Fatty acid synthesis

Fatty acid synthesis lecture - This lecture explains about the synthesis of fatty acids from acetyl coA and glycerol to make complex fat molecules in cell.
where fatty acid synthesis takes place?
Fatty acids are synthesized in the cytosol, whereas acetyl CoA is formed from pyruvate in mitochondria. Hence, acetyl CoA must be transferred from mitochondria to the cytosol. Mitochondria, however, are not readily permeable to acetyl CoA.
How is fatty acid synthesis regulated?
Acetyl-CoA is formed into malonyl-CoA by acetyl-CoA carboxylase, at which point malonyl-CoA is destined to feed into the fatty acid synthesis pathway. Acetyl-CoA carboxylase is the point of regulation in saturated straight-chain fatty acid synthesis, and is subject to both phosphorylation and allosteric regulation.
How is acetyl CoA transported out of the mitochondria?
This citrate is transported from the mitochondria to the cytosol, thus transporting the acetyl-CoA in the form of citrate. Once in the cytosol, the citrate is converted back to oxaloacetate, which is then reduced to malate.
Where does lipogenesis occur in the body?
Lipogenesis takes place in the cytoplasm of your fat cells and liver cells. The process begins with acetyl-CoA, also referred to as acetyl coenzyme A, which is a molecule that is formed from the metabolism of glucose
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Thank you for watching the biochemistry video lecture on fatty acid biosynthesis.

[@dollyvinod9378]

Beautifully explained.. Fun fact : you look so much Like the Money heist professor! 😹

[@vinithalekshmi1]

he already know we will be here :p

[@aggieruiru1999]

I swear I thought the same too 😂😂

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Are you drunk??? Not at alll please 😏😏😏

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@@eyshajam6980 well everyone has a right to their own opinion.. wouldn't call that being drunk really ^_^

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😂😂😂

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Sir my coarse is biotechnology .
If I feel any problem related to my coarse in any subject then yr video is available . means you are really amazing . All video are useful and in easy way......thank u very much sir😊😊😊

[@shomusbiologyofficial]

Thank you. Glad you liked my lectures

[@rachelshekinah5834]

Thanks you help me a lot during my biochemistry preparation during my 1st year MBBS

[@aathmikagovindh733]

Sir your videos are very helpful but I have one problem I am not sure if I am the only one who has the problem sir at the end of the video the audio is very poor so understanding the points is quite difficult.

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yes same me too.

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Same here also.

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Yes my condition is same

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Sss

[@jeeyaamonkar1199]

Same

[@saniyaaltaf7586]

Here is mnemonic for palmitate synthesis :-“Friends Are Always AwesoMe At Bday But Totally Alien At Planet” it stands for Fatty acid synthase,Acetyl coA ,Acetyl s acp,Acetyl s enzyme,malonyl coA,acyl malonyl enzyme,beta keto acyl ACP,b-OH acyl acp,trans enoyl acp,acyl acp,acyl s enzyme,palmitate😀👍🏻

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[@throughpassmedia11]

Nice

[@SaharSasi]

Simply; Your explanation is ''Awesome'' thank you so much''

[@shomusbiologyofficial]

+Sahar Sasi thank you. Glad you liked my lectures

[@harshadarokade1032]

U r last minute helper u videos always helps me during exms

[@MegaLukecage]

a very brief and amazing lecture on fatty acid synthesis. Thank You :)

[@annmartin1242]

hey manh! ...the lectures are awesome. here's a request. can u make videos for synthesis of triacylglycerol, phospholipids, cholesterol and ketone bodies

[@shomusbiologyofficial]

+Ann Martin thank you. Glad you liked my lectures. Please subscribe and share

[@amnakousar8910]

assalam o alaikum
apky lectures boht achy hoty hen . keep this effort up

[@secularfacts7914]

I like Ur teaching. It will easily understood

[@healthbabe2691]

Hi Shomu. The lecture is very organized and presented in the simple way that I can follow it easily. The audio is low during your pathway presentation. I can still hear you as the volume on my labtop set to maximum. Thanks for sharing and have wonderful day.

[@shomusbiologyofficial]

Thank you. Glad you liked my lectures

[@shabirhussain5555]

At 5:59, Sir there is no receptor for pyruvate on mitochondria, it cannot go outside and inside mitochondria. Pyruvate is transported in and out of mitochondria in the form of malate.
Thank U sir, really like ur lectures...
Stay blessed always

[@shomusbiologyofficial]

Thank you. Yes there is a shuttle converting pyruvate into malate for the transport

[@duaa6172]

Finally the concepts are clear. Thankyou

[@shomusbiologyofficial]

You're welcome

[@akshadasonawane2898]

Your knowledge and explanation is justttt Awesome sir...
Thanks for this vdo..
Also u r very cute 😅❤️

[@shomusbiologyofficial]

Thank you so much for appreciating my efforts

[@annapurnakoppisetty1773]

Nice explanation
I want lipid biosynthesis

[@anupriyadarshinihv]

thanks.. was searching for this video since yesterday.. finally u posted.. thanks😃

[@shomusbiologyofficial]

+Anu Priya well stay tuned for more. More biochemistry videos to come

[@chowpaliksha9012]

add more about bio synthesis of carbohydrates and proteins in details

[@snehasingh9364]

Audio is very low in the presentation part.

[@kritigupta9357]

I surely will share with my colleagues as well as sir to let him know how to teach

[@PoonamKumari_zoology]

Thankyou so much Sir...Beautifully explained...

[@shomusbiologyofficial]

Thank you

[@soumyaranjanmahanta9127]

Thank you so much sir 🙏🏼🙏🏼

[@shomusbiologyofficial]

You're welcome

[@ManishaKumari-ev1ke]

nice video sir... can you plz make video on short term n long term regulation of fatty acid synthesis... tomorrow is my examination but still i am so confused.. about this topic.. plz

[@heenakhan9936]

Thank you so much and u are very sweet ...this topic is now easy fore

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hey shomu,may i know what u are. i used your lecture during 12 grade and now even in 1st yr mbbs. damn curious, pls tell

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Same bruh!!

[@ashischatterjee7729]

His name is Suman Bhattacharya

[@akhilav6921]

Superb class

[@shomusbiologyofficial]

Thank you

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Ur videos are really helpful but when u add ppt in it really it becomes complicated and hard to understand

[@sonytambattilsonytambattil3673]

I mostly choose ur lecture
It was really better and more useful for me

[@sandipkale137]

Very nicely explained

[@shomusbiologyofficial]

Thank you

[@englishspoken8168]

Fatty acid biosynthesis
Start from Acetyl coA and and NADPH

[@sabikunnaharorthee1330]

It would've been great if you wrote the reactions on board as well! But thank you!❤

[@shomusbiologyofficial]

Ok

[@priyankabihari9393]

this really helps me a lot thank u so much

[@shomusbiologyofficial]

You're welcome

[@soumikchowdhury3980]

Many thanks for this explanation 😇

[@shomusbiologyofficial]

You're welcome

[@kajaljain5627]

Awesome video.. thank you sir for posting this video.. this video helps me a lot to understsnd about fatty acid synthesis... And this is awesome..thank you sir...

[@santanu6017]

Good teaching, thaQ sir.

[@shomusbiologyofficial]

You're welcome

[@soofiyanoushad3780]

Sir I have a doubt. Wht is the differents between branched and unbranched fatty acid synthesis?

[@aliyannasir2002]

Why All u tubers data different about fatty acid synthesis😒

[@msczoology9744]

ur vedeos r so help full plz make video on linkage numericals

[@mariahasan4825]

U xplain very nicely...its very helpful thanku sir ...

[@sanjh_sayani....5859]

Thank you so much 😊 🙏

[@shomusbiologyofficial]

You're welcome

[@fgnsdfnbnd]

I'd like to see a video comparing and contrasting the human biochemistry with regards to eating a pure fat diet versus a pure carbohydrate diet over a day, week, month and until death. With considerations to a hypo-caloric, iso-caloric and over-caloric calories of these single macronutrient diets. Biochemistry of liver, muscle and fat cells. Hormonal communication btn the various organs including the brain, heart, kidney and the aforementioned.

[@shomusbiologyofficial]

Okay. I will make a video on that soon

[@Mim-br9ns]

which book are you following for this reaction figure of fatty acid synthesis?
It is much more easier .
I don't understand Harper's Illustrated Biochemistry or Lehninger Principles of Biochemistry book's reaction figure

[@secularfacts7914]

Sir plzzz make video on topic cholesterol synthesis

[@riteshkumar5173]

Sir thoda mistake lg raha hai aapke lecture me cytoplasm me pyruvate se acetyl co-A banta hai jise Intermediate step kehte hai give 1 NADH2 aur fir acetyl co-A permiable hota hai mitochondrial memb ke

[@ashiwankhade5480]

Thanks somu for easy way to learn

[@shomusbiologyofficial]

You're welcome

[@priyakumar6769]

thanks sir i have a doubt pls explain about the elongase mediated fatty acid chain elongation

[@areebajameel2907]

I like your demonstration

[@shomusbiologyofficial]

+Areeba Jameel thank you.

[@chowpaliksha9012]

you are my favorite😍💕 teacher shomu

[@shomusbiologyofficial]

+Chow chow thank you. Glad you liked my lectures. Please subscribe and share

[@sinithomas427]

Thank you sir

[@shomusbiologyofficial]

You're welcome

[@ellaanderson5202]

Can somebody please tell me what's the connection between synthesis and oxidation of fatty acids and how the connection works? I got this question on my exam, I'm completely lost when it comes to it.

[@nikitasharma4311]

Can you help me in regards to topic"fatty acid synthesis in E. Coli(prokaryotes)

[@blessingo.josiah9477]

Thanks for the great job.

[@seles_sohal]

Thankyou so much. I got it👍👍

[@shomusbiologyofficial]

+Seles Sohal you're welcome

[@NeonTiger2701]

Does anyone know the main difference (if there's one) between fatty acids synthesis and DNL (De Novo Lipogenesis)? Thanks!

[@quratulan133]

Sir tomorrow is my paper plz reply
Beta oxidation of saturated fatty acid aur unsaturated fatty acids mai kya farak hai

[@lokeshpatel1006]

Hindi and english mixing vidio banaya karo sir aur detail bhi

[@ruatafambawl]

Useful for me. Thanl you

[@shomusbiologyofficial]

You're welcome

[@pushparajjoshi844]

Can't the so formed malate from OAA in cytosol enter the mitochondria directly without being converted into pyruvate?

[@farzanasharminnipa7812]

So helpful thnk u ..

[@shomusbiologyofficial]

You're welcome

[@kurakulanandini5603]

Plz make cholesterol biosynthesis vedio..

[@vinaysoni7893]

The sound was very low during strips of synthesis

[@swetasahoo3926]

From where to get this lecture notes

[@amitkaushal9525]

Thank you so much

[@shomusbiologyofficial]

You're welcome

[@_AarthiT]

Are the A Co a in mitochondria from byruvate and the A Co a in citrate produced by TCA cycle same???

[@swatisingh5301]

hello sir your videos are too good and helpful for me but animatic part me aapko aavaj bhut hi slow hai so plz improve it

[@abhisek175]

Why is there a volume drop in the middle of the video...🙄

[@Lifjunction]

really good

[@shomusbiologyofficial]

+Ritika Singh thank you.

[@rohannowal6258]

Sir can u plz reply What does SCoA stands for?
Thank u
And yes the video is amazing

[@shomusbiologyofficial]

+Rohan Nowal thank you. Glad you liked my lectures

[@aathmikagovindh733]

It is the co enzyme A

[@sreeramkumar1241]

Coenzyme A - sulphur

[@shubhamaggarwal3801]

Thank you sir👍🏻

[@itsfine1674]

sir around 0:44 second you said " the body has limited supply of glucose-related to the energy stored as fat" can u please explain it.

[@mbbsaspirant3727]

Thank you!

[@shomusbiologyofficial]

You're welcome

[@muskaangupta8263]

Can someone tell me what is the starting material for biosynthesis of lipid?? Please help have an exam tomorrow 😭

[@s2r188]

Sir please make a video on The topic Iodine number,, acetyl number

[@Kanhasevak]

Is it include biosynthesis of lipids

[@Sweet-hu4nk]

Faty Acid C18 why need 8 Atp to convertion Acety_coA to malonyl_COA why not nine????

[@pareshchaudhari1463]

Sir make a video on protein synthesis

[@santoshsid4174]

Sir u great teach for study but i need want hindi lauguage vdos so help

[@pareshchaudhari1463]

Nice video

[@uswasahito4074]

Sir why homones are composed of fatty acids? Plzzzz answer m

[@JaLLaM86]

6:40 Love it XD

[@meenakshimakhijani5851]

Voice problem after 9 minutes

[@shameempadinjarayil6661]

Hello..
Any one have solve a problam. ..
Fat solid in room temperature how to liquify it in all tim just lik oils. .?

[@aryaram8192]

Thank you Sir🙂

[@saravanan1120]

Volume is not adequate for the video part

[@mohsinfayaz2500]

I understood nothing when you left after 9 minutes . It had been better if you would have written the whole topic on the board with explanations

[@hawrahayder1084]

you are the best

[@VinayKumar-yq5hb]

Super sir g

[@shomusbiologyofficial]

You're welcome

[@katsrejola1925]

Is fatty acid a lipids?

[@vishalsaini4905]

De nono synthesis b yhi h Kya sr

[@priyangi6272]

Sir cant we use OAA for gluconeogenesis??

[@jyotirmayimahari4135]

Is ATP synthesized or converted to ADP?

[@dhanyakrithika4914]

nice video

[@joyisrawrsome]

will you be a teacher in real life? these videos are quite good!! :)

[@shomusbiologyofficial]

+joyisrawrsome I am a teacher

[@panayiotisantoniou5095]

I think at 5:43 you should say NADH not NADPH! But still, great video thank you sir :)

[@shomusbiologyofficial]

Thank you

[@faheemakhtar9815]

You are amazing... sir why you respone some and neglect others? Any reason?
From Pakistan

[@shomusbiologyofficial]

I don't get time always. When open, I reply

[@Litun123]

Sir from where I can read the theory please tell ???????????????🙏🏻🙏🏻🙏🏻🙏🏻🙏🏻🙏🏻

[@shomusbiologyofficial]

Lehninger

[@Litun123]

@@shomusbiologyofficial thank you sir 🙏🏻🙏🏻

[@MS-dz9nl]

Thankyou sir

[@priyaselvaraj334]

sir.can u plz xplain syntesis fatty acids inbacteria

[@sndpbamaniya]

kya lecture hindi me available ho sakte hai.

[@Shalinisingh-dh6pn]

thnk u sir.....
can u plzz make a video based on information for m.sc. entrance in Biotech .

[@shomusbiologyofficial]

+Shalini Singh Chauhan I will make it soon. Thank you for watching the lecture