Junctional Diversity

[@luciawang1805]

that's the best video ever to explain the N and P nucleotides clearly.

[@JoeDeMasiScience]

Thanks for the feedback!

[@Heat136Miami]

Great video. Am I mistaken, or is it actually a protein called Artemis, not RAG, that makes the random single-stranded nick to open the hairpin?

[@junholee3760]

It is Artemis, not RAG.

[@mesutdilber6758]

Thanks mister, it was a very good lecture that induced my love of immunology

[@noicedrinkzv2.015]

Honestly was so much easier to understand after this, god bless man

[@JoeDeMasiScience]

Bless you too!

[@reachtt]

Beautiful video!! :D Thank you for explaining! You are the only one making this so clear!

[@ycc3325]

This HELPS SO MUCH !! Thanks for the awesome explanation
my teacher literally just makes things way too complicated and my life too miserable 😀

[@JoeDeMasiScience]

👍🏻

[@victorgomez3566]

Ku70-Ku80, DNA Artemis..... nothing? Rag doesn't bind the DNA...

[@jongelb9603]

Amazing lecture.
But I have a dumb question. At 13:37 there are no junctional diversity segments between the J and the C. Why not? If you selected HC J6 then it makes sense that there's no junctional diversity since J6 and the constant region are contiguous. But what about J regions non contiguous with the constant region? Or does the RNA polymerase know only to translate the first encountered J region?

[@mKulwanTSesodiA]

So helpful! Thanks a lot! Made the concept crystal clear.

[@JoeDeMasiScience]

You're very welcome!

[@muhammadsaif3499]

Thanks a lot , This one helped me a lot

[@JoeDeMasiScience]

You are welcome!

[@himanshibakshi7304]

Very helpful 💯

[@kori4580]

thank you so much, this really helped with my exam :)

[@JoeDeMasiScience]

What program are you enrolled in? Just curious who's watching my videos.

[@kori4580]

I'm studying for the MCAT :)

[@everythingsmine13]

This was super helpful! Thank you!! :)

[@JoeDeMasiScience]

Glad it was helpful! Please subscribe!

[@amyobringer4855]

good explanation, but why mess it up and draw the basic antibody Y shape wrong at the end of the video?

[@JoeDeMasiScience]

What’s wrong with that drawing?

[@icekin10]

Great job - very helpful!!

[@docsraoof]

Thanks for that excellent video

[@akritino7437]

Thank you for this informative vid :) I loved it !

[@JoeDeMasiScience]

Great to hear! It's a complicated topic...

[@lexi6797]

Thank you. Clearly explained.

[@jacksonmulwa9406]

Am happy

[@je6874]

Amazing

[@ashtonronald]

thanks!

[@JoeDeMasiScience]

You are welcome.

[@yousufalifmirdha7408]

thanks a lot

[@JoeDeMasiScience]

You are welcome!

[@xJustKeeepSwimmingx]

beautiful