and eat anything and everything. LOL
@@MarmaladeINFP Yeast are fungi and vegans eat fungi, especially mushrooms. We just don't eat meat, dairy, or eggs....or 'animal' products. Bees and silkworms are considered 'animals', so no honey or silk. Vegans argue with each other about these things - often in a rather nasty way. Some vegans begin to sound like Medieval Christians calling for 'bad' Christians to be burned at the stake.
Ketosis raises NAD+.
Paper reference?