Thankyou so much for making these lectures public. I came across these by accident, and i have to say NO ONE explains genetics better then you do! There are so many concepts i feel i have finally understood all thanks to you. You break things down so they are simple and concise. Your love for the subject really shines through! Thanks again, all the way from India.
If I may ask, why we consider females as x-linked dominant or recessive if they have x-inactivation which in this case, there is no dominance and recessive. Thus, females will also considered as hemizygote or I mean the trait will only be expressed by one chromosome. So, why dominanace and recessive in the x chromosome in femles?
I had the same question. With X-linked inactivation, we have set of X's inactivated (Xi) from father and random Xi from mother. So, the cells will be a mosaic in the organism (such as with calico cats). Let us assume that a trait is X-linked dominant for a girl. That means half of her cells will have that affected X chromosome (assuming she did not have a defective allele from her father.) Because it is dominant, she will express the phenotype. Even though half of her alleles are unaffected (she has a healthy X chromosome from father), the dosage from the defective allele is enough to be expressed. In the case for x-linked recessive, the opposite is true, This is how I make sense of the information.
Thankyou so much for making these lectures public. I came across these by accident, and i have to say NO ONE explains genetics better then you do! There are so many concepts i feel i have finally understood all thanks to you. You break things down so they are simple and concise. Your love for the subject really shines through! Thanks again, all the way from India.
Thank you very much.. I've watching these lectures and they very helpful.
You're awesome! 💐💐
You are my hero.
I am taking prep for Olympiad and watching your videos to cover genetics part. Thank you ❤️
OMG, thank you for mentioning misuse of statin drugs!
awesome. thanks
If I may ask, why we consider females as x-linked dominant or recessive if they have x-inactivation which in this case, there is no dominance and recessive. Thus, females will also considered as hemizygote or I mean the trait will only be expressed by one chromosome. So, why dominanace and recessive in the x chromosome in femles?
@@thomasmennella5501 Thank you very much.
I had the same question. With X-linked inactivation, we have set of X's inactivated (Xi) from father and random Xi from mother. So, the cells will be a mosaic in the organism (such as with calico cats). Let us assume that a trait is X-linked dominant for a girl. That means half of her cells will have that affected X chromosome (assuming she did not have a defective allele from her father.) Because it is dominant, she will express the phenotype. Even though half of her alleles are unaffected (she has a healthy X chromosome from father), the dosage from the defective allele is enough to be expressed. In the case for x-linked recessive, the opposite is true,
This is how I make sense of the information.
What text book (title and edition) are you referring to? Thank you
What do you do for intersex individuals in a pedigree?
41:00 green
53:00 green
1:07:33 green