Excellent explanation: concise, jargon-limited, and straight to the point. We need more 3-5 minute videos explaining complicated processes to the public at large. Thanks again!
Highly impressed with this vedioclip and for the first time through your deliberation a professor has understood this complex process. Thank you very much indeed. Would love to learn from you more and more Sir! Regards
please correct me any part of the statements if they are wrong. I understood that: 1) promoter DNA methylation is a NORMAL action in response to the environment/epigenetics and ultimately results in gene silencing. 2) CpG site(s) methylation (another NORMAL nature of genome) ultimately creates different cell types and furthers their division (via unique methylation patterns per cell type, across the genome of cell types). 3) It is UNCOMMON for PROMOTER CpG islands to be methylated, because they (promoter regions) have important regulatory elements that control gene transcription (and shouldn't be 'messed' with).... and offset balance of promoter dna methylation and CpG island methylation..... 4) So, in cancer cells we not only have the UNCOMMONality of the methylation of DNA PROMOTER CpG islands, but they are HYPERMETHYLATED. This means the normal inactivation for silencing of the gene for suppressing tumors is otherwise, due to hypermethylation, now allowed to be activated (so NO silencing of gene for suppressing tumors) and thus, allowed to differentiate/divide/aka behave like a tumor and go crazy!....... Let me know. Thanks!
Do you have updated knowledge about this? For "promoter cpg islands", do you know if they can be methylated on purpose via, let's say, supplementation with methylated b vitamins?
Naive question: Could manipulation of the methylation on DNA cause a generation of a stem cell. Is a stem cell just one that has yet to undergo any methylation (expressing all genes)?
I have experienced very severe neurological disorders with the use of PPIs. I have the characteristics under methylation _ I learned this with my own research after the disorder_ I can't get rid of paresthesias, especially pins and needles. What can you suggest me about this?
DNMT1o is synthesized and stored in the cytoplasm of the oocyte and translocated to the cell nucleus during early embryonic development, while the somatic DNMT1 is always found in the nucleus of somatic tissue.
👍🏼💪🏾👑 Top thanks. A question please, the methylation and ipermethylation of the DNA can stopped celular neoplastic? SAM ( S- Adenosil Metionina) is it useful, is it good to take 400 mg every day to silence the transcription of cancer? thank you very much. Andrea Lacerenza
Question..... can anyone explain or give clarity on the following ... does any change to typical Purine & Pyrimidine, folate, B6 or B12 pathways during pre or early post natal periods result in heritable genetics that could be passed from that baby should they procreate in later life?
Very good, most of it I got it, but I didn't understand the flip part of CpG. If DNMT3a and DNMT3b already methylated, is that cause the flip and later when it obtains methyl from SAM it comes back?
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For a definitive and effective treatment of Cancer, hepatitis AB and C (bloating, swollen belly and intestinal gas), urinary tract infection, HIV AIDS, infertility, diabetes, cyst, myoma, fibroid, myopathy ... etc. we have products made from natural plants very very effective without side effects on health. please contact us on +22965969874 via WhatsApp
For a definitive and effective treatment of Cancer, hepatitis AB and C (bloating, swollen belly and intestinal gas), urinary tract infection, HIV AIDS, infertility, diabetes, cyst, myoma, fibroid, myopathy ... etc. we have products made from natural plants very very effective without side effects on health. please contact us on +22965969874 via WhatsApp
Do you know anything about how methylated b vitamins can affect these processes, especially within the 'tight regulation' of demethylation/methylation of DNA? Sorry if this is off topic.
Excellent explanation: concise, jargon-limited, and straight to the point. We need more 3-5 minute videos explaining complicated processes to the public at large.
Thanks again!
O
This is so straight to the point and easy to understand, thanks!
Glad you found it useful!
Highly impressed with this vedioclip and for the first time through your deliberation a professor has understood this complex process. Thank you very much indeed. Would love to learn from you more and more Sir! Regards
Thank you, Subhash!
Thank you for this explanation
Balance is important. Great short presentation.
So presumably hyper-methylation can deactivate a lot of DNA repair genes too.
Thanks so much for clear explanation : )
Glad you enjoyed it :)
So clear!! So useful!! Thanksss
please correct me any part of the statements if they are wrong.
I understood that:
1) promoter DNA methylation is a NORMAL action in response to the environment/epigenetics and ultimately results in gene silencing.
2) CpG site(s) methylation (another NORMAL nature of genome) ultimately creates different cell types and furthers their division (via unique methylation patterns per cell type, across the genome of cell types).
3) It is UNCOMMON for PROMOTER CpG islands to be methylated, because they (promoter regions) have important regulatory elements that control gene transcription (and shouldn't be 'messed' with).... and offset balance of promoter dna methylation and CpG island methylation.....
4) So, in cancer cells we not only have the UNCOMMONality of the methylation of DNA PROMOTER CpG islands, but they are HYPERMETHYLATED. This means
the normal inactivation for silencing of the gene for suppressing tumors is otherwise, due to hypermethylation, now allowed to be activated (so NO silencing of gene for suppressing tumors) and thus, allowed to differentiate/divide/aka behave like a tumor and go crazy!.......
Let me know.
Thanks!
Do you have updated knowledge about this? For "promoter cpg islands", do you know if they can be methylated on purpose via, let's say, supplementation with methylated b vitamins?
Awesome video, thanks for posting it
Super useful and easy to understand. Helped the big time! Thanks!
That's beautiful, TYSM for the explication.
Saludos desde México.
Cant thank enough for this video
Thanks for the your perfect explanation.
great explanation and drawing skills
Naive question: Could manipulation of the methylation on DNA cause a generation of a stem cell. Is a stem cell just one that has yet to undergo any methylation (expressing all genes)?
This is great, thank you!
excellent as always thank you, just need to slow delivery speed down a touch. thanks love all your amazing work.
This information is not getting out early enough to the masses. So sad!!!!
Where does *RNA* fit in?? Do the methylated spots on the DNA affect the transcription process into RNA?
Thank you very much for uploading this excellent video
Glad you enjoyed it :)
Alteration in methylated patterns, what if its hyper or hypomethylated ?
Thank you so much, sir..
I have experienced very severe neurological disorders with the use of PPIs.
I have the characteristics under methylation _ I learned this with my own research after the disorder_
I can't get rid of paresthesias, especially pins and needles.
What can you suggest me about this?
Very cool, but where does these DNMT comes from? What is regulating DNMT for us to take human shape?
DNMT1o is synthesized and stored in the cytoplasm of the oocyte and translocated to the cell nucleus during early embryonic development, while the somatic DNMT1 is always found in the nucleus of somatic tissue.
@@tievoli83 Thanks a lot for the info🙏
I love you Armando.
If you ever need a kidney transplant, you can have one of mine xx.
OMG Lol
best regards message ever
haha such devotion
Amazing video. Thank you
There is an "H" miising on each cytosine at the 1-N position. Or you could just write "Rest".
Amazing video , theank you
Thanks for sharing.
what does DNMT 1 do? produce more of a specific cell?
nice explaination...but how promoters of housekeeping genes remains unmethylated
Very nice for someone without a bio background.
👍🏼💪🏾👑 Top thanks. A question please, the methylation and ipermethylation of the DNA can stopped celular neoplastic? SAM ( S- Adenosil Metionina) is it useful, is it good to take 400 mg every day to silence the transcription of cancer? thank you very much.
Andrea Lacerenza
Methylation might affect the enlargement or maintenance of telomeres
Question..... can anyone explain or give clarity on the following ... does any change to typical Purine & Pyrimidine, folate, B6 or B12 pathways during pre or early post natal periods result in heritable genetics that could be passed from that baby should they procreate in later life?
Very good, most of it I got it, but I didn't understand the flip part of CpG. If DNMT3a and DNMT3b already methylated, is that cause the flip and later when it obtains methyl from SAM it comes back?
For a definitive and effective treatment of Cancer, hepatitis AB and C (bloating, swollen belly and intestinal gas), urinary tract infection, HIV AIDS, infertility, diabetes, cyst, myoma, fibroid, myopathy ... etc. we have products made from natural plants very very effective without side effects on health. please contact us on +22965969874 via WhatsApp
i didn't understand anything,, so methylation activates or deactivates gene transcription ??!!
Deactivates
For a definitive and effective treatment of Cancer, hepatitis AB and C (bloating, swollen belly and intestinal gas), urinary tract infection, HIV AIDS, infertility, diabetes, cyst, myoma, fibroid, myopathy ... etc. we have products made from natural plants very very effective without side effects on health. please contact us on +22965969874 via WhatsApp
macam mana nak buat?
excellent video! thanks :)
Great video! Is there a place I can buy or print that final graphic in high-res format? I searched your site but could not find anything. Thx!
For a definitive and effective treatment of Cancer, hepatitis AB and C (bloating, swollen belly and intestinal gas), urinary tract infection, HIV AIDS, infertility, diabetes, cyst, myoma, fibroid, myopathy ... etc. we have products made from natural plants very very effective without side effects on health. please contact us on +22965969874 via WhatsApp
Do you sell a poster of this? Would love to buy 10 for my big family. They need to learn this.
Very clear!
Do you know anything about how methylated b vitamins can affect these processes, especially within the 'tight regulation' of demethylation/methylation of DNA? Sorry if this is off topic.
Read this pls..i just took a tetanus vaccine and it has differential extraction-methylation CAN THIS CHANGE MY DNA ?
Thank you ❤️❤️
No problem :)
amzing video thanks.
No problem
exlnt video sir
ottimo video grazie
awesome
nearly 10k subs xd
subbed
2:58
Wrong !!
SAM will become SAH after the reaction
Good
4:40
dnmt2:
am I a joke to you?
Henriette Ports
Mueller Path