How does Niacin (B3) Work? (+ Pharmacology)

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  • Опубліковано 22 гру 2024

КОМЕНТАРІ • 883

  • @hahaaxd4041
    @hahaaxd4041 Рік тому +49

    The first time I took niacin I did not know you were meant to flush so I started panicking, then started googling it to find out it is a normal reaction and harmless. Ever since I really actually value the feeling of the flush, when the peak of it ends I start becoming deeply relaxed and free of anxiety and just overall tiredness, it makes me very calm and energetic. I'm taking 500mg every day now in the evening and it also helps me with insomnia from past benzodiazepine use. It's almost like my brain and chest are taking a really deep breath.

    • @rayvac7743
      @rayvac7743 10 місяців тому +1

      So you must have taken the jab. Do your research 😅

    • @ABhd84
      @ABhd84 5 місяців тому

      @@rayvac7743 Incorrect. Im jab free and the Niacin flush is relaxing once the redness goes. Using it to increase HDL

    • @Balingy
      @Balingy 5 місяців тому +1

      "You must have taken the jab."

    • @taniapankratova354
      @taniapankratova354 Місяць тому

      ⁠​⁠@@rayvac7743what do you mean? Can niacin reverse the effects of the jab?

  • @ivysummers5649
    @ivysummers5649 4 роки тому +200

    Fishermen in Alaska take b3 the night that the herring fishing season opens. it's so cold they take it to stay warm in the wee hrs of the morning

    • @manp1039
      @manp1039 3 роки тому +35

      That is interesting. I noticed when i take niacin or high dose multi B vitamins.. I regain warmth to my feet and hands. and i have a warm relaxing feeling when sleeping

    • @Mohammad-qr1vc
      @Mohammad-qr1vc 3 роки тому +8

      Thank you. My feet always cool. It may help me

    • @Pajtim2023
      @Pajtim2023 3 роки тому +5

      @@manp1039 same me
      I feel erected too lol

    • @megja1812
      @megja1812 3 роки тому +18

      I don’t need the electric blanket after taking niacin and my sleep is so much better

    • @magma9138
      @magma9138 3 роки тому +7

      That may be flushing niacin. You can get non flushing too. High doses of Niacin improve depression.

  • @eligreg99
    @eligreg99 2 роки тому +109

    To everyone asking about harmful dosage it works like any other drug. You start off with a small dose to build up your tolerance. You don’t immediately start with 2000mg. I recommend taking 250 mg to start off with for a couple days and then bump it up to 500 mg ONLY if you feel your body is ready. Remember everybody is different.

    • @or6144
      @or6144 2 роки тому +4

      I started at a 1000mg. I was fine with the flush but my legs swell and if I take it a day after or consecutively for 2 days or a day after I still get that swelling. I'll restart next month and start with 100mg and increase it from there after a few months to get my body used to it.

    • @hannaishak7206
      @hannaishak7206 2 роки тому

      @@or6144 see your uric acid

    • @or6144
      @or6144 2 роки тому +5

      @@hannaishak7206 Uric Acid not bad. I guess it was because I jumped the gun by taking 1000mg before saturating from a low dose or it can also be due to the brand of Nicotinic Acid I used which was Piping Rock.
      I'm up to 600mg now Nature's Way brand twice a day (Morning/Evening) working my way to 1000mg. I suppose my body is adjusting better to it since asides from the expected flush that clears up I've no other side effects.
      I take this with Bilberry (eyes) and Vitamin C for the Arteries along with my 2 Tbs of Sea Moss in the morning since your vasodilating your arteries no better time to infuse it with other nutrients.

    • @no_country_for_real_men
      @no_country_for_real_men Рік тому

      You are absolutely irrefutably spot on correct. I could not have said it any better.

    • @DaddyElfMan
      @DaddyElfMan 5 місяців тому

      I bought some Niacin from GNC in the last year, to help with blood pressure, (as it is a vasodilator), I bought the 500mg tablets, did not know about the flushing part, took me a couple days to figure out what I was taking (was also taking a prebiotic, may have been past expire date, so thought that was what was making me flush and my skin to tingle, mine did not actually itch, just tingled a bit) both the flush and tingling subsided after about 20 mins or so. I was not sure on how much to take daily, found some evidence to not take too much, so I quartered the tablets and take 1/4 every day. Did not know about taking at night before bed, to help with the flushing (not noticing as much at night), so I found this video informative. I was worried about taking too much and it causing damage to my liver or kidneys... so am opting for a lower dosage. I also found that taking with applesauce can help to reduce/negate the flushing/tingly itchy skin.

  • @mihakranjec3937
    @mihakranjec3937 3 місяці тому +6

    Over the past few years, my health condition has become more and more complicated. From digestive problems, high blood pressure, complete exhaustion, inexplicable pain and more. I went for various examinations, but nothing was found. I had a dream about a month ago. I was in the clinic and explained to the doctor that I drink a lot of water. She replied that I should take niacin. I admit that I didn't know what it was until then. I've been taking 500g a day for three weeks now and my condition has really improved a lot. All my thanks go to Jesus. I asked him for help.

    • @Starstorm111
      @Starstorm111 3 місяці тому +1

      You dreamed about niacin without knowing about it before the dream? Wow! That’s pretty amazinf

  • @marcosta183
    @marcosta183 Рік тому +23

    I kinda like the flush. It increases circulation and it also renews dead cells...😊

  • @SilviePaul
    @SilviePaul 4 роки тому +117

    *Thanks for updating,God bless you.
    Anothers benefits Vitamin B3
    1. Regulated digestion
    2. Treats pellagra
    3. Improves skin
    4. Reduces the symptoms of Arthritis
    5. Prevents the risk of heart disease
    6. Mental health
    7. Diabetes*

    • @leximohamed9532
      @leximohamed9532 3 роки тому +4

      Thank you

    • @HBToastedAlmond
      @HBToastedAlmond 2 роки тому +1

      Thank u! Do you have information about B3 regulating digestion? Which dosage? I want to take it to improve my stomach acidity on the long run

    • @leximohamed9532
      @leximohamed9532 2 роки тому +1

      @@HBToastedAlmond it's D3

    • @thetahexhodlhands4550
      @thetahexhodlhands4550 2 роки тому +4

      @@leximohamed9532 We are talking about B3. not D3.

    • @leximohamed9532
      @leximohamed9532 2 роки тому

      @@thetahexhodlhands4550 thank you so much

  • @dlg5485
    @dlg5485 Рік тому +73

    I've been taking 500mg 2x daily for at least 10 years. Heart disease runs deep in my family history so I decided in my early 40s that I wanted to protect my vascular health as much as possible. Niacin, fish oil, D3/K2, CoQ10, and a few other supplements have really helped me preserve my overall health, along with exercise and regular fasting. I only take full flushing niacin because it's the only one that really works. I've been taking it for so long that I almost never experience the flush anymore, only when I take it on empty stomach.

    • @Chaitanyaworld2692
      @Chaitanyaworld2692 Рік тому

      You have Hypocholestromia

    • @ReflectedMiles
      @ReflectedMiles Рік тому

      That much taken for that long, especially, may increase your chances of developing Type II diabetes according to a couple of studies, unfortunately.

    • @dlg5485
      @dlg5485 Рік тому +11

      @@ReflectedMiles I've never heard that in my life. I research every supplement that I take once or twice every year to keep up with the latest data and there is virtually no risk with 1000mg/day of B3, as long as you also fast regularly and take CoQ10, Omega3 which protect the liver. My metabolic profile is perfect and has been for as long as I can remember. I'm not concerned.

    • @ReflectedMiles
      @ReflectedMiles Рік тому

      @@dlg5485 That is certainly your choice, but social media sources are rarely scientifically literate and thorough--including many who are supposedly in healthcare in one form or another--and many GP's don't have the time to be. So it's just important to be aware of the current evidence on the subject, and that is why I mentioned it. Certainly not everyone who takes significant amounts regularly will then develop Type II, but current evidence shows that there is an increased risk. It is probably the single significant downside of using it for its benefits--it seems there are nearly always some risks or trade-offs.

    • @ash9x9
      @ash9x9 Рік тому

      Good to know, I am starting with Niacin from tom and was a little bid concerned about this developing into TypeII diabetes. Anyhow what other benefits have you seen over the years of consp. of 1000mg/day niacin?@@dlg5485

  • @alwayscuriousalwayslearnin
    @alwayscuriousalwayslearnin 2 роки тому +51

    I used to regularly take large does of Niacin just before my weightlifting at the gym( 1970s-80s) it seemed to help with many things even though I was flushing, now decades later I am taking it to hopefully lower my cholesterol levels instead of taking stains

    • @Meeeeeeeeeeeeeeeeeow
      @Meeeeeeeeeeeeeeeeeow Рік тому

      take fish oil high in EPA see iherb. minimum 2g epa per day or more, in few months will lower tryglicerides and cholesterol nicely. dont get on statins

    • @Test7017
      @Test7017 Рік тому +2

      How much are you taking? Also try taking large constant doses of vitamin C. Your body uses it to repair arterial walls. If your low on C your body will use a poor version of LDL to repair arteries

    • @bojax3434
      @bojax3434 Рік тому

      @@Test7017what is a high dose of C? I pretty regularly take 2-3 grams/day.

    • @rayvac7743
      @rayvac7743 10 місяців тому

      Carnivore, no problem .😅

  • @suepalmer4726
    @suepalmer4726 Рік тому +19

    You have really done an excellent job with this video. I am a nutritional therapist and this was even a reminder to me about niacin

  • @royjhamlin
    @royjhamlin 11 місяців тому +3

    Awesome content! Great useful information. I love the way you simplified the science and understanding of how to use Niacin, Vit B3 and how it works. Do you have any more video's on the Vitamin supplement topics? I am preparing to teaching nursing students Fundamentals and nutrition and you were right. We basically tell them B, metabolism and nerves. But you get to the science on how this works simplified to understand why. Love the presentation and I will guide students to this video in case they want info to the point and clearly presented. I will look to your other pharmacology videos when I get to those topics. Thank you.

  • @chrisdell5679
    @chrisdell5679 3 роки тому +122

    Cholesterol dropped 86 points after taking Niacin.

    • @outofthebox5441
      @outofthebox5441 2 роки тому +3

      Are you still taking it? What's your mg dosage?

    • @christymartinez2078
      @christymartinez2078 2 роки тому +13

      @@outofthebox5441 once your LDL is stabilize you can take 3 times a week. You don't need to take it everyday. It should keep your LDL at a good place

    • @outofthebox5441
      @outofthebox5441 2 роки тому +1

      @@christymartinez2078 sounds good. Thanks

    • @dzim8822
      @dzim8822 5 місяців тому

      Wow, that's great.. I have a prescription for a statin, but I think I'm gonna try taking Niacin instead. Is your dosage above 1,000 mg?

    • @Meadows191
      @Meadows191 3 місяці тому

      @@dzim8822I started with sustained release 0:55 0:55 0:55 Enduracin 250 mg 2x day taken with 750 mg Vit C and with a meal. I increased it to 500 mg, 2x day with meal and 750 mg Vit C. . Sometimes I’ve taken a little applesauce sometimes. I’ve only had a slight flush one time. My ND will retest lipids in 6 months. My liver enzymes have been fine. I’m trying to reduce my lp (a)

  • @rluo462
    @rluo462 2 роки тому +93

    very very succinct! Just the way an explanatory video should be! No BS, no fluffy stuff, just the useful content. One of the very few on youtube who really aims to educate, not marketing or showing off. Love the animation!

    • @kevino6756
      @kevino6756 2 роки тому +2

      YOU DID NOT GIVE THE ANSWERS

  • @urseldoran2991
    @urseldoran2991 2 роки тому +51

    Good video sir. I have been taking it for years. Getting the flush is desirable as it indicates it is working to dilate the capillaries on the skin, but MOST importantly the capillaries around the heart and in the brain. Obviously very desirable to dilate one's capillaries for enhanced blood flow!!

    • @billbob7982
      @billbob7982 Рік тому +3

      It seems to improve my scalp hair growth, as my hair is thicker(?). Perhaps, someone may research this hypothesis?

  • @davelelonek
    @davelelonek Рік тому +6

    Last week I started taking non flushing Nature’s Bounty brand but unlike video, it has 400 mg of niacin with inositol hexanicotinate for flushing. I’ve thus far had no flushing. Was taking it at night and found interrupted sleep and mild stomach issues. Started taking in morning and wow super energy. Noticeable lowering of BP too.

    • @mrofnocnon
      @mrofnocnon Рік тому +3

      Non flushing niacin is not effective for cholesterol control.

  • @carlsapartments8931
    @carlsapartments8931 4 роки тому +28

    BEFORE TAKING SLOW RELEASE OR NO FLUSH OPTIONS INSTEAD OF REGULAR NIACIN DO YOUR RESEARCH ABOUT THE DOWNSIDE . Regular niacin will not cause flushing if you slowly build up your dose over days or weeks ---- FLUSHING DOES NOT HARM YOU --- ITS JUST UNCOMFORTABLE FOR A SHORT PERIOD --- YOU FEEL HOT AND ITCHY FOR 15-30-60 MIN OR SO. it depends how sensitive you are to it so start with the low dose maybe 50mg/day and build up.

    • @deedee2218
      @deedee2218 3 роки тому +3

      Great suggestion, thanks!

    • @anxietina_
      @anxietina_ 3 роки тому +2

      first time taking niacin, i experienced flushing for about 2 hours and days after that just 20mins max

    • @bradleyparis5821
      @bradleyparis5821 3 роки тому +1

      I always take with food about half way through a meal and chew up the tablet completely, no flushing, If flushing occurs drink lots of liquid.

    • @josephinelai4638
      @josephinelai4638 2 роки тому +2

      I experienced flushing(scary red all over the face and hands) right away after taking 50mg of Niacin the first tiime!

    • @arthurdolle5257
      @arthurdolle5257 2 роки тому +2

      I enjoy gentle scratching, just be careful to keep it gentle

  • @wilburadams9848
    @wilburadams9848 Рік тому +6

    Thank you. Your explanation was absolutely informative, and comprehensive.

  • @kcpoodlesofpa
    @kcpoodlesofpa 2 роки тому +19

    I’m so glad I found this channel! Someone shares my love of pharmacology 😀

  • @jimdale6476
    @jimdale6476 Рік тому +5

    I enjoy that niacin "flush" when I hit the hay. It feels cool & refreshing ... as if I'd just completed a steam bath (even when that's far from the case). People are always startled, scared and misjudge it when they don't know to expect the flush. When they DO know ahead of time, however, they can enjoy its uplifting effects ... presented at the RIGHT time & environment . Best to take it just before you go to sleep. It's so comfortable while you just lay there motionless, you won't feel like moving. Even feels like it reboots the mind ... feeling more rested afterward ... both physically & mentally. (Just be prepared for its slightly extra cooling effect ... with an adequate sheet or light blanket.) :)

    • @Chip_eater48
      @Chip_eater48 Рік тому +1

      I agree , how comes I don’t get the flush every time I take it ?

    • @mcr3105
      @mcr3105 Рік тому

      Do you feel the itch on the chest and arms too?

    • @mcr3105
      @mcr3105 Рік тому

      @@Chip_eater48 You could be taking the flush free niacin

  • @debbietaylor20
    @debbietaylor20 4 роки тому +14

    It relaxes me helps for anxiety Better then an antidepressant or valium
    Im on keto and HDL gone up and tryglicerades gone down LDL is still high.

    • @Shurmash
      @Shurmash 4 роки тому

      How much do you normally take at a time?

    • @peacewins3281
      @peacewins3281 3 роки тому +2

      check dr. Berg's "why your LDL is high on keto",,,,,then you would relaxxxxxx.

    • @johanitalouw9315
      @johanitalouw9315 2 роки тому

      Totally agree!

    • @GreenCheese500
      @GreenCheese500 Рік тому

      What dose do you take?

  • @enmukeeenmukee3254
    @enmukeeenmukee3254 3 роки тому +252

    Be careful when taking Niacin. I took regular flush 500mg of Niacin and within 30 mins, the flush effects were crazy, my heart rate went to 120 and I felt dizzy and blacked out for 5 mins. Luckily, I did not hurt myself. Effects were gone in an hour but it was a torture. So start with a small dose to see how your body tolerates it.

    • @meme-tf8ih
      @meme-tf8ih 3 роки тому +35

      Wow, u r brave...when taking any supplements, start with small dose, and then up it. At lease you didn't stop taking with the bad experience you had. Smart move. B3 is very good for the body.

    • @Foxterrier
      @Foxterrier 3 роки тому

      If you are interested, there is a video how flushing occurs. ua-cam.com/video/BXU370RA1C4/v-deo.html&ab_channel=Foxterrier

    • @enmukeeenmukee3254
      @enmukeeenmukee3254 2 роки тому +33

      @@Foxterrier Thanks. One lesson I learnt the hard way is to be very well hydrated when taking Niacin and never take Niacin if there is any significant alcohol in your blood as it greatly exacerbates flushing.

    • @Foxterrier
      @Foxterrier 2 роки тому +21

      @@enmukeeenmukee3254 Also antibiotics and even grapefruit juice can potentiate niacin effect. So be aware of such drug interactions.

    • @meghanzoll6447
      @meghanzoll6447 2 роки тому +16

      same! had an awful reaction and i didn’t even realize jt was the niacin just thought it was the hot sauce i had lol. so i took it again and ended up crying in the school bathroom. side effects are awful!!!

  • @ninawildr4207
    @ninawildr4207 4 роки тому +41

    Get rid of vegetable oils and most sugars

    • @Jetsetrichinfo
      @Jetsetrichinfo 8 місяців тому

      What about peanut oil filtered at home?

  • @johanitalouw9315
    @johanitalouw9315 2 роки тому +5

    Why no mention of dr Abram Hoffer's work on niacin for schizophrenia?
    Also use for ADHD?

  • @edmitchell9307
    @edmitchell9307 2 роки тому +45

    Niacin is a vitamin you must start slowly and gradually work your way up to your desired dose. The first time I took it it startled me because I wasnt expecting the side effects. The flushing doesn't last long and as you increase your dose the flushing can eventually go away completely. I have found all the "Take with X and you wont flush" to be bogus. The only thing that worked for me was dosage saturation. I am currently on 4grams and I no longer flush at all. I had debilitating arthritis and am mostly pain free now. I also noticed an increase in cognitive function. 3 years now and no down side except peeing a lot. Stay hydrated.

    • @jamescalifornia2964
      @jamescalifornia2964 2 роки тому

      Ha ! Same with me. The first dose was a doozy ! I now use _SloNiacin_ .

    • @dwaynemorris3079
      @dwaynemorris3079 2 роки тому +1

      @@jamescalifornia2964 i take Endur-acin and very little flushing. i took Nialor prior to that.

    • @jamescalifornia2964
      @jamescalifornia2964 2 роки тому +1

      @@dwaynemorris3079 - Sustained release niacin should not cause flushing 👌

    • @osopapi
      @osopapi Рік тому

      @@jamescalifornia2964 but it does. Go figure.

    • @jamescalifornia2964
      @jamescalifornia2964 Рік тому +1

      @@osopapi ~ Sustained release does not cause the uncomfortable flush for me. Try splitting the does 2 - 3 times daily. _SloNiacin_ comes in 500 & 750 mg.

  • @Mulazim.
    @Mulazim. 3 роки тому +21

    Some people claim that Niacin increases Nitric oxide and could be used as an alternative of L-arginine and L-Citrulline

    • @lancer717
      @lancer717 2 роки тому

      It does. Take it before sex and viola

  • @lonnieke
    @lonnieke 2 роки тому +2

    BEST VIDEO I FOUND ON UA-cam ON THIS SUBJECT

  • @Dauseana
    @Dauseana 2 роки тому +45

    I take niacin regulary. It makes me feel extremely warm. Too dark to flush lol. But it really helped lower my high cholesteral.

    • @texanboiii562
      @texanboiii562 2 роки тому +1

      Lucky you 😭

    • @hazeboy8981
      @hazeboy8981 2 роки тому +2

      Didn’t knew grabbed a mtn dew kickstart And I’m like wtf is that just by curious but still drank it

    • @Dauseana
      @Dauseana 2 роки тому +1

      @@texanboiii562 🤣🤣🤣🤣🤣🤣

    • @vinlondon8904
      @vinlondon8904 2 роки тому +4

      @@Dauseana how much did it lower your cholesterol and how fast it did it ?

    • @johnnyflores1978
      @johnnyflores1978 2 роки тому

      Just take omega 3 krill oil and healthy fats also take soluble fiber for cholesterol

  • @herbertvonsauerkrautunterh2513

    I've been taking a B3 supplement for years and not for cholesterol. I take it for skin and DNA repair. No side effects at all

  • @itsatrap4986
    @itsatrap4986 Рік тому +20

    For first timers, get B3 500mg in tablet form and break it in half. Start off low and work your way up. It also helps to eat first and drink lots of water before taking it.

    • @pattyloader8013
      @pattyloader8013 Рік тому +2

      Because I had a bad flushing reaction years ago when I took 500 mg, now I started off at only 100 mg...and will increase a bit at a time.....That flush reaction can be scary the first time.

  • @mybuddyjustin73
    @mybuddyjustin73 2 роки тому +4

    Welp, I guess I’ll be adding your vids to my binge list. Great stuff. 👍🏻

  • @micaonyx5301
    @micaonyx5301 Рік тому +23

    I took a pretty good amount of niacin last year when I had covid, because my body wanted to get out and breath fresh air. It was an average of 10-15 degrees in my area. I had just watched Andrew Saul and he seems to think niacin and vitamin C can cure everything except death. I didn't take it for covid I was taking it to keep me warm which it did. I'm anemic and I felt so good I walked on average two hours every day. I barely had any symptoms of covid. This year had a severe case of covid forgot to take niacin because I try to cycle my supplements. First week too sick to get out of bed least of all go walking. Took me 3-4 weeks to recover taking the same supplements except niacin. . Coincidence I don't know, what I do know no matter what I'm keeping niacin in my supplements stack 🤣

  • @kiaratoves9472
    @kiaratoves9472 3 роки тому +22

    Hi, please post more content!! Your videos are literally the only ones i can find on here that properly explain each topic with perfect visuals!

  • @florramirez6744
    @florramirez6744 4 роки тому +15

    thanx for these videos. You make everything so easy to comprehend. Love ur voice btw!

    • @DrugChug
      @DrugChug  4 роки тому +2

      Thanks for watching! Glad it helped😁

  • @makarov138
    @makarov138 10 місяців тому +1

    A no-flush type of niacin is inositol hexanicotinate, which I take daily. It is a slow-release form that ensures the body always has niacin in the bloodstream.

  • @ReflectedMiles
    @ReflectedMiles Рік тому +1

    Several older clinical studies have demonstrated that IHN may have a beneficial effect on endothelium-dependent vasodilatation. The clinical research literature includes several positive studies on the use of IHN for improving blood flow in conditions where blood flow is compromised (Ring and Bacon 1977; Head 1986; O’Hara et al. 1988).

  • @juanitahardy8583
    @juanitahardy8583 3 роки тому +36

    My radiologist recommended 500 mg regular release to treat skin cancer. This is common practice in other countries. My Bowens skin cancer has virtually disappeared but other skin cancers are down but not as significantly. I understand this is a common recommendation in Australia where skin cancer is prevalent. Flushing becomes less with regular use. I do use low dose aspirin but I will try homemade no sugar applesauce. I do not eat sugars.

    • @morpheusbott3370
      @morpheusbott3370 2 роки тому +1

      How do u avoid sugars in fruits? I’m guessing u mean other types of sugars but I’m curious how u do it as I’m interested in cutting out sugar. Thank you

    • @katesun2957
      @katesun2957 2 роки тому +1

      My son thinks that's so funny when he hears that from people. He always says, almost everything breaks down to sugar in your system.

    • @supermariiio
      @supermariiio 2 роки тому +1

      @@katesun2957 then we dont need to add sugars in the products if our body converts it to sugar anyway

    • @hbh4276
      @hbh4276 2 роки тому +2

      Thank you so much for your post. I didn’t know it helps with skin cancer which I got. I came here for high cholesterol but found this piece of information by chance. 😊

    • @hopenunyahbiz
      @hopenunyahbiz 2 роки тому +2

      Supposedly "CrabApples" are the ones to go to all others are full of sugar..

  • @augustmosco
    @augustmosco Рік тому +3

    This is wonderful information for the concerned novice. Thank you.

  • @yoshiytt2834
    @yoshiytt2834 4 роки тому +6

    Niacin helps with tinnitus, lowers the ringing big time especially if you're fit and are No Fap

    • @Littleprinceleon
      @Littleprinceleon 2 роки тому

      Research study on the correlation of tinnitus with fapping?

  • @lewis20002000
    @lewis20002000 4 роки тому +11

    VERY WELL DONE....great narration and graphics

    • @DrugChug
      @DrugChug  4 роки тому +2

      Thank you Lewis! Appreciate the support!😁

  • @luckyhanger1326
    @luckyhanger1326 4 роки тому +19

    Nicotinic acid also has a pathway to help recharge the NAD+ which powers the mitochondria. It is a cheap version of NMN or NR. Not sure about the dosing but I take 200 mg in my daily STAC.

    • @kerzhemanov
      @kerzhemanov 4 роки тому +5

      Perhaps 500 mg will be closer to optimal. I am not an expert though

  • @steveamor8103
    @steveamor8103 4 роки тому +9

    Life saver! Need more content !

    • @steveamor8103
      @steveamor8103 4 роки тому +1

      I leave a comment for the algorithm gods!

    • @DrugChug
      @DrugChug  4 роки тому +2

      Thank you some much for the support! 😁

    • @jackjones4043
      @jackjones4043 4 роки тому

      twitter.com/3PIDEMIOLOGY Dmitry Kats, Ph.D., M.P.H. he will lead you to tons of research papers.

  • @TheSilverlover999
    @TheSilverlover999 4 роки тому +20

    I took swansons 100mg Niacin within 10 mins i feel like i have taken a shot of brandy but a little milder. my body feels hot but nice to take in cold weather.

    • @intheworldbutnotofit8002
      @intheworldbutnotofit8002 3 роки тому

      The Irony is that brand makes their products from harmful to toxic ingredients. They use an ingredient that are found in cement compounds. You toot and praise them all the way to your grave.

    • @AlbionRising
      @AlbionRising 3 роки тому

      Was it nicotinic acid?

  • @nsgreen1796
    @nsgreen1796 Рік тому +3

    Thank you very much for the clearest valuable information ❤

  • @huseyinmuhtar3095
    @huseyinmuhtar3095 11 місяців тому +1

    Hi, does nicotinamide(no flush niacin) 500mg is good for improving NAD level?

  • @marcosta183
    @marcosta183 Рік тому +2

    In the shopping, a few years ago, Niacine was the threefold price of Niacinamide. Later on, this difference went the other way around and today, Niacinamide is the one which price is the highest. Any one there to explain this change?

  • @ketocajun7451
    @ketocajun7451 Рік тому +10

    You should inform people (since you state it several times) that LDL is not bad because it is the same as HDL just with higher concentration of fatty acids (same protein structure) just the phenotype of LDL is something to watch. Differentiate the LDL into it's 7 components and see if you have high glycated end products. Maybe that is beyond this video but people should not be afraid of LDL. You cannot live without it.

  •  3 роки тому +7

    I need to know WHAT İSTHE DIFFERENCE in between of Niacin and Niacin hexagonite?

    • @Littleprinceleon
      @Littleprinceleon 2 роки тому +2

      Hexagonite? Surely?
      Non-flush version has six (=hexa) niacin molecules chemically bonded to one inositol molecule...
      The nicotinic acid (= niacin) is slowly and not very efficiently stripped off of the inositol.

  • @Droidzi
    @Droidzi 2 роки тому +8

    nice one - any views on the better versions (least man-made "natural"/less chemical) versions of B3?

  • @didgeridooblue
    @didgeridooblue 3 роки тому +7

    If B3 blocks the decomposition of adipose tissue how can someone lose weight (fat) while taking B3?

    • @Littleprinceleon
      @Littleprinceleon 2 роки тому

      Niacin is transforned into NAD which is part of the basic cellular metabolism... If there is enough NAD in the cells perhaps they burn more calories...
      Although they should also work more efficiently (meaning less waste, so less energy needed... so maybe the excess is stored as fat 🤔😉): I would say that under 50 one should NOT normally need extra B3 uptake. Perhaps it helps with muscle building with regular exercise.
      If you start to search after how complicated are the networks affected by most of the supplements, you'll realise that one can only rely on good quality clinical studies: even those produce many times more or less contradictory results. But those are at least explained after some more investigation, while most of the problematic issues found via basic or epidemiologic research have no satisfactory answers even after three decades and hundreds of studies

  • @josephinelai4638
    @josephinelai4638 2 роки тому +2

    Glad to find your channel. I have been taking flush free niacin for years and didnt know the effect until now! Thanks for sharing.

    • @seanoconnor1731
      @seanoconnor1731 2 роки тому +2

      Flush free does NOT reduce triglycerides - refer to end of video.

  • @MAGZIVE
    @MAGZIVE 4 роки тому +109

    Watching this video while my ears are magma hot from the flush lmao

    • @DrugChug
      @DrugChug  4 роки тому +2

      Hahaa hopefully the video helped!

    • @abc_cba
      @abc_cba 4 роки тому +1

      Lol

    • @XWDaniel
      @XWDaniel 4 роки тому +5

      I definitely popped 2 pill first day not reading the label. I know the feeling 1000mg at once ain't it. 😂

    • @intelligentdesignmorty8112
      @intelligentdesignmorty8112 4 роки тому +1

      @@XWDaniel 500 mg already white me hard xD

    • @HopeAndrea_HFG
      @HopeAndrea_HFG 4 роки тому

      Same

  • @LindaSparks813
    @LindaSparks813 5 місяців тому +1

    Good information great video love your graphics. 😊

  • @itsmeforsure5475
    @itsmeforsure5475 Рік тому +5

    I just started taking 300mg of Niacin and I've never taken any vitamin or drug, that had that big of an effect. Even at 300mg, I got the face flushing and tingling skin. I didn't know this lowers triglycerides and mine are high so I will probably take it most nights. I don't want to walk around looking like I spent 2 hrs too long in a tanning bed.

  • @davidtrindle6473
    @davidtrindle6473 2 роки тому +18

    Don’t take 1000mg!! Start at 50mg and gradually increase as body adjusts.

  • @FlickSh0tt
    @FlickSh0tt Рік тому +1

    I feel like the flushing has its purpose. Reducing it or taking a slow release might take away form of the benefit

  • @SableFox72
    @SableFox72 10 місяців тому +1

    I was having some liver pains yesterday, then intuitively felt to take 500mgs of B3 before bed. My entire upper body got very itchy while my entire body swelled a bit & my every single hair felt like a spike in my body. I felt like a hedgehog. My heartbeat quickened as my blood pressure & temperature rose. Woke up this morning feeling refreshed. Not sure why my body reacted so strongly but Im guessing its because Im riddled with spike protiens from touching the vaxed public at work which is inflaming my joints terribly after each shift.

  • @17mazes17
    @17mazes17 Рік тому +2

    Does it spike blood sugar? My FBS is consistently between 5.3 to 5.7. I took niacin the night before and had a considerably higher FBS in the morning!

  • @afh1695
    @afh1695 Рік тому +1

    Natures Way nicotinic acid 100mg capsules is the easiest to split into 50mg starting dose on empty stomach first thing in the morning before coffee. Allow yourself the chance to see if you are sensitive to the flushing/heat effects before upping the dosage.

  • @TK-hv7eb
    @TK-hv7eb Рік тому +1

    How about Niacinamide for cholesterol?

    • @razvedka9979
      @razvedka9979 Рік тому +1

      Only regular niacin has lipid benefits

  • @erandeser5830
    @erandeser5830 Рік тому +1

    Why is the very slow release drug prescription only ? How slow can be bad ?

  • @71160000
    @71160000 Рік тому +10

    My doctor prescribed niacin years ago. I took one pill. In an hour by arms were on fire, my legs were both vibrating. An hour and a half later it subsided and then within the next hour it started over again. It was so painful I was ready to go to the emergency room when it finally quit hurting. It was like the worse sunburn of my life. I don't remember turning very red though. Just a burning sensation.

    • @phil.1
      @phil.1 Рік тому +7

      I love the flush now. I take 2-4g a day. My neck burns and my chest itches so bad if i take it at night. I mix more than 1g in my citrus flavor fiber powder drink. After a nice hot shower before bed with the niacin flush, it's super rejuvenating. Once you get used to it, it's a game-changer. Like my brain fogs completely disappears after the flush, it is super sauna-like and relaxing in a good way... something about opening up the capillaries and flushing fresh oxygenated blood to my brain and under my skin makes the post-flush feeling really youthful. Biggest plus is my HDL went from 52 -> 84 and VLDL 102 -> 83.

    • @TinaRossetti-ty6zy
      @TinaRossetti-ty6zy 7 місяців тому

      This made me laugh. I would have had a major panic attack with those symptoms. It sounds as bad as my atrial fibrillation, which is why I'm looking into niacin....

  • @MaxAmerica.Freedom
    @MaxAmerica.Freedom 7 місяців тому +2

    Thanks for letting us know to avoid flush free. No wonder it didn't work. At about 7:00

  • @MichaelCzajka
    @MichaelCzajka 5 місяців тому

    The inositol version of niacin has a niacin molecule at each of the 6 corners.
    Enzymatic action breaks down the bond to the niacin releasing it.
    Inositol hexanicotinate is the most effective form of niacin because of this slow release mechanism.
    :-)

  • @teresitaang2759
    @teresitaang2759 2 роки тому +1

    Pls discuss how to take K2 and should take calcium too.

  • @mrofnocnon
    @mrofnocnon Рік тому +3

    Thank you for this video. A few tips, the flush lasts only about 15 mins and reduces a great deal in a short time, the Niaspan is a disgusting rip off of what is basically niacin in a slow release form sold with the word play "extended release" it should never have been allowed a patent. Slo-Niacin is just as effective for a fraction of the price. these slow release forms of niacin have stronger effect and can be a strain on the liver, so try the regular niacin first.

    • @Erikacarriel1982
      @Erikacarriel1982 Рік тому +4

      The med pharma people said that niacin (Nicotinic Acid) raises blood sugar levels on people with diabetes. I have pre diabetes, but it does not affect me. It only raises it from the time frame of the flush beginning to end, and it doesn't go that high, does not harm you like pharma people say. I really live the flush.

    • @mrofnocnon
      @mrofnocnon Рік тому

      @@Erikacarriel1982 Me too.

  • @Chip_eater48
    @Chip_eater48 Рік тому

    I take 100 mg for the flush once or twice a week helps with my depression

  • @suellenmaforte12
    @suellenmaforte12 3 роки тому +8

    Soo… out of curiosity here, you mentioned that Niacin increases the uric acids, but since uric acids are broken down purines waste in the blood, wouldn’t niacin assist in easing the pain of gouts and such? Because it breaks down the triglycerides, assisting with better blood flow and giving less chances of uric acids building up.

    • @Littleprinceleon
      @Littleprinceleon 2 роки тому +1

      While great that you are trying to deduce some connections: As a biologist I don't think that these can be such straightforward.
      The level of TGs in blood is regulated...
      Certainly the pathway mentioned is only one of those that lead to the formation of TGs.
      But may be that this one is mainly responsible for elevated TGs. Maybe.
      Where have you heard that lower TGs alone would increase blood flow? 🤔🙃 There are so many, much more voluminous or dense constituents in the blood. Also, lowering the "bad" cholesterols (actually there is a whole range of different densities, sizes of good and bad...) doesn't always lower the clot formation. Things in biology are always more complicated than one can think of ... 🤫

  • @sickofcrap8992
    @sickofcrap8992 Рік тому

    You can't buy stand alone B3/Niacin anywhere in my town. It is not sold as a separate vitamin here at all.

    • @alancadieux2984
      @alancadieux2984 Рік тому

      Nutritional yeast has plenty in it. Along with other b vitamins.

  • @falconone7230
    @falconone7230 3 роки тому +3

    I also heard of anti aging benefits from b3 100mg

    • @CAdams93
      @CAdams93 2 роки тому

      It does because it flushes toxin from your body and it also helps your hair grow

  • @stephanygates6491
    @stephanygates6491 2 місяці тому

    I'm taking niacin to address decreasing NAD+ as I age. I have no blood lipid issues (lucky me). I do appreciate how niacin keeps the LDL particles in the fat cell until they become big enough to not be a problem in the bloodstream.

  • @manalalzubi671
    @manalalzubi671 3 роки тому +24

    How much is the dose of niasin that could harm the liver? Is there any tests that I should do first for my liver to see if it is safe to take this vitamin?

    • @tootienottoofruitie1726
      @tootienottoofruitie1726 3 роки тому +2

      250 mg to start. ,500 mg per day once you can handle the flushing.. when I take it I skin brush that feels so good

    • @Littleprinceleon
      @Littleprinceleon 2 роки тому

      Basic liver enzymes levels (which are routinely checked) should suffice.... If you (or your genetic relatives) haven't had problems with liver, then 250mg should be safe...
      Start with lower doses though

  • @MichaelCzajka
    @MichaelCzajka 5 місяців тому

    Inositol hexanicotinate most certainly improves your cholesterol.
    HDL goes up and LDL goes down.
    It also appears to help reduce homocysteine, free fatty acids and many markers of inflammation.
    :-)

  • @Bulldoghartl
    @Bulldoghartl 4 роки тому +6

    Been waiting for this! Found it today!

    • @DrugChug
      @DrugChug  4 роки тому +1

      Woohoo! Glad it helped!😀

    • @Bulldoghartl
      @Bulldoghartl 4 роки тому

      Slow ride.... slow ride........ sloe ride

  • @edj2745
    @edj2745 Рік тому +2

    Can niacin be taken with other vitamin supplements like magnesium and cod liver oil?

  • @creepycrawler4690
    @creepycrawler4690 Рік тому +10

    I recently started 500mg. Been having some extreme side effects. My whole body turns red with burning and stinging for a couple of hours. I'm thinking it could be the fact that I'm taking with all of my other vitamins at the same time. I mean it's almost unbelievable.

    • @mrofnocnon
      @mrofnocnon Рік тому +1

      Take it with food to reduce the flush.

    • @Skinny_Pimp
      @Skinny_Pimp Рік тому +1

      Get in hot water with Epsom salt
      Or a hot tub. The water will soothe your skin and allow it to be more tolerable.

    • @paulharrisonadventuregearm5457
      @paulharrisonadventuregearm5457 Рік тому +4

      Totally normal...it's nothing to be concerned with

    • @mrofnocnon
      @mrofnocnon Рік тому +1

      @@Skinny_Pimp Totally false.

    • @pattyloader8013
      @pattyloader8013 Рік тому +3

      Start off at a low dose!!!! you can get 100 mg to start... Very uncomfortable side effects at higher doses.......and after meals

  • @sheilamore3261
    @sheilamore3261 Рік тому +1

    Thank you so very much for explaining what niacin does🥰💕

  • @barryfennell9723
    @barryfennell9723 5 років тому +5

    i had once taken niacin fasted and i think i may have over dosed on potassium lucky though my blood sugar dropped and i urinated with my blood ketones being at a level that i could have higher alkaline products and not keel over from dangerously low blood sugar.

    • @SCAMDEMIC2023
      @SCAMDEMIC2023 4 роки тому

      Can you explain your comment. I'm new.

    • @barryfennell9723
      @barryfennell9723 4 роки тому +2

      @@SCAMDEMIC2023 people take niacin to lower blood pressure but if you go keto your kidneys will release salt and your blood pressure will drop. therefor making niacin somewhat dangerous. the low blood pressure will result in headaches, nausea, lethargy, loss of color in the face. Sometime hydrating with saline isn't enough and you might have to eat something.

    • @SCAMDEMIC2023
      @SCAMDEMIC2023 4 роки тому

      @@barryfennell9723 Oh ok I started taking niacin yesterday. I was about 35 hours faster. I got bright red in about 5 minutes. I took 500 mg. I continued fasting and ate at 41 hours. Today, I ate keto 4 eggs 2 avocados + salt for breakfast took another 500mg and had hardly any reaction. So I took another 500 mg after dinner, and no flush at all. I'll be careful and probably avoid niacin when fasting. Thanks.

  • @MichaelCzajka
    @MichaelCzajka 5 місяців тому

    Niacin has been known to spike liver enzymes in the first week or so... but then they drop down back into the normal range.
    Niacin has been known to spike blood glucose... but that also returns to normal after a few days:
    Niacin helps improve carbohydrate metabolism.
    🙂

  • @bobcocampo
    @bobcocampo 3 роки тому +5

    What is the effect of Niacin to Hs CRP?

  • @kyberuserid
    @kyberuserid 2 роки тому +2

    Inspires confidence in medical education.

  • @retribution999
    @retribution999 2 роки тому +2

    Is Niacin better than taking a statin? If so why don't doctors recommend it to lower cholesterol?

    • @christymartinez2078
      @christymartinez2078 2 роки тому +4

      Yes Niacin I'd better than Statin. Doctors won't recommend because there is no profit. Statins weakens nerves & muscles. Weak nerves & muscles causes heart attacks & strokes

    • @christymartinez2078
      @christymartinez2078 2 роки тому

      Read my previous msg. I thought I had reply directly to you. Anyway there is an amino acid called Coq10 that our body produces. As we get older, we produce less. When a statin is taken, this drug cause not to produce Coq10 (closes door). Coq10 is necessary for nerves & muscles. So for anyone taking a statin, one needs to supplement with Coq10.

    • @retribution999
      @retribution999 2 роки тому

      @@christymartinez2078 excellent, thanks for confirming. My doctor wants to put me on a statin but so far I've resisted. My LDL is flagged as high so maybe Niacin is the solution I need.

    • @christymartinez2078
      @christymartinez2078 2 роки тому +3

      @@retribution999 if doctor insist on a statin, you just tell them that you decided to try natural. Remember it's your body & you can decide what you will take

  • @bobcocampo
    @bobcocampo 3 роки тому +4

    Does Niacin have an effect on Vitamin D3

  • @SajSajidmk
    @SajSajidmk Місяць тому

    Which is natural sources of B complex b3 vitamin.. please?

  • @sophiebuzora9616
    @sophiebuzora9616 3 роки тому +6

    I have Atrial Fibrillation, SVT. I really would like to take B3 Niacin, but I have a feeling that my heart rate will go up and triggers an episode which I really afraid of. Does anybody have any suggestions about this? Thanks.

    • @ResearcherJournalist
      @ResearcherJournalist 2 роки тому +1

      Hey Did you try Niacin in the end? If so how was your Afib response? Or have you found any guidance or advice on using Niacin with Afib??

    • @johnnyflores1978
      @johnnyflores1978 2 роки тому +1

      Hello hows your afib? Did you get an ablation or are on beta blockers?

    • @christymartinez2078
      @christymartinez2078 2 роки тому +1

      Magnesium will help for A fib

  • @gerdz101
    @gerdz101 Рік тому +1

    Hi can anyone shed some light on my question. If niacin blocks adipose tissue from converting to free fatty acids then wouldn't be niacin be bad for fatloss?

    • @bobbylee2853
      @bobbylee2853 Рік тому +1

      I stop taking it when I go on my monthly 3 day fast.😊

  • @hope2911able
    @hope2911able Рік тому

    great info and visual mapping but where are the answers to the 4 quiz questions?

  • @joseanker2059
    @joseanker2059 4 роки тому +6

    Flushing is not harmful and with use it actually disappears

    • @Pajtim2023
      @Pajtim2023 3 роки тому +2

      I see flushing like detox bro
      Colesterol and metal detox
      My brain start working better
      Memorizing better thinking better
      My erection are better
      Blood flow is rocking

  • @isaacwinton
    @isaacwinton 4 місяці тому +1

    This channel is sick. Gg bro

  • @teddybear4020
    @teddybear4020 Рік тому

    HOW LONG DOESit take to drop triglycerdes , ldl cholesterol.

  • @masoodabbas3144
    @masoodabbas3144 2 роки тому +4

    Well explained and very informative

  • @Gustavo-bi4hv
    @Gustavo-bi4hv 2 роки тому +1

    If I have fatty liver it is not recomnended to take it?

  • @abc_cba
    @abc_cba 4 роки тому +8

    I began noticing that Niacin flush doesn't happen that large if you consume it with Pomegranate, or with unsweetened Soy Milk and even at times with Green Grapes.
    Infact, it just occurs for two minutes and fades away.
    Give it a try and notice it yourself.

    • @DrugChug
      @DrugChug  4 роки тому +4

      I've never heard of that before! 😁

    • @krane15
      @krane15 4 роки тому +7

      Soy milk? I don't think so.

    • @abc_cba
      @abc_cba 4 роки тому +4

      @@krane15 Well, I'm talking based on my own personal experience. It doesn't happen to me at all if I have it with these 3 foods.
      It may not be factual if you compare it with you.
      All bodies differ. For some even Niacin doesn't work, for some statins don't work, doesn't mean it won't work on everyone.
      Did you understand my analogy ?
      But yes, I try Niacin immediately after my dinner and that also doesn't give me a heavy flush at all.

    • @victorpetrescu6586
      @victorpetrescu6586 4 роки тому

      @@krane15 let me guess, you're someone who eats up anti soy propaganda

    • @krane15
      @krane15 4 роки тому +6

      @@victorpetrescu6586 Let me guess, you're someone who profits from the industry?

  • @sadiqakhan2545
    @sadiqakhan2545 3 роки тому +2

    Wow thank you its great video n thanks for doing the quiz in the end .Thank you so much

  • @javaChai
    @javaChai Рік тому +2

    Is it naturally available in foods? If so what’s foods are high in B3?

    • @Step-n-Wolf
      @Step-n-Wolf Рік тому

      I checked Cronometer for my own info and the highest source was beef steak and salmon followed by coffee and avocado.

  • @animated6875
    @animated6875 2 роки тому +3

    what are the foods rich in niacin?

  • @no_country_for_real_men
    @no_country_for_real_men Рік тому +1

    Hands down best short lecture on Niacin I have ever seen

  • @naomimara3340
    @naomimara3340 Рік тому +2

    I started taking 250-500mg B3 for anxiety (trying to reduce Benzo Clonazepam 0.5mg).I realised it's a Nicotinamide, the no-flush-kind. Will I still be getting anti anxiety effects?

  • @Jetsetrichinfo
    @Jetsetrichinfo 8 місяців тому

    Is it same as nicotine in tobacco? Can u share difference between them or similarities

  • @Darkedge361
    @Darkedge361 2 роки тому +9

    Well I came here to learn about the vitamins I randomly started putting in my body because of a hunch, Would like to say thanks!! Turns out it does more than I thought it would,
    I'm starting with a 250mg per day for 30 days then I'll increase to 500mg for the long term, I was honestly looking for something to help with erectile disfunction that wasn't a $38 per pill solution because I knew it dilated blood vessels, and I deduced that it maybe a solution because my legs feeling cold on occasions. it's been working as I expected, and your video gives me a much better understanding of why.

    • @eligreg99
      @eligreg99 2 роки тому +2

      Try Ashwagandha pills brother.

    • @Darkedge361
      @Darkedge361 2 роки тому +2

      @@raulbeck3722 i feel pretty good, i don't get the flush very often unless i take a double dose

    • @Darkedge361
      @Darkedge361 2 роки тому +1

      @@raulbeck3722 A1c actually dropped a bit,no issues on blood screens though

    • @andrewfinlay5160
      @andrewfinlay5160 Рік тому

      Marc Cuban cost plus pharmacy..tadalifil is cheap with prescription...25$. 90 days supply

  • @ruebenshaw
    @ruebenshaw 4 роки тому +59

    I don't care if people see me as being red And I like the feeling of itching and burning and heat!!!

    • @PandaA-cv3mm
      @PandaA-cv3mm 4 роки тому +6

      👍 Same here! Love it 😉

    • @tarwamccound5308
      @tarwamccound5308 4 роки тому

      Lmao

    • @AK-kv2fl
      @AK-kv2fl 4 роки тому +1

      Bloody love ya

    • @fightcrime4216
      @fightcrime4216 4 роки тому

      Same me I bloody love it if I don't get the flush sm piss off 🤣🤣🤣🤣

    • @chejvasquez5202
      @chejvasquez5202 4 роки тому +2

      Oh. I have dark skin and my skin turn purple 😈😈😈😁😁

  • @dompage6076
    @dompage6076 7 місяців тому

    One of the side effects is muscle pain and muscle breakdown, i took mine yesterday without food and later in the day my biceps were in severe pain, i didnt know about having it with food.
    Can you please talk about this please because im waiting to hear from a doc tomorrow. Healthline niacin will talk abit on this subject

    • @vvv2878
      @vvv2878 4 місяці тому

      It depletes methyl donors. You can lower dosage or take with TMG