16.1y Younger Biological Age (Blood Test #3 In 2024, Test #51 Since 2015)

Поділитися
Вставка
  • Опубліковано 21 лип 2024
  • Join us on Patreon! / michaellustgartenphd
    Discount Links:
    Epigenetic, Telomere Testing: trudiagnostic.com/?irclickid=...
    Use Code: CONQUERAGING
    NAD+ Quantification: www.jinfiniti.com/intracellul...
    Use Code: ConquerAging At Checkout
    Oral Microbiome: www.bristlehealth.com/?ref=mi...
    Enter Code: ConquerAging
    At-Home Metabolomics: www.iollo.com?ref=michael-lustgarten
    Use Code: CONQUERAGING At Checkout
    At-Home Blood Testing (SiPhox Health): getquantify.io/mlustgarten
    Green Tea: www.ochaandco.com/?ref=conque...
    Diet Tracking: shareasale.com/r.cfm?b=139013...
    If you'd like to support the channel, you can do that with the website, Buy Me A Coffee: www.buymeacoffee.com/mlhnrca
    Conquer Aging Or Die Trying Merch! my-store-d4e7df.creator-sprin...
    -----------------------------------------------------------------------------------------------------------------------------------------------------------------
    The Excel file to calculate Levine's Biological Age is embedded in this link from my website:
    michaellustgarten.com/2019/09...
    -----------------------------------------------------------------------------------------------------------------------------------------------------------------
    Papers referenced in the video:
    Red blood cell distribution width is significantly associated with aging and gender pubmed.ncbi.nlm.nih.gov/24897...
    Association between fasting glucose and all-cause mortality according to sex and age: a prospective cohort study pubmed.ncbi.nlm.nih.gov/28811...
    Age and sex variation in serum albumin concentration: an observational study pubmed.ncbi.nlm.nih.gov/26071...
    The baseline levels and risk factors for high-sensitive C-reactive protein in Chinese healthy population pubmed.ncbi.nlm.nih.gov/30202...
    Predicting Age by Mining Electronic Medical Records with Deep Learning Characterizes Differences between Chronological and Physiological Age
    www.ncbi.nlm.nih.gov/pmc/arti...
  • Наука та технологія

КОМЕНТАРІ • 110

  • @jamesgilmore8192
    @jamesgilmore8192 2 місяці тому +3

    For hsCRP another candidate is: Metabolic factors and high-sensitivity C-reactive protein: the HUNT study 2011, Laugsand et al. This paper splits into metabolic risk categories, which is sensible given your diligence here.

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  2 місяці тому

      Great paper with a larger sample size, thanks James!

    • @jamesgilmore8192
      @jamesgilmore8192 2 місяці тому

      @@conqueragingordietrying1797 Another couple of papers are:
      -Sex and age differences in the association between high sensitivity C-Reactive Protein and all-cause mortality: A 12-year prospective cohort study, 2023. Sadly this one is paywalled, but I believe it has a nice plot vs age.
      -Socioeconomic status and C-reactive protein levels in the US population: NHANES IV, 2005, Alley et al. This one has a plot with a fraction higher than a certain value vs age, and has an interesting odds ratio analysis.

  • @Maple597
    @Maple597 2 місяці тому +3

    Fabulous video! Thank you for sharing this.

  • @espinosalexis
    @espinosalexis 2 місяці тому +3

    Amazing video and project. You are the best anti-aging communicator out there!
    I wonder what biological age you would get if you change ALL the biomarkers to the expected population values?

  • @HarryJensen-kr4qz
    @HarryJensen-kr4qz 2 місяці тому +3

    Absolutely fabulous! Great job!

  • @barrie888
    @barrie888 2 місяці тому +2

    Always look forward to studying your content

  • @richardheck3794
    @richardheck3794 2 місяці тому +1

    Amazing! Appreciate the insights

  • @KoiRun50
    @KoiRun50 2 місяці тому +2

    Very insightful perspective on how much each variable can affect biological age.

  • @berdi4berdi4
    @berdi4berdi4 2 місяці тому +5

    Michael, you said you decreased your fat intake to improve your glucose levels. How did you replace those fat calories? Complex carbs? Protein? Great video, thanks for sharing!

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  2 місяці тому +3

      Thanks @berdi4berdi4. Initially, with whole grains (barley, oats), which has been since replaced with chickpeas.

  • @darciayur
    @darciayur 2 місяці тому +2

    Thank you, you are so generous with your information.

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  2 місяці тому +1

      Thanks @darciayur. It's in the video's description, but also,
      michaellustgarten.com/2019/09/09/quantifying-biological-age/

    • @darciayur
      @darciayur 2 місяці тому

      @@conqueragingordietrying1797 found it!

  • @jeanvoeux7062
    @jeanvoeux7062 2 місяці тому +1

    Excellent video . Thanks !

  • @jamesgilmore8192
    @jamesgilmore8192 2 місяці тому +2

    For RDW I think you are aware of the other candidate: Effect of age and gender on reference intervals of red blood cell distribution width (RDW) and mean red cell volume (MCV), 2015, Hoffmann. Much larger N, but wide age categories. Its hard to find plots with individual points these days with stronger ethics standards.

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  2 місяці тому

      Another great find, thanks James. I had the RDW plot saved in my files, but forgot to include it!

  • @mikeghafoori8227
    @mikeghafoori8227 2 місяці тому +1

    Thank you great job

  • @philmartz
    @philmartz 2 місяці тому

    Excellent and informative analysis. Thank you, Michael! Keep on! I'm always puzzled about the inclusion of calendar age in Levene's BA calculation. The calculator is highly (overly) dependent on calendar age. For example, if you keep the same biomarkers that you reported here but change your age to 35 it will say your BA is 20.93. If you keep the same biomarkers and enter 70 as your age, your BA comes up as 51.63. So, if someone manages to keep their biomarkers constant over time, the calculator still says you got older. I'm sure you are aware of this behavior of the calculator. I think a better way to do this is to remove the calendar age input. Thus, a better calculator would just be one that determines the total biomarker deviation from optimal values and calculates a "total biomarker score" with a reporting on a scale from 1-100.

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  2 місяці тому +1

      Hi Phil, yep, a maximal PhenoAge reduction is ~20y, even with the most youthful biomarkers at older chronological ages.
      Chronological age on its own is associated with an increased all-cause mortality risk, but the inclusion of the biomarkers improves upon only including CA as a predictive tool for risk of death.
      Outside of biological age clocks, I think tracking individual biomarkers, as shown in the video, is a good approach, too.

  • @6681096
    @6681096 2 місяці тому +1

    Yikes, my RDW was 18.1, but it went way down after I resolved my anemia.
    If someone is similar then if you're due for a colonoscopy also get an endoscopy at the same time. Mine was caused by long-term bleeding from hemorrhoids and possibly from ulcer (per the endoscopy and I went on antibiotics).

  • @espinosalexis
    @espinosalexis 2 місяці тому +2

    Paul Saladino recently exposed his new blood work. Could you analize it again and calculate his biological age? Thanks!

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  2 місяці тому +1

      This is great, thanks @espinosalexis. I don't want to pick on Paul (again) in a video, so I'll likely reach out to him directly, to see if he'd be open to a collab

    • @espinosalexis
      @espinosalexis 2 місяці тому +1

      ​@@conqueragingordietrying1797 Yes, that sounds much better! I already suggested him to expose his biological clocks and to contact you, but no luck!

  • @Hail2MasterChief
    @Hail2MasterChief 2 місяці тому +1

    Congratulations Michael. Well done. 🎉😂

  • @raghad758
    @raghad758 2 місяці тому +1

    I’m really curious to know if there is a test that measures collagen content in-the skin ? I would love to know

    • @jamesgilmore8192
      @jamesgilmore8192 2 місяці тому +3

      You can do a pinch and/or snap test and measure how long it takes to return flat. Its the most relevant and least invasive.

  • @jpintero6330
    @jpintero6330 2 місяці тому

    Such an informative video! What, other than normal aging, could cause a drop in serum albumin? Could overtraining before a blood test cause a temporary dip? Could iron deficiency cause it? You are right about not sweating a change on one blood test! It is stressful.

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  2 місяці тому +1

      Thanks @jpintero6330. Maintenance of albumin levels involves synthesis vs degradation. The latter can be impacted by inflammation...
      In terms of overtraining, it's an easy experiment to test-if you rest for a day or 2 before blood testing, is albumin the same, or higher? For me, and prior to every test, the day prior is as close-to a rest day as possible.

    • @jpintero6330
      @jpintero6330 2 місяці тому

      @@conqueragingordietrying1797 Thanks!

  • @jamesgilmore8192
    @jamesgilmore8192 2 місяці тому +2

    On the lymphocyte % plot, looks like some outliers are there, probably silent infections. Whether they are from low lymphocytes or immune cells need further digging because of the percentage ratio.

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  2 місяці тому

      Definitely, including the latest test, which was my lowest % to date

    • @jamesgilmore8192
      @jamesgilmore8192 2 місяці тому

      @@conqueragingordietrying1797 If you subtract the polynomial fit and compute a cooks distance (or deviation) they will show up as outliers.

    • @abdelilahbenahmed4350
      @abdelilahbenahmed4350 2 місяці тому +1

      Maybe it's a reminiscence of the vax... Who knows?

    • @jamesgilmore8192
      @jamesgilmore8192 2 місяці тому +1

      @@abdelilahbenahmed4350 I'm not sure what your referring to, but you'll probably see it revert to baseline next time as Mike usually only makes small changes test to test.

    • @abdelilahbenahmed4350
      @abdelilahbenahmed4350 2 місяці тому

      @@jamesgilmore8192 certainly.It's not a big deal.Personally,I would focus more on the excellent levels of RDW and hsCRP.

  • @RiadhChandarli
    @RiadhChandarli 2 місяці тому

    Great insight as usual 👍
    in 2015 your biological age was already 6years younger than your actual age, 42 chronological 36 biological,
    how was your lifestyle before you started testing frequently? were you living a similar healthy lifestyle or it's because of good genetics?

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  2 місяці тому +1

      Generally healthy, but without the guidance that I have now from following correlations with diet
      That plus a ~20lb weight loss have helped improve most biomarkers
      I don't have good genetics-prior to my dad (still alive at 81y), all men were dead before 67y, no women > 100y

  • @maestroharmony343
    @maestroharmony343 2 місяці тому

    I noticed that my glucose reading is heavily impacted by the time and the amount of my last meal. The lab asks for 12 hours fasting, but if I skip the dinner on the night before, or eat a little, my glucose can be 10 points lower. If I ate a lot, even 12 hours before, it affects it. Also, if I do my morning exercise before the test, it messes with it, too. So, to get a meaningful data sequence from glucose, it takes a lot of consistency. Alternatively, I can wear CGM and take the averages after sleep, for example.

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  2 місяці тому +1

      Yep, that's a good point. before every test I've standardized the fasting window (16-18h), with minimal activity (close-to a full rest day) on the day before each test. I also eat close to the same diet on the day prior, too, to try to standardize that, too.

    • @jamesgilmore8192
      @jamesgilmore8192 2 місяці тому

      You shouldn't exercise before a blood test if you are interested in a fasted and rested state. It will change many of the biomarkers. It sounds like you have a slow GI passage time, so you'll need to be consistent with meals to get repeatable glucose values.

  • @justsaying7065
    @justsaying7065 2 місяці тому

    Hi Mike, Did you eliminate yogurt recently? If so, why?

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  2 місяці тому

      Hi @justsaying7065, yep-I cut strawberry intake to bring oranges (proline betaine) into the diet. Oranges didn't mix well with the yogurt, so I took it out and replaced those calories with chickpeas and sprouts...

  • @HopeItStixStudios
    @HopeItStixStudios 2 місяці тому

    Also have you ever done mesenchymal stem cells and hyperbaric o2?

  • @1985fj60
    @1985fj60 Місяць тому

    Hi Can you please explain the MortScore or "Mortality Score" is lower better ? If you correlate closer to 1 your likely to die?

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Місяць тому

      Hi @1985fj60, I don't pay any attention to that, as a relatively older PhenoAge on its own is associated with an increased mortality risk.

  • @UniCatt-hc5dz
    @UniCatt-hc5dz 2 місяці тому

    Hi, I see you are always in a calorie deficit, but do you also want to build muscle or just maintain it? Have you seen that you can build muscle even in a deficit?

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  2 місяці тому

      The goal is to be as lean as possible with enough muscle mass to be strong and fit, in combination with optimal biomarkers
      There's a recent pic on the Community tab...

  • @maestroharmony343
    @maestroharmony343 2 місяці тому +1

    Do you know what you're doing specifically to lower ALP? I can't make it lower than 59, but I know that the good reading is below 48.

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  2 місяці тому +1

      Yep-I can't say if it's causative, but the strongest correlations in my data are for calorie intake (0.71) and body weight (0.62). So getting leaner over the past 3y might've lowered it...

  • @darciayur
    @darciayur 2 місяці тому

    Hi again :) Ok, im really into tracking so im doing this xcell spread sheet and I have some questions... I'm not seeing ...Where does it calculate your biological age?? can you please tell us more about row 16 please and thank you :)

  • @newdata
    @newdata 2 місяці тому

    mcv ( lower better ) and urea ( lower better ) and bmi ( lower better ) and albumin ( higher better ) and especially ferretin ( lower better ) read this week in some report is most predictive of biological age .

  • @maestroharmony343
    @maestroharmony343 2 місяці тому

    Creatinine datapoint in Levine's estimator is a suboptimal choice. I eat a lot of meat, and my Creatinine is high, which is translated into a low eGFR, but when I measured Cystatin C, it was very good, and eGFR based on it was perfect. Unfortunately, it's a lot more expensive test.

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  2 місяці тому +1

      I don't disagree, but the good news is that creatinine contributes relatively little to the PhenoAge score relative to other biomarkers (i.e. RDW).
      What was your Cystatin C level?

    • @maestroharmony343
      @maestroharmony343 2 місяці тому

      ​@conqueragingordietrying1797 0.78 mg/L, which is 111 for eGFR, but creatinine is 1.16 - 1.22, which is eGFR 73-78.

    • @jamesgilmore8192
      @jamesgilmore8192 2 місяці тому

      @@maestroharmony343 That's a fairly high creatinine in a young person. Do you body build with lots of eccentrics by any chance?

    • @maestroharmony343
      @maestroharmony343 2 місяці тому

      ​@jamesgilmore8192 I don't bodybuild, I sit a lot at work, so I mostly try to walk and hike when I can. I also do some exercises in the morning to break the sweat. I supplement with 5 g of creatine though.

  • @chris-lk4ml
    @chris-lk4ml 2 місяці тому +1

    What kind of fat and how mich did you take at the beginning?
    Im more or less on a high fat diet: 80-115g of fat, mostly by nuts and olive oil and some fat fish.

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  2 місяці тому +1

      Mostly SFA via coconut butter. I'm working my way back up (from 81 - 95g/d), but this time increasing MUFA while keeping SFA from coconut butter relatively low.

    • @chris-lk4ml
      @chris-lk4ml 2 місяці тому

      I have no problems with blood glucose on my high MUFA/PUFA diet. Its 85mg/dl.
      Good luck!

    • @jamesgilmore8192
      @jamesgilmore8192 2 місяці тому

      @@chris-lk4ml How much zone 2 exercise do you do and what your age category?

  • @ShislasMkholo
    @ShislasMkholo 2 місяці тому

    Can this model be done on children 5-15yrs, if not what model can you suggest

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  2 місяці тому

      That's tricky, imo
      At those ages, I think the best approach is to ensure at least the RDA in terms of dietary intake-I wouldn't do all the blood testing that young
      Once they're older (> 18y), they can choose for themselves if they want to test, and how often

  • @whatthefunction9140
    @whatthefunction9140 2 місяці тому +1

    Hope you don't run out of blood bro

  • @MrStarchild3001
    @MrStarchild3001 2 місяці тому +1

    My most recent blood tests. I don't track my food. The improvement is purely from drugs and supplements (+ some luck).
    Calendar Age 45.78 45.82 45.87
    Ptypic Age 30.57 30.21 28.73
    Calendar Age - Ptypic Age 15.22 15.61 17.13

  • @paulfiedler9128
    @paulfiedler9128 2 місяці тому +1

    I'd like to know if your parents are roaming the Earth and their overall health. Also, do you have health and longevity in your DNA from your grandparents? I guess you are the lab test guy for the longevity trial you are running---but it would be interesting to me to know if you already have a family lineage with long and robust health. Thanks.

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  2 місяці тому +1

      Hi Paul, my dad is 81 and in decent shape, and myy mom is 77. Before that, no men in my family lived past 67y, and my grandmothers lived to 86 and 85y.
      One reason for my passion in this field is that I don't have longevity genetics, and I'll need to science the **it out of aging to break the human longevity record!

    • @paulfiedler6820
      @paulfiedler6820 2 місяці тому

      Wow, now I’m wondering if the males in your family smoked or drank.
      Bothe my grandmothers lived to be 94 but not that I’ve done the 23andMe test it freaked my world out when I found out my dads mother couldn’t have been his biological mother and my fathers maybe father died at 42 from colon cancer.
      I guess my dad was adopted and never knew cause he thought he was German and that was 100% wrong.
      But, my dad died at 62 from cigarettes and my Irish grandfather was an alcoholic who managed to live until 72 but he was a mess for 10 years before his death of heart disease.
      Did you ever have your DNA tested? It can be very upsetting if you your results opens a five gallon can of worms and with not many clues to follow.

  • @jonathonmills3563
    @jonathonmills3563 2 місяці тому +1

    Is chronological age used as a metric in pheno age? If not why is it required to do the calculation?

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  2 місяці тому +1

      Yep, and that's a question for Morgan Levine

    • @maestroharmony343
      @maestroharmony343 2 місяці тому

      If you want a test of your biological age with no input of your chronological age, you can take OMICage from Trudiagnostic, but it's 10 times more expensive than this test. But it is likely a lot more precise. Levine's test gives me 8-9 years lower age, OMIC gives me my age.

    • @jonathonmills3563
      @jonathonmills3563 2 місяці тому

      @@maestroharmony343 I have. It’s a completely different methodology, blood test markers versus DNA methylation.
      I asked the question because if the calculation of Levines phenotypic age requires chronological age as an input as a biological age adjusted measure, that artificially skews the results

    • @maestroharmony343
      @maestroharmony343 2 місяці тому

      ​@jonathonmills3563 it would be hard for such a small set of markers, only 9, to accurately predict your age with no hint of your real age. As I understand, about 88% of this calculated phenotypic age is explained by your calendar age, but the rest 12% depend on the biomarkers. So, it is not completely useless.

    • @jonathonmills3563
      @jonathonmills3563 2 місяці тому

      @@maestroharmony343 The Pheno age calculation is useful as is modifying the components, as Dr Lustgarten does. My argument is that Dr Levine accurately refers to it as PhenoAge , not Biological age. Dr Lustgarten should make that distinction

  • @neilquinn
    @neilquinn 2 місяці тому +1

    I wonder why women's mean glucose is so much lower on average

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  2 місяці тому

      Good question-could that be a reason why women live longer than men?

    • @neilquinn
      @neilquinn 2 місяці тому

      @@conqueragingordietrying1797 I was thinking exactly the same thing... that it may be one of the key variables. Men's average glucose there is equivalent to a woman's almost 12-15 years older.

  • @HopeItStixStudios
    @HopeItStixStudios 2 місяці тому

    How to I get my blood cell width to be healthy? I’m in the bottom 2 percent!

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  2 місяці тому

      Hi @HopeItStixStudios, I can't say what may work for you, but Omega-3 intake and weight loss may play a role:
      ua-cam.com/video/cOg91UU6NNY/v-deo.html

    • @maestroharmony343
      @maestroharmony343 2 місяці тому

      Did you take a real blood test for RDW or read Trudiagnostic estimation in OMICmAge? Because they are off a lot usually, since they don't measure it directly.

    • @HopeItStixStudios
      @HopeItStixStudios 2 місяці тому

      @@maestroharmony343 thanks for letting me know it was trudiagnostic

    • @maestroharmony343
      @maestroharmony343 2 місяці тому

      ​@HopeItStixStudios they only do the prediction of it based on epigenetic data. I talked to them directly, they told me not to pay attention to those numbers (blood marker equivalents), they even think to remove them altogether since they may be confusing more than useful. But the percentile number is important.

  • @brandybarnett-rq8pp
    @brandybarnett-rq8pp 2 місяці тому

    I downloaded the calculator bur don't see a biological age changing, like Michael in the far right??

  • @whatthefunction9140
    @whatthefunction9140 2 місяці тому

    Why profession are you in? Are you a doctor?

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  2 місяці тому +1

      Research scientist, and yep
      Ha, hoping to change the profession to "UA-camr" sooner vs later

  • @bottlenecks
    @bottlenecks 2 місяці тому +1

    4:35: An RDW of 11.7% would be more likely to be found in youth? Sorry, but I can barely see any circle below 12% for people below 70, but many for older than 70.

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  2 місяці тому

      RDW increases during aging, lower is more likely to be found in youth. If you have published data that disagrees with that, please post it

    • @jamesgilmore8192
      @jamesgilmore8192 2 місяці тому +2

      Pheno age is based on nhanes, see: Red blood cell distribution width and mortality risk in a community-based prospective cohort: NHANES III. RDW Quintile 1, mean age 39 has a range 10.90-12.35. Whereas the figure is from an Italian study. The difference is probably from different analysers.

    • @bottlenecks
      @bottlenecks 2 місяці тому

      @@conqueragingordietrying1797 I merely commented on that particular other statement about the 11.7%. The dots/circles in your own chart disagree with 11.7% more likely being found in youth because only people older than 70 had such low values.

  • @allurbase
    @allurbase 2 місяці тому

    seems like you need a higher sensitivity hsCRP test to properly track it.

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  2 місяці тому +1

      Yep-LabCorp can measure below 0.3 mg/L, but I'd have to drive 17-20 miles to go there
      With that in mind, I'm ok with Quest's detection limit (< 0.3 mg/L)

    • @jamesgilmore8192
      @jamesgilmore8192 2 місяці тому

      @@conqueragingordietrying1797 I would agree with that, with correlations becoming less useful with lots of measurements below the threshold. Maybe ESR is worth doing instead.