Sir u are just awesome...hats off...these videos help me a lot in making mol bio so easy...now i actually can relate one process with other..thank you so much sir....
Sir I am one of your greatest fans... please make more videos & if possible give more description about the topics in the description box so that it could help us in getting a note making idea too
@@Abeliever000 mistakes to sb se hoti hain and he is also a human being so instead of degrading appreciate his efforts he made for the students🙂sorry if you mind..
In the histones video you said n-terminal tails are more suited for chemical modifications. Here,you talked about c-terminal. Can you clarify this. Brilliant content over all and thanks a lot.
I also wondered about this. I can confirm from reading the literature that acetylation modifications primarily occur on the n-terminals. Reference - www.ncbi.nlm.nih.gov/pmc/articles/PMC3193420/
Shomu's Biology ji aapke videos ne study easy bana di he ,me choti jagah rahti hu or koi coaching and notes avilable nhi ,me gov job me up me primary me teacher hu or aabhi hal hi me aage update krne ke uddashy se msc botany me bhoj university se top kiya ,pr june ka net dekr thoda nirash ho gai thi but jab se aapke videos dekhe hei dubara se study pr focus kr rhi hu.
Asslam o alaikum! I am from pakistan! Sir you are so amazing really.. Very well explained.. And i actually learn from your videos more than anywhere.. Thank you soooo much for all of your videos and concepts.. I easily understand the concept from your videos really.. Keep uploading your new concepts😊
Sir, great video. The only improvement that I could suggest is that you slow down when you speak. You are a little hard to understand at some points. But other then that great video!
Great video! Although, I think you meant methylation of Lys 4 for transcriptional activation of gene promoters. Rather than Lys 3? Would you please clarify this?
Sir, Good video but you mentioned methylation or any modifications occured in N-terminals of Histones in previous video but you completely explained those on C-Terminal. Please dont confuse the viewers.
sir how r u,, ur lectures help me a lot,,,and most of the time I used to see ur lecture,,do u have any lecture on epigenetices and diseases, and epigentices and environmental effect
Does Unmethylated CpG DNA exist in humans,- although to a lesser degree as in mammals? Can unmethylated CpG DNA lead to activation of the innate immune response in humans presenting with type 1 Interferonopathies of SLE? What is the role of p38 mapk in the methylation of this innate activation?
Sir really really help full video thanks a lot sir Sir from this video I get the common prosedure of modification but what actually happened there ... I mean process off .. Sir please make a another video on It please sir
I am PhD scholar working on chromatin biology. please correct the video statement that histone modification occurs at n terminal not at c terminal as it can mislead other students
Hi Shomu, loved the video, just one question. If a histone has been methylated and the DNA is tightly wound around the histone, is it possible acetylate the DNA to unwind it?
Is it true if the dna is unpacked the genes are activated and when packed the genes are inhibited ? Videos online say the opposite but my lecture tells me this
sir i have little bit confused ..in the previous video you said N-terminal is very important, now you saying c-terminal plz sir correct it, which one is correct
hi Mr. Suman the acetyl group will bind to the C-Terminal or to the N - tail ? because you said in the previous video that histones have N - tails , but here you said C - Terminal. Regard
When you write single letters for amino acids please stick on to the correct form. You can't write 'L' to denote lysine because 'L' is used for Leucine.
how do we call it adenosyl methyl transferase .... just a few moments back you told that the methyl group is getting attached to lysine (either 3rd or 9th) and not a neucleoside
+Chandrachur Mukherjee acetyl action and methylation can take place in both DNA as well as in histone. Adenosyl methyl transferase add methyl group to the DNA
This man has single-handedly been carrying my grades in this pandemic.
Thank you so much for appreciating my efforts. Glad to hear that you're getting benefit from my lectures
SAME. im binge watching:)
you have literally helped me during my bachelors, my masters, and now studying for the MCAT. Shomu you are the best! THANK YOU
Thank you so much for appreciating my efforts
Hi can you pls respond , which country are you now pursuing your studies from ?
@@aashi1524 US
I would never miss your class of you were my professor. You are an awesome teacher, and we need more professors like you.
This was exactly what I needed for my molecular biology final, thank you!
Thank you.
Share ur no 🙏
INDIAN MEN TEACH ME MORE THAN ANY TEACHER
I love these 10 minute bites of knowledge! They're super easy to follow. Thank you!
Glad to hear that you're getting benefit from my lectures
Your videos helped me to clear DBT BET. Thank you so much sir!
Congratulations
Cannot thank u enough for all this u do for us🙏🏽👏🏼
You're welcome
Sir u are just awesome...hats off...these videos help me a lot in making mol bio so easy...now i actually can relate one process with other..thank you so much sir....
+anu anand thank you. Glad you liked my lectures
Sir I am one of your greatest fans... please make more videos & if possible give more description about the topics in the description box so that it could help us in getting a note making idea too
Thank you sir I found this was very hard to understand but you made me understand very clearly
Glad to hear that you're getting benefit from my lectures
My interest is physics but I find your uploads very interesting . Thanks
You're welcome
Histone H3 Lys 4 is the active histone mark... and histone N terminal domain, instead of C- is the modification hotspot.
Thanks a lot, Somu. You explained the acetylation of histone very clearly .
histone modifications actually occurs on the N-terminal tail of histones
Yes they occur at the N terminal
if it's on n tail... y u said c termn
Please add note in the video or record it again, this is going to mislead everybody watching this.
This somu always makes such mistakes....please learn properly before you teach!
@@Abeliever000 mistakes to sb se hoti hain and he is also a human being so instead of degrading appreciate his efforts he made for the students🙂sorry if you mind..
Really make it very easy for us ....really helpful video ....make more video on biochem ....
You're welcome. Glad to hear that you're getting benefit from my lectures
In the histones video you said n-terminal tails are more suited for chemical modifications. Here,you talked about c-terminal. Can you clarify this. Brilliant content over all and thanks a lot.
I also wondered about this. I can confirm from reading the literature that acetylation modifications primarily occur on the n-terminals. Reference - www.ncbi.nlm.nih.gov/pmc/articles/PMC3193420/
Itz n terminal babe ......dnt confuse
@@allyb1271 Thanks for the link
It will really be helpful to build my thesis.
It's N terminal . He said it by mistake may be...don't confuse
@@allyb1271 thank you so much ❤️
Happy teacher's day to our secret teacher ❤️
Thank you so much for appreciating my efforts
Thank you so much for your efforts, you are helping me a lot in my master.
You're welcome
thankx for ur videos for csir net ,it explain all topics in v easy way ,really i m v thankful for it .
+Richa Agrawal thank you. Glad you liked my lectures
Shomu's Biology ji aapke videos ne study easy bana di he ,me choti jagah rahti hu or koi coaching and notes avilable nhi ,me gov job me up me primary me teacher hu or aabhi hal hi me aage update krne ke uddashy se msc botany me bhoj university se top kiya ,pr june ka net dekr thoda nirash ho gai thi but jab se aapke videos dekhe hei dubara se study pr focus kr rhi hu.
Beautiful done presentation,keep up the good work
Thanks sir ... For clearing our doubts ... You are really great....
Superb 👌👌
You're welcome
Asslam o alaikum! I am from pakistan! Sir you are so amazing really.. Very well explained.. And i actually learn from your videos more than anywhere.. Thank you soooo much for all of your videos and concepts.. I easily understand the concept from your videos really.. Keep uploading your new concepts😊
Thank you. Glad you liked my lectures. Please subscribe and share
Amazing brother your lecture are awesome
Tha
You are a legend! Thank you for all the videos!
Thank you. Glad you liked my lectures
How brilliant personality you are..🎉❤
Thank you so much for appreciating my efforts
Sir, great video. The only improvement that I could suggest is that you slow down when you speak. You are a little hard to understand at some points. But other then that great video!
Or you can try to adapt to his teaching style rather than him to you.
You can modify the speed of the video in the settings.
Make it on 0.75x
Welldone sir Keeep it Up
Best wishes 👌❤
From Pakistan KpK
You're welcome. Glad to hear that you're getting benefit from my lectures
I love all of your videos! Great job! Please keep making them! :)
Thank you so much sir for the awesome explanation.....
You're welcome
u r vedio helped me to crack net jrf.thnk u verymuch
Glad to hear that. Can you write review about it in our website?
sir........... realy ur notes are very helpful................thanku very much..............
Thank you so much. All the best. Keep watching.
thank u so much... i completed my max syllabus by u.. thank u.. nucleosome soliniod model is my need.. plz do a clasa..
+Ankita Paul thank you. Glad you liked my lectures
You are really great sir. Hats off you
Thank you
Thank you this has really helped, stay safe
Well explained !
Thank you !
You're welcome
THANK you sir
Kindly make a video on
Regulation of the chromatin structure .
Ur videos are very helpful .
Thank You
Masha Allah! very helpful video, thank you very much
thank you for clarifing my ideas Good job continue
Great video! Although, I think you meant methylation of Lys 4 for transcriptional activation of gene promoters. Rather than Lys 3? Would you please clarify this?
Great video, but I think it's 4th position of lysine for transcription activation
Sincere effort. U r a good teacher
Thank you
You are the best sir .....
Thank you
Great explanation sir
Thank you
Welcome sir
Thank you! This video was so helpful
really nice..sequential and detailed
Sir, Good video but you mentioned methylation or any modifications occured in N-terminals of Histones in previous video but you completely explained those on C-Terminal. Please dont confuse the viewers.
N terminal is correct
0.75x speed is perfect to those who find him too fast.
Best explanation ❤
Thank you. Glad you liked my lectures
thank you so much. i really appreciate your chanel it helps me a lot. :)
extraordinary explanation thank u so much somu sir
Glad dyou liked it
This video is very helpful! Just one thing: lysine is K not L (as he wrote in the top right of the board)
@ Rohonda Marshall you are so Sexy!
Thanks a lot for clear me the concept
sir how r u,, ur lectures help me a lot,,,and most of the time I used to see ur lecture,,do u have any lecture on epigenetices and diseases, and epigentices and environmental effect
Acetylation and methylation of h3 occurs on which terminals c or n?
Absolutely great...!!
Thank you
Bio statistics lectures to resolve a problem I need to understand.
Dear Shomu, I believe that you meant methylation of Lysine 4 on H3 to induce an activation, not Lysine 3...
He explained methylation of lysine3 in the H3 subunit helps to unwrapp DNA for replication or transcription
That is not true it is Methylation on lysine reside 4 i.e H3 K4 which causes activation ....not on 3 as he said
Sir which is the correct ans....residue 3/4?
Thank youIt was really interesting!!!
Very nice video.
Thank you
Very good lecture
This is so helpful! Thank you :)!
+Ann Behanan glad to hear that
thankyou so much sir 😊🙏
You're welcome
Very Nice good job thank you very much
Sorry sir and thanks ...
I found the videos of the histone modification in your channel in details thank u ...sir ...
Glad you liked it
Thank you very much. Is it possible that permanent high or
too low “cortisol level” leads to gene methylation? Your answer is appreciated.
Good teacher
Thanks
So helpful, thank you!
thank u sir for making this video
Nice sir, but what about H1 protein
Does Unmethylated CpG DNA exist in humans,- although to a lesser degree as in mammals? Can unmethylated CpG DNA lead to activation of the innate immune response in humans presenting with type 1 Interferonopathies of SLE?
What is the role of p38 mapk in the methylation of this innate activation?
Sir Is Modification occur in both the terminal c and n because in histone video you mentioned the n terminal for modi..?
N terminal
Sir really really help full video thanks a lot sir
Sir from this video I get the common prosedure of modification but what actually happened there ... I mean process off ..
Sir please make a another video on It please sir
I am PhD scholar working on chromatin biology. please correct the video statement that histone modification occurs at n terminal not at c terminal as it can mislead other students
Hi Shomu, loved the video, just one question. If a histone has been methylated and the DNA is tightly wound around the histone, is it possible acetylate the DNA to unwind it?
Histone modification
Sir plz confirm whether methylation occur on c terminal of histone or on the bases of DNA such as cysteine.if mistake do correct it
Difference between histone acetyltransferase and N acetyltransferase???
awesome..great job!!
Sir I have doubt ... Is methylation occur in both lysins and arginine or only in lysine . I hope you will reply fastly because Monday I have exam
Is it true if the dna is unpacked the genes are activated and when packed the genes are inhibited ? Videos online say the opposite but my lecture tells me this
sir i have little bit confused ..in the previous video you said N-terminal is very important, now you saying c-terminal plz sir correct it, which one is correct
Yes he corrected in one of his comment that modification is at n terminal
very very concept full vedio.
I think methylation procces occures in H3 histone and aceytlation in H4 histone.
Can I write histone acetylation and methylation brief in chromatin remodeling..
here in this video you talk about lysine methylation , what about arginine methylation ?
Acetylation happens on the N-terminal tail
Thank you . It is very goooooooood
Sir, its not C terminal, it is N terminal where modifications mainly occurs.
Sir can you suggest a book on genetics? Of Msc level, zoology
hi Mr. Suman
the acetyl group will bind to the C-Terminal or to the N - tail ?
because you said in the previous video that histones have N - tails , but here you said C - Terminal.
Regard
There is both N and C terminal tail but histone modifications occur mostly (not 100%) on N-terminal tail.
Can you please tell me What is an epigenetic inheritence?
When you write single letters for amino acids please stick on to the correct form.
You can't write 'L' to denote lysine because 'L' is used for Leucine.
good work
I love this teacher aha.
You're welcome
nice video but i forget many things related to your viedos something are clearly understood but some are not...likr role of enzymes in DNA packaging
Actually it is not clear that which terminal of histone protien is modified by different modifications??
what is histone code hypothesis?
What is differences between global and targeted acetylation of histones?
Kindly answer plz?
how do we call it adenosyl methyl transferase .... just a few moments back you told that the methyl group is getting attached to lysine (either 3rd or 9th) and not a neucleoside
+Chandrachur Mukherjee acetyl action and methylation can take place in both DNA as well as in histone. Adenosyl methyl transferase add methyl group to the DNA
oh... thanks..
Which of the X chromosome will be inactivated? On what does that depend? Or is it random, any of the x chromosome is inactivated?
Random
@@shomusbiologyofficial ok.. thanks