Recrystallization of Amines: A Step-by-Step Purification Guide

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  • Опубліковано 13 січ 2025

КОМЕНТАРІ • 30

  • @michaeljacques7336
    @michaeljacques7336 7 місяців тому +14

    This is just about the worst way to go about this. Yields will be terrible and it will take forever. Most HCL salts of amines are very soluble in water , usually around 1g per ML. so if you have even a tiny bit of liquid to pour off you are loosing grams of product. Also amines in water like to form an oily liquid tat can take a week to dry even in very low humidity. if you allow this liquid to dry completely globs of crystals bind together trapping impurities that wont come out in the washing step.
    The best way to purify amines without vacuum distilling them is to re crystallize from boiling alcohol. put your product in a beaker with just enough dry alcohol to make it completely wet, heat until the alcohol begins to boil. Add more alcohol a few drops at a time until all of your amine dissolves . remove from heat and let your mixture cool as slowly as possible. finish by putting it in the freezer over night. in the mourning you will have large crystals in your solution. filter off the crystals and wash with ice cold acetone. you can get to 99% purity tis way with less then a 5% loss if you do it well.

    • @kulled
      @kulled 6 місяців тому +1

      what would you recommend for slow cooling? my first thought was to completely wrap the beaker in a few layers of tin foil and let it sit for as long as it needs, but that might be overkill.

    • @EbbeLoos
      @EbbeLoos 6 місяців тому

      ​@@kulled you can heat the solution untill it boils quite fast with a heat gun, and afterwards you can put it in a (pre heated) oil bath. You can choose to manually decrease the temperature of oil bath (10°C/2h for example) or just turn off the heating and let it cooldown on itself

    • @chemistryofquestionablequa6252
      @chemistryofquestionablequa6252 6 місяців тому

      ​@@kulledtowels and a cooler work well for slow cooling without specialized equipment.

    • @SandyWilson-o1l
      @SandyWilson-o1l 3 місяці тому

      Sp​@@EbbeLoos

  • @jaimeortega4940
    @jaimeortega4940 7 місяців тому +7

    Yes, it looked like you got a better purification out of the recrystallization process than from the acetone filter rinse? Usually, acetone rinses get those quite white and clean. However, even after slow recrystallization I still detected some orange/yellow impurity still present in the crystal? What is that?

  • @uuball
    @uuball 3 місяці тому +2

    Aaa, my favourite amine.🤓

  • @DEVILGAMERS-w4b
    @DEVILGAMERS-w4b Місяць тому

    how the sarurated solution is made, for that can dissolve the powdered amine and used for that

  • @karamisa2272
    @karamisa2272 7 днів тому

    does this work for methoxy-amines? 😀

  • @anthenriqe909
    @anthenriqe909 7 місяців тому +6

    Took almost 2 months crystallize from evaporated ethanol. Thats crazy

    • @SafroleBlog
      @SafroleBlog  6 місяців тому +4

      We have nowhere to rush

    • @danielweber7019
      @danielweber7019 3 місяці тому

      ​@@SafroleBlogCan you Help me? I have a Mixture of 60 mg Pseudoephedrin, 2,5 mg Triprolidin hcl,
      Lactose - Monohydrat, Magnesium- Stearat, 🌽 Mais Stärke/ Powder and Povidon.
      Ist there a easy Way to extract Pseudoephedrin? Thank you

    • @max3eey
      @max3eey 2 місяці тому

      ​@@danielweber7019 column chromatography

  • @johannweidinger5480
    @johannweidinger5480 5 місяців тому

    Can the amine hydrochloride also be used as a powder and dissolved in water?

  • @dreamer_sim
    @dreamer_sim 7 місяців тому +7

    bro is casualy recristing meth on yt

    • @Krzysix.io11
      @Krzysix.io11 7 місяців тому +2

      Yeah why not

    • @kulled
      @kulled 6 місяців тому +4

      check out the bb forums for more naughty chemistry videos

    • @johannweidinger5480
      @johannweidinger5480 5 місяців тому

      @@kulled Is that crystal meth in the video?

  • @jakubpetka8663
    @jakubpetka8663 7 місяців тому +2

    Hmmm…. what amine was recrystallised?

    • @SafroleBlog
      @SafroleBlog  6 місяців тому +1

      This recrystallization method is suitable for various amines. To watch more videos without censorship, visit our blog and forum.

    • @shaunaustralia9906
      @shaunaustralia9906 5 місяців тому

      Safrole

  • @criator2
    @criator2 Місяць тому

    😂

  • @samerSaleh-gs3uq
    @samerSaleh-gs3uq 7 місяців тому +3

    This is meth*😂😂😂

    • @Krzysix.io11
      @Krzysix.io11 7 місяців тому +2

      No shit, for real???

    • @samerSaleh-gs3uq
      @samerSaleh-gs3uq 7 місяців тому

      @@Krzysix.io11 of course

    • @spiderdude2099
      @spiderdude2099 6 місяців тому +2

      It’s not. If I had to guess it’s triethylamine hydrochloride

    • @samerSaleh-gs3uq
      @samerSaleh-gs3uq 6 місяців тому +1

      @@spiderdude2099 No, you're wrong, it's meth, and I don't have to explain that to you here

    • @spiderdude2099
      @spiderdude2099 6 місяців тому

      @@samerSaleh-gs3uq lol, sure whatever dude.