Genetic Factors Contributing to the Severity of COVID-19
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- Опубліковано 22 кві 2020
- Please join Dr. Casanova, who is now leading a project to identify the genes that predispose individuals to severe forms of COVID-19 in conversation with Russ Altman, a leading medical bioinformatics researcher and Editor of the Annual Review of Biomedical Data Science. Dr. Altman also hosts the radio show The Future of Everything.
- Наука та технологія
I've been looking for this topic! Thank you!
Thanks for this great webinar
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I was told in 2004 that I had 2 copies of the CCR5-Delta 32 gene. I've been around 3 people whom have tested positive for the Coronavirus and I have yet to catch it. Is it possible that my gene mutation keeping from catching it?
I was told over 18 years ago that I have one copy of CCR5 delta ..... No treatment for over 18 years with an immune virus ... I started treatment for this virus about three years ago...on antivirals.. I have caught covid several times.... And have antibodies... The first time I caught it I had very mild symptoms... A light fever a cough and mild fatigue...for about 2 days ... I don't know if I have caught it again... But I have definitely been around a lot of people that have had it .. one being my dad who was hospitalized... And he survived ... My entire immediate family has cought covid ... And we are all still alive and well! So there are some real questions we need to be asking ... But right now I think we're all asking the wrong ones.... remember roughly 610,000 people have died of covid in America that is less than 0.1% of the population ... But one thing I can say is that you are lucky you have two copies of ccr5 Delta 32 and that is so rare.. its something like 0.1 percent of the population of the world 8 billion.... Also remember Dr frauci in the 80s
1 copy of Delta32 gives resistance. 2 copies provided complete immunity. At least from the plauge and HIV. Maybe other dieses too.
@@bookman2407 well, I've since caught both the Covid 19 and the Delta so apparently it doesn't keep someone from catching it .
I know this is just a simple question which may have no relevance to the coronavirus, because I haven’t had a chance to study it yet, but has anybody considered the Delta 32 Jean Aza means of avoiding the virus?
Just thinking of the solutions even a basic machine learning model could apply to genomics is mind blowing.
It'd be interesting to develop a transformer or DNA based GPT with genomes. Text is fine, music I believe has been used as training data too, and there is that iGPT thing for images... I don't see why a GPT trained on gene sequences or full genomes would be a problem.
Cos as a prediction method? Well the GPT models are astounding.
How do you choose a gene as a candidate for being involved in the susceptibility for vivid-19 ? 🤔
Now you're thinking, has it already been done?
It all starts with a Pubmed literature review. For instance, scientists have known for a long time that human ACE2 gene/ allele polymorphisms may have a role in betacoronavirus disease susceptibility. There are dozens of others such known suspect genes and more can be found by doing mutational analysis of WGS data.
Plz i have antithrombin 3 deficinecy and protien c deficiency .. high fibrinogen level .. mthfr mutation .. what if i get covid infection???
Comparison with similar diseases and also with genes that play an important role in the function of the immune system
Does the Delta 32 deletion mutated gene prevent you from getting covid-19?
its been a year, there has to be more proven data on which snp's contribute to worse outcomes. can you make an updated video?
Russ Altman was acting like an academic bully and Casanova slowed him down. Lesson for everyone!