Xiaodong Wang - Dissecting Biochemical Pathways of Regulated Cell Death

Professor Wang introduced the biochemical pathways of aging in the mammalian reproductive system. He illustrated the pathways of programmed cell apoptosis and necrosis, providing an overview of his team's research on regulating the signaling pathways of programmed cell death.
Next, he delved into the discovery of the protein kinase RIP3 and associated MLKL, elucidating the molecular mechanisms that underlied programmed cell necrosis. Their research involving the deletion of RIP3 and MLKL genes in male and female mice revealed that RIP3, as opposed to MLKL, played a pivotal role in overseeing the aging process of the male and female reproductive systems. Specifically, RIP3 was found to oversee programmed necrosis in male mice by influencing spermatogonial stem cells, and in female mice, it regulated apoptosis in ovarian granulosa-luteal cells. In summary, the research outlined how RIP3 governed the aging of the mammalian reproductive system.