Celebrating DNA Double Helix's 70th
Celebrating DNA Double Helix's 70th
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Відео

Closing Remarks by Sunney Xie
Переглядів 376 місяців тому
Closing Remarks by Sunney Xie
Tom Maniatis - The Protocadherin Gene Cluster: A Bar Code Generator for Single Neuron Self-Recogniti
Переглядів 686 місяців тому
Professor Maniatis discussed the mechanisms by which clustered Pcdh genes regulate the distribution of serotonergic neurons in the brain. He emphasized the importance of individual neurons accurately distinguishing "self" from "non-self", and mechanisms that prevent neurites from the same neuron to form synaptic connections. Through their research, Professor Maniatis's team discovered that the ...
Xiaoqun Wang - Human Brain Genomics: A Journey through Development, Evolution and Disease
Переглядів 326 місяців тому
The presentation primarily focused on the classification, distribution, and development of neural progenitor cells, including radial glial cells (RG cells), intermediate progenitor cells (IPC) and outer radial glial cells (oRG). Through techniques such as single-cell sequencing and spatial transcriptomics, Professor Wang's team decoded the molecular characteristics of various types of neural pr...
Dennis Lo - Creating a Paradigm Shift in Prenatal Diagnostics using Circulating DNA
Переглядів 376 місяців тому
Professor Lo developed an interest in prenatal testing when he was a medical student at the University of Oxford. He dreamt about the possibility of testing fetal DNA and chromosomes just from a peripheral blood sample from the pregnant mother. He made a breakthrough in 1997 when he boiled maternal blood plasma and showed that he was able to observe a Y-chromosomal DNA PCR signal in samples obt...
Joseph Ecker - What Lies Above? Mapping the Human Brain Epigenome
Переглядів 656 місяців тому
Professor Ecker highlighted the potential impact of DNA methylation in brain cells on human cognitive abilities. He discussed how this specific DNA methylation in the brain primarily occurred at CH sites and was closely associated with synaptic events, particularly around birth. Employing snm3C-seq technology, which allowed for the simultaneous measurement of DNA methylation and chromatin confo...
Hesheng Liu - Advances in Functional Brain Imaging Technology
Переглядів 206 місяців тому
Hesheng Liu - Advances in Functional Brain Imaging Technology
Jie Qiao - Searching for Keys from the Genome: Thirty Years of PGT
Переглядів 196 місяців тому
Jie Qiao - Searching for Keys from the Genome: Thirty Years of PGT
Live Sand Painting Performance of DNA Double Helix 70
Переглядів 76 місяців тому
Live Sand Painting Performance of DNA Double Helix 70
Don Cleveland - Designer DNA Drug Therapy for Neurodegenerative Disease
Переглядів 596 місяців тому
Professor Cleveland discussed the molecular mechanisms underlying various gene mutations associated with neurodegenerative diseases and the use of antisense oligonucleotides (ASOs) in treating these conditions. Professor Cleveland's team discovered that ASOs can enter neurons and selectively pair with mRNA, resulting in RNA degradation and the inhibition of gene expression. Leveraging this feat...
Xiaodong Wang - Dissecting Biochemical Pathways of Regulated Cell Death
Переглядів 556 місяців тому
Professor Wang introduced the biochemical pathways of aging in the mammalian reproductive system. He illustrated the pathways of programmed cell apoptosis and necrosis, providing an overview of his team's research on regulating the signaling pathways of programmed cell death. Next, he delved into the discovery of the protein kinase RIP3 and associated MLKL, elucidating the molecular mechanisms ...
Bing Ren - Unlocking the Genome’s Regulatory Code
Переглядів 1116 місяців тому
The human genome is the blueprint of life. Its 3-billion base DNA encodes the information necessary for the development of the human body from fertilized eggs to adults. Tiny changes in this blueprint underlie the phenotypic traits and disease risks of each person. Reading this book of life, however, has been difficult because only a tiny fraction (1.5%) of the genome is functionally annotated ...
Feng Shao - Pyroptosis: From Antibacterial Immunity to Antitumor Immunity
Переглядів 1206 місяців тому
Professor Shao reviewed the discovery of pyroptosis and a key molecule in the pathway, Gasdermin-D. Bacterial lipopolysaccharide (LPS) regulated the non-canonical inflammasome/pyroptosis in antibacterial defense and sepsis. LPS also modulated IL-18 activation through Caspase-4 rather than Caspase-11. Caspase-4/pro-IL18 complex crystal structure revealed a recognition mechanism resembling the re...
Robert Langer - From Nanotechnology to mRNA Vaccines
Переглядів 436 місяців тому
Professor Langer discussed how he applied his chemical engineering background to addressing basic and applied issues in the life sciences,starting with his postdoctoral research with Judah folkman where they isolated the first angiogenesis inhibitors. Critical to this was developing biocompatible nanoparticle and microparticles that could deliver large molecular weight molecules- which the angi...
Yunlong Cao - Broad-spectrum SARS-CoV-2 Therapeutics and Prophylactics designed based on Viral Evolu
Переглядів 2956 місяців тому
In this report, investigator Yunlong Cao systematically introduced the work conducted by his group about SARS-CoV-2 evolution prediction and the development of broadly neutralizing antibodies. He pointed out that SARS-CoV-2 is undergoing continuous evolution, giving rise to numerous immune-evasive mutants. Furthermore, the pace of viral mutation surpasses that of vaccine and antibody drug devel...
Zemin Zhang - Tumor Heterogeneity at the Microenvironment Level and its Implication in Personalized
Переглядів 356 місяців тому
Zemin Zhang - Tumor Heterogeneity at the Microenvironment Level and its Implication in Personalized
Long Cai - Spatial Genomics
Переглядів 2866 місяців тому
Long Cai - Spatial Genomics
William Greenleaf - Exploring the Physical Genome
Переглядів 846 місяців тому
William Greenleaf - Exploring the Physical Genome
Fuchou Tang - Single Cell Omics Sequencing Technologies: The Third Generation
Переглядів 526 місяців тому
Fuchou Tang - Single Cell Omics Sequencing Technologies: The Third Generation
Yi Zhang - 5mC Oxidation and Beyond
Переглядів 516 місяців тому
Yi Zhang - 5mC Oxidation and Beyond
Yiqin Gao - Relating Cell State Dependent Methylation to the DNA Sequence and 3D Genome
Переглядів 86 місяців тому
Yiqin Gao - Relating Cell State Dependent Methylation to the DNA Sequence and 3D Genome
Zhijian “James” Chen - The Dark Side of DNA - How the Immune System Senses DNA as a Danger Signal
Переглядів 586 місяців тому
Zhijian “James” Chen - The Dark Side of DNA - How the Immune System Senses DNA as a Danger Signal
Tak Wah Mak - Neuro-immune Modulations in Health and Diseases
Переглядів 396 місяців тому
Tak Wah Mak - Neuro-immune Modulations in Health and Diseases
Feng Zhang - Exploration of Biological Diversity to Improve Human Health
Переглядів 3746 місяців тому
Feng Zhang - Exploration of Biological Diversity to Improve Human Health
Wensheng Wei - Gene Editing and Beyond
Переглядів 186 місяців тому
Wensheng Wei - Gene Editing and Beyond
Fred Alt - The Fundamental Mechanistic Roles of Chromatin Loop Extrusion in Antibody Gene ...
Переглядів 556 місяців тому
Fred Alt - The Fundamental Mechanistic Roles of Chromatin Loop Extrusion in Antibody Gene ...
Yanhui Xu - Structural Insights into Transcription Initiation
Переглядів 276 місяців тому
Yanhui Xu - Structural Insights into Transcription Initiation
Xiangdong Fu - RNA: Beyond a Message from DNA to Protein
Переглядів 406 місяців тому
Xiangdong Fu - RNA: Beyond a Message from DNA to Protein
Yanyi Huang - Fluorogenic DNA Sequencing
Переглядів 186 місяців тому
Yanyi Huang - Fluorogenic DNA Sequencing
Sunney Xie - The Central Dogma Choreography: Regulation of Gene Modules via Transcription Factor
Переглядів 546 місяців тому
Sunney Xie - The Central Dogma Choreography: Regulation of Gene Modules via Transcription Factor

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