16.1y Younger Biological Age (Blood Test #3 In 2024, Test #51 Since 2015)
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- Опубліковано 11 чер 2024
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The Excel file to calculate Levine's Biological Age is embedded in this link from my website:
michaellustgarten.com/2019/09...
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Papers referenced in the video:
Red blood cell distribution width is significantly associated with aging and gender pubmed.ncbi.nlm.nih.gov/24897...
Association between fasting glucose and all-cause mortality according to sex and age: a prospective cohort study pubmed.ncbi.nlm.nih.gov/28811...
Age and sex variation in serum albumin concentration: an observational study pubmed.ncbi.nlm.nih.gov/26071...
The baseline levels and risk factors for high-sensitive C-reactive protein in Chinese healthy population pubmed.ncbi.nlm.nih.gov/30202...
Predicting Age by Mining Electronic Medical Records with Deep Learning Characterizes Differences between Chronological and Physiological Age
www.ncbi.nlm.nih.gov/pmc/arti... - Наука та технологія
Always look forward to studying your content
Thanks @barrie888!
Amazing video and project. You are the best anti-aging communicator out there!
I wonder what biological age you would get if you change ALL the biomarkers to the expected population values?
Thanks @espinosalexis. Close to chronological, 52y
Absolutely fabulous! Great job!
Thanks @HarryJensen-kr4qz!
Michael, you said you decreased your fat intake to improve your glucose levels. How did you replace those fat calories? Complex carbs? Protein? Great video, thanks for sharing!
Thanks @berdi4berdi4. Initially, with whole grains (barley, oats), which has been since replaced with chickpeas.
Fabulous video! Thank you for sharing this.
Thanks @Maple597!
Very insightful perspective on how much each variable can affect biological age.
Thanks @KoiRun50!
For hsCRP another candidate is: Metabolic factors and high-sensitivity C-reactive protein: the HUNT study 2011, Laugsand et al. This paper splits into metabolic risk categories, which is sensible given your diligence here.
Great paper with a larger sample size, thanks James!
@@conqueragingordietrying1797 Another couple of papers are:
-Sex and age differences in the association between high sensitivity C-Reactive Protein and all-cause mortality: A 12-year prospective cohort study, 2023. Sadly this one is paywalled, but I believe it has a nice plot vs age.
-Socioeconomic status and C-reactive protein levels in the US population: NHANES IV, 2005, Alley et al. This one has a plot with a fraction higher than a certain value vs age, and has an interesting odds ratio analysis.
Amazing! Appreciate the insights
Thanks @richardheck3794!
Thank you, you are so generous with your information.
Thanks @darciayur. It's in the video's description, but also,
michaellustgarten.com/2019/09/09/quantifying-biological-age/
@@conqueragingordietrying1797 found it!
Excellent video . Thanks !
Thanks @jeanvoeux7062!
For RDW I think you are aware of the other candidate: Effect of age and gender on reference intervals of red blood cell distribution width (RDW) and mean red cell volume (MCV), 2015, Hoffmann. Much larger N, but wide age categories. Its hard to find plots with individual points these days with stronger ethics standards.
Another great find, thanks James. I had the RDW plot saved in my files, but forgot to include it!
Excellent and informative analysis. Thank you, Michael! Keep on! I'm always puzzled about the inclusion of calendar age in Levene's BA calculation. The calculator is highly (overly) dependent on calendar age. For example, if you keep the same biomarkers that you reported here but change your age to 35 it will say your BA is 20.93. If you keep the same biomarkers and enter 70 as your age, your BA comes up as 51.63. So, if someone manages to keep their biomarkers constant over time, the calculator still says you got older. I'm sure you are aware of this behavior of the calculator. I think a better way to do this is to remove the calendar age input. Thus, a better calculator would just be one that determines the total biomarker deviation from optimal values and calculates a "total biomarker score" with a reporting on a scale from 1-100.
Hi Phil, yep, a maximal PhenoAge reduction is ~20y, even with the most youthful biomarkers at older chronological ages.
Chronological age on its own is associated with an increased all-cause mortality risk, but the inclusion of the biomarkers improves upon only including CA as a predictive tool for risk of death.
Outside of biological age clocks, I think tracking individual biomarkers, as shown in the video, is a good approach, too.
Thank you great job
Thanks @mikeghafoori8227
Paul Saladino recently exposed his new blood work. Could you analize it again and calculate his biological age? Thanks!
This is great, thanks @espinosalexis. I don't want to pick on Paul (again) in a video, so I'll likely reach out to him directly, to see if he'd be open to a collab
@@conqueragingordietrying1797 Yes, that sounds much better! I already suggested him to expose his biological clocks and to contact you, but no luck!
Yikes, my RDW was 18.1, but it went way down after I resolved my anemia.
If someone is similar then if you're due for a colonoscopy also get an endoscopy at the same time. Mine was caused by long-term bleeding from hemorrhoids and possibly from ulcer (per the endoscopy and I went on antibiotics).
I’m really curious to know if there is a test that measures collagen content in-the skin ? I would love to know
You can do a pinch and/or snap test and measure how long it takes to return flat. Its the most relevant and least invasive.
Congratulations Michael. Well done. 🎉😂
Thanks @Hail2MasterChief!
Hi again :) Ok, im really into tracking so im doing this xcell spread sheet and I have some questions... I'm not seeing ...Where does it calculate your biological age?? can you please tell us more about row 16 please and thank you :)
Column D18 for Ptypic Age
@@conqueragingordietrying1797 It cant be correct, I'm 16.25 LOL
Hi Mike, Did you eliminate yogurt recently? If so, why?
Hi @justsaying7065, yep-I cut strawberry intake to bring oranges (proline betaine) into the diet. Oranges didn't mix well with the yogurt, so I took it out and replaced those calories with chickpeas and sprouts...
Great insight as usual 👍
in 2015 your biological age was already 6years younger than your actual age, 42 chronological 36 biological,
how was your lifestyle before you started testing frequently? were you living a similar healthy lifestyle or it's because of good genetics?
Generally healthy, but without the guidance that I have now from following correlations with diet
That plus a ~20lb weight loss have helped improve most biomarkers
I don't have good genetics-prior to my dad (still alive at 81y), all men were dead before 67y, no women > 100y
Hi Can you please explain the MortScore or "Mortality Score" is lower better ? If you correlate closer to 1 your likely to die?
Hi @1985fj60, I don't pay any attention to that, as a relatively older PhenoAge on its own is associated with an increased mortality risk.
Do you know what you're doing specifically to lower ALP? I can't make it lower than 59, but I know that the good reading is below 48.
Yep-I can't say if it's causative, but the strongest correlations in my data are for calorie intake (0.71) and body weight (0.62). So getting leaner over the past 3y might've lowered it...
On the lymphocyte % plot, looks like some outliers are there, probably silent infections. Whether they are from low lymphocytes or immune cells need further digging because of the percentage ratio.
Definitely, including the latest test, which was my lowest % to date
@@conqueragingordietrying1797 If you subtract the polynomial fit and compute a cooks distance (or deviation) they will show up as outliers.
Maybe it's a reminiscence of the vax... Who knows?
@@abdelilahbenahmed4350 I'm not sure what your referring to, but you'll probably see it revert to baseline next time as Mike usually only makes small changes test to test.
@@jamesgilmore8192 certainly.It's not a big deal.Personally,I would focus more on the excellent levels of RDW and hsCRP.
Such an informative video! What, other than normal aging, could cause a drop in serum albumin? Could overtraining before a blood test cause a temporary dip? Could iron deficiency cause it? You are right about not sweating a change on one blood test! It is stressful.
Thanks @jpintero6330. Maintenance of albumin levels involves synthesis vs degradation. The latter can be impacted by inflammation...
In terms of overtraining, it's an easy experiment to test-if you rest for a day or 2 before blood testing, is albumin the same, or higher? For me, and prior to every test, the day prior is as close-to a rest day as possible.
@@conqueragingordietrying1797 Thanks!
Hi, I see you are always in a calorie deficit, but do you also want to build muscle or just maintain it? Have you seen that you can build muscle even in a deficit?
The goal is to be as lean as possible with enough muscle mass to be strong and fit, in combination with optimal biomarkers
There's a recent pic on the Community tab...
Also have you ever done mesenchymal stem cells and hyperbaric o2?
Nope, but I'm open to both
I noticed that my glucose reading is heavily impacted by the time and the amount of my last meal. The lab asks for 12 hours fasting, but if I skip the dinner on the night before, or eat a little, my glucose can be 10 points lower. If I ate a lot, even 12 hours before, it affects it. Also, if I do my morning exercise before the test, it messes with it, too. So, to get a meaningful data sequence from glucose, it takes a lot of consistency. Alternatively, I can wear CGM and take the averages after sleep, for example.
Yep, that's a good point. before every test I've standardized the fasting window (16-18h), with minimal activity (close-to a full rest day) on the day before each test. I also eat close to the same diet on the day prior, too, to try to standardize that, too.
You shouldn't exercise before a blood test if you are interested in a fasted and rested state. It will change many of the biomarkers. It sounds like you have a slow GI passage time, so you'll need to be consistent with meals to get repeatable glucose values.
What kind of fat and how mich did you take at the beginning?
Im more or less on a high fat diet: 80-115g of fat, mostly by nuts and olive oil and some fat fish.
Mostly SFA via coconut butter. I'm working my way back up (from 81 - 95g/d), but this time increasing MUFA while keeping SFA from coconut butter relatively low.
I have no problems with blood glucose on my high MUFA/PUFA diet. Its 85mg/dl.
Good luck!
@@chris-lk4ml How much zone 2 exercise do you do and what your age category?
Hope you don't run out of blood bro
Ha, I have plenty, no worries!
My most recent blood tests. I don't track my food. The improvement is purely from drugs and supplements (+ some luck).
Calendar Age 45.78 45.82 45.87
Ptypic Age 30.57 30.21 28.73
Calendar Age - Ptypic Age 15.22 15.61 17.13
Nice job Gokhan! Next is making videos to document the journey!
Can you share what drugs and supplements you take?
Can this model be done on children 5-15yrs, if not what model can you suggest
That's tricky, imo
At those ages, I think the best approach is to ensure at least the RDA in terms of dietary intake-I wouldn't do all the blood testing that young
Once they're older (> 18y), they can choose for themselves if they want to test, and how often
I'd like to know if your parents are roaming the Earth and their overall health. Also, do you have health and longevity in your DNA from your grandparents? I guess you are the lab test guy for the longevity trial you are running---but it would be interesting to me to know if you already have a family lineage with long and robust health. Thanks.
Hi Paul, my dad is 81 and in decent shape, and myy mom is 77. Before that, no men in my family lived past 67y, and my grandmothers lived to 86 and 85y.
One reason for my passion in this field is that I don't have longevity genetics, and I'll need to science the **it out of aging to break the human longevity record!
Wow, now I’m wondering if the males in your family smoked or drank.
Bothe my grandmothers lived to be 94 but not that I’ve done the 23andMe test it freaked my world out when I found out my dads mother couldn’t have been his biological mother and my fathers maybe father died at 42 from colon cancer.
I guess my dad was adopted and never knew cause he thought he was German and that was 100% wrong.
But, my dad died at 62 from cigarettes and my Irish grandfather was an alcoholic who managed to live until 72 but he was a mess for 10 years before his death of heart disease.
Did you ever have your DNA tested? It can be very upsetting if you your results opens a five gallon can of worms and with not many clues to follow.
mcv ( lower better ) and urea ( lower better ) and bmi ( lower better ) and albumin ( higher better ) and especially ferretin ( lower better ) read this week in some report is most predictive of biological age .
Is chronological age used as a metric in pheno age? If not why is it required to do the calculation?
Yep, and that's a question for Morgan Levine
If you want a test of your biological age with no input of your chronological age, you can take OMICage from Trudiagnostic, but it's 10 times more expensive than this test. But it is likely a lot more precise. Levine's test gives me 8-9 years lower age, OMIC gives me my age.
@@maestroharmony343 I have. It’s a completely different methodology, blood test markers versus DNA methylation.
I asked the question because if the calculation of Levines phenotypic age requires chronological age as an input as a biological age adjusted measure, that artificially skews the results
@jonathonmills3563 it would be hard for such a small set of markers, only 9, to accurately predict your age with no hint of your real age. As I understand, about 88% of this calculated phenotypic age is explained by your calendar age, but the rest 12% depend on the biomarkers. So, it is not completely useless.
@@maestroharmony343 The Pheno age calculation is useful as is modifying the components, as Dr Lustgarten does. My argument is that Dr Levine accurately refers to it as PhenoAge , not Biological age. Dr Lustgarten should make that distinction
Creatinine datapoint in Levine's estimator is a suboptimal choice. I eat a lot of meat, and my Creatinine is high, which is translated into a low eGFR, but when I measured Cystatin C, it was very good, and eGFR based on it was perfect. Unfortunately, it's a lot more expensive test.
I don't disagree, but the good news is that creatinine contributes relatively little to the PhenoAge score relative to other biomarkers (i.e. RDW).
What was your Cystatin C level?
@conqueragingordietrying1797 0.78 mg/L, which is 111 for eGFR, but creatinine is 1.16 - 1.22, which is eGFR 73-78.
@@maestroharmony343 That's a fairly high creatinine in a young person. Do you body build with lots of eccentrics by any chance?
@jamesgilmore8192 I don't bodybuild, I sit a lot at work, so I mostly try to walk and hike when I can. I also do some exercises in the morning to break the sweat. I supplement with 5 g of creatine though.
How to I get my blood cell width to be healthy? I’m in the bottom 2 percent!
Hi @HopeItStixStudios, I can't say what may work for you, but Omega-3 intake and weight loss may play a role:
ua-cam.com/video/cOg91UU6NNY/v-deo.html
Did you take a real blood test for RDW or read Trudiagnostic estimation in OMICmAge? Because they are off a lot usually, since they don't measure it directly.
@@maestroharmony343 thanks for letting me know it was trudiagnostic
@HopeItStixStudios they only do the prediction of it based on epigenetic data. I talked to them directly, they told me not to pay attention to those numbers (blood marker equivalents), they even think to remove them altogether since they may be confusing more than useful. But the percentile number is important.
I wonder why women's mean glucose is so much lower on average
Good question-could that be a reason why women live longer than men?
@@conqueragingordietrying1797 I was thinking exactly the same thing... that it may be one of the key variables. Men's average glucose there is equivalent to a woman's almost 12-15 years older.
Why profession are you in? Are you a doctor?
Research scientist, and yep
Ha, hoping to change the profession to "UA-camr" sooner vs later
I downloaded the calculator bur don't see a biological age changing, like Michael in the far right??
Hi @brandybarnett-rq8pp, the PhenoAge calculation is in column D18
@@conqueragingordietrying1797 Thanks so much!
4:35: An RDW of 11.7% would be more likely to be found in youth? Sorry, but I can barely see any circle below 12% for people below 70, but many for older than 70.
RDW increases during aging, lower is more likely to be found in youth. If you have published data that disagrees with that, please post it
Pheno age is based on nhanes, see: Red blood cell distribution width and mortality risk in a community-based prospective cohort: NHANES III. RDW Quintile 1, mean age 39 has a range 10.90-12.35. Whereas the figure is from an Italian study. The difference is probably from different analysers.
@@conqueragingordietrying1797 I merely commented on that particular other statement about the 11.7%. The dots/circles in your own chart disagree with 11.7% more likely being found in youth because only people older than 70 had such low values.
seems like you need a higher sensitivity hsCRP test to properly track it.
Yep-LabCorp can measure below 0.3 mg/L, but I'd have to drive 17-20 miles to go there
With that in mind, I'm ok with Quest's detection limit (< 0.3 mg/L)
@@conqueragingordietrying1797 I would agree with that, with correlations becoming less useful with lots of measurements below the threshold. Maybe ESR is worth doing instead.