CYP450 Enzymes Drug Interactions MADE EASY in 5 MINS
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- Опубліковано 16 чер 2024
- Managing drug interactions is a vital skill for all pharmacists. In this video I breakdown the CYP450 system and how these enzymes impact drug interactions.
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thank you so much. was finding it so hard to understand this, until i found this video!!
Thank-you for sharing. Watching your video was the first time I understood this
Thank you for making it easy!
-PA student
Thank you so much for the making the concept more understandable.
You’re welcome
I have had no education except for some years in primary school. I'm currently teaching myself to gain some more knowledge.
Just wanted to let you know that although this is difficult study material, I understood more or less or let's say most of it. This thanks to your way of teaching. I love your explanations so much. Thank you kindly.
This is the best explanation of this ive ever found. THANKS SM!!!
You’re welcome.
WOW! thank you, I have my A&P exam next month and it includes Pharmacology and this just made it easier to understand.
Thank you for this video. It helped me understand how inducers and inhibitors affect drug concentration. I appreciate it
You’re welcome
Thanks friend. It helped me a lot!
Such a good explanation thank you sooo much
Thank you so much for sharing your wisdom! I personally really liked the graphics of the enzyme inducer.
You’re welcome:)
Literally an entire semester of APRN Pharmacology... and reviewing for the final and decided to search for an easier way of understanding this content... THANK YOU For this. 5 minutes and i understood it so much better than a whole semester of pharmacology....
That’s amazing thank you for sharing
😢b
right!! exactly... this NP is grateful for the simplicity!
Thank you! Loved it
You really dumbed this down to the T! Thank you !!!
Thank you straight forward and good❤
Brilliant video, thanks for mentioning the St John's wort
What is it?
Thank you for this!
Even more important to understanding the importance of the CYP enzymes are two other factors.
Most important: many of use either completely lack function of some CYP enzymes, or have hyper function of the enzymes. This is vastly more important to know than is the inducer or inhibitor character.
Second and also far more important tied the the first is that some drugs are in their active form as ingested (e.g. benzodiazepines). The enzyme (if functional) converts the enzyme into a less or non-functional form. For people lacking the functioning enzyme, these drugs either need to be avoided entirely, or downward dose adjustments are essential.
For other drugs, the CYP enzymes (e.g. 2D6 for some opiates like codeine, Vicodin, or tramadol) convert the ingested drug into its active form (e.g. codeine converts to morphine). People lacking a functional 2D6 enzyme gain no benefit at all from these drugs.
Testing should be widespread for these gene functions either through genotyping of phenotypic, but is still rare. Even with full genome sequencing, determining the precise gene variants and there effect on functionality is difficult.
It is not uncommon for a person to be missing functional forms of many of these enzymes. And this much more so than the competition for function by inducers or suppressors leads to a lot of drug dangers, injuries and deaths. There are also broad differences in the likelihood of having hypo, non, or hyper functional CYP variants based on country, region, or ethnic group origin. This too can be critical for patient health.
Common references focus on substrates, inducers, and suppressors and entirely omit these vitally important ideas.
That was amazing 👌
Thank you this was very helpful and informative!!
Glad it was helpful!
thank youuuuuuuuu so muchhhhh - شكرا جدددددنن استفدتتت god bless u
I am currently studying for Naplex, this was a great explanation! Thank you for posting! 😃😃
This is amazing! Thank you!
You're so welcome!
Great explanation.
Excellent !
Loved this video and your teaching! I am researching content for a video on Azole Antifungals for nurses and the CYP450 is an important element to include .. I will be sharing your video with my students
Thank you, that’s amazing !
incredible!
Can you do more NYS compounding videos? The 2021 exam is coming up soon and I would appreciate it!
amazing explanation thank you!
You’re welcome. Please share 😁
thanks, very helpful
beautiful!
easy to understand thank you!!
You’re welcome :)
Thank you
Great explanation! At 2:52 of the video, why is Drug A causes reduces of CYP enzymes for Drug B? From my understanding, reduction and increase of CYP enzymes does not depend on the drug itself, but rather than the the production in the liver (perhaps) or addtional enzymes that the person is taking.
A 2nd year pharmacy students here. I just got scolded in class because I don't know an answer regarding the CYP. This video is really helpful :)
Initially I thought CYP (along with random number and letter after it) is just a random specific things that I don't need to understand deeply yet. Turns out it just an enzyme. Thank you so much.
well it's not only an ezime, CYP450 it's a diverse superfamily of hemoproteins found in bacteria, archaea, and eukaryotes.[1] Cytochrome P450 proteins use a wide range of exogenous and endogenous compounds as substrates for their enzymatic reactions.
They are usually part of multicomponent electron transfer chains, called P450 container systems. The most common reaction catalyzed by cytochrome P450 is a monooxygenase reaction, that is, the insertion of an oxygen atom from molecular oxygen (O2) into an organic substrate (RH) while the other oxygen atom is reduced to Water. Greetings from Argentina!
Tsk tsk tsk
and what path follows this enzime? cytosolic or secretory? and pdt: the video is amazing
Thank you!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
You’re welcome :)
Thank you! 🙌🏾
You’re welcome. Hope it helped.
ua-cam.com/play/PLO2O9UjkQxLe1kALvk5mcOzATvb0NUsGb.html
Yo bro love the video I have a rly important question that would rly help me in my daily life if it’s possible for me to reach out to you? Ofc it’s about the same topic in the video. Amazing video greetings from the Netherlands
Thanks
thanks :D
So I'm an ultra rapid metabolizer. Found out after liver donation.
Means alcohol doesn't make me drunk, weed doesn't make me high, acid does very little, molly is weak and lasts 1 minutes, I can drink red bull and a five hour energy and fall asleep, and anti-depressants don't do much.
Thank you wow
You’re welcome. Hope it helped.
Main Question, Does processing Drug A, speed up the proccessing of drug B when multiple drugs are involed. does the production of enzymes for drug A speed up the whole proccess for drug B????? this seems to be true in my experience.
I don't know why I'm struggling so much with this concept 🤦🏾♀️. For instance, when drug A acts as an inducer on an enzyme that normally metabolizes drug B, in the presence of drug A what happens to drug B. Does it bind to proteins? Is it free in serum? Or excreted? What does it mean for serum concentrations?
The drug B will bind to the enzyme and then converted to a more polar form for it to be excreted thru kidneys usually. Hope that helps.
Grapefruit juice seems to be a big issue with a lot of drugs.
Haha.. you got that right Pal
👏👏👏👏👏
❤❤
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CBD is a P450 enzyme inducer.
I really do appreciate you Dr Igudia youtube,your commitment towards saving human lives is steadfast ,all the knowledge I got from you and,the help with the herbal meds, I was recently tested negative of my type 2 Diabetes,I’m so happy thanks doc
ua-cam.com/play/PLO2O9UjkQxLe1kALvk5mcOzATvb0NUsGb.html
5:07 i don't think that the job of cyp enzymes is to activate drugs;
cyp enzymes metabolize drugs; and metabolism of a drug means inactivating it
Prodrugs are inactive in their initial state. CYP enzymes activate them through metabolism.
ua-cam.com/play/PLO2O9UjkQxLe1kALvk5mcOzATvb0NUsGb.html
great video. lol but I swear I can hear a NYC accent.
😂😂😂😂 you’re right on
Black Professionals!! Love To See It!!!!! 🤎🤎🤎
ii upuzi ya wokeness ya Instagram toa apa bana,,,we are strictly here to learn,nobody is concerned about race ma'am
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We all come from the dirt, children of God. Skin color don't mean 'nothin
I watched a middle school graduation video where a black administrator was removed from the stage by a white parent bc the parent didn’t approve of the black staff member handing out certificates to his child. Black discrimination still exists all over the country so celebrating black achievements are important as barriers against the ascension of their people still exist today.