Metabolism | Triglyceride Synthesis
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- Опубліковано 3 жов 2024
- Official Ninja Nerd Website: ninjanerd.org
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In this lecture Professor Zach Murphy will present on the process of triglyceride synthesis and all of the associated enzymes involved. We hope you enjoy this lecture and be sure to support us below!
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#ninjanerd #FattyAcidSynthesis #Metabolism
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sir please zoom out the camera in the end so that we could take a screenshot of the lectures.
thanks
Agreed
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The ⁻O-CO-(CH₂)ₙ-CH₃-CoA notation is a bit weird, I guess you mean H₃C-(CH₂)ₙ-CO-S-CoA or something like this? Usually, there is no 5-bond-carbon and the FA-synthesis should result in something like R-CO-S-CoA.
Yes.. the notation is not weird. I would call it wrong. It misleads. H₃C-(CH₂)ₙ-CO-S-CoA this one is correct.
Biochemistry become my favorite subject after watching your videos 😃❤️
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Loved this video! You explained this process very well and I was able to make sense of it all. Thank you :D
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Thankyou sir. This vedio is very easy to understand .Very nice explanation. 👍
Best ever , love your concepts and how u make it easy ! Great job ✅❤
Man,you're better than my lecturers, what am i paying my money for when i can study online with you
thanks so much, this is very helpful. may God bless u
Thank you 🙏
you are honestly the reason why i love biochemistry! i actually hate and despise chemistry all my life but all your videos are so great in explaining every process in our body and right now my favourite and top scored subject in medschool is biochemistry! T_T Thank you so much you're a life changer really
+cupcakechip So happy to help! Glad we were able to make you enjoy it!
Zach you have helped millions of students in making MBBS easy ❤
Really we owe you a lot sir
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Great video as always. There are a few things I wish you'd mentioned. First of all I only learned later that Glycerol 3-phosphate is made directly from DHAP via Glycerol 3-phosphate dehydrogenase. I don't believe you mentioned that. Also a mention about glyceroneogenesis would have been great.
Anyway. Thanks for the video. Maybe I'll actually survive Biochem with this.
+SeptimusCreed thank you very much I hope the video was able to help. Best of luck in your future endeavors
We love you thanks a million just keep going
Thanks a lot ❤
I am medicine student and I am preparing for my exam by your videos I had watched the 30vvideos of biochemistry and until now I didn’t found any one better than you in explaining biochemistry
my hero
When a phosphate group linked to a glycerol molecule its formula become C3H7O3PO3-2, you guys add an additional oxygen atom and a negative charge. The rest is awesome thank you :DD
pKa1=1.0, pKa2=8.0 for phosphatidic acids, so at physiological pH, almost all are singly-protonated, that is -HP04-1
@@johnpowell9174 I think the main issue he is pointing out is that it should be PO3 linked to the glycerol backbone (resulting in O-PO3), instead of the O-PO4 that is shown
@@seanluong6064 Agreed.. There a structural formula issue
I’m watching this after five years and thaaanks❤ just a question.. you told the fatty acid chain that is gonna attach to carbon No. 2 in glycerol should be unsaturated but how simple saturated triglycerides are made? Or we don’t have simple saturated triglycerides naturally?
Thank you. It really helped a lot!!!
these triglycerides are synthesized by glucose breakdown? Pyruvate? Meaning the initial process.
It’s really satisfying to take nap in biochem lectures after attending ninja….
thank you
Very lovely video, thank you so much for you content Ninja Nerd. However I do think the 3 fatty acyl-CoA you have made in the beginning is a little bit misleading, since it should be CoA-SH bound to the carbonyl group with a thioester bond right? The CoA should be drawn in the other end and the Oxygen shouldn't be present right? Please correct me if I'm wrong.
You're completely correct. CoA is bound by a thioester bond and there is no carboxyl group at the end of the fatty acid chain. The second oxygen comes from the glycerol chain itself where it forms an ester bond between the glycerol chain and the fatty acid chain allowing the CoA-SH to dissociate. Also to nit-pick a tad, What he calls a "DAG" is only technically incorrect in that "DAG" refers to the dephosphorylated form of Phosphatidic acid. It's not a huge deal conceptually because he still does a great job at explaining the flow of events for TAG synthesis but since DAG itself is involved in other metabolic pathways and is itself a second messenger in cellular signaling cascades, I thought it worth it to know that DAG itself is a bit more distinct from PA.
Questions: Is the second fatty acid in a TAG always an unsaturated fatty acid? Does this mean that fatty acids 1 and 2 will always be saturated? Furthermore, are the answers important in the context of nutritional ketosis?
Wow, what an informative video!
Sir is there something called glycerol -3-phosphate? It is glycerol phosphate ig!!!
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IT WAS REALLY HELPFULL
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Amazing!!!!!!
To the person who said their watching this for fun; Well,me too!
firstly thanks a lot for your great explanation you and the team works with you to create such an amazing stuff like this
I have a question 🙋 can adipose tissue contain a glycerol or not.
I know it only get the glycerol 3- phosphate from the glycolysis because it's doesn't have glycerol kinase but I think you said in this videos the glycerol come from the adipose tissue when it breakdown or something like that ....... explain it to me please.
thanks a lot
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What do you think about the people with genetic variations that do not process fats the way 78% of people do? I am hearing geneticists say that DNA analysis of people that had ancestors that survived food shortages pass on genes that cause people to have more triglycerides than average people. Is this a different pathway. These scientists say these people need to tailor there diet to add in nutrients in excess of RDA like choline.
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Great
greetings, in this lecture, you said that the 2nd fatty acid that is to be added to the glycerol backbone has to be unsaturated, so what about the 1st fatty acid that is to be added? does the 1st fatty acid have to be saturated fatty acid??
thank you in advance.
great
So what’s the point of breaking down TAGs via lypolysis and then form TAGs again?
Same question
Usually the two process take place in s different time and nutritional status
Why should the second fatty acid necessarily be unsaturated??
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You are awesome! I can’t find the video of fatty acid synthesis part 2. Can someone add link?
Currently being remade due to an error. We are reposting this ASAP! Thanks!
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I think there's a little mistake.
Phosphatidic acid and diacylglycerol are not the same thing.
DAG gets phosphorylated to form PA.
Unpopular statement: I'm watching this for fun.
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We cannot call MAG (Monoacylglycerol) and DAG (Diacylglycerol) without removing the phosphate group attached to the respective compounds.
and in Step #3 conversion of Phosphatidic acid to DAG should take place first using phosphatase enzyme and in the next step we add the last Fatty acyl CoA to make it TAG.
Anyways, Thank you for this amazing video. Love to revise through this.
It can be called a DAG phosphate or a MAG phosphate
Hi. Are phospholipids and DAG the same?
Thank you👍
I didn't understand the structure of fatty acyl COA .So please help me out.
Biochemistry become my favorite subject after watching your videos 😃❤️
Same here
What reference do you use?
You’re the king of biochem
And my other question is that why are we taking fatty acyl co A s but not just fatty acids?????
Because those fatty acids need to be activated
Where does the O from fatty acyl coa and H from glycerol-3-P go when they form the bond?
I still cant believe that this is free.. thank you sooo much
Awesome videos! I felt like I'd never get metabolism. Thank God I found you💕.
Please male vid. About nucleotide metabolism and phospholipids.
neutral lipids or triacylglycerides sythesis*
I think we can call the lysophosphatidic acid MAG only if we get to dephosphorylate it and similarly phosphatidic acid once dephosphorylated is when we get DAG if not so they are different structures.However, the lecture is great.
I'm first year medical student in Brazil, thanks a lot for this biochem playlist!! We both are visual learners so it's easy to understand your explanations! :)
Is it bad to have high triglycerides? Why?
For the steps from DAG to TAG, not just phosphate isn’t H2O also be lost in this process am I right? Could you clarify this for me ?
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such a good video!! maybe you can explain also one for unsaturated FA or unodd FA :)
thank you so much!!
Benefiting medical students is a great jop ❤
This video made it so so clear thank you !
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I have my Biochemistry exam on monday and i've been studying it since February :(, your videos helped me to love and learn this subject, thank you so much!
how did it go?
@@theaizere really well! 27/30💕
@@camillamicucci1155 that’s wonderful! Great job. aspirational
What chooses which types fats are added to the glyceride base. Fully saturated fats are flatter and the resulting try g is more dense.
Thank you so much
Can anyone tell me what are the energetics of neutral lipids ?
can the excess of the free fatty acid inhibit the palmitate
is that true the palmitate can inhibit the acetyl co A carboxylase
if all of the above true let me now how it possible be right
thanks
triglyceride synthesis inhibitors antiddote
Fatty acid synthesis part2 is not available
idk do u know but u are creating a new gen docs who got their infos from u.