Love the video! There is actually since 2019 an Antidot for Factor Xa inhibitors, called Andexanet alpha, which is a Factor X fragment, that competitively inhibit the binding of anticoagulants to Factor Xa.
We had a patient overdosed with a huge amount of eliquis(a couple of dozens at least). He was bleeding heavily with minor cuts when shaving. The doctor ordered PT/INR, PTT. I was like "it is not gonna work because it is an Xa inhibitor......but fine. We will do it. There is no loss for the pt except a little bit amount of blood. He probably lost more in this shaving activity......" Amazingly, the lab came back, showing the time was prolonged. I was like "what???!!!". That pt got lots of education from every nurse every day when he was hospitalized.
I'm not sure how far, or how near is my question in relation to the current topic, but I'll still ask. I've been having problems that include: join pain, GERD, abdomen swelling, overall numbness, brain fog, dry eyes(hella red) and mouth(it burns), dry scaly and red skin(the redness is conditioned by the position of extermities, if I have my hands up, it pretty much disappears, if down, then it starts to swell and is red again -- does not affect scaling and dryness), shortness of breath, as well as extreme fatigue. Did a bunch of tests. Blood tests' came sort of fine(decreased MPV, PDW, and IG -- increased Mono). My thyroid is k. Liver, only has decreased ALT. IgE is elevated(1616 IU/ml), had done tests and I'm only allergic to mites(d pteronyssinus). Haven't done allergy tests only for mold/fungi. Ana came positive though. 1:320. The thing is, as I did specific ANA, as well as more specific antibodies for SSc and Dermatomyositis/Polymyositis, and every antibody there wasn't in a concentration high enough to be considred as positive( I did Sm/RNP, Sm, SSA, RO-52. SS-B. PM-Scl, Jo, CB, PCNA, DNA, NUC, KU2, Mi-2, Hi, RIB, DFS70, PDGFR, Th/To, PM100, PM75, NOR90, Fib, RP1, RP155). Currently doing Lupus Anticoagulant test. So here's my question. Is there anything I can do to get a diagnosis? This range of testing cost me a shitton of money, the symptoms are getting worse pretty much on a weekly-to-monthly basis, and I'm on the verge of mental collapse. Would be grateful for an advise from your perspective.
I’m doing a trial for a new anticoagulant that inhibits FXIa and i want to know why they theorise it’s better than FXa. Would really appreciate your explanation! It’s a new drug coming out so your video would be very educational as FXIa videos are so limited on youtube.
Can u make a video about superficial and deep reflexes ... Physiologically and in pathology condition .... I tried to find out ... But couldn't have a complete clear idea ... Hope u will help me ....
Is there any chance to talk to you for 5 minutes? You could safe my life. Casual Doktors csnt help, because they don't understand the medications on your level.
❤️ 💊 Cardiac Phrmacology: www.medicosisperfectionalis.com/products/cardiac-pharmacology-course/
Love the video! There is actually since 2019 an Antidot for Factor Xa inhibitors, called Andexanet alpha, which is a Factor X fragment, that competitively inhibit the binding of anticoagulants to Factor Xa.
I WAS LOOKING FOR THIS COMMENT
You make learning so much fun 😂
Thank you ☺️
It is the first time for me to watch a video on your channel but they are really amazing ❤ ❤
Thank you 🙏
We had a patient overdosed with a huge amount of eliquis(a couple of dozens at least). He was bleeding heavily with minor cuts when shaving. The doctor ordered PT/INR, PTT. I was like "it is not gonna work because it is an Xa inhibitor......but fine. We will do it. There is no loss for the pt except a little bit amount of blood. He probably lost more in this shaving activity......" Amazingly, the lab came back, showing the time was prolonged. I was like "what???!!!". That pt got lots of education from every nurse every day when he was hospitalized.
you are by far my fav person
Thank you!
YOU'RE A LIVING LEGEND
I'm not sure how far, or how near is my question in relation to the current topic, but I'll still ask.
I've been having problems that include: join pain, GERD, abdomen swelling, overall numbness, brain fog, dry eyes(hella red) and mouth(it burns), dry scaly and red skin(the redness is conditioned by the position of extermities, if I have my hands up, it pretty much disappears, if down, then it starts to swell and is red again -- does not affect scaling and dryness), shortness of breath, as well as extreme fatigue.
Did a bunch of tests. Blood tests' came sort of fine(decreased MPV, PDW, and IG -- increased Mono). My thyroid is k. Liver, only has decreased ALT. IgE is elevated(1616 IU/ml), had done tests and I'm only allergic to mites(d pteronyssinus). Haven't done allergy tests only for mold/fungi. Ana came positive though. 1:320. The thing is, as I did specific ANA, as well as more specific antibodies for SSc and Dermatomyositis/Polymyositis, and every antibody there wasn't in a concentration high enough to be considred as positive( I did Sm/RNP, Sm, SSA, RO-52. SS-B. PM-Scl, Jo, CB, PCNA, DNA, NUC, KU2, Mi-2, Hi, RIB, DFS70, PDGFR, Th/To, PM100, PM75, NOR90, Fib, RP1, RP155). Currently doing Lupus Anticoagulant test.
So here's my question. Is there anything I can do to get a diagnosis? This range of testing cost me a shitton of money, the symptoms are getting worse pretty much on a weekly-to-monthly basis, and I'm on the verge of mental collapse. Would be grateful for an advise from your perspective.
Best lecturer ❤ and making learning easier n funny 😂😂
Thanks a ton!
Medicosis, Why does argatroban and Lepirudin affect PTT? Do they also inhibit some intrinsic pathway clotting factors?
I’m doing a trial for a new anticoagulant that inhibits FXIa and i want to know why they theorise it’s better than FXa. Would really appreciate your explanation! It’s a new drug coming out so your video would be very educational as FXIa videos are so limited on youtube.
Medicosis, but what about andexanet Alfa? Is that not an antidote?
Amazing video😮 I love it 🙏🏼😍😇😇❤❤
Cheers mate, awesome series!
Thank you so much 😊
Bravo 👏🏼👏🏼👏🏼
Thank you so much 😊
Perfect time to upload this video few days from my hematology final. You're amazing doc
Thank you so much 😊
🥇🥇🥇Take off that mask we know that you are Einstein's cousin
Haha 😂
Hello u make pharma really very easy
.. can u please make a video on diuretics
Thank you so much 😊
I have many videos on all diuretics in my Cardiac Pharmacology Course: www.medicosisperfectionalis.com/
How do I get the filled out table 😗?
Why ArgaTROBAN montitored by PTT ?does it have something to do with intrinsic pathway?
THANK YOU VERY MUCH FOR YOUR VIDEOS .
My pleasure 😇
love your videos! thank you so much, they are really helpful
My pleasure 😇
Love your humor lol
Thank you 😊
U teach so amazingly 😍😍loved watching Ur videos..keep teaching us!
NICE
Thank you 🙏
Can u make a video about superficial and deep reflexes ... Physiologically and in pathology condition .... I tried to find out ... But couldn't have a complete clear idea ... Hope u will help me ....
Good idea
Thanks Dr,can u make a next video on fibrinolytic drugs
I did already...Check out the playlist "bleeding and coagulation"
@@MedicosisPerfectionalis okay 👍 thanks .
❤
🙏
You use notability or good notes?
Send me an email
Tq doc
My pleasure 😇
Andexaner alpha is antidote for DOAC
Is there any chance to talk to you for 5 minutes? You could safe my life.
Casual Doktors csnt help, because they don't understand the medications on your level.
ive never laughed while studying for pharm until now
:)
BANANA REPUBLIC LMAO
The god save you
Thank you 🙏
You too!