Could Amphetamine Hold the Key to Treating Methamphetamine Withdrawal? A Groundbreaking Solution?
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- Опубліковано 4 лют 2025
- In this video, Dr. Sanil Rege, a consultant psychiatrist, takes you on an in-depth exploration of a fascinating and emerging area in addiction psychiatry: methamphetamine withdrawal and the potential use of lisdexamfetamine as a treatment.
Understanding methamphetamine withdrawal is crucial. We'll explore the symptoms, the different phases, and the challenges individuals face during withdrawal. Currently, the treatment options are limited, with supportive care and symptomatic management being the primary approaches. However, these methods often fall short, leaving a significant gap in effective treatment.
That's where lisdexamfetamine, also known as Vyvanse, comes into play. We'll delve into the science behind this medication and the recent research exploring its potential as a treatment for methamphetamine withdrawal. A particularly promising study we'll discuss is an open-label study that provided insightful results on lisdexamfetamine's effectiveness in this context.
Looking ahead, we'll also consider the future directions for this research, including the exciting LiMA study, which investigates lisdexamfetamine as a potential substitution therapy for methamphetamine dependence. This could be a groundbreaking development, similar to how methadone is used for opioid dependence.
Methamphetamine withdrawal poses a significant challenge due to the lack of approved pharmacotherapies. Could lisdexamfetamine be the game-changer we've been waiting for? Join us as we unravel the research and possibilities surrounding this intriguing treatment option.
Don't forget to like, subscribe, and hit the notification bell to stay updated with all things psychiatry, neuroscience, and mental health. Share your thoughts in the comments, and let us know what topics you'd like to see next. Stay curious!
#Amphetamine #MethamphetamineWithdrawal #AddictionPsychiatry #Lisdexamfetamine #Vyvanse #WithdrawalTreatment #MethamphetamineAddiction #StimulantTherapy #AddictionTreatment #MethamphetamineDetox #FutureOfAddictionTreatment #SubstanceAbuseResearch
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As a former user of methamphetamine... i would say the main reason i was on it for as long as i was is because i had/have a good job. It took me about 10 days to fully come down. (Sleeping almost 90% of the time) then for about 30 days after, i was still consistently tired. My body was trying to learn how to function. The problem was finding the time to stop doing it and also keeping my job and maintaining my performance. This is obviously anecdotal. But if there were a way to shorten that withdrawal process, while also not gaining a dependency for a different drug, i would have jumped at the opportunity. I tried about 12 times before i finally got through the withdrawal. I made a mistake by getting involved with it. But you never would've picked me out of a lineup as a guy suspected of being on meth. I kept all my teeth. I just used it like what a cup of coffee in the morning is to most people. Just to maintain functionality.
Thank you for sharing . I’ve had individuals using meth in this manner - and holding a job - first thing in the morning. Glad you were able to overcome it
many addicts do this in the Midwest. Specifically volumes in weight from a consistent supplier daily like a dose of adderall.
Finally! Ive have been studying this topic for months. Been a user for years. Local doctors are crap. Im a professional. A closet user. I want a different way of life. I want to experience joy not heart palpatations. Not brain inflamation. Not dementia. Had somebody, anybody told me that i risk one day losing my ability to feel Joy, I never would have done it. I guarantee it. That just means I have been alone in this journey. Poverty being a huge trigger. I know that sounds stupid but it's true. Can't afford good healthcare dont know how to take care of myself. Never was taught. Therefore never a thought. I am aware now. I regret not being aware before, but now I have NOT been able to find people who think and research and educate themselves, local medical professionals included. It's heartbreaking and discouraging and hard. I wish this was more widely known and accepted. This is so much better than the alternative, being death. And stigma. 😭🙌
amen my brother. I feel like you precisely. turning 64 in 2 weeks.aoart from an 8 year stretch in NA I'm happier on opiates and stimulant Meds .
Climbing Mt Everest is risky AF but they are heroes and we are zeroes
I'm off topic but methylphenidate really helped me quit a pretty bad crack/coke addiction. ...maybe I was self medicating my adhd
@@Mmcermes thanks for sharing . It’s a possibility.
@@PsychiatrySimplified it helped with meth 4 month daily taking about 250 mg a day plus genericic methandianone,but i slept alwys well with flunitrazepam 4 tbl.
TY. I support your agenda
Please do a video for teeth grinding psychological treatment or other methods of treatment xx
Yes! ❤
Hey, I find your videos really interesting! I was wondering if OROS methylphenidate could also be an option in treating meth withdrawal, as it could be slighly less « neurotoxic » and have less of an influence on BP. IIRC it has been studied for cocaine dependence with success, even though here the mechanism is slighly different (release vs reuptake inhibition)
Also for the treatment of protacted cognitive and depressive symptoms, I see great potential in the use of tranylcypromine, as it has slight stimulant properties while being very effective in treating the cognitive deficits in severe depression. And it is also compatible with methylphenidate, even though you´d probably have to start the treatment inpatient to closely monitor BP.
Anyways, I’d love to hear your thoughts!
From a paychopharm perspective Yes and Yes within the right framework.
Generally in meth addiction / withdrawal - a multi-pronged approach works well - for example clonidine can be a very good addition as well.
Wow... I love that we're having these conversations. Brings hope to my heart and tears to my eyes. I am speechless. And here to learn. Please don't stop this work. It's vital. Thank you! ❤🙌
Thank you. Your channel is excellent!
Thanks for your feedback 🙏🏼
Please keep us updated with this, Doctor. Its revolutionary and i wannna be a part of it. God help us get there, help us to get the people there. Amen. 🙏🤍 Thank you Doctor, for sharing your/these gifts with us. 🤍
Will do!
So my friend thought they would try to get off methamphetamine by getting an Adderral prescription to replace their habit. Now they have a habit plus they take Adderral. In other words their plan didn’t work. They have not tried Vyvanse. I’d really like to see my friend kick the habit. Should I recommend they try switching to Vyvanse?
plz make video about difficulty of increasing frontal dopamine signal without worsening mesolimbic dopamine. it's a hard topic.
I’ve covered principles in this video. ua-cam.com/video/Ej9yyOsGYNg/v-deo.htmlsi=PgfIFxrbBVhDEF3n
Can Modafinil helps ? Also for Adderal withdrawal?
My drugs of choice were always stimulants, particularly amphetamines like meth and Adderall. I've thought about this before too, and it seems like a good idea. But the thing with alcohol and opioid withdrawal is that it can literally kill you if you go cold turkey. They have comedown drugs for those addictions to keep you alive so that you can actually experience sobriety. With meth, it's not the same mechanism for addiction. It doesn't have the same chemical hooks that alcohol and opioids have. It's all in your head. If you go cold turkey off meth, you might FEEL like you're going to die, or like you want to die, but it's not gonna happen. There's no real need for a comedown drug. With meth it's better to just go through the detox and get all the stimulants out of your system. It would only be worse to add more stimulants to the mix, because you would just get addicted to the comedown drug, due to the nature of stimulants. With opioids, people hate them. They make you sick, constipated, depressed, all of that. You don't WANT to use more, but you literally have to because it's a matter of life or death. With meth, people LOVE it. It creates so much dopamine in your brain that all you want is more meth. It's not life or death, but it makes you feel like it is. You'll do absolutely anything to get more meth, because you know that it's gonna be the best feeling ever. You know that you're gonna have a blast and feel amazing. You're gonna feel super productive and focused. The addiction is all in your head because of how meth rewires your brain. You won't die from not having it
Thanks for the detailed description. I guess the issue is the risk of relapse so while the withdrawal may not medically be dangerous - the risk of relapse is so high that the medical risk is equally high with ongoing use in a way. Vyvanae is to assist that risk of relapse
Hello doctor since I quit Ritalin and nicotine cold turkey two weeks ago I am having bad brain fog, depression, anxiety and many symptoms physical and mental.I am Also on Lexapro initially only 5mg . After the symptoms started I consulted my doctor and he insisted increasing Lexapro dosage from 5-10 since then I have been feeling even worse (not a scientifically established answer but I guess the increase in serotonin drives my dopamine even lower.Is there a solution to recover in a descent amount of time from stoping these "relatively mild stimulants"I mean mild compared to methamphetamine?The reason for stoping by the way is that they were driving my blood pressure really high and giving me rebound anxiety so I had to stop.I don't have ADHD at least from what my doctors say I was taking Ritalin off label for depression and concentration since my focus is really bad.Thanks in advance doctor I appreciate your content and your efforts educating people!!!
Sorry to hear. While i can't give personal advice - please see the videos on melancholic depression and mixed features. If depression is primary, this should be treated; however, SSRIs may not suit all individuals as, in some, they result in emotional blunting. This can happen in individuals with melancholic-type depression, and they may need more dopaminergic and noradrenergic antidepressants. However sleep and mixed features shoukd be addressed concurrently. Moroever anxiety should be dofffernetiated from Hyperarousal and agitation ( see video ). Wish you well. PS not advice
@@PsychiatrySimplified Thanks doctor!I know that you can't give personal advice but I appreciate your effort to guide me towards the right direction through mentioning the right videos to watch.I will definitely watch the videos that you mentioned and have a discussion with my doctor on our next appointment!❣️❣️❣️
Sir, if possible make a video on cymbalta in details....
I've done two videos on SNRI. Please have a look
I watched your video on Meth. Is moving from goal directed behavior --> habitual behavior along with other problems mentioned a risk with vyvanse at therapeutic doses ?
Due to its longer acting nature and less of phasic DA release the risk is lower when used at therapeutic doses. The individual does not ‘feel the need ‘ to rely on ‘extra vyvanse’ to function. Please have a look at the video on what happens when stimulants stop working. Those are the principles to consider. PS not advice
@@PsychiatrySimplified my dr kept me on too high a dose for too long and now I can’t experience pleasure from anything
This may not necessarily be related directly to vyvanse. It becomes important to rule out depression as anhedonia is more closely linked to Depresion. Vyvanse does not tend to address this part effectively
As someone who started vyvanse for adhd a week ago and having experienced drug induced psychosis once in the past the lima study is sooooo unbelievably promising news. Thank you! ❤
Please monitor for relapse symptoms closely nonetheless.
@@PsychiatrySimplified I will, thank you for looking after me!
So do we see the same effects from high dose MAO inhibitors? I would assume selegeline abuse could certainly be a thing
Selegline gets broken down to Methamphetamine
MAOI prevent breakdown - methamphetamine has multi-pronged effects including MAOI resulting in significant extracellular release and accumulation of dopamine
Interesting.
Sure is
Hi i am struggling without cannabis withdrawals and i had to take respiredon for 3 months and i cant think about anything and there is no time in my mind . What medication do you think would help ?
Are you joking right?
@@Animal-Reaction-Clips why ?
@imanderdumme8706 the reason why he probably didn't reply to you is that cannabis doesn't have withdrawals. This stuff like he's talking about is on many levels above marijuana.
@@Animal-Reaction-Clips i need what he is talking about
in a Pharmacodynamic and Neuropharmaceutical take you have to think that crystaline MAMP releases much more dopamine 3-6 times than ADHD PILLS. and this is one of several neuro toxic effects reaching brain ASAP. Also a lot of people that use Methamphetamine have ADHD, obesity, sleep disorders, and other things that cause them to be further stigmatized for their dual diagnosis when they can benefit from medical stimulation. This isnt a one size fits all butt even things like the way the "Clear" acts on adrenaline to causes meth mouth is so horrendous. Adderal, Desoxyn, Vyvance and Ritalin are much safer alternatives than a potent but tainted crystaline speed.
but only if it s d-opical isomer
1:20 link to other videos
3:33
It will never get better. I hope it does 😭
How long meth stay in body for havvy users
in blood few days,urine 1,5-2 weeeks,hairs 90 dazs +/- but you could became ns skinhead or thug,or raver or soccer right wing hoooligan and shaved your head.
But vyvanse got lisdexamfetamine in it
Yes correct
@@PsychiatrySimplified for what it is good,if Dededrine SR spansules do exist doctor?
Could beer hold the key to vodka withdrawal? There’s already an issue with the over prescribing of stimulants. Let’s find another reason to get people hooked on these.
Thanks for the comment but that's not comparing apples with apples. They are already ‘hooked’. Methamphetamine addiction is a devastating addiction (have a look at the videos )- with an impact on the individual, family and society. Even if you don't watch the videos - just read the comments-heartbreaking stories. Harm reduction and treatment are sorely needed. Due to its significant potency, it's not easy to treat the addiction, and the withdrawal ( protracted) increases the risk of relapse. So having an agent like amphetamine would not be ‘hooked on’ but a harm reduction strategy. Many may come off - we just don't know enough yet.
beer was literally used to manage mild withdrawals historically in hospitals
@@muhammadaadil414sure but what im trying to say is that a substite agonist is an established strategy. I was highlighting that saying hooked on may have been unfair
I work as an emergency psychiatrist for one of the biggest hospitals in the country, and also for my state's department of corrections. The amount of substance use -- specifically methamphetamine -- that I see in both settings is astounding (somewhere between 60 to 70 percent of the patients). Patients will preset to the ER with "schizophrenia" symptoms of hallucinations, delusions, agitation, and so on, when in fact they are intoxicated with methamphetamine or another stimulant. They washout after 24ish hours, and are discharged with referrals to substance treatment. They rarely follow-up, and we see them back again in a few months. Every time this cycle -- which is mostly preventable -- repeats, there is a significant cost to society in terms of health care delivery (e.g. increased wait and response times for medical emergencies) and finances. The societal costs in between ER visits are arguably even larger. If we can find a way to implement harm reduction for methamphetamine use, I am all for it. Side note: I was expecting a video on Desoxyn. Also, thank you for the videos; they helped when studying for general boards.
@@PsychiatrySimplified can you please dedicate some space to an abandoned stimulants, like pemoline or amineptine?
I've done a lot of meth in my day and I never had withdrawals. Not a one time. I was on it for years at one point. I got cravings but no withdrawals. This has to be a joke 🤣
You are not everyone 😃. Thanks for sharing your experience though. Good to know it was different in your case
What was your ROA? I’ve experienced first hand it’s the individuals ROA/habitual-ritual that carry’s the weight of the addiction, for the majority of users. I am a lucky I naturally have a serious dopamine deficiency, so for me(and like you also) it’s not something that effects us the way most people are effected by it
And thank you doc for all your informative videos on these subjects. The more you know the better always.
Substitute one potent stimulant for another and ppl are like OMG GROUNDBREAKING lmao
and with opioid it isn t the same?sometime with benzos also