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The Broken Science Initiative
United States
Приєднався 1 сер 2022
In 2022, Greg Glassman and Emily Kaplan launched The Broken Science Initiative to free any man from the tyranny of broken science and its scientists. Through a shared interest in the replication crisis in medicine, this intellectual exploration led to a fascination with predictability and the lack of probability theory in most of science (we joke, all the ologies and medicine). We'll break down why p-values, confidence intervals, and a misplaced emphasis on method are tools of Broken Science. Then we'll share alternative ways of deriving validation --in fact, we'll argue our ways are the only real ways to find predictable outcomes. We will show you how and why we've gotten things so dangerously wrong, who's responsible and hopefully provide you with a new perspective on what science is and what it is not. When predictive value is replaced by consensus thinking, one is left with nonsense that won't replicate, that's Broken Science.
Chris Palmer - Brain Energy: The Metabolic Theory of Mental Disorders and New Treatment Strategies
Chris Palmer - Brain Energy: The Metabolic Theory of Mental Disorders and New Treatment Strategies
Переглядів: 21 070
Відео
Cancer as a Mitochondrial Metabolic Disease: Thomas Seyfried
Переглядів 69 тис.28 днів тому
Cancer as a Mitochondrial Metabolic Disease: Thomas Seyfried
Emily Unleashed Bonus Ep: Anton Garrett & James Franklin
Переглядів 347Місяць тому
Emily Unleashed Bonus Ep: Anton Garrett & James Franklin
Emily Unleashed Episode 7 with James Franklin
Переглядів 559Місяць тому
Emily Unleashed Episode 7 with James Franklin
Emily Unleashed Episode 6 with Dr. Ed Calabrese
Переглядів 450Місяць тому
Emily Unleashed Episode 6 with Dr. Ed Calabrese
Emily Unleashed Episode 5 with Josh Vietti
Переглядів 182Місяць тому
Emily Unleashed Episode 5 with Josh Vietti
PREVIEW: Emily Unleashed Episode 3 with Pashtana Durrani
Переглядів 169Місяць тому
PREVIEW: Emily Unleashed Episode 3 with Pashtana Durrani
MetFix-The Metabolic Fix, coming soon #bsi #gregglassman
Переглядів 1,5 тис.Місяць тому
MetFix-The Metabolic Fix, coming soon #bsi #gregglassman
Emily Unleashed Episode 4 with Dr. Jay Bhattacharya
Переглядів 6 тис.2 місяці тому
Emily Unleashed Episode 4 with Dr. Jay Bhattacharya
Emily Unleashed Episode 3 with Pashtana Durrani
Переглядів 2482 місяці тому
Emily Unleashed Episode 3 with Pashtana Durrani
PREVIEW: Emily Unleashed Episode 2 with Dr. Drew
Переглядів 1682 місяці тому
PREVIEW: Emily Unleashed Episode 2 with Dr. Drew
The Three-Dimensional Definition of Fitness and Health
Переглядів 8682 місяці тому
The Three-Dimensional Definition of Fitness and Health
Emily Unleashed Episode 2 with Dr. Drew
Переглядів 7172 місяці тому
Emily Unleashed Episode 2 with Dr. Drew
Emily Unleashed Episode 1 with Adam Carolla
Переглядів 2,8 тис.2 місяці тому
Emily Unleashed Episode 1 with Adam Carolla
PREVIEW: Emily Unleashed Ep. 1 - Adam Carolla
Переглядів 6432 місяці тому
PREVIEW: Emily Unleashed Ep. 1 - Adam Carolla
Journal Club 2 Preview: The Broken Science Initiative
Переглядів 2543 місяці тому
Journal Club 2 Preview: The Broken Science Initiative
The Method and Meaning of True Science - Greg Glassman
Переглядів 1 тис.3 місяці тому
The Method and Meaning of True Science - Greg Glassman
Evolution of the Revolution Tour. New dates added.
Переглядів 1313 місяці тому
Evolution of the Revolution Tour. New dates added.
Sunday Discussion, Part 3: Epistemology Camp 2024
Переглядів 3144 місяці тому
Sunday Discussion, Part 3: Epistemology Camp 2024
Sunday Discussion, Part 2: Epistemology Camp 2024
Переглядів 3495 місяців тому
Sunday Discussion, Part 2: Epistemology Camp 2024
Sunday Discussion, Part 1: Epistemology Camp 2024
Переглядів 7935 місяців тому
Sunday Discussion, Part 1: Epistemology Camp 2024
5 Buckets of Death | And The Covid Trashcan Fire
Переглядів 11 тис.6 місяців тому
5 Buckets of Death | And The Covid Trashcan Fire
Intersections of Probability, Philosophy, and Physics: Anton Garrett
Переглядів 1,6 тис.6 місяців тому
Intersections of Probability, Philosophy, and Physics: Anton Garrett
THANK YOU!! More people need to hear this 👏🏻👏🏻👏🏻
Government is a fraud magnet.
😳!!!!
Wow
MEN cause depression in women then they profit from it. They have no interest in fixing it because it's their cash cow.
🥩🧈🥓🍳 that's the cure for Alzheimer's
The big pharma might not be fond of this idea. I hope Prof. Seyfried stays well and healthy! Thank you for your research ❤
Soooo close to the truth. Missing the requirement for invasiveness. Cancer Is A Metabolic Disease aka Invasive Inflammation Malignant Neoplasia is a multifaceted metabolic disease that has at least three requirements. First, Apoptosis needs to be turned off via dysfunction of the Mitochondria and/or the Mitochondrial - Lysosomal Interaction, down-regulation of Death Receptors and/or Endoplasmic Reticulum dysfunction. Second, “fuel(s)” or out-of-range hormone(s) need be present ie: insulin, cortisol, prolactin, estrogen, progesterone, androgens like testosterone, etc (these first two make up the cellular definition of inflammation.) Examples of fuels: Alcohol alters many hormone levels, sugars and carbohydrates are the driver of elevated fasting insulin, stress is the driver of elevated cortisol and prolactin, endocrine disruptors like corticosteroids lower TSH, LH, etc and birth controls alter estrogen, progesterone and other levels, etc. And third is Nuclear Alterations need be present which allow the cells to become invasive, this is through disruption of the Wnt/β-catenin signaling pathway which controls cellular replication. Nuclear Alterations can be caused by dysbiosis, malnutrition and carcinogens, some of which also act as fuels and are toxic enough to turn off the Apoptosis pathways like Alcohol, Tobacco Products, Certain Chronic Fungal, Viral, Bacterial and Parasitic Infections, Birth Control, etc. How to treat properly = remove the carcinogen(s) + change to an organic ketogenic or carnivore diet + use extremely high doses of specific antioxidants that have very low toxicity to healthy cells (Cannabinoids, Astaxanthin, Alpha and Beta Santalol, Linalyl Acetate and Linalool, Vitamin D, IV Vitamin C, Punicic Acid, Anthocyanins, Polyphenols, etc.) + repair the gut microbiome using specific dietary additions (ACV Pickles, Kimchi, Sauerkraut, Olives, etc) and probiotics (60B Probiotic Blend, Lactobacillus Salivarius.) Oxidative stress and metabolic diseases: Relevance and therapeutic strategies www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.994309/full Cancer as a metabolic disease nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-7-7 Cancer as a Metabolic Disorder www.ncbi.nlm.nih.gov/pmc/articles/PMC8835572/ Cancer as a metabolic disease: implications for novel therapeutics www.ncbi.nlm.nih.gov/pmc/articles/PMC3941741/ Cancer and Obesity: The Link is Insulin medicine.yale.edu/news-article/cancer-and-obesity-the-link-is-insulin/ Diabetic-level glucose spikes seen in healthy people med.stanford.edu/news/all-news/2018/07/diabetic-level-glucose-spikes-seen-in-healthy-people.html New Clarity on the Warburg Effect www.cancer.gov/research/key-initiatives/ras/news-events/dialogue-blog/2021/vander-heiden-warburg-effect Ivermectin: A Multifaceted Drug With a Potential Beyond Anti-parasitic Therapy pmc.ncbi.nlm.nih.gov/articles/PMC11008553/ Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways www.nature.com/articles/s41598-018-30158-6 Wnt/β-catenin signaling: function, biological mechanisms, and therapeutic opportunities www.nature.com/articles/s41392-021-00762-6 Wnt signaling in cancer www.nature.com/articles/onc2016304#:~:text=The%20APC%20gene%20was%20found,4/%CE%B2%2Dcatenin%20signaling.&text=These%20findings%20established%20a%20direct,signaling%20and%20human%20colorectal%20cancer. Wnt/β-catenin signaling in cancers and targeted therapies www.nature.com/articles/s41392-021-00701-5#:~:text=As%20an%20evolutionarily%20conserved%20signaling,%2Dcatenin%2Dassociated%20targeted%20therapies. Targeting the Wnt/β-catenin signaling pathway in cancer pmc.ncbi.nlm.nih.gov/articles/PMC7716495/#:~:text=The%20aberrant%20Wnt/%CE%B2%2Dcatenin,%CE%B2%2Dcatenin%20signaling%20in%20cancer. Apoptosis www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/apoptosis#:~:text=Mitochondria%20play%20a%20central%20role,Danial%20and%20Korsmeyer%2C%202004). Lysosomal-mitochondrial cross-talk during cell death www.sciencedirect.com/science/article/pii/S1567724910001376#:~:text=lysosomal%20content%20into%20the%20cytosol%20can%20initiate,links%20to%20the%20mitochondrial%20cytochrome%20c%20release Connecting lysosomes and mitochondria - a novel role for lipid metabolism in cancer cell death pmc.ncbi.nlm.nih.gov/articles/PMC6664539/ Caspase‐mediated programmed cell death pathways as potential therapeutic targets in cancer pmc.ncbi.nlm.nih.gov/articles/PMC6495317/#:~:text=Caspases%20are%20involved%20in%20two,subsequently%20activated%20by%20caspase%E2%80%909 The Death Receptor Pathway of Apoptosis pmc.ncbi.nlm.nih.gov/articles/PMC8805650/ Mitochondrial apoptosis: killing cancer using the enemy within www.nature.com/articles/bjc201585 The Mitochondrion www.ncbi.nlm.nih.gov/books/NBK26894/#:~:text=Mitochondria%20can%20use%20both%20pyruvate,fatty%20acids%20come%20from%20fats. 3 Genetics and Health www.ncbi.nlm.nih.gov/books/NBK19932/#:~:text=Although%20there%20are%20many%20possible%20causes%20of ***Analyzing the role of cannabinoids as modulators of Wnt/β-catenin signaling pathway for their use in the management of neuropathic pain pubmed.ncbi.nlm.nih.gov/30871771/ ***Cannabidiol regulates apoptosis and autophagy in inflammation and cancer: A review pmc.ncbi.nlm.nih.gov/articles/PMC9899821/ ***Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression pmc.ncbi.nlm.nih.gov/articles/PMC3005548/ Needs To Be Taught In Medschool: - [ ] The Gut Microbiome & Dysbiosis - [ ] The EndoCannabinoid System - [ ] Liver-Renal Axis & Lipogenesis - [ ] Inflammation and Metabolic Diseases - [ ] Natural Low Toxicity Antioxidants in Full Spectrum Form - [ ] Proper Nutrition & Diet All Human Ailments Stem From One Or More Of The Following: - [ ] Acute Cell Death - [ ] Acute Inflammation - [ ] Chronic Inflammation - [ ] Dysbiosis - [ ] Infection - [ ] Malnutrition - [ ] Physical Trauma - [ ] Truly Genetic (5%) - [ ] Birth Defects (3%) - 20% of which are genetic
I don't think we mostly ate meat in our ancient past. Likely it is the opposite with very little meat according to current peer reviewed research
Yesss! Finally! Halleluja! Thank you, thank you, thank you! Some 20+ years ago, being obese and a wreck after several waves of burnout, I was called depressed but could feel in the core of my soul that wasn't the problem, so I rejected the pills. Started testing and investigating, vitamins and minerals, amino acids and low carb diets. I got better. Still obese but less so. Diagnose of PTSD and eventually hypothyrodism (after having been called hypocondriac for four years). Constant stress, got double sided iritis from the shock (but succeeded to heal myself from this incurable disease). Fast-forward to 2022. I am still unable to work (totally arbitrary sleep patterns and non-functional GI system, now mostly controlled by stomach enzymes and Betaine HCl) one health care worker started seeing a pattern. Psychologists investigated: Asperger's. Remembering that the psychiatrist dr William Walsh had found that 96% of 3000 of his patients with Asperger's had a mutation in the MTHFR gene, I compared my own earlier findings about needed supplements with his prescribed panel of supplements. It coincided almost to the T with my own. I'm so glad science is catching up. Maybe I may even get som actual help before it's too late. Hoping at least that I co-inspired someone to give diet and nutrients a try.
What is the research of Prof Thomas Seyfried on Mega Dose Vitamin D
Dr Matthew Phillips, a neurologist living in Hamilton New Zealand . He is originally Canadian and is head of Neurology at his hospital. The role of mitochondria and our metabolism is at the very heart of neurological disorders. He is a pioneer in his field and gives lectures internationally. He has been conducting clinical studies over the past few years . nosilverbullet4pd
Where can a mother in Mississippi get help for her son??? Please I want to get involved. I want to help however I can, starting with my son ❤️🙌🏼❤️
Professor have you ever studied mitochondria in Rett syndrome? My daughter has been 32 years in to this Syndrome. I am always searching how to improve her life. Mitochondria in Rett syndrome are swollen, also Mitochondria in Rett have altered respiratory rates and leaks protons. Thanks
wow honestly I dont understand how people can do this. are they really that stupid and unknowledgeable? did they never present their study in WIPs or conferences ? noone thought it was dodgy? IT GOT PUBLISHED?? science really isnt what my profs in undergrad made it out to be... now that I have a PhD myself I left the field... too much bullshiting from people pretending they only care about knowledge and not the prestige and money and bullshiting.
Yes. It's a horror I've had to go broke fighting cancer....and do it on my own, as no insurance will cover any method except chemo
When I heard this doctor trying to push statins on people I knew he was batting the wrong way
Well, that’s what happens when objective truth is no longer valued.
once you go carnivore, everything gets better... sleep quality, thinking, movement, agility, vision... my 1600m swim time got 3 mins faster after cutting out carbs and going full (90%) carnivore. Just like pretty much everything else the government tells you, its 180 degrees wrong. We have to take back responsibility from the corrupt medico/pharma cabal. Do your research... see how medicine was corrupted by Rockefeller in 1913. I wish you well in your journey of truth...
The metabolical HYPOTHESIS of mental disorder and IF in the future the HYPOTHESIS isn’t disprove THEN treatment(s) …
He's got a promising career in pharmaceuticals and / or government health agencies. I hear Fauci is looking for an assistant. Rule 1 it's more important to seem right than to be right.
Redox Signaling Molecules are the foundation of cellular health. If your cells aren't healthy you can't be healthy. I drink them every day to replenish them
What if someone doesn't have insurance and can't afford treatment?
So interesting coming from a wonan who had ER breast cancer 3 years ago . Had mastectomy, radiation but refused chemo as all pushed on to me . Then oh you must take letrozole for 5/10 years . A hormones blocker . Horrendous side effects. I did my own research on everything i could find . I was on hrt before diagnosis. Told to immediately stop yet my estrogen level monday gone is the same as back in 2022 . Scratching my head , so all those side effects yet wasn't lowering my estrogen. Ps stopped taking letrozole few weeks back . My poor body just suffering . Oh and recently taking L glutamine for muscle, joints . Threw them in the bin . 😮
So should we give up all fermented foods?
The relationship between cancer and metabolism isn’t a straightforward cause-and-effect scenario; rather, for cells to become cancerous, they must go through numerous steps and acquire a range of complex characteristics. These include proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and activating invasion and metastasis, as well as reprogramming energy metabolism and evading immune detection. Achieving this intricate array of changes requires multiple genetic, chemical, physical, and electrical alterations, painting a picture of immense complexity. Consequently, while there are many potential targets for treatment, pinpointing the specific few that could disrupt this formidable machinery remains a significant challenge.
I had radiation and only my left leg has Edema they can’t find the cause it blows up twice the size of my right leg and the pain from radiation was intense from rectal cancer. I should sue 31:14
I am going through chemo now and I think it’s killing me breaking down my bones they are weaker than normal. I am changing my diet to keto
Great!!! This information is really good... Planet Ayurveda's Neuroplan syrup is one of the best for brain health and boosting the memory.
I’m wondering about the Research out of University of Louvain , France where tumours disintegrate in the presence of DHA.
It might have something to do with late stage capitalism
Agree. Humans are mammals. People weren't designed for oppression. It's literally breaking us.
No, salt causes diabetes.
Big Pharma will NEVER let Cancer be cured. At $10,000+ per treatment it's their biggest Cash Cow! 💰
A bit tangential, but illustrating how even intelligent, educated people can find it hard to change mindset and habits. In the early 2000s, I attended a physicians’ luncheon during a neurosurgical conference in Italy. Stunned to see a thick blue haze of cigarette smoke hanging in the air. Culture shock. 😏
Personally I was blessed with an easily recognizable metabolic dyscrasia. I say this even though I had to figure it out on my own. This Doctor has figured it out for sure. Unfortunately, most of his colleagues are still living in the dark ages. I returned to a normal symptom free metabolism. My particular disorder was rife with not only physical symptoms (obesity, cancer, murmur, etc.) but mentally challenging symptoms (paranoia, anxiety, phobias worsening, etc.). Mild autonomous cortisol secretion from a tumor in my adrenal gland was excised leading to a full metabolic recovery. The battle was convincing my professional healthcare providers.
What about ovarian cancer
I like this Dr!!❤
Please can you use multi language close captions so we can share this to ppl who don't know English or post a link to the ppt , l need a way to translate this to Romanian for my parents
How come narcolepsy and catalepsy ain't on the mental illness??????????????
Yes I'm sure loneliness has a lot to do with it but I sure think that a hell of a lot of it is the food supply as well do people remember you are what you eat and we all eat a bunch of toxic poison food that's not real at all
Speaking to the choir Dr. Dhand. Years back my dentist worked out of an older house in a small town and he always took care of my oral needs. Since moving several hours from that location another dentist was in order. I’ve attended dental schools, UNC chapel Hill, ECU in Greenville to name names. They go through the same routines you mentioned in your video. So we know where they are taught these money grabbing techniques. Currently, visited a recommended dentist in Greenville, NC after several months of waiting due to their patient back log, totally under that. Before the dentist would ask about my problem I had to get an assessment and a gum measurement, very nice you lady, very pleasant. Then the Dentist came in very stoic and said you need this, this and this. Well Dr. I have problem with a previous root canal from a dental school. He said we’ll come back for a cleaning and we will go from there. He would not address my problem without me have roughly paid 600.00 and three visits in total. I just want the tooth removed. Getting on my soap box now, what the hell happened to the ole school dentist that initially would ask what are you here for today. On another similar note the Veterinarian are sailing this same ship.
Are you replying to the correct talk?
Bring back the temples of Asclepius.
This is a meritorious discussion, I feel.
Amazing man hope he does not have an accident…….
I forgot to thank you for answering my question. Appreciate it!
Mitochondria from mother. ? Imprinting dysfunction?
This is the beginning of the end of the medicine as we know it. The reductionist nature of it is what's going to kill it. The topics discussed here have been known and explored by eastern medicine it for over 5 thousand years. You cannot separate mind, body and spirit!
When talking about asd in previous videos, he's mentioned that genetics don't determine genetic expression. What does this mean? If autism is metabolic then why do autistic people have different brain structures? Or is the brain structure a result of metabolism??
I believe these are not opposing views, but rather both are true at the same time. As i understand it, autism is (usually) a genetic/structural abnormality that makes certain parts of your brain extremely vulnerable to metabolic dysfunction. And that metabolic dysfunction can then reflect back in structural development of the brain. Plus, this is in itself very simplified because other things play into it as well (gut microbiome, trauma... etc. etc. - have a look at the graphic at 28:00) Throughout the history of medicine and science people have been looking for a single root cause of illnesses and disorders. Sometimes there is one (you get bitten by an infected mosquito - you get malaria). But things like autism, depression, schizophrenia, autoimmune conditions etc. don't usually have a single root cause, they're caused by a complex interplay of a huge number of factors, internal and external.
A complex of a huge number of factors is an intrinsic part of our lives.
Metabibolis disorders? Nah, poor parenting causes disheveled, non-functioning lives. And big pharma does not cure, or help, except in crisis.
Most of today's mental illness is caused by the bad Western diet. Too much sugar and processed food. And low fat diets, the brain needs fat.