Friedel-Crafts Acylation

We know how to use Friedel-Crafts alkylation to attach an alkyl group onto a benzene ring. So now let's learn how to attach an acyl group, by using Friedel-Crafts acylation. It's super similar, as you might guess!
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My god Professor Dave you posted this exactly when I covered this in lecture. U are some sort of Patron Saint of Organic Chem Students.

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[@KL-tq3eh]

Sir, what will be the reaction to hexane when chloroform and anhydrous aluminum chloride are added?

[@karenopt]

How can I determine if a structure is electron withdrawing/donating by inductive or resonance effect?

[@anushkasingh6383]

Sir please tell the mechanism when acid anhydride react with 2 eq of alcl3 with benzene.sir please reply...

[@m.c.6559]

Idk if you still see the comments on old videos but: In literature that I have the Acylion is formed rather by attack of the carbonyl-oxygen on the Al at the beginning. From there, through resonance, the acylion is the formed with AlCl4.
In your example, the Cl from the Acylhalide is attacking the Al.
Is both correct?
For reference, the book I have is "Structure and Function" by Neil Shore and Peter Vollhardt.
I am a student. Ty :)

[@poonamramawat7637]

yes

[@manoharuna]

Superb

[@playboymaniak]

Thanks

[@JackoRAE]

If you have o-Xylene for example where does the acyl get directed? And what stops all the carbons on the ring to react instead of just 1?

[@ProfessorDaveExplains]

I bet there's a lot of substitution at every position. But it's possible there is slightly more substitution at the positions that are meta to one methyl and para to the other, due to sterics.

[@nik4len101]

thank you

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Your saving a whole semester of german chemistry students

[@ibrhmmcht3907]

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[@ibrhmmcht3907]

Sir i a have a question. Why Al is partially - an Cl is partially +? Isn't Cl atom more electronegative?

[@ProfessorDaveExplains]

aluminum is partial + but then when chlorine coordinates it gets a formal negative charge because it gains an electron domain

[@rassimsimou1594]

Good

[@MyProjectsTV]

I've learned that AlCl3 is not regenerated anf forms some sort of bond with the end product and is not regenerated. So it's can't be just in catalytic quantities. Which is different from the alkylation. Why is noone talking about that?

[@simonefratta7157]

Grazie.

[@rajeshannamdevula1893]

Sir do atoms react only with atoms and ions with only ions in a chemical reaction?

[@ProfessorDaveExplains]

well ions are atoms, but no, ions and neutral atoms can react with one another.

[@rajeshannamdevula1893]

Could you please give me an example sir

[@ProfessorDaveExplains]

check out my clip on oxidation-reduction reactions in the general chemistry playlist

[@rajeshannamdevula1893]

I saw it just now sir thanks a lot

[@rajeshannamdevula1893]

Sir can activation energy be zero?

[@ProfessorDaveExplains]

nope!

[@joeinc1236]

Could the Al be replaced with any other element?

[@ProfessorDaveExplains]

No it's quite specific to aluminum catalysts.

[@priscagraf3527]

Chemistry King

[@ADITYAGUPTA-bo8br]

when phenol is treated with alkyl halides in presence of anhydrous alcl3 undergo alkylation to form alkyl substituted phenol

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how to know its a meta director?

[@ProfessorDaveExplains]

check out my tutorial on o/m/p directing groups it is very thorough!

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Professor Dave´s videos have the most annoying intro, but he really knows what he´s talking about! As one of many students struggling with organic chemistry during the corona self-study approach, I highly appreciate this. Thank you!

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You seem like a pretty sick guy!

[@ProfessorDaveExplains]

uh... thanks?

[@aightman340]

@@ProfessorDaveExplains I mean sick in a good way!

[@ProfessorDaveExplains]

ah! well then yes, thanks :)

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[@ProfessorDaveExplains]

the second one i do i will make sure it's a good time for you guys, don't worry!

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