Blood Test #1 in 2024: What's My Biological Age?
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- Опубліковано 27 січ 2024
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The Excel file to calculate Levine's Biological Age is embedded in this link from my website:
michaellustgarten.com/2019/09...
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Papers referenced in the video:
Effects of blood triglycerides on cardiovascular and all-cause mortality: a systematic review and meta-analysis of 61 prospective studies
pubmed.ncbi.nlm.nih.gov/24164...
Implication of liver enzymes on incident cardiovascular diseases and mortality: A nationwide population-based cohort study
pubmed.ncbi.nlm.nih.gov/29491...
Age and sex variation in serum albumin concentration: an observational study
pubmed.ncbi.nlm.nih.gov/26071...
Age-related changes in clinical parameters and their associations with common complex diseases
pubmed.ncbi.nlm.nih.gov/26623... - Наука та технологія
As a guy in my mid-60s, I've found that supplements - even high quality stuff - just destroy my ALT. Without supplements, my ALT hovers around 18-22. But in my latest test, after taking Glycine, NAC and Collagen daily for a few months, it went up to 42. Others like NR and Creatine don't seem to affect my ALT, but drive my eGFR down to the low 50s and my creatinine up to 125.
It's sad, because I want to believe the longevity/healthy aging claims regarding such supplements on youtube. But I trust my biomarkers more. Diet and exercise is the only approach that works for me.
Yep, and this is a great point that many in the longevity community should pay more attention to.
Creatine supplementation does increase creatinine levels, but doesn’t substantially impact eGFR. I would get a cystatin-c test to get a better idea of kidney function as that is independent of muscle breakdown from weight training and Creatine supplementation.
@@LeEternelleVieWell, something lowered my eGFR down to 52 (normally it's in the mildly decreased kidney function range in the 60s). Creatine mononucleotide seems like the most likely suspect.
That is strange since in studies NAC has been shown to reduce ALT
@@joebartles3986Interesting. Maybe it was the collagen. I've been too impatient to try supplements one by one before getting a blood test. After I get my ALT back down to ~20, I'll try it again. BUT, how do I get the glycine to go with the NAC? I was relying on collagen to provide glycine, although I could just try glycine supplements. Is there a point to taking NAC without glycine?
Hello Michael: I think that instead of the graph of biological age over time, a graph of the difference between chronological age and biological age would be more useful. If the slope of that graph is zero, it means that you do not have an improvement over time, if the slope is positive it would mean that you age slower than your chronological age and if the slope is negative it would indicate that you age faster than your age. biological. That slope would indicate the rate at which you age or rejuvenate... Excellent video and I look forward to the next one. You can also observe or deduce if there are changes in that slope, which would better indicate the direction it is going. Thank you.
Thanks @jaimemarun2841, and I can definitely do that for future iterations of this video...
What about making photos every month.. Then make a photo collage with 100s of photos over the years. Says more than any number
@@conqueragingordietrying1797Although a good suggestion, plotting just the difference would lose information. In the current plot you could overlay age as a linear line, and you could also add the Levine training data with transparency so people can see how far you are from typical data now. A difference plot in time could be next to this. Maybe also for specific biomarkers being focused on in a video.
Superb results - excellent to see & your dedicated efforts are certainly paying off - congratulations & thanks for sharing & inspiring us all. 👍
Thanks @kst157!
Your stats are stellar. You beat me on almost every marker, yet I'm younger and I consider myself living quite a healthy lifestyle.
Thanks @allehelgen! I have room for improvement, though...
My longevity powerhouses. Chaga and Reishi Mushrooms. Astragalus. Black Cumin Seed Oil. Red Pine Needle Oil. Brazillion Red and Green Propolis. Progurt Pro Biotic. Just turned 60. Last time I was sick was 2013. Health Guru. I also juice Raw Cannabis.
You are doing amazing, way to go! Did you see an improvement (drop) in RDW with intake of more sardines? I’ve heard omega 3 index is correlated with RDW and yours is impressive. Especially considering it’s one of the highest weighted markers.
Thanks @tylero9568. In my case, sardines are inversely correlated with RDW (r=-0.49, p=0.004, 32 tests), but a stronger correlation is with calorie intake (r=-0.68, p=2E-07, 46 tests).
@@conqueragingordietrying1797 that's very interesting, thanks for responding!
great info well presented tks
Thanks @barrie888!
Lower end of Hct and hgb seems to correspond with longevity so long as you feel sharp, strong, and not get dizzy.
Hey @KoiRun50, I disagree with that assessment. Anemia is a common problem in the elderly-with that in mind, I'd prefer RBCs and Hgb to be closer to 4.8 and 15, respectively.
I agree that ‘anemia’ is very common in the elderly. Anemia in terms of cutoffs is arbitrary. So long as Oxygen delivery is optimal and you are asymptomatic, as mentioned, all is good. I believe I see similar patterns in your study of supercentinarians.
Awesome job with your bio markers. In addition to the markers you mentioned, are you considering lowering LDL from 80 to a range somewhere between 25-60, which is the range, I believe, that young adults have. It seems that LDL increases with age notwithstanding diet and exercise for most people which may be a marker of aging.
Thanks @ericoshea9382, and I'm not. Even after adjusting for statins and lots of other variables, LDL < 60 mg/dL is associated with an increased CHD mortality risk. Please see Figure S3 in this paper:
www.ahajournals.org/doi/10.1161/JAHA.123.030496
Also, there's an inverted U-shape for LDL's age-related change: an increase up to 50-60y, then a decline until end of life.
@@conqueragingordietrying1797 thanks so much for this information!
@@conqueragingordietrying1797 Come on, surely you know that the decline into end-of-life is reverse causality with fraility and poorer eating habits. That's basic epidemiology as far as I'm aware. And then the paper you link - it literally says "The ... higher CHD death in patients with a low cholesterol level, was a reflection of reverse causality, especially among older participants. Our results support ... that lower blood cholesterol is associated with reduced CHD.". Don't get me wrong, I'm not one to blindly read the abstract or summary, but this is all very cut and dry. Unlike the average longevity blood biomarker, we *know* that LDL particles are causative in CHD, and so optimising it is of distinct importance, who benefits from telling an alternate fairytale? Not you, me, or Eric here.
And if you're going to make an argument from messing with the supplementary data, then consider graph S4, where non-HDL-c monotonically increases CHD mortality risk, particularly strongly in the younger 18-45 group (similar to S3 but stronger and clearer here, as non-HDL-c is most and very strongly correlated with apoB, as I'm sure you know). This certainly reflects the fact that a given higher value is a greater perturbation from their healthy and natural 'equilibrium' and so more highly optimised levels matter more for them (especially as it reflects cumulative damage over the decades to come). Why get distracted with what may or may not be the case for LDL in the elderly anyway? Does their data relate to your case better, or does the younger subset? By your optimised biomarkers alone, surely we'd say the younger. And given that, I can tell you that lower is unambiguously better for you. And based on other data, a target of
@@conqueragingordietrying1797 Well... I notice what I said has been hidden. That's a first for me. Would that be YT or you?
Excellent results, congratulations Mike! A glucose of 90 is quite impressive, especially given all the fruit you consume. Do you attribute that to the high consumption of fiber, to a disciplined eating window, or both, or something else? Even if I avoid all junk food and refined carbs altogether, I find it quite hard to reduce glucose below 94.
Thanks David. I think more important than the glucose level is HbA1c, which was recently 5.1%
90 is a bit on the high side nonetheless, I'd prefer it to be closer to 80, but likely leanness, the eating window, and fiber are the main drivers of it being less than expected based on chronological age
Thx Prof LUSTGARTEN for this interesting presentation.
Can we detect any impact of trigonelline on your biomarkers. Are you planning to take trigonelline from foods or from supplements.
Optimizing creatinine is key,especially as we age.Waiting for the results of your cystatin c lab test.
Thanks Abdelilah. Outside of homocysteine (a potential small impact), not yet-it might've impacted NAD, but also by a small amount, and I'm waiting for epigenetic results for the 1/15/24 tests.
If not, no worries, as I've doubled trigonelline intake since this test...
Cystatin C video is coming relatively soon, but there are so many videos to make, and so little time! Ha, another reason to Conquer Aging or Die Trying
I also noticed agingai disappeared. It was useful, in that it gave an overall picture and some insight into how important any problems were in blood biomarkers (by sensitivity analysis).
I agree-some are working behind the scenes to try to get it reinstated, hopefully it will get reinstated.
Michael - I get crp at both quest and labcorp over past several yrs. As fyi- labcorp reports lower then 0.3. You mention your reading with quest only gives that as lowest. I know labcorp is lower as they just provided my value at
Thanks @michael-qp9xd. Unfortunately, I can't use Labcorp through Lef.org in MA-I have to drive 1hr to NH to do that. Quest is a 15 minute drive, in contrast.
A video about "what I eat in a day and how" would be nice. Knowing all things is interesting. But it would also be interesting, when you eat what, how you prepare and mix it etc. As the food is not much calory dense, it is a huge amount of food (in grams).
Hi @dirkh0, I post daily diet info on Patreon, but sharing it in a video is definitely on the to-do list...
Tomorrow's video will have the diet composition that corresponds to this test, including average daily dietary intake.
@@conqueragingordietrying1797 I'm not talking about the composition, but more about "how". E. g. all strawberries once a day and stand-alone? Or some stand-alone and others in a fruit salad with dates? Do you prepare meals, cooking, or do you eat most things raw? E. g. you can eat broccoli raw or cooked. My idea would be a video: at 9 a.m. I eat these things, at 12 these meals (not just the ingredient lists), ...
Mike, often wonder if a history of glandular fever when younger shows as stubbornly high ALT
Packed with perfect information again, thank you. How can I lower my creatinine? a higher amount of protein intake so that my muscles don't solve that quickly, or reduce my muscle mass by decreasing my weight training? or is it to find the perfect ratio of protein intake and weight training? Also, the amount of cardio after the weight training is important because cardio eats muscle mass. So then you are in a loop of building muscle and breaking it down?
I prefer the approach of tracking diet in conjunction with biomarkers, which is a better approach than general recommendations. That said, there's published data for a higher fiber intake lowering creatinine:
pubmed.ncbi.nlm.nih.gov/22739658/
Great results. How do you plan to lower triglycerides?
Thanks @justsaying7065. In my data, a higher fiber/body weight ratio is significantly correlated with lower TGs (r=-0.35, p=0.02, 47 tests), so the plan is to aim for ~90g/d, relative to ~85g/d, which is where fiber intake has been for the past few tests.
A 5g increase may not seem like much, but if correlation = causation, we'd expect to see a small TG reduction. If so, I can go higher for fiber on future tests
@@conqueragingordietrying1797 Which food(s) do you plan to eat more of to increase fiber?
Measuring TGs postprandial or across the day with an at home meter could give a better idea of how high the peak is and AUC. I mention because higher fructose intake can cause higher TGs.
Definitely, good idea
Are you taking vitamin d supplements?
Hi michael, kinda off topic sorry but do you have you seen bart kay videos (on youtube)? and if yes what it's your opinion of him
Ha, it looks like Bart's gonna review my video, nice
What is your current Homocysteine levels? Did eggs help?
Homocysteine data is coming in the next video, and unfortunately eggs didn't help...
OT: Have you seen the recent report on the discovery of 'obelisks' in human mouth and gut? These are virus-like circular RNA structures (like viriods?). Anyway, I was wondering what implications this discovery could have for health. News article in Science with title: '‘It’s insane’: New viruslike entities found in human gut '
I haven't, but thanks for the heads-up!
3:48 FBI is coming for those alien artifacts monkaOMEGA
Sounded like a fire truck to me.
Ha, yep, fire truck, I live across the street from the fire station
Any concern with your total cholesterol level and/or any interest in trying to increase. Recent studies seem to show a U shaped curve where 200 or so is optimal for longevity, with higher ACM in both directions away from that number.
No concern at all-have a look at this recent study-the U-shaped association, in particular at lower levels is mostly driven by comorbidity. That said, absolutely lower levels (< 60 for LDL) is associated with an increased CHD risk, so I'm good at an LDL of 80:
www.ahajournals.org/doi/10.1161/JAHA.123.030496
Greetings Doc. I am 51 years old. I started measuring Sex Hormone Binding Globulin at 48. Then this indicator was 64.2 nmol/l. At the age of 51 (3 months ago) it was 50.2 nmol/l . Many endocrinologists and andrologists adhere to the theory that this is a marker of a man's biological age. What is your opinion?
Hi @maximlevytsky SHBG increases during aging in conjunction with lower free and total T, but on the other hand, is dramatically increased by CR, which is arguably the best pro-longevity intervention (in animal models). How can both be true?
If one has high SHBG in conjunction with low total Testosterone, and low RBCs, as testosterone can impact their production, then high SHBG within that context may be a bad sign.
However, if SHBG is high, total T and RBCs are high, that could be a marker of youth, especially for those on CR.
@@conqueragingordietrying1797 Thanks doc for the reply. Yes, during this time I also increased the level of testosterone, and albumin does not change its value in any way. I am on interval(6|18) LCHF. My total cholesterol is 322 mg/dl, HDL 86 mg/dl, triglycerides 33 mg/dl, fasting glucose 4.83 mmol/l, HbA1c 5.6%. All risk ratios are in the "green zone". Ultrasound (Doppler) does not see any hints of plaques. But I use a lot of dietary supplements, including vitamins C, all vitamins B, K2MK7, D3 and trace elements. I study biochemistry so that I don't get sick and live a long time. My uncle (mother's brother) lived to be 91 years old. Therefore, I also want to surpass his achievements. Your research also helps to understand what to pay attention to. Thank you!
Is there some finding you'd consider your biggest breakthrough in this project? (though it's likely that bigger ones are still coming)
Doubling HDL since 2015, cutting liver enzymes and Lp(a) in half, no increase for biological age and a few year reduction over the past 4y are decent example...
@@conqueragingordietrying1797 Have you done a Lp(a) video? I can't remember seeing one and what was associated with a decrease?
@@jamesgilmore8192 Lp(a) was in an earlier video, but not as its own video...At my highest, Lp(a) has been 145 nmol, whereas for the 15 most recent tests, 86.1 average. I could drop it lower, but the intervention that best lowers it (in my case), a high-fat diet, starts to mess up other biomarkers.
Mild immunosupression (like your bloodwork) is longevity promoting. Inflammation ~ too many WBC, neutrophils etc.
Hey Gokhan, I generally agree, but I wouldn't call it immunosuppression, but instead relatively low systemic inflammation, thereby reducing the need for so many immune cells. If systemic inflammation was higher but I'm unable to make immune cells, that would be bad for health...
was going to ask why you don't just track ApoB instead of the various standard lipids as ApoB seems to be recommended by lipidologist and cardiologist who study markers. But I went back and looked at your video of 7 months ago and am puzzled by results. My takeaway from experts is that an ApoB < 80 mg/dL (with no CVD) is a good goal but that < 60 mg/dL is also recommended, but your video seems so show no value and maybe harmful (for the old) in being < 100 mg/dL. LabCorp ref rang is < 90 mg/dL with > 100 being high. just FYI.
my goal is < 60 mg/dL
Hey @peterz53, I measured AopB 16x in the summer of 2022, and it was an average of 77 mg/dL. My lipid panel is similar to then, so I don't expect that ApoB be would be currently worse. ApoB is definitely a good marker relative to only LDL, VLDL-a decent approximation of ApoB can be with use on non-HDL cholesterol using the standard lipid panel.
You have surprisingly low LDL-C. Is in natural that way or are you on cholesterol lowering drugs?
No statins, ll diet and exercise
@@conqueragingordietrying1797 are you on vegan/plant based diet if I may ask? I am also 47 and have very similar biomarkers (some better some slightly worse) apart from LDL-C and apoB. I am still on the fence what to do.
@@conqueragingordietrying1797 and what is the diet if you don’t mind me asking? I am also 47 with very similar biomarkers (apart from LDL-C). I like to check your channel to see where I have to improve :) super helpful!
I’m very surprised with this diet plan to see such high triglycerides and ldl… I think same results for myself even when I try to eat all same foods.
63 for Trig is not high. Triple digit is.
Hey Tommy, LDL = 80 is not high. Statin free...
@@conqueragingordietrying1797 it is great! I’m just wondering if fasting is recommended to get it lower
Why aren’t you doing the blood test that counts all the ldl particles. 90 glucose is pretty high too. Sounds like you’re doing the ultra low fat diet
I'm not sure that LDL particle size adds more info other than the standard lipid panel and/or ApoB. The diet is definitely not low-fat, ~44% of total calories are from fat.
@@conqueragingordietrying1797 there are half a dozen ldl particles and only the smaller ones are supposed to be risk factors for heart disease. Some recent studies suggest high ldl correlation to old age and a U shaped chart which suggests this might be something to it
90-95 is normal. Above 100 is high. Under 90 is stellar.
@@kkostadinof i had 90-93 or so back when i was 40 and felt horrible then. the reports have to divide it up but in your body there is no magic divider that 99 is normal and 100 you turn into pre diabetes. 90 you're in the danger zone especially since glucose is the sugar at the test time and A1C is a 3-4 month average and it could have been higher in the recent past.
UA-cam. Dr Ron Rosedale The cholesterol myth.
Mike -- If you can get the red cell markers back to youthful with just diet, you might find yourself consulting for some pro cyclist teams.
I've done it already, so it should be an easy fix:
ua-cam.com/video/3JpyDiNxNeE/v-deo.html
@@conqueragingordietrying1797 Are you going to try cream to limit dairy protein this time?
@@jamesgilmore8192 Not this time-Instead, I'll increase cacao bean intake, which I've been reducing based on TL correlations. Cacao intake currently has the strongest correlation with RBCs (r=0.78, p=2E-07, 32 tests).
Mirin your extremely low Eosinophil level
Thanks @robertdaymouse3784. Average since 2015 = 72, but can be as high as 153 during allergy season