Human Breast Organoid Models for Cancer Research

Presented By:
Xiaojiang Cui, PhD
Speaker Biography:
Xiaojiang Cui, PhD, is a cancer researcher at Cedars-Sinai Medical Center. The focus of his research is to decipher biochemical and signaling mechanisms of breast cancer development, metastasis, and therapeutic resistance. The goal is to utilize these mechanisms to identify potential targets for therapeutic interventions and cancer risk reduction. His findings of growth factor signaling in the development of the mammary gland and breast cancer have important implications for understanding hormonal therapy response and the increased breast cancer risk after hormone replacement therapy. Dr. Cui obtained his doctorate in molecular biology from the University of Texas at Austin, and did his postdoctoral training at the Baylor College of Medicine Lester and Sue Smith Breast Center in Houston. Later, he was recruited to the John Wayne Cancer Institute as an assistant professor and led the institute’s translational breast research program. In 2011, he joined Cedars-Sinai Medical Center.
Webinar:
Human Breast Organoid Models for Cancer Research
Webinar Abstract:
Breast cancer is the most common type of cancer and the leading cause of cancer deaths for women. Despite considerable ongoing research efforts focused on increasing our understanding breast cancer tumorigenesis and progression, the factors that regulate human breast cancer development at the cellular and molecular level remain poorly understood. And there is a growing need for immune-competent human breast ex vivo models that recapitulate the native breast tissue microenvironment to help elucidate the underlying mechanisms of breast cancer risk factors. In this webinar, Dr. Xiaojiang Cui of Cedars-Sinai Medical Center will provide an overview of the most recent advances in 3D organoid models derived from induced pluripotent stem cells (iPSCs) and patient-specific breast tissue. He’ll discuss how his lab:
Develops novel human breast tissue mimetic organoid model systems derived from fresh human breast tissue specimens from reduction mammaplasty reduction and prophylactic surgeries
Studies cellular marker expression using a combination of imaging analysis techniques, including immunohistochemistry, immunofluorescence, and highly-multiplexed CODEX® spatial technology
Plans to build on this foundational model system to faithfully recapitulate the physiology of human breast tissue in culture - and pave the way for novel screening systems that reveal pathogenic effects of breast cancer risk factors
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