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Thank you. Videos with subtitles are great for foreigners who are not that good at english. These people can turn on automatic translation to any language.
I have prostate cancer Gleason 3+3=6, I'm 62 and have been watching this channel for a week or so. My father, died this year, age 93. He had his prostate removed in the 1980's (age~ 58) surgically from the rear (at that time this was state of the art and promised less side effects). Then a few months later, he had radiation for three or four months. The cancer returned and his PSA was over twenty in around ten years. He was put on hormone therapy every time his psa would go up very quickly to the upper teens or over twenty. Anyway, his prostate cancer was in his bones ect.. The last three year of his life he began taking some sort of chemo tablets, two per day. This was a last resort by an oncologist and he lived a few more years and was fairly happy despite having to run to the mens room often. Let's hope we can all live to our nineties cancer be darned.
This just happened in the land down under. Follow them. >>Undetectable levels of Prostate Specific Antigen (PSA) have been reported from the first patient with metastatic castrate-resistant prostate cancer (mCRPC) to ever receive two cycles of Clarity’s 67Cu-SAR-bisPSMA at the 8GBq dose level. PSA is a marker of tumour burden, clinical response to treatment and an indicator of the recurrence of disease for prostate cancer.
Don't know your biopsy results, PSA, ..., but GS6(3+3) cannot metastasize, so it means that the cancer should be localized only in prostate. You should definitely buy and read the book by Mark Scholz MD: "The Key to Prostate Cancer" from 2018. You should consider also other options than surgery: Active Surveillance and radiation.
The City of Hope is adding Ivermectin to TNBC treatment, University at Glasgow is adding Mebendazole to Docetaxel for PC, Dr. Marc-Eric Halatsch is using Itraconazole in a 9 repurposed drug protocol for Glioma and Glioblastoma. Dr Tom Rogers YT video on Artemisisin and Fenbendazole has some comments you may be interested in.
@@FightingProstateCancer could be it doesn't metastasize however it can mutate into something that will, being sure is a mistake when it comes to cancer
Dr Kwon's presentation was very informative and easy to understand. I first got prostate cancer in 2011 and have had 3 reocurrences since. Starting with my 2nd go-round, I have worked with Dr. Kwon and his staff at Mayo Clinic. Care has been excellent. Last visit, all scans were clear! There are 7 boys in my family and 5 of us have had prostate cancer. Mine is connected by the VA with Agent Orange, while serving in Viet Nam. Dr Kwon, has been very professional and yet personal in his meetings with me. I believe he is the expert in this field and I attribute my good health to his advance knowledge in the area of prostate cancer. Because of his continued research and looking for possibilities, I'm sure he has helped many patients with prostate cancer. He truly has helped me. Thank you, Dr. Kwon. Please continue the good work!
I found the presentation on the topic of prostate cancer to be the most amazing and comprehensive one I've seen to date. I would like to express gratitude to Dr. Kwon and the PCRI (Prostate Cancer Research Institute) for the presentation and for sharing. I am 66-year-old individual with prostate cancer, specifically a Gleason Score (GS) of 9, and have undergone a prostate operation (2017), hormone therapy, and salvage radiotherapy (2021). My PSA (Prostate-Specific Antigen) has risen to 0.12 ng/mL. I am in a stage of contemplating their next steps in treatment and found the information session to be educational and helpful in providing guidance for their future treatment plan.
There can be no better lucid and indepth explanation all about prostate cancer and it's ramifications. I am an advance prostste cancer with metastatis..but the way this dr is pressenting so passionately and qualitatively , at 72 I wish I was a dr like this dr ..I have forgotten about my cancer after listening this dr .great..i am from India
I'm 60 and had a radical robot prostatectomy 7 months ago. I just had a PSA .10 and I am now on Androgen and started 48 radiation treatments as we think the cancer is in my Lymphatic near operation site nothing showed on bone scan or other scans, but we believe this treatment plan should be done anyway as one of my nodes that was removed had cancer. I only had 5 radiation treatments so fare and only had talked to doctor about my treatment plans for only 5 minutes, so I know very little about my condition and treatments at this time. Thank you for helping me get up to speed. I'm so hungry for info that I hit up all sites to learn all I can, and this site was the most informative by far.
Dr. Kwon and his team and associates are national treasures. I remember sitting on a chair for my first visit and the APRN introduced herself and asked me if I wasted to pursue containment or cure. I was speechless. Cure was not on the radar. Cure is not guaranteed. An associate said I had a 14 percent chance of not being cured. Meeting Dr Kwon was one of the most awesome moments of my life. I have trouble believing he is human and not angelic. Humility, compassion, empathy and caring do not always accompany genius. May God and the real angels protect and bless Dr. Kwon as he is a National treasure and his team sent by God to battle for our lives. Hopefully his understanding of Prostate cancer will spread across the world. God bless the Kwon Team. Thank you.
Probably the most concise and informative video I have seen since I was diagnosed with prostate cancer in 2018. wish I saw back then. Thanks to you Dr. Kwon and your entire staff.
Dr Kwon has been my Doctor for over 3 years the guy knows what he’s doing so listen to him. I started with stage 4 and a PSA of 93 and a Gleason 8. My first doctor started me with 44 radiation treatments. After that luckily my wife got me into Dr Kwon. I have had several different treatments that helped but always came back.I have done 5 of 6 treatments called Lutitium 177. So far my PSA is undetectable nothing new and nothing showing. I am hoping for a remission to last for longer 6 months. I’m very fortunate to have Dr Kwon and once he gets ahold of you he doesn’t let go. Thanks for all he has done.
Good luck and hope Lu177 works for you...I'm on my 3rd Radium223 in the UK and similarly had mets and PSA 294 in 2009. Still active at 73, good oncologists are worth their weight in gold.... Keep the Faith!
Absolutely brilliant presentation. UK based here, starting PSA over 1300. Enzalutamide working so far. Long conversation with my oncologist needed now.
Hi. Also in UK. PSA of 310 with multiple bone lesions. Did you start treatment with 14 days Bicalutamide followed by Decapeptyl. If Decapeptyl how soon after did you start on Enzalutamide - was the latter your choice of drug. Thanks
@@stitcheruk1150 I started with a Bicalutamide for 28 days. I then started on Prostap (Lupron) ADT injections, first one was one month then quarterly. Started on Enzalutamide 8 weeks after diagnosis. That was over 3 years ago. PSA currently 0.03, incredible really. Good luck to you.
@@stitcheruk1150 I should add that I wasn't given any choice on the drug. Oncologist just said we're giving Enzalutamide instead of chemotherapy because of Covid.
Great video that covers all the important points of advanced prostate cancer treatment in plain English. If you want a detailed overview and you are new to this disease, start with this video. Dr. Kwon's approach to curing advanced prostate cancer rather than using a palliative approach gives hope to afflicted patients. Thank you, Dr. Kwon!
Dr. Kwon, this presentation was excellent and extremely informative. I will be meeting with my doctor shortly and plan to discuss some of your points presented here. Thank you again.
Extremely interesting presentation. I was diagnosed in March with 525 PSA. Metastatic. Prostate cancer in 5-6 areas (back, ribs, pelvis). Started Orgovyx right away and NUBEQA. Soon after, Lutetium. So far I've had 4 of 6 infusions. PSA down to 2.3 so far and next read-out should be around 1.1. No increase in lesions and decrease in cancer presence. I have been told that there is no "cure" for what I have, so it's encouraging to hear a different perspective here. My own fight has involved shifting to a plant-based diet (not a big shift), daily resistance exercise, white, green and black tea drinking, and a lot of quick walking/fast running in spurts (morning and evening). For me, hot flashes are minimized significantly by exercise and some supplement additions (D3, B1, Calcium, Magnesium Glycinate, 5-HTP and Melatonin). The drugs (Orgovyx mostly) definitely increase my anxiety (something I had little of before), but, as I just mentioned, all side effects are reduced or neutralized by vigorous exercise in particular. I've gained no weight, have gained muscle mass, and focus on this form of exercise as loss of bone and muscle mass is common. My "fantasy," which is to ultimately take ADT's in intervals, or go off them altogether, seems a little closer after this discussion. Appreciate this presentation very much.
What a clear and didactic presentation of prostate cancer, and it's different forms of treatment!!!!! My doctor never informed me anything about this and just sent me to ADT for 9 months. And now I am worried to learn that ADT does not kills the cells so my treatment may extend to years ,
Thanks for the video! Gleason 9 @51 years old, prostatectomy (2016) which needed salvage radiation and hormone therapy after 4 years psa is again rising.
A big thank you for all the information in this video. 58 yrs old, diagnosed last week with skeletal metastasized prostate cancer PSA 2,000, Gleason score of 9. Started Firmagon yesterday, meeting the oncologists tomorrow to discuss starting radiation treatment within the next three weeks. I now have a lot more confidence in the diagnostic process (PSA, prostate biopsy and bone density scan completed) and will take the lists with me tomorrow. Thanks again.
@@Mark_Lacey Most certainly - I was also diagnosed two weeks ago with skeletal ( multiple lesions ) metastasised prostate cancer, although my PSA was 310. Also have had a biopsy. No idea how long I have had it as no symptoms apart from getting up in the night. Initially refused a PSA by my doctor in 09/2022, who said ‘come back if anything changes’. Nothing changed, however I decided to ask for a Health check which did not include the doctor. At this check in 09/2023 I asked the nurse to also do a PSA test as part of the bloods - this came back PSA 310. So far been given 14 days Bicalutamide ( finished those ) followed by a Decapeptyl injection (3mg) at 14 days to be followed by a larger dose of 11.5mg a month after the first. Still ‘researching’ - hence my interest in your situation and treatment. Thanks for getting back.
Thank you so much for this clear and informative video! My husband is a Mayo Clinic/Rochester patient- diagnosed with low volume mets , Gleason 9, 2 1/2 years ago. Initially treated with 26 rounds of radiation and has been on ADT (Lupron/Abiraterone) since then. PSA remains at
@@alchristensen165 He's 66. We were thrilled to learn that his latest PSMA PET scan shows no signs of cancer! An option now is to take a holiday from the ADT treatment, keep monitoring him, and see what happens. Not gonna lie, it is a scary proposition. My best wishes to you on this journey.
@@alchristensen165 As expected, the Zytiga and Lupron have caused hot flashes, but they've diminished with time. He's lost some muscle strength and energy, but remains pretty active. As you have likely been told, it does affect sexual function. He takes a low dose of predinose, which is required with the Zytiga. That has caused a gradual thinning of his skin, so he bruises easily and it takes longer for scrapes and cuts to heal. (After the first month of ADT, his PSA dropped from a high of 23 to 2.5. Two months later it was negligible and continues to be three years later.) All things considered, he's felt pretty good. We're just thankful that the treatment has been working and he's been here to hold and cuddle his first grandchild. Of course, there are no guarantees, but we try our best to keep postive. The treatments for PC have made great strides the past few years, so there's every reason to be hopeful that even advanced disease can be managed for a long time. Make sure your family knows this. I highly recommend having someone come to appointments with you. It helps a lot to have two people hearing the information and asking questions. Good luck to you! 🤗
Wow! Thank you again for such a detailed presentation. So much data!! Like your other presentation, I will return to this several times to get it in my head. I was a Gleason 9 and had a RP including lymph nodes and all surrounding tissues, but 2 years out still have an undetectable PSA. But I continue to pay attention to the progress in the treatment of metastatic disease.
Absolutely brilliant! Thank you for the privilege of becoming semi-competent in this area. Just finished exhaustive Suppressive Therapy with a rising PSA, thanks to your video, I now have reduced stress an road map to success! Hopefully I can access Chemo and swing back to ARPI if it doesn't work. Thanks again!
It's as amazing to hear you quoting a CCR song from the 70's iirc, as it it to hear your depth of knowledge regarding PC. Thank you for this priceless dissertation.
Fascinating presentation. I am not like a lot of others here because I am just starting and scared out of my shoes. I don't want to make an error. Local Urologist in Greenville SC. I want to do what is best but have no idea where to start. Travel to someplace like Mayo?WU here? of 6 segmennts Gl score of 6 in 5 and 7 in one. However my PSA is>30 which started this.Dr Kwon is the first person who has given me any hope at all. PET Scan scheduled locally.
I was diagnosed with prostate cancer in 1993. PSA was 300 with every bone in my body having cancer. Given 6 months to live. Oncologists told me Thai is unlikely I will walk in 3 months. My urologist decided to try Lupron to see it would help. Also added casidex. Within one year my PSA dropped to zero. Stayed that way for 28 years testosterone was less than 3.for the last 2 years, psa started creeping up. Reaching 3.3 this year. Started Nubeqa earlier this year. PSA dropped to 0.2. Getting weaker each year. Can’t open soda bottle. I will be 84 next year. Made decisio last week to stop all treatments. Will test again in 3 months to see results. What do you think of my decision?
Thanks for this very personal info. It's good to know what works for different people. You might want to edit the part where it says Thai. obviously you meant 'that' but DAC! dam auto correct can sometimes be wrong.
Low carb/sugar. D3w/K2-MK7. Cod liver oil, alpha lipid acid. TUDCA! Vit C B's. Minerals mag pot zinc. AND immunological mushrooms, especially phellinus linteus, but including chaga, ganoderma applanatum, tramedes versicolor. Adaptogenic tea would be helpful, too, with eleutherococcus, schizandra, rhodiolia, the logic I'm carthamoides, and ginseng. Research available on pubmed. In particular read on phellinus linteus mushroom. There's more if you have other factors such as weight, insulin, blood pressure issues; they can all be addressed though. I admire your courage!
Thank you very much Dr Kwon for sharing such important information for those of us trying to understand the complexities of Prostate Cancer. This info was easy to understand and take notes. Nice job...
Hi from the Uk, following for some considerable time,❤ Eugene and his presentations , has been 12 years to the day presented to oncology with T3a G7 margins clear, up to this point I’ve mostly flatlined PSA from 0.01 to 4.6 since surgically the prostate being removed. As I type it has moved into bone with PSA 40 doubling time four weeks , had the first Chemotherapy last Monday I’ve been treated with the same plan more or less as presentation here suggests.
This is very timely for me. I was treated for Stage IV Prostate Cancer that had spread to my lymph nodes, with a Gleason of 9, in 2018. I had ADT for 18 months and IGRT and was doing very well until a few weeks ago, when my latest PSA had jumped to 30! I’ve just done a PSMA PET scan and it shows that the Cancer has spread to many places in my bones. I just went back on 1st Gen ADT, and I’m looking at options. My Doc had said that maybe I can do Lu177 at an earlier stage, along with 1st and 2nd Gen ADT. We don’t know if they’ll allow me to do Lu177 at this stage, but it might be possible since I’m in the Philippines and they’re not as strict about when to use it here. The argument is that using it earlier, when the Cancer hasn’t become resistant to ADT and therefore more hardy, might have better results. If they won’t allow it, I’ll do Chemotherapy and then do Lu177 if it seems to be coming back. Im hoping to buy as much time as I can, until new treatments come along. What the Doctor said about using these treatments earlier, seems to make sense to me. Im only 61, so I think my body can handle more treatments now, than when I’m older. This presentation was excellent and made me believe that I’m on the right track with triple treatment and adding either Lu177, or Chemo to my treatment plan.
Hi, very sorry to hear about your current PC, I’m 61 , and recently had a PMSA PET scan as my PSA jumped to 5 , waiting for results. I’ve had it since 2021, I was just wondering with the jump to 30 and having a terrible result from the scan , were there any symptoms , I ask as at the moment I feel fine, I have come to the conclusion this illness is a sneaky bugger..
Anthony, I had a bad lower back for many years, so I was in constant back pain, so I assumed the back pain was just increasing due to age, however it turned out that exactly where my back issues were, is where the Cancer migrated to, perhaps because it was already inflamed there and the Cancer was drawn there due to the existing damage. I'd also had a broken rib before, and I was having a bit of pain where that had long since healed, so I stupidly assumed that maybe it was just some arthritis there from the previous damage, but once again, the Cancer migrated there as well, and spread to the ribs closest to that area. So the symptoms were really increased pain from other existing injuries. Other than that, nothing else. Also, I'm on Zytiga now, as well as Zoledronic Acid infusions every 28 days. They won't allow Lu177 yet until I've done one round of Chemo, however, my PSA is down to 0.02 now, so the Doc is saying that maybe we'll wait on the Chemo until it seems to be climbing up a bit again since the Chemo attacks dividing cells, and it looks like the hormones have stopped them from doing that, at least for now, so giving me Chemo at this stage would be counterproductive. He'd rather get me through six rounds of the Zoledronic Acid and do another PSMA PET scan and see what things look like.
Thanks for your reply, glad to hear PSA down and you have future options, we are all guilty for putting some symptoms down to age or previous injuries, wish you all the luck moving forward 👍
Excellent overview. Spouse has been diagnosed with Gleason 9 with mets to bone and lymph in the 12th month of ongoing treatment for “prostatitis” with antibiotics. I recommend you get an MRI right away when symptoms start, especially when your father had prostate cancer.
Wow! Great video, I have gone through a lot of treatments and, according to my doctors, am kind of at the end of options except RA223. Your info gave me ideas about what to do now.
For my localised Prostate Cancer, Cyberknife turned out to be a most effective treatment. I had a PSA of 52 and biopsy showed Gleason 3+4 around 7 months back (just before opting for Cyberknife). No adjuvant therapy. Today my PSA is down to 2 with no trace of the disease. Absolutely no side effects. Best to do some research before jumping to any treatment plan out of panic.
Thank you for this fantastic presentation. It is possible to get a link to your lists. Would be helpful for next consult with my husband and urologist. Thank you.
Thank you very much doctor!! Incredible and open mind presentation, my father is battling with cancer right now his second chemotherapy and many Arpis!! Thank you for the presentation God bless everyone of the Mayo Clinic and the prostate center. I live in Bolivia how can I contact the doctor
What a goldmine of informations. And I love your humor, and all those allusions, musical or onthers. Thanks a lot ! (p.s. where I could find the 176 hours presentation please ? )
Thanks so much for this presentation, really well organized and has provided me with the knowledge I need to have when I go meet a different Oncologist to discuss my treatment plan. I had low PSA scores 4.5, high Gleason scores of 6+ and 8+ on two core samples. Completed 44 EBRT radiation treatments, and have been on ADT Hormone Therapy for 9 months, they want me to do 9 more months. This video has confirmed what I thought which is that sufferring through 18 months of ADT Hormone therapy is really palliative and not curative. So again, thank you for all you do and taking the time to publish this video as it at least lets me prepare for the next meeting on Jan 19 to discuss more "optimal" curative therapies moving forward rather than just waiting another year to determine if what's been done has really addressed the aggressive PC.
Exellent presentation, where can I find information based on possible microscopic prostrate cancer and what treatment plan is recommended for this case?
I am so thankful for this presentation, it makes advanced prostate cancer management more understandable. I do have a question, is there a link to download the ' List to bring to with you to physician meetings' ? Thank you in advance.
Thank U so much!!! 38 months in ,small break from trelstar,but,,failed 1st at16 months then xtandi failed at26 months ,then abirotimone failed ,, branched me out. To a cancer center in SC,,,psa up to 250,,,did taxatere,,knocked it to 125,,,then bone Mets radiated psa to24,,then jeftona only down to 8,,psa creeping up to48 then more radiation same spot but other hip started hurting ,still on trelstar psa124 ,,skipped trelstar 2 months psa now148,did geno test said I was bracket 1 and 2 positive ,did a month of Casodex psa is148 ,,,dr said he could try new med which I hope is a part thatU made it seem might help for that?thanks again for this super packed info,,I feel better already, I've always had great faith in JESUS ,,THAT IS SO IMPORTANT ALSO ,,WERE ALL IN HIS HANDS ,YOUR AWSOME TO DR
This may or may not be of use to you, I'm hoping it is. >>Cooperating with the downregulation of homologous recombination repair ability after AR signaling inhibition, ivermectin increased intracellular DNA double-strand breaks and finally triggered cell death. Our findings demonstrate the anticancer effect of ivermectin in prostate cancer, indicating that its use may be a new therapeutic approach for prostate cancer. >On the other hand, IP6 treatment was able to significantly decrease the expression of Shh across all the study time points.
Thanks for the great informative video. Is there any way to get the slides from this presentation? Once again, outstanding job. Keep up the good work. Thank you Dr Kwan.
Thankyou for the best explanation of options ever. Is it possible to hire you to direct my husbands treatment via video meetings while receiving the treatments locally in the Seattle area? My husband has treatment history with Providence Cancer Center (Everett, WA) and has approached Fred Hutch (Seattle) for a treatment plan as the ADT and ARPI treatments have failed. Suggestion - can you provide your presentation and lists in printable form - with letters on a white background instead of black background?
My dr tried triple attack but I had allergic reaction and couldn’t get chemo . I just had my first pluvicto treatment. My initial psa was 603 first round of meds brought it down to 0.57only lasted few months started rising back to 25. The next round of meds lynparzza and abberaterone brought it down to 10 and held it for 6 months or so. After that they started failing and psa rose rapidly was at 218 before pluvicto. My pmsa scan showed almost every bone was compromised with tumors
Im 65yrs old and for the last 14 months my psa has been 12.4. My Urologist sent me for an MRI scan and the results came back as no cancer but showing inflammation and enlarged prostrate. My Urologist told me ive prostatitis which is the reason for high psa. I mentioned a biopsy but he assured me their is no need for biopsy as their is no target for the needle as no cancer is showing. My Dad and Grandad both passed away with prostrate cancer. So im a little nervous. This morning i had another psa blood test hoping it has come down 3 months after my last blood test. Need to wait a week for results. 🙏
@@stephenpisani1730Your Dr. is right. If there were cancer it should show on MRI. This is what showed on my spouse’s MRI and triggered the biopsy. You responded PI Rad 2, which means means low, cancer unlikely to be present. But get another opinion maybe because of the elevated PSA…
I am 65 PSA went from 4 to 4.5. Had the MRI done, they initially told me not to worry, they said the scan showed some small spots, which might, or might not be cancer, and they would follow up with me after Christmas 2022. Fortunately the urologist proceeded with the biopsy procedure, although he and his assistant were sure it wouldn't show anything serious. Well turned out two biopsy cores scored a 7 and an 8 on the Gleason scale. Had 44 radiation treatments and am going through ADT hormone therapy for 18 months, Ugh... I am not doing well with the side effects, bone mass and muscle tissue loss are significant. In any event, I would go to another Urologist with your results so far and get a 2nd opinion about getting biopsy done. I am going to get a 2nd opinion myself from another Oncologist as I'd really rather do something curative about the cancer rather than put it to "sleep" for 18 months and then find out at age 67 that metastasis has occurred. Good luck
I had a MRI with no showing. But later had a biopsy and PSMA scan and cancer was present. Gleason 8, but not outside my prostate. Now seeking the best possible treatment. Listening to all this, it's all a crap shoot. Changing diet, and metabolic may be the way for me.
My Prostate was removed and the PSI was 1.4 but I did'nt follow up due to Insurance and Jobs.Finally got Insurance & tested. My PSI is 43,400. At the Hospital now . I will update you.................
Next week is the date that I hear just how bad my cancer is. And seeing that dandelion portion of the video, just wants me to throw up my hands and say f it. I just hope that I have a fighting chance, but even the word fighting means that I lost.
My dad was diagnosed 18months ago at the age of 74 with prostate cancer, he’s undergone 4 surgeries then started taking chemotherapy, he took 8 sessions of chemo, just finished chemo last month, but again there’s prostate enlargement and blockage of urine.. Dr suggested surgery again but my Dad said I can’t undergo any further surgery because of poor health now. We are really worried about them, he’s pain in all body, he cries bcz of body ache.
Urolift completely and permanently destroyed my life !!!! Now I am faced with my new urologist wanting to do another surgery (greenlight) to correct to the botched UROLIFT procedure. I am told I would have to self catheterize everyday possible for the rest of my life. My symptoms now are WORSE than before Urolift. Please be advised and don't say I didn't warn you if you get this procedure !!!!!
Doctors / Survivors, need your help.. my dad is going through the advanced prostate cancer with metastatic to bones.. he went through turp surgery and then hormone therapy for few months, in Oct 2023 he had 3 cycles of Chemotherapy but the PSA went up to 59, chemo was stopped and given Enzalutamide for 2 months psa went down from 59 to 26, he felt better but eventually he started feeling the bone pain again ; now the doctors gave radiation therapy and apalutamide.. he is very drowsy, tired and I could see he is loosing his strength slowly; any other treatment methods or meds that I should check for my dad to get him back to the normal life.. we are from India and dad gets treated in Chennai .. I appreciate your comments or support to save our family!
My psa was 3.9 Gleason 9 , had surgery, 2 years later psa went up to.20 had radiation 37 treatments, 1 year later psa went to 6.8 been on Lupron for 3 years, so far psa .001 , but side effects are awful
What side effects, those of the ADT or of radiation? I am G9, have been on ADT, both generations, for 4 montgs and now contemplating radiation, but concerned about side-effects. Thank you for your comment.
My dad is 67 yrs old he has been diagnosed with prostate cancer which has metastised to the lymphnodes and pelvis girdle as per CT scan and mri with psa of more than 100 with Gleason of 8 he has been put on zoladex injection, zytiga and casodex for 3 months then once tumor burden has reduced he will start on radiation therapy, how aggressive is this treatment kindly reply many blessings to you all
Recently on a Joe Rogan podcast with Graham Hancock they discussed using a “repurposed” drug fenbendazole for cancer treatment. This treatment is becoming very popular because of the success rates. Minimum downside with a cure on the upside. What do men have to loose?
Checkout the recent John Campbell’s YT on “Ivermectin and Cancers” in the comments are dozens of success es using IVM and Fen Ben, both anti parasitic safe drugs.
This video was very good but it doen't help in my husband's situation. He has been prescribed all categories of treatment but his PSA is rising - now 500. What are the next steps? His doctors have said therr is no available treatment at this present. A video about the next step would be helpful.
Hello, we are not able to answer case questions on our comment section but we can help you through our Helpline who can speak with you either by phone or email. Here is the link to contact them: pcri.org/helpline
Have followed you for several years and wonder why you have now eliminated beam radiation from your list. Before, you have stated that radiology treatment like SBRT would become the standard for treating advanced metastic prostate cancer.
🎯 Key points for quick navigation: 00:00:00 *🎓 Presentation Focus: Dr. Kwon introduces a presentation on advanced prostate cancer and its evolving treatment landscape, emphasizing the complexity and need for informed treatment strategies.* 00:01:09 *🚨 Problem Highlighted: Many patients with advanced prostate cancer are not offered the full range of available diagnostics and therapies, often due to the tendency to oversimplify treatment plans.* 00:02:06 *🏥 Diverse Influence: The management of prostate cancer is influenced by various entities including urologists, oncologists, insurance companies, and pharmaceutical companies, each with their own perspectives and agendas.* 00:03:36 *📚 Presentation Goals: Dr. Kwon aims to update the audience on advanced prostate cancer biology, clarify misunderstood terms, and provide a resource for optimal therapy decision-making.* 00:04:30 *🌿 Prostate Cancer Metaphor: Prostate cancer is likened to a dandelion, with cancer cells spreading like seeds throughout the body, leading to metastases.* 00:06:15 *🧬 Cancer Heterogeneity: Dr. Kwon explains the concept of cancer heterogeneity, where prostate cancer cells are genetically diverse, complicating treatment plans.* 00:07:56 *🔍 Cancer Cell Selection: When treatments are applied, certain resistant cancer cells may survive and proliferate, leading to treatment-resistant cancer.* 00:10:04 *💊 Array of Treatments: A range of systemic treatments is available to manage the heterogeneity of advanced prostate cancer, focusing on both suppressive and cytotoxic approaches.* 00:11:19 *⚔️ Treatment Classification: Systemic therapies for prostate cancer are categorized as either suppressive (putting cells into dormancy) or cytotoxic (killing cancer cells), each with differing longevity of effects.* 00:14:29 *🚀 Understanding MOA: Understanding the mechanism of action of different treatments is crucial for constructing an effective plan against prostate cancer.* 00:17:37 *🛡️ ARPIs Role: Androgen-receptor pathway inhibitors block mutated receptors in hormone-resistant prostate cancer, causing cancer cells to become dormant again.* 00:18:28 *🚨 Counterfeit Testosterone: Abiraterone targets cancer cells that produce counterfeit testosterone, shutting down this process and causing the cells to become dormant.* 00:20:41 *☢️ Radioligand Therapy: Radioligand therapy like 177 PSMA Lutetium targets specific proteins on cancer cells, delivering radiation to destroy them.* 00:21:55 *🏆 Treatment Strategies: The strategy is to use diverse treatments to manage prostate cancer heterogeneity, focusing on transitioning from one therapy to another to achieve potential cure.* 00:23:56 *🎯 Aggressive Approach: The approach to advanced prostate cancer treatment is aggressive and multifaceted, aiming for cure rather than serial palliative treatments.* 00:26:00 *💪 Triple Therapy: For newly diagnosed advanced prostate cancer, especially in healthy men, triple therapy combining hormone suppression, ARPIs, and chemotherapy is recommended for effective management.* 30:15 *📈 Rising PSA indicates hormone-resistant prostate cancer, where PSA should be undetectable during hormone therapy.* 31:32 *💊 Four ARPI agents are generally used after hormone therapy failure, providing a favorable response in about 75% of cases.* 32:42 *💉 Chemotherapy with docetaxel is favored for healthier patients failing hormone therapy, potentially more durable than ARPI agents.* 33:54 *🔄 Combined treatment with ARPI agents and taxane-based chemo is potentially superior, with positive results in 80-90% of patients.* 36:18 *🔄 Switching between different ARPI agents can sometimes lead to strong therapy responses due to varying mechanisms of action.* 38:02 *⚡ PSA levels are not always indicative of cancer progression, especially in advanced cases; imaging is crucial for monitoring.* 40:06 *🔍 Genetic testing is essential for therapy decisions, needing frequent updates due to the evolving nature of cancer genetics.* 43:48 *🚫 PARP inhibitors and checkpoint inhibitors may become viable options after multiple therapy failures due to cancer's genetic evolution.* 51:53 *🌟 Serial genetic testing helps identify mutations for targeted therapies, with PARP inhibitors showing a 33% response rate with certain mutations.* 54:11 *🎸 Serial genetic testing is crucial; it identifies candidates for immunotherapy or PARP inhibitors even after multiple failed treatments.* 00:59:14 *🏥 Mayo Clinic Approach: Surgery is used to eliminate residual cancer after systemic therapy, leading to significant reductions in PSA levels.* 00:59:43 *💥 Radiation Advancements: Stereotactic radiation, like SBRT, can effectively treat oligometastatic disease and prevent further therapy needs.* 01:01:19 *❄️ Minimal Invasive Procedures: Cryotherapy and thermal ablation are effective for residual disease after systemic treatment.* 01:02:17 *🌟 Full Spectrum of Care: Many patients are not offered the full range of advanced prostate cancer treatments due to misunderstandings of "standard of care."* 01:04:28 *🚦 Understanding "Standard of Care": It signifies the minimum acceptable treatment, not the gold standard. Patients should seek the highest levels of care.* 01:05:26 *🛤️ Role of Guidelines: Guidelines are important but flexible; patients should consider second opinions if told treatments are outside standard guidelines.* 01:06:22 *🧪 Clinical Trials Caution: Clinical trial treatments are not necessarily state-of-the-art, and success rates for new drugs are low.* 01:09:00 *📜 Informed Consent: Participation in trials is voluntary; patients can withdraw anytime without repercussions.* 01:09:45 *🧠 Complex Management: Advanced prostate cancer care is multifaceted but manageable with the right guidance and treatment plans.* Made with HARPA AI
PCRI needs to comment on this recent revelation. >>Undetectable levels of Prostate Specific Antigen (PSA) have been reported from the first patient with metastatic castrate-resistant prostate cancer (mCRPC) to ever receive two cycles of Clarity’s 67Cu-SAR-bisPSMA at the 8GBq dose level. PSA is a marker of tumour burden, clinical response to treatment and an indicator of the recurrence of disease for prostate cancer.
@@FightingProstateCancer Phase 1 2A From what I see, and I watched the videos on how it works, Pluvicto hangs onto cells for hours, the double radio ligand Cu67 hangs on for days iirc. There are videos in here.
Wouldn't chemotherapy be safer without the hormone deprivation?? Why do they need it if the chemotherapy is killing the cancer? Wouldn't the hormone deprivation supress the immune system and allow inflammation to run wild etc, etc?
It is unethical to recommend "curative pathways for treatment of advanced prostate cancer." Metastatic prostate cancer is not curable in over 99% of patients - it is a lethal disease. "Curative" should be replaced with the word "aggressive"
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How can I contact Dr. Kwon? I am a fellow guitarist and stage 4 PC on triplet therapy, I have a couple of questions for him :-)
Thank you. Videos with subtitles are great for foreigners who are not that good at english. These people can turn on automatic translation to any language.
@@73maxoneit at the end of the video he leaves his contact info
I have prostate cancer Gleason 3+3=6, I'm 62 and have been watching this channel for a week or so. My father, died this year, age 93. He had his prostate removed in the 1980's (age~ 58) surgically from the rear (at that time this was state of the art and promised less side effects). Then a few months later, he had radiation for three or four months. The cancer returned and his PSA was over twenty in around ten years. He was put on hormone therapy every time his psa would go up very quickly to the upper teens or over twenty. Anyway, his prostate cancer was in his bones ect.. The last three year of his life he began taking some sort of chemo tablets, two per day. This was a last resort by an oncologist and he lived a few more years and was fairly happy despite having to run to the mens room often. Let's hope we can all live to our nineties cancer be darned.
This just happened in the land down under. Follow them.
>>Undetectable levels of Prostate Specific Antigen (PSA) have been reported from the first patient with metastatic castrate-resistant prostate cancer (mCRPC) to ever receive two cycles of Clarity’s 67Cu-SAR-bisPSMA at the 8GBq dose level. PSA is a marker of tumour burden, clinical response to treatment and an indicator of the recurrence of disease for prostate cancer.
Don't know your biopsy results, PSA, ..., but GS6(3+3) cannot metastasize, so it means that the cancer should be localized only in prostate.
You should definitely buy and read the book by Mark Scholz MD: "The Key to Prostate Cancer" from 2018.
You should consider also other options than surgery: Active Surveillance and radiation.
Thanks for sharing this.Really encourages not to loose hopes
The City of Hope is adding Ivermectin to TNBC treatment, University at Glasgow is adding Mebendazole to Docetaxel for PC, Dr. Marc-Eric Halatsch is using Itraconazole in a 9 repurposed drug protocol for Glioma and Glioblastoma. Dr Tom Rogers YT video on Artemisisin and Fenbendazole has some comments you may be interested in.
@@FightingProstateCancer could be it doesn't metastasize however it can mutate into something that will, being sure is a mistake when it comes to cancer
Dr Kwon's presentation was very informative and easy to understand. I first got prostate cancer in 2011 and have had 3 reocurrences since. Starting with my 2nd go-round, I have worked with Dr. Kwon and his staff at Mayo Clinic. Care has been excellent. Last visit, all scans were clear! There are 7 boys in my family and 5 of us have had prostate cancer. Mine is connected by the VA with Agent Orange, while serving in Viet Nam. Dr Kwon, has been very professional and yet personal in his meetings with me. I believe he is the expert in this field and I attribute my good health to his advance knowledge in the area of prostate cancer. Because of his continued research and looking for possibilities, I'm sure he has helped many patients with prostate cancer. He truly has helped me.
Thank you, Dr. Kwon. Please continue the good work!
This gives me a lot of hope for my dad. Thank you.
agree, my father, 70y, has been diagnosed with advanced met. disease and after watching Dr Kwon, I see there is great promise in treatment.
I found the presentation on the topic of prostate cancer to be the most amazing and comprehensive one I've seen to date. I would like to express gratitude to Dr. Kwon and the PCRI (Prostate Cancer Research Institute) for the presentation and for sharing. I am 66-year-old individual with prostate cancer, specifically a Gleason Score (GS) of 9, and have undergone a prostate operation (2017), hormone therapy, and salvage radiotherapy (2021). My PSA (Prostate-Specific Antigen) has risen to 0.12 ng/mL. I am in a stage of contemplating their next steps in treatment and found the information session to be educational and helpful in providing guidance for their future treatment plan.
There can be no better lucid and indepth explanation all about prostate cancer and it's ramifications. I am an advance prostste cancer with metastatis..but the way this dr is pressenting so passionately and qualitatively , at 72 I wish I was a dr like this dr ..I have forgotten about my cancer after listening this dr .great..i am from India
This is the best summary I have ever seen -- excellent information, clearly organised and presented!
I'm 60 and had a radical robot prostatectomy 7 months ago. I just had a PSA .10 and I am now on Androgen and started 48 radiation treatments as we think the cancer is in my Lymphatic near operation site nothing showed on bone scan or other scans, but we believe this treatment plan should be done anyway as one of my nodes that was removed had cancer. I only had 5 radiation treatments so fare and only had talked to doctor about my treatment plans for only 5 minutes, so I know very little about my condition and treatments at this time. Thank you for helping me get up to speed. I'm so hungry for info that I hit up all sites to learn all I can, and this site was the most informative by far.
Dr. Kwon and his team and associates are national treasures. I remember sitting on a chair for my first visit and the APRN introduced herself and asked me if I wasted to pursue containment or cure. I was speechless. Cure was not on the radar. Cure is not guaranteed. An associate said I had a 14 percent chance of not being cured. Meeting Dr Kwon was one of the most awesome moments of my life. I have trouble believing he is human and not angelic. Humility, compassion, empathy and caring do not always accompany genius. May God and the real angels protect and bless Dr. Kwon as he is a National treasure and his team sent by God to battle for our lives. Hopefully his understanding of Prostate cancer will spread across the world. God bless the Kwon Team. Thank you.
Where does he work?
As usual, Dr, Kwon is articulate and to the point. Best presenter out there!
Probably the most concise and informative video I have seen since I was diagnosed with prostate cancer in 2018. wish I saw back then.
Thanks to you Dr. Kwon and your entire staff.
Excellent overview of treatments and options - thankyou!!
Dr Kwon has been my Doctor for over 3 years the guy knows what he’s doing so listen to him. I started with stage 4 and a PSA of 93 and a Gleason 8. My first doctor started me with 44 radiation treatments. After that luckily my wife got me into Dr Kwon. I have had several different treatments that helped but always came back.I have done 5 of 6 treatments called Lutitium 177. So far my PSA is undetectable nothing new and nothing showing. I am hoping for a remission to last for longer 6 months. I’m very fortunate to have Dr Kwon and once he gets ahold of you he doesn’t let go. Thanks for all he has done.
Where is he located? Thanks
Good luck and hope Lu177 works for you...I'm on my 3rd Radium223 in the UK and similarly had mets and PSA 294 in 2009. Still active at 73, good oncologists are worth their weight in gold.... Keep the Faith!
@@Fishflorida59 Mayo Clinic, Rochester, MN.
@@Fishflorida59Mayo Clinic, Rochester, Minnesota
@@mikebojczuk6969 what your Gleason score?
Absolutely brilliant presentation. UK based here, starting PSA over 1300. Enzalutamide working so far. Long conversation with my oncologist needed now.
Hi. Also in UK. PSA of 310 with multiple bone lesions. Did you start treatment with 14 days Bicalutamide followed by Decapeptyl. If Decapeptyl how soon after did you start on Enzalutamide - was the latter your choice of drug. Thanks
@@stitcheruk1150 I started with a Bicalutamide for 28 days. I then started on Prostap (Lupron) ADT injections, first one was one month then quarterly. Started on Enzalutamide 8 weeks after diagnosis. That was over 3 years ago. PSA currently 0.03, incredible really. Good luck to you.
@@stitcheruk1150 I should add that I wasn't given any choice on the drug. Oncologist just said we're giving Enzalutamide instead of chemotherapy because of Covid.
Great video that covers all the important points of advanced prostate cancer treatment in plain English. If you want a detailed overview and you are new to this disease, start with this video.
Dr. Kwon's approach to curing advanced prostate cancer rather than using a palliative approach gives hope to afflicted patients.
Thank you, Dr. Kwon!
Dr. Kwon, this presentation was excellent and extremely informative. I will be meeting with my doctor shortly and plan to discuss some of your points presented here. Thank you again.
Extremely interesting presentation.
I was diagnosed in March with 525 PSA. Metastatic. Prostate cancer in 5-6 areas (back, ribs, pelvis). Started Orgovyx right away and NUBEQA. Soon after, Lutetium. So far I've had 4 of 6 infusions.
PSA down to 2.3 so far and next read-out should be around 1.1. No increase in lesions and decrease in cancer presence.
I have been told that there is no "cure" for what I have, so it's encouraging to hear a different perspective here. My own fight has involved shifting to a plant-based diet (not a big shift), daily resistance exercise, white, green and black tea drinking, and a lot of quick walking/fast running in spurts (morning and evening).
For me, hot flashes are minimized significantly by exercise and some supplement additions (D3, B1, Calcium, Magnesium Glycinate, 5-HTP and Melatonin). The drugs (Orgovyx mostly) definitely increase my anxiety (something I had little of before), but, as I just mentioned, all side effects are reduced or neutralized by vigorous exercise in particular.
I've gained no weight, have gained muscle mass, and focus on this form of exercise as loss of bone and muscle mass is common.
My "fantasy," which is to ultimately take ADT's in intervals, or go off them altogether, seems a little closer after this discussion.
Appreciate this presentation very much.
What a clear and didactic presentation of prostate cancer, and it's different forms of treatment!!!!! My doctor never informed me anything about this and just sent me to ADT for 9 months. And now I am worried to learn that ADT does not kills the cells so my treatment may extend to years ,
May cause heart attacks and or strokes ...did they tell you that?
Excellent presentation! Thanks for providing a great guide for patients.
Thanks for the video! Gleason 9 @51 years old, prostatectomy (2016) which needed salvage radiation and hormone therapy after 4 years psa is again rising.
@@notdisclosed4597 my dad has Gleason 9 about to start radiation therapy, in his lymph nodes in groin area,
Wonderful presentation.. factual and clearly explained and enunciated
Thank you Dr. Kwon
A big thank you for all the information in this video. 58 yrs old, diagnosed last week with skeletal metastasized prostate cancer PSA 2,000, Gleason score of 9. Started Firmagon yesterday, meeting the oncologists tomorrow to discuss starting radiation treatment within the next three weeks. I now have a lot more confidence in the diagnostic process (PSA, prostate biopsy and bone density scan completed) and will take the lists with me tomorrow. Thanks again.
Please update as and when. As another person suffering, it’s somewhat reassuring to follow a person’s journey through this awful disease.
@@stitcheruk1150 Are you really interested in an update?
@@Mark_Lacey Most certainly - I was also diagnosed two weeks ago with skeletal ( multiple lesions ) metastasised prostate cancer, although my PSA was 310. Also have had a biopsy. No idea how long I have had it as no symptoms apart from getting up in the night. Initially refused a PSA by my doctor in 09/2022, who said ‘come back if anything changes’. Nothing changed, however I decided to ask for a Health check which did not include the doctor. At this check in 09/2023 I asked the nurse to also do a PSA test as part of the bloods - this came back PSA 310. So far been given 14 days Bicalutamide ( finished those ) followed by a Decapeptyl injection (3mg) at 14 days to be followed by a larger dose of 11.5mg a month after the first. Still ‘researching’ - hence my interest in your situation and treatment. Thanks for getting back.
Mark - I can no longer see your reply to me.
@@stitcheruk1150 I think because I tried to put my email address here comments got deleted.
Excellent video. Thank you!
Thank you so much for this clear and informative video!
My husband is a Mayo Clinic/Rochester patient- diagnosed with low volume mets , Gleason 9, 2 1/2 years ago. Initially treated with 26 rounds of radiation and has been on ADT (Lupron/Abiraterone) since then. PSA remains at
Can I ask what age is your Husband? I am 58 with same diagnosis & just starting the process…
@@alchristensen165 He's 66. We were thrilled to learn that his latest PSMA PET scan shows no signs of cancer! An option now is to take a holiday from the ADT treatment, keep monitoring him, and see what happens. Not gonna lie, it is a scary proposition.
My best wishes to you on this journey.
@@ga6589thank you for your quick reply!! Any bad side effects from the Zytiga? I too am a Rochester Mayo patient… so grateful for that…
@@ga6589and Big Congratulations on the PSMA pet scan!!! Please let me know how he handled the Zytiga when u have time?
@@alchristensen165 As expected, the Zytiga and Lupron have caused hot flashes, but they've diminished with time. He's lost some muscle strength and energy, but remains pretty active. As you have likely been told, it does affect sexual function. He takes a low dose of predinose, which is required with the Zytiga. That has caused a gradual thinning of his skin, so he bruises easily and it takes longer for scrapes and cuts to heal. (After the first month of ADT, his PSA dropped from a high of 23 to 2.5. Two months later it was negligible and continues to be three years later.)
All things considered, he's felt pretty good. We're just thankful that the treatment has been working and he's been here to hold and cuddle his first grandchild. Of course, there are no guarantees, but we try our best to keep postive. The treatments for PC have made great strides the past few years, so there's every reason to be hopeful that even advanced disease can be managed for a long time. Make sure your family knows this. I highly recommend having someone come to appointments with you. It helps a lot to have two people hearing the information and asking questions.
Good luck to you! 🤗
Wow! Thank you again for such a detailed presentation. So much data!! Like your other presentation, I will return to this several times to get it in my head. I was a Gleason 9 and had a RP including lymph nodes and all surrounding tissues, but 2 years out still have an undetectable PSA. But I continue to pay attention to the progress in the treatment of metastatic disease.
Dr Eugene kwon...too good ..i am touched with gratitude that this presentation is too good for pstients awareness..
Absolutely brilliant! Thank you for the privilege of becoming semi-competent in this area. Just finished exhaustive Suppressive Therapy with a rising PSA, thanks to your video, I now have reduced stress an road map to success! Hopefully I can access Chemo and swing back to ARPI if it doesn't work. Thanks again!
It's as amazing to hear you quoting a CCR song from the 70's iirc, as it it to hear your depth of knowledge regarding PC. Thank you for this priceless dissertation.
Fascinating presentation. I am not like a lot of others here because I am just starting and scared out of my shoes. I don't want to make an error. Local Urologist in Greenville SC. I want to do what is best but have no idea where to start. Travel to someplace like Mayo?WU here? of 6 segmennts Gl score of 6 in 5 and 7 in one. However my PSA is>30 which started this.Dr Kwon is the first person who has given me any hope at all. PET Scan scheduled locally.
thanks for having a sense of humor! and adding new words to the vocabulary. I have 4 + 3 and I'm trying to get HiFU but what a wait.
Thanks for sharing, I have GS4+4, 66YO, 2 years into the combat against PC
Dr Kwon,
Thank you for your excellent presentation.
Please direct me to the PDF file documents that I can take to my doctor.
I was diagnosed with prostate cancer in 1993. PSA was 300 with every bone in my body having cancer. Given 6 months to live. Oncologists told me Thai is unlikely I will walk in 3 months. My urologist decided to try Lupron to see it would help. Also added casidex.
Within one year my PSA dropped to zero.
Stayed that way for 28 years testosterone was less than 3.for the last 2 years, psa started creeping up. Reaching 3.3 this year. Started Nubeqa earlier this year. PSA dropped to 0.2.
Getting weaker each year. Can’t open soda bottle. I will be 84 next year. Made decisio last week to stop all treatments. Will test again in 3 months to see results.
What do you think of my decision?
Thanks for this very personal info. It's good to know what works for different people. You might want to edit the part where it says Thai. obviously you meant 'that' but DAC! dam auto correct can sometimes be wrong.
U are a fighter u don’t surrender keep strong take vitamin supplements and drink lemon ginger infuse water 💦 Witt a half spoon of Turmeric God bless 🙏
You know your story. Heroic stance vs prostate cancer. It’s a Quality & Quantity journey. I salute you and admire your courage.
Low carb/sugar. D3w/K2-MK7. Cod liver oil, alpha lipid acid. TUDCA! Vit C B's. Minerals mag pot zinc. AND immunological mushrooms, especially phellinus linteus, but including chaga, ganoderma applanatum, tramedes versicolor. Adaptogenic tea would be helpful, too, with eleutherococcus, schizandra, rhodiolia, the logic I'm carthamoides, and ginseng. Research available on pubmed. In particular read on phellinus linteus mushroom. There's more if you have other factors such as weight, insulin, blood pressure issues; they can all be addressed though. I admire your courage!
Automistake: rhaponticum cartamoides
Thank you very much Dr Kwon for sharing such important information for those of us trying to understand the complexities of Prostate Cancer. This info was easy to understand and take notes. Nice job...
Hi from the Uk, following for some considerable time,❤ Eugene and his presentations , has been 12 years to the day presented to oncology with T3a G7 margins clear, up to this point I’ve mostly flatlined PSA from 0.01 to 4.6 since surgically the prostate being removed. As I type it has moved into bone with PSA 40 doubling time four weeks , had the first Chemotherapy last Monday I’ve been treated with the same plan more or less as presentation here suggests.
0.42 after eight sessions of chemo to date
@@paulmartin2429 C
Congrats, Paul! Hang in there!
Very thankful for pcri also glad u all get together to share info,my situation below ,next message
This is very timely for me. I was treated for Stage IV Prostate Cancer that had spread to my lymph nodes, with a Gleason of 9, in 2018. I had ADT for 18 months and IGRT and was doing very well until a few weeks ago, when my latest PSA had jumped to 30! I’ve just done a PSMA PET scan and it shows that the Cancer has spread to many places in my bones. I just went back on 1st Gen ADT, and I’m looking at options. My Doc had said that maybe I can do Lu177 at an earlier stage, along with 1st and 2nd Gen ADT. We don’t know if they’ll allow me to do Lu177 at this stage, but it might be possible since I’m in the Philippines and they’re not as strict about when to use it here. The argument is that using it earlier, when the Cancer hasn’t become resistant to ADT and therefore more hardy, might have better results. If they won’t allow it, I’ll do Chemotherapy and then do Lu177 if it seems to be coming back. Im hoping to buy as much time as I can, until new treatments come along. What the Doctor said about using these treatments earlier, seems to make sense to me. Im only 61, so I think my body can handle more treatments now, than when I’m older. This presentation was excellent and made me believe that I’m on the right track with triple treatment and adding either Lu177, or Chemo to my treatment plan.
Dx maj'21, dit/do docetaxel, lupron and Xtandi, Zometa for skeletton, march'22 I begann LU177 at my own initiativ, I'm fine 🙏
Hi, very sorry to hear about your current PC, I’m 61 , and recently had a PMSA PET scan as my PSA jumped to 5 , waiting for results.
I’ve had it since 2021, I was just wondering with the jump to 30 and having a terrible result from the scan , were there any symptoms , I ask as at the moment I feel fine, I have come to the conclusion this illness is a sneaky bugger..
Anthony, I had a bad lower back for many years, so I was in constant back pain, so I assumed the back pain was just increasing due to age, however it turned out that exactly where my back issues were, is where the Cancer migrated to, perhaps because it was already inflamed there and the Cancer was drawn there due to the existing damage. I'd also had a broken rib before, and I was having a bit of pain where that had long since healed, so I stupidly assumed that maybe it was just some arthritis there from the previous damage, but once again, the Cancer migrated there as well, and spread to the ribs closest to that area. So the symptoms were really increased pain from other existing injuries. Other than that, nothing else. Also, I'm on Zytiga now, as well as Zoledronic Acid infusions every 28 days. They won't allow Lu177 yet until I've done one round of Chemo, however, my PSA is down to 0.02 now, so the Doc is saying that maybe we'll wait on the Chemo until it seems to be climbing up a bit again since the Chemo attacks dividing cells, and it looks like the hormones have stopped them from doing that, at least for now, so giving me Chemo at this stage would be counterproductive. He'd rather get me through six rounds of the Zoledronic Acid and do another PSMA PET scan and see what things look like.
Thanks for your reply, glad to hear PSA down and you have future options, we are all guilty for putting some symptoms down to age or previous injuries, wish you all the luck moving forward 👍
Thank you very much Dr.Kwon.
Clear, calm and thought provoking thank you .
Thank you once again Dr. Kwon.
Excellent overview. Spouse has been diagnosed with Gleason 9 with mets to bone and lymph in the 12th month of ongoing treatment for “prostatitis” with antibiotics. I recommend you get an MRI right away when symptoms start, especially when your father had prostate cancer.
Wow! Great video, I have gone through a lot of treatments and, according to my doctors, am kind of at the end of options except RA223. Your info gave me ideas about what to do now.
For my localised Prostate Cancer, Cyberknife turned out to be a most effective treatment. I had a PSA of 52 and biopsy showed Gleason 3+4 around 7 months back (just before opting for Cyberknife). No adjuvant therapy. Today my PSA is down to 2 with no trace of the disease. Absolutely no side effects. Best to do some research before jumping to any treatment plan out of panic.
Thanks! You folks are appreciated!
Excellent presentation.
Thank you for this fantastic presentation. It is possible to get a link to your lists. Would be helpful for next consult with my husband and urologist. Thank you.
Thank you for a great presentation it was very helpful
Thank you very much doctor!! Incredible and open mind presentation, my father is battling with cancer right now his second chemotherapy and many Arpis!! Thank you for the presentation God bless everyone of the Mayo Clinic and the prostate center. I live in Bolivia how can I contact the doctor
What a goldmine of informations. And I love your humor, and all those allusions, musical or onthers. Thanks a lot !
(p.s. where I could find the 176 hours presentation please ? )
Great Job. God bless the team.
Thanks so much for this presentation, really well organized and has provided me with the knowledge I need to have when I go meet a different Oncologist to discuss my treatment plan. I had low PSA scores 4.5, high Gleason scores of 6+ and 8+ on two core samples. Completed 44 EBRT radiation treatments, and have been on ADT Hormone Therapy for 9 months, they want me to do 9 more months. This video has confirmed what I thought which is that sufferring through 18 months of ADT Hormone therapy is really palliative and not curative. So again, thank you for all you do and taking the time to publish this video as it at least lets me prepare for the next meeting on Jan 19 to discuss more "optimal" curative therapies moving forward rather than just waiting another year to determine if what's been done has really addressed the aggressive PC.
Exellent presentation, where can I find information based on possible microscopic prostrate cancer and what treatment plan is recommended for this case?
very useful information and explanation, thank you
20:00 this sounds perfect
I am so thankful for this presentation, it makes advanced prostate cancer management more understandable. I do have a question, is there a link to download the ' List to bring to with you to physician meetings' ? Thank you in advance.
Thank U so much!!! 38 months in ,small break from trelstar,but,,failed 1st at16 months then xtandi failed at26 months ,then abirotimone failed ,, branched me out. To a cancer center in SC,,,psa up to 250,,,did taxatere,,knocked it to 125,,,then bone Mets radiated psa to24,,then jeftona only down to 8,,psa creeping up to48 then more radiation same spot but other hip started hurting ,still on trelstar psa124 ,,skipped trelstar 2 months psa now148,did geno test said I was bracket 1 and 2 positive ,did a month of Casodex psa is148 ,,,dr said he could try new med which I hope is a part thatU made it seem might help for that?thanks again for this super packed info,,I feel better already, I've always had great faith in JESUS ,,THAT IS SO IMPORTANT ALSO ,,WERE ALL IN HIS HANDS ,YOUR AWSOME TO DR
Aggressive curative approaches for prostate cancer, but without patient directives for quality of life, are no longer universally desirable.
This may or may not be of use to you, I'm hoping it is.
>>Cooperating with the downregulation of homologous recombination repair ability after AR signaling inhibition, ivermectin increased intracellular DNA double-strand breaks and finally triggered cell death. Our findings demonstrate the anticancer effect of ivermectin in prostate cancer, indicating that its use may be a new therapeutic approach for prostate cancer. >On the other hand, IP6 treatment was able to significantly decrease the expression of Shh across all the study time points.
Thanks for the great informative video. Is there any way to get the slides from this presentation? Once again, outstanding job. Keep up the good work.
Thank you Dr Kwan.
Thankyou for the best explanation of options ever. Is it possible to hire you to direct my husbands treatment via video meetings while receiving the treatments locally in the Seattle area? My husband has treatment history with Providence Cancer Center (Everett, WA) and has approached Fred Hutch (Seattle) for a treatment plan as the ADT and ARPI treatments have failed. Suggestion - can you provide your presentation and lists in printable form - with letters on a white background instead of black background?
It's interesting that there is no mention of metabolic therapy.
My dr tried triple attack but I had allergic reaction and couldn’t get chemo . I just had my first pluvicto treatment. My initial psa was 603 first round of meds brought it down to 0.57only lasted few months started rising back to 25. The next round of meds lynparzza and abberaterone brought it down to 10 and held it for 6 months or so. After that they started failing and psa rose rapidly was at 218 before pluvicto. My pmsa scan showed almost every bone was compromised with tumors
Is a handout of the presentation slides available?
Im 65yrs old and for the last 14 months my psa has been 12.4. My Urologist sent me for an MRI scan and the results came back as no cancer but showing inflammation and enlarged prostrate. My Urologist told me ive prostatitis which is the reason for high psa. I mentioned a biopsy but he assured me their is no need for biopsy as their is no target for the needle as no cancer is showing.
My Dad and Grandad both passed away with prostrate cancer. So im a little nervous. This morning i had another psa blood test hoping it has come down 3 months after my last blood test. Need to wait a week for results. 🙏
What is your PSI Rad score given by the radiologist? It should show on your report.
@@tatianaschoenfield9819 my mri scan on my prostrate says it's normal and classified as PIRADS 2. Whatever that means...
@@stephenpisani1730Your Dr. is right. If there were cancer it should show on MRI. This is what showed on my spouse’s MRI and triggered the biopsy. You responded PI Rad 2, which means means low, cancer unlikely to be present. But get another opinion maybe because of the elevated PSA…
I am 65 PSA went from 4 to 4.5. Had the MRI done, they initially told me not to worry, they said the scan showed some small spots, which might, or might not be cancer, and they would follow up with me after Christmas 2022. Fortunately the urologist proceeded with the biopsy procedure, although he and his assistant were sure it wouldn't show anything serious. Well turned out two biopsy cores scored a 7 and an 8 on the Gleason scale. Had 44 radiation treatments and am going through ADT hormone therapy for 18 months, Ugh... I am not doing well with the side effects, bone mass and muscle tissue loss are significant. In any event, I would go to another Urologist with your results so far and get a 2nd opinion about getting biopsy done. I am going to get a 2nd opinion myself from another Oncologist as I'd really rather do something curative about the cancer rather than put it to "sleep" for 18 months and then find out at age 67 that metastasis has occurred. Good luck
I had a MRI with no showing. But later had a biopsy and PSMA scan and cancer was present. Gleason 8, but not outside my prostate. Now seeking the best possible treatment. Listening to all this, it's all a crap shoot. Changing diet, and metabolic may be the way for me.
"10" presentation Doc~
Thank you for this information. Where can these lists be downloaded for printing?
All the case studies were high volume disease. I’m curious if Dr. Kwon would still use Triplet Therapy for a pt with low volume disease?
My Prostate was removed and the PSI was 1.4 but I did'nt follow up due to Insurance and Jobs.Finally got Insurance & tested. My PSI is 43,400. At the Hospital now . I will update you.................
Praying for you.
Please reach to our helpline is you need any help: pcri.org/helpline
We stand with you and hope and pray for the best.
Next week is the date that I hear just how bad my cancer is. And seeing that dandelion portion of the video, just wants me to throw up my hands and say f it. I just hope that I have a fighting chance, but even the word fighting means that I lost.
My dad was diagnosed 18months ago at the age of 74 with prostate cancer, he’s undergone 4 surgeries then started taking chemotherapy, he took 8 sessions of chemo, just finished chemo last month, but again there’s prostate enlargement and blockage of urine.. Dr suggested surgery again but my Dad said I can’t undergo any further surgery because of poor health now. We are really worried about them, he’s pain in all body, he cries bcz of body ache.
What four surgeries? 🤔
Hello so sorry, perhaps he can see a pain management specialist
Urolift completely and permanently destroyed my life !!!! Now I am faced with my new urologist wanting to do another surgery (greenlight) to correct to the botched UROLIFT procedure.
I am told I would have to self catheterize everyday possible for the rest of my life. My symptoms now are WORSE than before Urolift. Please be advised and don't say I didn't warn you if you get this procedure !!!!!
Hoping AOH1996 will bear some benefit.
What are the sideeffeckts of chemotheraphi
Doctors / Survivors, need your help.. my dad is going through the advanced prostate cancer with metastatic to bones.. he went through turp surgery and then hormone therapy for few months, in Oct 2023 he had 3 cycles of Chemotherapy but the PSA went up to 59, chemo was stopped and given Enzalutamide for 2 months psa went down from 59 to 26, he felt better but eventually he started feeling the bone pain again ; now the doctors gave radiation therapy and apalutamide.. he is very drowsy, tired and I could see he is loosing his strength slowly; any other treatment methods or meds that I should check for my dad to get him back to the normal life.. we are from India and dad gets treated in Chennai .. I appreciate your comments or support to save our family!
My psa was 3.9 Gleason 9 , had surgery, 2 years later psa went up to.20 had radiation 37 treatments, 1 year later psa went to 6.8 been on Lupron for 3 years, so far psa .001 , but side effects are awful
What side effects, those of the ADT or of radiation? I am G9, have been on ADT, both generations, for 4 montgs and now contemplating radiation, but concerned about side-effects. Thank you for your comment.
My dad is 67 yrs old he has been diagnosed with prostate cancer which has metastised to the lymphnodes and pelvis girdle as per CT scan and mri with psa of more than 100 with Gleason of 8 he has been put on zoladex injection, zytiga and casodex for 3 months then once tumor burden has reduced he will start on radiation therapy, how aggressive is this treatment kindly reply many blessings to you all
I am 68 years old i got malignant biopsy on prostate i got surgery last 2021 and it was growing up 38 gm what should I do Sir?
Recently on a Joe Rogan podcast with Graham Hancock they discussed using a “repurposed” drug fenbendazole for cancer treatment. This treatment is becoming very popular because of the success rates.
Minimum downside with a cure on the upside. What do men have to loose?
Isn't that a dog wormer? Any clinical trials?
I looked into this, a lot of positive results from people who were out of options
Checkout the recent John Campbell’s YT on “Ivermectin and Cancers” in the comments are dozens of success es using IVM and Fen Ben, both anti parasitic safe drugs.
This video was very good but it doen't help in my husband's situation. He has been prescribed all categories of treatment but his PSA is rising - now 500. What are the next steps? His doctors have said therr is no available treatment at this present. A video about the next step would be helpful.
I would call the helpline of this pcri channel.
Is it possible to get this standard of treatment in Canada?
Hello, we are not able to answer case questions on our comment section but we can help you through our Helpline who can speak with you either by phone or email. Here is the link to contact them: pcri.org/helpline
Beverly Alejos n Harper Alejos ♥️
Have followed you for several years and wonder why you have now eliminated beam radiation from your list. Before, you have stated that radiology treatment like SBRT would become the standard for treating advanced metastic prostate cancer.
Opps - should have waited until the 95th minute. Sorry
🎯 Key points for quick navigation:
00:00:00 *🎓 Presentation Focus: Dr. Kwon introduces a presentation on advanced prostate cancer and its evolving treatment landscape, emphasizing the complexity and need for informed treatment strategies.*
00:01:09 *🚨 Problem Highlighted: Many patients with advanced prostate cancer are not offered the full range of available diagnostics and therapies, often due to the tendency to oversimplify treatment plans.*
00:02:06 *🏥 Diverse Influence: The management of prostate cancer is influenced by various entities including urologists, oncologists, insurance companies, and pharmaceutical companies, each with their own perspectives and agendas.*
00:03:36 *📚 Presentation Goals: Dr. Kwon aims to update the audience on advanced prostate cancer biology, clarify misunderstood terms, and provide a resource for optimal therapy decision-making.*
00:04:30 *🌿 Prostate Cancer Metaphor: Prostate cancer is likened to a dandelion, with cancer cells spreading like seeds throughout the body, leading to metastases.*
00:06:15 *🧬 Cancer Heterogeneity: Dr. Kwon explains the concept of cancer heterogeneity, where prostate cancer cells are genetically diverse, complicating treatment plans.*
00:07:56 *🔍 Cancer Cell Selection: When treatments are applied, certain resistant cancer cells may survive and proliferate, leading to treatment-resistant cancer.*
00:10:04 *💊 Array of Treatments: A range of systemic treatments is available to manage the heterogeneity of advanced prostate cancer, focusing on both suppressive and cytotoxic approaches.*
00:11:19 *⚔️ Treatment Classification: Systemic therapies for prostate cancer are categorized as either suppressive (putting cells into dormancy) or cytotoxic (killing cancer cells), each with differing longevity of effects.*
00:14:29 *🚀 Understanding MOA: Understanding the mechanism of action of different treatments is crucial for constructing an effective plan against prostate cancer.*
00:17:37 *🛡️ ARPIs Role: Androgen-receptor pathway inhibitors block mutated receptors in hormone-resistant prostate cancer, causing cancer cells to become dormant again.*
00:18:28 *🚨 Counterfeit Testosterone: Abiraterone targets cancer cells that produce counterfeit testosterone, shutting down this process and causing the cells to become dormant.*
00:20:41 *☢️ Radioligand Therapy: Radioligand therapy like 177 PSMA Lutetium targets specific proteins on cancer cells, delivering radiation to destroy them.*
00:21:55 *🏆 Treatment Strategies: The strategy is to use diverse treatments to manage prostate cancer heterogeneity, focusing on transitioning from one therapy to another to achieve potential cure.*
00:23:56 *🎯 Aggressive Approach: The approach to advanced prostate cancer treatment is aggressive and multifaceted, aiming for cure rather than serial palliative treatments.*
00:26:00 *💪 Triple Therapy: For newly diagnosed advanced prostate cancer, especially in healthy men, triple therapy combining hormone suppression, ARPIs, and chemotherapy is recommended for effective management.*
30:15 *📈 Rising PSA indicates hormone-resistant prostate cancer, where PSA should be undetectable during hormone therapy.*
31:32 *💊 Four ARPI agents are generally used after hormone therapy failure, providing a favorable response in about 75% of cases.*
32:42 *💉 Chemotherapy with docetaxel is favored for healthier patients failing hormone therapy, potentially more durable than ARPI agents.*
33:54 *🔄 Combined treatment with ARPI agents and taxane-based chemo is potentially superior, with positive results in 80-90% of patients.*
36:18 *🔄 Switching between different ARPI agents can sometimes lead to strong therapy responses due to varying mechanisms of action.*
38:02 *⚡ PSA levels are not always indicative of cancer progression, especially in advanced cases; imaging is crucial for monitoring.*
40:06 *🔍 Genetic testing is essential for therapy decisions, needing frequent updates due to the evolving nature of cancer genetics.*
43:48 *🚫 PARP inhibitors and checkpoint inhibitors may become viable options after multiple therapy failures due to cancer's genetic evolution.*
51:53 *🌟 Serial genetic testing helps identify mutations for targeted therapies, with PARP inhibitors showing a 33% response rate with certain mutations.*
54:11 *🎸 Serial genetic testing is crucial; it identifies candidates for immunotherapy or PARP inhibitors even after multiple failed treatments.*
00:59:14 *🏥 Mayo Clinic Approach: Surgery is used to eliminate residual cancer after systemic therapy, leading to significant reductions in PSA levels.*
00:59:43 *💥 Radiation Advancements: Stereotactic radiation, like SBRT, can effectively treat oligometastatic disease and prevent further therapy needs.*
01:01:19 *❄️ Minimal Invasive Procedures: Cryotherapy and thermal ablation are effective for residual disease after systemic treatment.*
01:02:17 *🌟 Full Spectrum of Care: Many patients are not offered the full range of advanced prostate cancer treatments due to misunderstandings of "standard of care."*
01:04:28 *🚦 Understanding "Standard of Care": It signifies the minimum acceptable treatment, not the gold standard. Patients should seek the highest levels of care.*
01:05:26 *🛤️ Role of Guidelines: Guidelines are important but flexible; patients should consider second opinions if told treatments are outside standard guidelines.*
01:06:22 *🧪 Clinical Trials Caution: Clinical trial treatments are not necessarily state-of-the-art, and success rates for new drugs are low.*
01:09:00 *📜 Informed Consent: Participation in trials is voluntary; patients can withdraw anytime without repercussions.*
01:09:45 *🧠 Complex Management: Advanced prostate cancer care is multifaceted but manageable with the right guidance and treatment plans.*
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What about the new treatment vidh laser, to heat upp the tumor, Clinical Laser system from Sweden have invent this , i th8nk you have this system
Interesting
My father had a surgery first week of this year 2024
PCRI needs to comment on this recent revelation.
>>Undetectable levels of Prostate Specific Antigen (PSA) have been reported from the first patient with metastatic castrate-resistant prostate cancer (mCRPC) to ever receive two cycles of Clarity’s 67Cu-SAR-bisPSMA at the 8GBq dose level. PSA is a marker of tumour burden, clinical response to treatment and an indicator of the recurrence of disease for prostate cancer.
The response you're looking for is in this video: 1:05:58 Clinical trials
@@FightingProstateCancer clinicaltrials.gov/study/NCT04868604
@@FightingProstateCancer The link to the clinical trial for Cu67 has been removed. Twice.
@@DCGreenZone It's only a trial in Phase 1, nothing fancy so far.
@@FightingProstateCancer Phase 1 2A From what I see, and I watched the videos on how it works, Pluvicto hangs onto cells for hours, the double radio ligand Cu67 hangs on for days iirc. There are videos in here.
Wouldn't chemotherapy be safer without the hormone deprivation?? Why do they need it if the chemotherapy is killing the cancer? Wouldn't the hormone deprivation supress the immune system and allow inflammation to run wild etc, etc?
Having listened to this I want to die even more . I do not see the point of living like this
Gentlemen, grab your ankles!
Está enfermedad es difícil con tratamiento imaginen aquellos que no lo tenemos Dios termina con el sufrimiento del pueblo cubano
It is unethical to recommend "curative pathways for treatment of advanced prostate cancer." Metastatic prostate cancer is not curable in over 99% of patients - it is a lethal disease. "Curative" should be replaced with the word "aggressive"