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Marc Bubbs
United Kingdom
Приєднався 27 сер 2013
Welcome! I am Dr. Marc Bubbs.
For the last 15+ years I've worked as Performance Nutritionist, author, speaker and consultant for a portfolio of professional and Olympic athletes and Fortune 100 companies.
My plan with this podcast is to connect you with world-class experts in their field so you can perform your best at work, home and play (whether it's in the gym, on the field, outside in nature!).
For the last 15+ years I've worked as Performance Nutritionist, author, speaker and consultant for a portfolio of professional and Olympic athletes and Fortune 100 companies.
My plan with this podcast is to connect you with world-class experts in their field so you can perform your best at work, home and play (whether it's in the gym, on the field, outside in nature!).
The MOST Important Factor for Longevity
In this clip, Marc sits down with Dr. Michael Roizen, MD, of the Cleveland Clinic and 7x NY Times best-selling author.
SUMMARY
tbd
LINK TO DR. ROIZEN:
Twitter: x.com/DrMikeRoizen
...
CONNECT:
Website: www.drbubbs.com/
Instagram: drbubbs
BOOKS:
Peak: The New Science of Athletic Performance That Is Revolutionizing Sport (#1 BEST SELLER)
www.amazon.com/Peak-Science-A...
Peak40: The New Science of Midlife Health for a Leaner, Stronger Body and Sharper Mind.
www.amazon.com/Peak-40-Scienc...
COACHING:
High Performers/Executives: www.drbubbs.com/peak40coaching
Athletes: www.drbubbs.com/athletecoaching
SUMMARY
tbd
LINK TO DR. ROIZEN:
Twitter: x.com/DrMikeRoizen
...
CONNECT:
Website: www.drbubbs.com/
Instagram: drbubbs
BOOKS:
Peak: The New Science of Athletic Performance That Is Revolutionizing Sport (#1 BEST SELLER)
www.amazon.com/Peak-Science-A...
Peak40: The New Science of Midlife Health for a Leaner, Stronger Body and Sharper Mind.
www.amazon.com/Peak-40-Scienc...
COACHING:
High Performers/Executives: www.drbubbs.com/peak40coaching
Athletes: www.drbubbs.com/athletecoaching
Переглядів: 230
Відео
Iron Deficiency in Women & Impacts on the Brain
Переглядів 27121 день тому
In this clip, Marc sits down with Dr. Georiga Ede, MD, psychiatrist to discuss how nutrition can impact mental health. SUMMARY 0:05 - Protein and ageing and the brain 0:35 - Key micronutrients for brain health 1:25 - Who might benefit from a micronutrition supplement? 1:55 - What impairs digestion as we age? 2:40 - Why the brain needs iron? 3:50 - Mental health and kids - advice for parents 4:4...
5 WORST Foods for Your Brain & Longevity
Переглядів 96921 день тому
In this clip, Marc sits down with Dr. Michael Roizen, MD, of the Cleveland Clinic and 7x NY Times best-selling author. SUMMARY tbd LINK TO DR. ROIZEN: Twitter: x.com/DrMikeRoizen ... CONNECT: Website: www.drbubbs.com/ Instagram: drbubbs Twitter: x.com/DrBubbs BOOKS: Peak: The New Science of Athletic Performance That Is Revolutionizing Sport (#1 BEST SELLER) www.amazon.com/Peak-Sc...
The Power of Protein for Brain Health & Mood
Переглядів 80721 день тому
In this clip, Marc sits down with Dr. Georiga Ede, MD, psychiatrist to discuss how nutrition can impact mental health. SUMMARY 0:05 - Impact of protein on brain health 1:20 - How much protein is optimal to eat for the brain? 2:45 - Essential amino acids - why meat is key for the brain 4:25 - Key nutrients for the brain 6:05 - Phytates and mineral absorption 7:00 - Importance of iron for the bra...
How To Overcome Fear in Midlife to Learn New Skills?
Переглядів 2828 днів тому
In this clip, Bubbs interviews Steven Kotler, best-selling author, journalist and entrepreneur. SUMMARY 0:05 - Ego, shame and how it impacts your ability to take on new challenge 1:20 - Steven's greatest fear in overcoming challenges 2:45 - Why it's key to 'know' how you like to learn 3:45 - Why you should LIMIT expectations 5:25 - What happens when you feel fear? LINKS STEVEN'S WORK: Twitter: ...
8 Key Tests for Living Longer (From Your Doctor)
Переглядів 110Місяць тому
In this clip, Marc sits down with Dr. Michael Roizen, MD, of the Cleveland Clinic and 7x NY Times best-selling author. SUMMARY 0:05 - 8 key tests for longevity summarized 1:00 - Blood pressure and cholesterol profiles 2:05 - Inflammatory markers to track 3:05 - Why and are key to healthy ageing 4:25 - Where Dr. Roizen starts with patients? 6:10 - Why friendship is key to longevity? LINK TO DR. ...
How Chronic Inflammation WORSENS Mental Health
Переглядів 47Місяць тому
In this clip, Marc sits down with Dr. Georiga Ede, MD, psychiatrist to discuss how nutrition can impact mental health. SUMMARY 0:05 - State of mental health in today's world 1:30 - Root causes of mental health challenges? 2:30 - What causes chemical imbalances in the brain? 4:00 - How chronic inflammation hampers the brain? 5:10 - Pitfalls of sugar on brain health LINK TO DR. GEORGIA: Twitter: ...
How to Get Into 'Flow' in Your 40s and 50s
Переглядів 39Місяць тому
In this clip, Bubbs interviews Steven Kotler, best-selling author, journalist and entrepreneur. SUMMARY 0:01 - What does flow optimize? 1:00 - What does 'stretch but not snap' mean? 2:30 - Why 'play' is key as you get into your 40s and 50s. 4:00 - How 'dynamic motion' helps to build a better brain 5:15 - VO2 max and longevity LINKS STEVEN'S WORK: Twitter: x.com/steven_kotler ... CONNECT: Websit...
How Your Brain Changes in 40s & 50s (What It Means for Peak Performance Ageing)
Переглядів 1,1 тис.Місяць тому
In this clip, Bubbs interviews Steven Kotler, best-selling author, journalist and entrepreneur. SUMMARY 0:25 - How brain changes in 40s and 50s 1:25 - 'Big picture' thinking in midlife 1:55 - Empathy and wisdom increase markedly 2:55 - How physical and mental perspective changes 4:45 - Neuro-protective cognitive traits LINKS STEVEN'S WORK: Twitter: x.com/steven_kotler ... CONNECT: Website: www....
7 Principles for 'Good' Metabolic Health
Переглядів 56Місяць тому
In this clip, Bubbs interviews Dr. Philip Ovadia, MD, a heart surgeon who experienced his own great health transformation through better nutrition. SUMMARY 0:30 - Treating 'sickness' vs. promoting wellness 1:45 - How Dr. Ovadia became interested in nutrition? 3:10 - The pitfalls of being 'outcome' goal oriented for health 4:30 - Mindset change system to build better habits 6:30 - Exercise and m...
High 'LDL' vs. Metabolic Health for Heart Disease Risk
Переглядів 43Місяць тому
In this clip, Bubbs interviews Dr. Philip Ovadia, MD, a heart surgeon who experienced his own great health transformation through better nutrition. SUMMARY: 0:25 - Connection between weight gain & metabolic health 1:10 - What percentage of adults are metabolically healthy? 2:10 - If you're obese % chance you're metabolic health is poor. 3:40 - Ultra-processed foods and impact on waist lines? 5:...
Dopamine, Cravings, The Brain & Weight Gain
Переглядів 29Місяць тому
Dr. Marc Bubbs sits down with expert neuroscientist and obesity researcher Dr. Stephan Guyenet PhD to talk about his book The Hungry Brain SUMMARY OF EPISODE: tbd CONNECT with STEPHAN: Twitter: x.com/sguyenet ... CONNECT: Website: www.drbubbs.com/ Instagram: drbubbs Twitter: x.com/DrBubbs BOOKS: Peak: The New Science of Athletic Performance That Is Revolutionizing Sport (#1 BEST ...
Can Berberine Lower HIGH Blood Sugar Levels?
Переглядів 622 місяці тому
Dr. Marc Bubbs interviews Dr. Chad Kerksick, PhD, associate professor of exercise science in the Exercise Science Department in the College of Science, Technology, and Health at Lindenwood University SUMMARY OF EPISODE: tbd CONNECT w CHAD: Twitter: x.com/chadkerksick ... CONNECT: Website: www.drbubbs.com/ Instagram: / drbubbs Twitter: x.com/DrBubbs BOOKS: Peak: The New Science of Athletic Perfo...
How The Brain Impacts Hunger & Weight Gain
Переглядів 472 місяці тому
Dr. Marc Bubbs sits down with expert neuroscientist and obesity researcher Dr. Stephan Guyenet PhD to talk about his book The Hungry Brain SUMMARY OF EPISODE: tbd CONNECT with STEPHAN: Twitter: x.com/sguyenet ... CONNECT: Website: www.drbubbs.com/ Instagram: / drbubbs Twitter: x.com/DrBubbs BOOKS: Peak: The New Science of Athletic Performance That Is Revolutionizing Sport (#1 BEST SELLER) www.a...
Body Image, Disordered Eating & Young People
Переглядів 252 місяці тому
Body Image, Disordered Eating & Young People
Youth Athlete Eating for Health vs. Performance
Переглядів 1342 місяці тому
Youth Athlete Eating for Health vs. Performance
Why YOU Should Test Your Composition (And Best Way How)
Переглядів 602 місяці тому
Why YOU Should Test Your Composition (And Best Way How)
Fear of Carbs (And How It Impacts Your Training)
Переглядів 1823 місяці тому
Fear of Carbs (And How It Impacts Your Training)
What To Eat DURING Endurance Training Sessions?
Переглядів 4113 місяці тому
What To Eat DURING Endurance Training Sessions?
Fasting vs. High Protein (Low Carb) Breakfast: Effects on Fat-Burning & Training
Переглядів 4203 місяці тому
Fasting vs. High Protein (Low Carb) Breakfast: Effects on Fat-Burning & Training
How Exercise Impacts Appetite (And Weight Loss!)
Переглядів 843 місяці тому
How Exercise Impacts Appetite (And Weight Loss!)
Nutrition for Weight Loss - Where to Start?
Переглядів 2153 місяці тому
Nutrition for Weight Loss - Where to Start?
Can You Get BIGGER & LEANER at the Same Time?
Переглядів 2563 місяці тому
Can You Get BIGGER & LEANER at the Same Time?
Can Creatine Improve Memory & Cognition?
Переглядів 2463 місяці тому
Can Creatine Improve Memory & Cognition?
What Should Athletes Eat During Ramadan? (How to Overcome 3 Common Challenges)
Переглядів 1039 місяців тому
What Should Athletes Eat During Ramadan? (How to Overcome 3 Common Challenges)
Level Up Your Performance Nutrition! (Under Armour Rewards)
Переглядів 989 місяців тому
Level Up Your Performance Nutrition! (Under Armour Rewards)
Level Up Your Performance Nutrition!
Переглядів 2629 місяців тому
Level Up Your Performance Nutrition!
Why Eat MORE Vegetables on a Carnivore Diet?
Переглядів 4,6 тис.9 місяців тому
Why Eat MORE Vegetables on a Carnivore Diet?
Excellent ! So, joint pain. Muscle pains. Exercise progress stopped. Waking up at night. Sometimes I wake up at 4-5 am after 4-5 hours of sleep. Can’t get back to sleep. Nap during the day. Fasting every other day since years. Low carb. Was easy. It’s weird but now I got cravings which I didn’t have before. Some fluid retention. Drank more coffee. No effect. On eating days, at least 1 meal is full fat yoghurt or sour cream (I.e. no salt). Just love the stuff, increasingly over the past 2-3 months. Last week, salted pistachios caught my eye. Had them daily since (so fasting went down the drain). After 1 week of regular salted pistachios, noticed everything went back to normal…. Made serious progress in exercising. Weight dropped. Craving for pistachios and yoghurt gone. Magic ! Will reduce the yoghurt. I guess that created the salt deficit. Live and learn !
Glad to hear you found it useful!
dr. ede's looking healthy and vibrant.
indeed!
Just another quack selling his app. Nope.
No need to buy the app. Just listen (take what resonates, leave what doesnt)
@@DrMarcBubbs Ah, the very scientific approach "take what resonates". IMHO you don't sound like a Dr. that I would be interested in listening to. Between the sales pitch at the beginning of the video, and your current response is very noncommital. I wish you the best tho'.
@@justbeingmybestbob I've been working in clinical practice for 15 years. Seeing and helping clients. Have you got a question? Happy to answer.
@@DrMarcBubbs Not for the fake UA-cam doctor, nope. Do you?
@@justbeingmybestbob Your reply reminds me of a great Bruce Lee quote... “A wise man can learn more from a foolish question than a fool can learn from a wise answer”. All the best Bob.
Bologna
Cured meats ... tasty ... but eat in moderation!
PS. Question about protein? Hit me below...
Kár volt végignéznem. Aki azt állitja, hogy a gabonák a bab és a magvak tápanyagokban szegények azt nem lehet komolyan venni. Ráadásul a húsevésre buzdít. :( Gondolom a ketogén átbaszós diétát preferálja mert megemlíti, hogy a szervezetnek nincs szüksége szénhidrátra elég a zsír meg az állati eredetű fehérje. Hallot már a hölgy a TMAO szintről? Tudja-e, hogy mi az az MTOR? Tudja-e a hölgy, hogy mit okoz a szervezetben a túlzott állati eredetű fehérje? A kék zónákban élők táplálkozási szokásainak mondanak ellent.
I had not previously heard the terms "carb periodization" . Must have been another soviet scientific invention...☀
Where can I see the full episode
Listen to the full conversation here - podcasts.apple.com/gb/podcast/s7e11-come-back-skinfolds-all-is-forgiven-body-comp/id1197134623?i=1000622384074
@DrMarcBubbs these are great you should put all the full episodes on utube. Do get tommy wood on again soon! Laura
@@lfeldman8320 Thanks for watching... please share w friends... lots of great content to come in 2025!
I kinda of see that at 35. 😮 Bigger picture
Great point... it feels like mid-30s is the start!
PS. Do you test your body composition? How? Please share below...
Big picture thinking.😎
100%!
PS. What's the biggest change for you - in your 40s and 50s - in cognitive function? Please share in comments
Thanks for caring about our health.
Glad you found it helpful!
I drank the most weirdest green smoothies and juices. Some of them were really nasty tasting, but for the health benefits I forced myself, but I never really felt good. I became more miserable, nothing changed on my skin or brain function. Yes I lost weight, but I felt not good at all. I am trying the carnivore now. Let’s see.
Great🫡 love from punjab🇮🇳
Appreciate you!
Can I take creatine when I am using Animal cut 42 pack
Why are you taking that?
Great talk, but I disagree with Cordain’s take on calcium. I’ve constructed many dairy free diets in Cronometer, and without going way out of your way it’s very hard to get enough calcium. You basically have to eat a ton of greens or bone in canned fish, and few people are doing that. I’ve also looked into records of various hunter gatherer diets, and many were getting around 1.5g calcium, which most people eating dairy don’t even achieve today. In additional they were drinking unfiltered water which was likely high in calcium and no even accounted for in those reports.
Agreed. Dairy is a great source of protein, calcium and micro-nutriiton (for individuals who can digest effectively).
Is there a brand that you recommended for a High quality Omega 3 DHA/ EPA supplement ?
Question? Hit me in the comments below...
I love the carnivore diet and it's helped me to get rid of my Arthritis and other things as well. But when you show a program like this and you do not show the data, I think that's bad.
This is one of the authors of the first ever study on the carnivore diet. The data is in the actual paper, I've provided you with the link here: pubmed.ncbi.nlm.nih.gov/34934897/
Waist-loss is more important than weight-loss as the key metric of gauging your fitness/health journey success.
I like that line... very, very true! Central adiposity - aka belly-fat - is a great simple heuristics for men... The more you have, the greater your risk of heart disease, type-2 diabetes, low lidido, low testosterone, depression, etc.
awful
You can't go on how you feel if you're an athlete. If you have a week off, you'll be rested but you'll feel like crap!
What? I was at a recent performance conference for professional teams - and unanimously - performance leads said 'how the players feels' is the MOST important thing. (How you get there - using more objective or subjective - is up for debate.
Ok, 2.5 minutes.
You need to listen more carefully... [0:30] "Maybe it's what he DOESN'T do..." To support your longevity, what area(s) of your life you could trim/reduce/omit to support longevity? (Rather than starting by adding a new behaviour).
First 5 minutes, yada-yada-yada. Is there content?
Great conversation. Thank you!
You're welcome! You may be interested in this conversation on CBD and concussion - ua-cam.com/video/L1tYN_oQkfc/v-deo.html
This is fascinating and very helpful
Thank you!
Carnivore plus plenty of high end supplements takes care of the phytonutrients issues
You could just add some veggies and fruit... Or, like you said, a high end micronutrition solution. Choice is yours
Amazing... Over the last century we have replaced the beneficial and necessary amount of salt with an unnecessary and detrimental amount of sugar. Look where it got us !
Dan John: I don't believe in pre or post nutrition.
Interesting... can you expand a little more?
why dont people who do podcasting use good microphones?
Haha... sometimes the set up is better than others. (Is it the guest? Myself? Both?)
@@DrMarcBubbs it is probably more on your side, maybe it is just the room you are in or the audio settings, the guest is just talking a bit too fast, kind of like Elon 😆
@@kumamonkumamoto3844 Thanks for the note!
What is more important? Is how you genetics impact upon your appetite. If you want to be slim the first thing to do is choose your parents very carefully.
The takeaway here is exercise will help (1) reduce hunger between meals (2) limit overeating during meals. Big 'win-win' for maintaining good body composition and overall health.
Where do you start when it comes to weight loss? What are YOUR biggest roadblocks? Please share below...
Do you try to ADD size and get LEANER at the same time? What about your clients? Please share below...
Lifestyle, not a diet. The cows eat the grass, I eat the cows, eggs, bacon, butter...It is a very simple way of life that simply heals your body, and dare I say mind. It increases energy, and strengthens your bones. Carnivore is a proper human way of eating
Cows are indeed built for eating grass (and upcycling nutrients)... but humans can eat plants too. Protein is certainly great for bones (along with resistance training) as well!
Is coconut water a good substitute for tap water or something like Relyte?
A tap purifier is a nice strategy if your water supply is poor quality.
Carnivore could be done with any homogeneous food, for example egss and avocado. Most people who went on the diet were fat tubs of lard, with auto immune sufferers outlyrrs. Load of bullocks
Bullocks for autoimmune sufferers or everyone?
11 benefits in 11 minutes and 11 seconds.
Whoa.... strange.
LOL
Creatine with EAA and Collagen posr workout. 🏋🏻🏊🧨🦊
Yessir!
It's a bit misleading and a bit of a 'poke' to say "now we see a lot of the carnivores saying we're going to include a lot of fruit." A few people in the carnicom have begun to discuss the pros and cons of eating small amounts of certain fruits. Some have added a bit, others not. Some feel that 'seasonal' eating of local fruit may be ok, others have tried it and found it triggers a desire for more sugar and carbs, so they don't. I'm 69 and switched to carnivore nine months ago. I haven't had this much energy, stamina and focus in thirty years. All kinds of 'minor' health issues that have been creeping up on me since I turned 60 have disappeared since I went carni. Things like blood pressure being a bit high, polyps, severe dry skin problems, lack of flexibility (I can sit in the cross-legged yogi position for the first time since my 30's now without PAIN!), minor bloating, digestive problems, and more. I'm not an evangelist for carnivore and I'll never tell someone how to eat, live or love. Decisions and choices as significant as these should come mostly from within, with a little help from your friends. Cheers and EAT THE BACON!
At the end of the day, ensuring more micro-nutrition from fruits and veggies is going to be a good thing. A major group of people who benefit from carnivore are those with gut and skin conditions... so these folks just need to be a little more cautious with bringing certain foods back into their regime.
@@DrMarcBubbs You may be right, but more research is needed to determine if those who eat only animal products are lacking in specific essential nutrients. There are so many variables that come into play. Eating animal products is a simple choice. Adding back fruits and veggies is complicated. It could take someone years to determine which fruits and which veggies they can eat without causing issues. How much do I eat? How often can I eat them? Can I tolerate high-oxalate fruits and greens? Which ones do I avoid? Can I handle only low sugar fruits or can I eat any of them? Can I eat them in small quantities every day all year? Or should I follow the 'seasonal' idea? I'm fortunate to have apples, pears, plums, blueberries, blackberries and figs in my garden. I'll eat small amounts as they ripen, that's it. The rest I give away. I also have large veggie garden beds that have been empty this past year, except for my garlic beds! Thank you DrBubbs for engaging in these discussions and being open to consider personal stories and anecdotal evidence as having validity. Cheers and EAT THE BACON!
@@gregpastic6910 Adding fruits and veggies back can be complicated; it can also be very simple. Great to see you're growing your own fruits/veggies and appreciate you sharing your experience as well!
I wish this video had continued longer. I was 6 weeks eating carnivore and was not feeling optimal. I was adding a lot of salt to my food but just a little to my drinking water. My blood pressure went from had always been 120/80 to 90/60. I was feeling light headed and lots of low grade headaches. Now I add a full teaspoon of salt to my drinking water at LEAST twice a day and doing much better. I also supplement with potassium.
What's your blood pressure?
It’s a great book.
I agree! Thanks for sharing.
Are statins advisable for someone with 5 stents ( never had a heart attack )
I find it funny that “doctor” Jake mey who is supposed to be a nutritionist has zero knowledge about what is exactly in food. Has zero knowledge about how man evolved and what we ate for a million years. This is just more evidence of the pathetic shape our medical system is in. Basically anyone can be a doctor and they can spout off nonsense because the are sure that paper degree means something.
How do you infer all of this from the convo we had? You sure you're not the one spouting off nonsense? Jake is simply sharing what's in the research - which he's invested his time in as well - and insights from practice.
@@DrMarcBubbs you are kidding right? Do you not listen to your own videos? He has been strictly book trained in a very narrow field of nutrition. And a massively flawed field I might add. This is why I mentioned he has zero botanical knowledge and the way he speaks about everything being antithetical to his training shows all of us he has not done any research outside of his narrow field. And he speaks as if you knows everything which reminds me of the Krueger Dunning effect. I wouldn’t let this guy feed my dog.
can you put the reference for the FH that do not get heart disease. thanks!
I'll have the team take a look... thanks for listening!
So many thoughts…. A carnivore diet means no ultra processed food, no added sugars, seed oils, gluten, and anti nutrients such as oxalates, phytates, and lectins. Removing those things alone is a vast improvement. But carnivore also adds back the most nutritionally dense bioavailable foods at a lower calorie level. Eggs and beef (and other animal foods) have the most bioavailable nutrients, protein, and fat - all things we’ve told for decades not to eat. Yet a lot of people are deficient in iron, B12, fat soluble vitamins, and develop diabetes, osteoporosis and sarcopenia. Carnivore also corrects the balance of hunger hormones. Removing all the ultra processed crap and eating fatty rich foods means leptin kicks in and satiety comes back. And grehlin activates when we’re hungry but it’s not an insatiable monster that’s never satisfied and drives us to overeat. I’ve been following the carnivore diet for about 6 months now. I’ve lost 34 lbs and my bloodwork is best it’s ever been. I’ve also come off Zoloft and Adderall and have much better mental clarity, lost visceral fat without even exercising (now I am). Here’s a typical day coming in at 1147 calories, 91 grams protein, 4 grams carbs, 81 grams fat: Breakfast: - 3 pasture raised eggs with 7 slices of pepperoni - 6 slices of bacon Snack: - 1 slice of mozzarella Dinner: - 7 oz of beef chuck roast Yes, it goes against all the nutritional guidance we’ve been given. But where has the guidance brought us? Why should we continue following advice that is clearly flawed? If you dig just a little bit into the nutritional guidance you’ll find there is no science behind it. None. It’s mostly food industry manipulation and the medical community not asking enough questions. I’m referring here to the sugar industry bribing Harvard professors to declare sugar was harmless and point the finger at fat instead. Now we have this ridiculous food pyramid and most of the guidance about foods effect on cholesterol (and cholesterol in general) has been reversed but the guidance hasn’t changed.
It's always all about the money.
Banger video!
Glad you enjoyed... please share!
New research reveals that keto and carnivore diets lead to premature death: ua-cam.com/video/gzeP1obBe30/v-deo.htmlsi=rrzR2HzuTXQuEU5n
Can someone clarify from him if the hadza diet was fatty meat or real lean meat. So was their diet low fat iron hight fat
Fatty meats (and yes, meat is high in iron).
@@DrMarcBubbs so there diet was low fat or high fat, low carb or high carb
@@Primetime_dads Here are some studies to check out if you've got an interest: - pubmed.ncbi.nlm.nih.gov/30511505/ - pubmed.ncbi.nlm.nih.gov/29800635/ -