"Aggressive" Angiomyxoma (Deep Angiomyxoma) (Yale case 1) pathology dermatology dermatopathology

This is an excerpt from my virtual slide session for the Yale pathology residents on 3.4.2021. Full video of the entire session is available for free here: kikoxp.com/pos.... WSI Digital slide for this case: kikoxp.com/pos...
A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/pos... (dermpath) & kikoxp.com/pos... (bone/soft tissue sarcoma pathology).
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This video is geared towards medical students, pathology or dermatology residents, or practicing pathologists or dermatologists. Of course, this video is for educational purposes only and is not formal medical advice or consultation.
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[@JMGardnerMD]

This is an excerpt from my virtual slide session for the Yale pathology residents on 3.4.2021. Full video of the entire session is available for free here: kikoxp.com/posts/4739. WSI Digital slide for this case: kikoxp.com/posts/4598

[@katlegonhlapo4040]

How do I cure it😢

[@Natasha1004100]

I recently removed mine . The healing part is a mofo! Such a hard place to keep clean. Started from my right pubic bone , to my booty hole 😆🤭 didn’t close it correctly!!! A week later it opened back up and had to go for a second surgery to close it.

[@JMGardnerMD]

I’m so sorry to hear that. It is a difficult place to have surgery. I hope you heal soon. Best wishes.

[@kierandouglas147]

My partner had hers removed in November 22, with very high morbidity. The frustration thing was they tested it for hormones and it came back negative, it was strange they didn’t think to restest it since all of these tumours in women are positive for hormones. Also didn’t help that they then pumped her full of hormones to remove eggs the week before carrying out the removal!
Anyway she was also left with an open wound and is back in hospital because she was having severe pain. I hope you’re recovering well, it’s an awful awful tumour and the recovery is intense. Look after yourself ❤

[@brandoncelaya3563]

Great summary on the pathology for AA.
About a 6:1 female to male ratio anecdotally and some reports showing that female patients are somewhat responsive to hormone therapy but male tumors don't express ER or PR on the surface.
Having had this neoplasm which is pretty rare, aside from desmin staining and the spindly muscle growth, should there be any other anatomical, staining or IHC to look out for? Do you know of any American based surgical oncologists with experience with this tumor type for consult?

[@kierandouglas147]

I’m interested to her any thoughts on how you would go about treating this?
My partner had hers removed with very high morbidity and she is 32 years old, it didn’t sit right with me and still doesn’t

[@JMGardnerMD]

I’m so sorry to hear that. My expertise is only in diagnosis; I don’t treat these tumors so not an expert in how to manage them. Best wishes for health and healing and recovery for your partner.

[@andresangel62]

Putting Jerad conference in few words: Better called Deep Angiomyxoma than aggressive Angiomyxoma, Rare anogenital deep pelvic/gluteal lesion, a lot more in women, large/infiltrative/hard to remove and commonly recur. Micro is myxoid but not blue, more pink edematous with low cellularity of bland spindle myofibroblastic cells desmin+, variable # of vessels (from large to capillary), wisps or collagen and thin long wisps of pink smooth muscle close to vessels, entrapped fat and RBC extravasation possible. ER+/PR+, HMGA2 rearrangement in subset, do not confuse with the small superficial cutaneous angiomyxoma (small, benign and well circumscribed).

[@JMGardnerMD]

I should have you give these lectures for me! I could never be this succinct! 😉

[@RaulRodriguez-sh6vb]

Despite the fact they are infiltrating and prone to recurrence they look really fancy and original. Very good case to keep in mind Thanks a lot