A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/posts/5084 (dermpath) & kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology). Also, Correction - I made a mistake in the video. I said that sebaceous gland secretions are turned into smelly substances by bacteria and that this makes body odor. That is incorrect. That is actually true of APOCRINE gland secretions not sebaceous secretions. Sorry about that!
Jerad Gardner, MD yes I thought so too thanks for correcting.. u usually keep the arrow to point out minor structures plz keep arrows pointing on each structure to make it more clear.sometimes the arrow is lost..thanks so much for wonderful videos
Hey, Doctor Jerad. How are you? I'm from Brasil and I have a channel on youtube. Could I use this video, without the audio, to explain the skin? I mean, I just want the images of the tissues, I will take off your voice and I will explain this all in my voice. I'll put the creditis down bellow the video and a link for your channel and this video. What do you say?
I am a professor of pathology in Brazil. I always watch your videos, because it is a mirror where I can try to level myself. You have a didactic talent, showing in a simple and direct way how it works and how our body is attacked. Congratulations.
I'm a medical student in Portugal and I could not be more grateful for your effort. It enabled me not just to learn some concepts that will be essential for my studies, but also allowed me to start liking this. It is amazing to learn all this material by listening to your explanations rather than reading a book and finding all this boring, when it is great fun. Thanks, Sir. 😊
I'm a layman with nerdy hobbies like Microscopy. I have a Lomo Research Microscope circa 1960 that I've used to examine many tissue slides over the years and I loved your video. I'm 76 years old and I just subscribed to your channel and watch more of your videos in an effort to continue my education. Thank you.
Went through the whole video once again. It is so packed with "pearls of wisdom" that every time I see it, I get something new out of it. So thanks once again Dr Jerad Gardner.
Thank you! Also you might find this helpful...A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/posts/5084 (dermpath) & kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology).
Thank you so much for making these videos. I appreciate it so much!!!!! I am a dermatology resident in Germany and this is so much better than most clinics teach their residents. I love these videos and will hopefully get through all of them step by step. Greetings from Germany
Mr. Gardner, I am really excited that I can finally attend your video! So happy to find that there are closed subtitles, it was very difficult for me to attend the video without subtitles because of my hearing impairment. Thus, I would like to thank you and the volunteer medical student Abigail Cline for the amazing work. Thank you very much!
is there any chance you will make more videos like this? you are a natural gifted teacher. we would definitely appreciate videos in pathology ... thanks for this one!
A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/posts/5084 (dermpath) & kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology)
Thank you for this. I am a first year pathology trainee and I so appreciate you taking the time to go through what normal looks like. I find a lot of people skip what normal looks like and go straight to the pathology of whatever organ they are teaching on, which makes it difficult to recognise normal down the microscope
I am a Turkish medical student and i want to thank you for bringing this amazing video. Its really better than other videos, showing us whole content in a video directly from microscopic view is truely educational.
Thank you very much for your excellent videos. I am a senior dermatologist living in Italy and recently happened to read your book “survival guide to dermatopathology” that is in my opinion the very best introduction to this subject I had ever seen out there. I appreciate your teaching skill. You make a difficult subject easy to understand. Sincerely yours, Riccardo
Thank you! Can I ask a small favor? Since you liked my #dermpath survival guide book, could you please rate it & write a short honest review on Amazon? Thank you! 🙏🏻 buff.ly/366R7va
How can you be so generous in sharing what you know? I have great respect and admiration for you. Your contribution to the world's pathologists and patients is very sacred. You are a very special scientist.
I love this video. I hope that in the future you might make a video on the normal hair follicle anatomy, stages, how to differentiate different types of alopecia... I love your book too!Thanks for all you do
Thank you! And I’m so glad you like the book. Hair follicle Histology I could do, but alopecia is still so complicated for me. Maybe once I get a better grasp of it can make a video! What I should do is partner up with Len Sperling or one of the other alopecia gurus to make a video. That would be pretty awesome. If I get a chance to make that happen, I will go for it.
Thank you for publishing these! I am a beginning A&P student. Histology is brand new to me and I was struggling to find it relevant to put in the time to figure it out. I found your videos on synovial sarcoma. My cousin (same age) passed over 10 years ago from synovial sarcoma so that video anchored my learning to something that I care about, but many concepts went over my head (which is great since you made me curious). Then I found this video which is really bringing alive the concepts I am learning in class. THANK YOU!
Holy smokes, Doc. Do you have podcast? You will make an exceptional podcast speaker for sure! Thank you for this, Doc. I'm a first year medical student and our exams this dec 17. Understanding the concepts will surely boost my memory retention.
WHAT A LECTURE! WOW! I've studied histology in biology school, for 2 years now in medical school, and never have i ever seen the skin explained so thoroughly and so well. I'm currently studying the histology of skin carcinomas and i thought I'd go back a little and refresh my memory on what normal looks like and found your video. man, it's the basics! and i didn't know that i didn't know shit about the basics. NOW I know the basics, thanks to you! so grateful! and so wowed! thank you!
So glad you found it helpful. Thanks for the kind words! A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/posts/5084 (dermpath) & kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology).
Hi Dr. Gardner! I am a sophomore in High School where I was selected to be in the Advanced Science Research Program. Over this course of this upcoming summer I will be conducting my own graduate-level dermatology research which will transpire to the next 3 years of my high school career. Your videos have taught me so much and vastly increased my background knowledge on dermatology which will surely help assist me through my research path. I have such a passion for dermatology and hope you keep making these videos!
That is awesome! Bravo on being selected for such an ambitious research program at such a young age. You are way ahead of where I was at your age! I’m so glad my videos helped you. Thanks so much for giving me that feedback. Knowing that I can help even a few high school students as they pursue a STEM career is so meaningful to me. If you need any other help along the way, just let me know and I’ll do my best. Best of luck!
Thanks Jerad. I really appreciate your work a lot. I am a pathologist in Nicaragua. I have seen many of your videos and for me they are truly invaluable for colleagues, Pathology residents and Medical students.
Thank you so much for your lessons. I am a pathology resident and i think i would not have known the subject as i do now had not seen your videos. Honestly, cannot thank you enough. May Allah bless you. Love your work.
Sir I have watched the whole video but in the 15th minute i had to come to the comment section to tell you how amaizing and professional lecturer you are. Thank you so much. I will be watching many od your other videos as comming medical student........
I am a dermatology attending in my country and now aspiring to be a pathologist in US. Your videos have taught me alot about dermpath. So thanks for such great teaching🙏
im a first year dentistry student at wits university and this is my first time encountering this content and i already feel like i mastered it. that you Dr Gardner.
I just started my pathology residency in germany, and your videos are helping me a lot to understand the fundamentals, thank you for your clear and good explanations
You channel is awesome for any pathologist esp in derm and bone soft tissue pathology. I no more find it difficult as it used to be for me. You way of showing no.of cases gives a lot more confidence about the tumors. Your way of teaching the aproach to see any slide is soo good. Thank you so much.
Thank you very much dear Dr Gardner!I am now a faithful fans of you.Your teaching is so excellent and you try your best to share what you know,to help people who want to learn dermpath and those lovely petients.Your English is so beautiful and perfect for us non-English-speaking doctors to learn professional English.Wait for your subsequent update.May god bless you.Take care!
Sir actually I had a lot of doubts in histology spotters, but most of doubts got clarified to me after watching this video. Please continue to make more videos like this. Thank u soooooooo much sir.
Thank you SO MUCH for the video sir. I have never understood histology and pathology so well! 🎉 Now I like this science. Immediately subscribed to your channel ☑️
Thank you Dr.Gardner for providing so comprehensive explaination of features in a histology image of normal skin. This video helped me to clear a few confusions that reside in my mind for a long time. I still have one question, I hope you will see this comments and give me some information. The question is about stratum lucidum. According to text book and also your description that stratum lucidum is only seen at two situations: acral skin and chronically rubbed skin. My question is: have you ever seen stratum lucidum on thin skin? what skin location is the histology slide used in the video acquired from (4:51)? It seems not a typcial thick skin. Thanks!
Thank you! I'm glad the video helped. I guess the stratum lucidum is probably present in all skin, but it is not usually obvious histologically except on acral (palm/sole) skin or on skin that has been rubbed or scratched (lichen simplex chronicus). The skin at 4:51 is from the trunk, if I recall. So either this skin had been rubbed or irritated a little bit before it was removed (I believe it was from a melanoma excision specimen), or maybe this is evidence that the stratum lucidum actually can be seen in normal non-acral skin sometimes. Thanks for pointing this out!
Thank you! A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/posts/5084 (dermpath) & kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology).
I don't know how to thank you very much .. in my country there is no senior to help us learning histopathology so your lectures and your amazing explaination do alot for us 🥺 so you are our hero so pls keep updating
I keep doing it because of people like you telling me this. Thank you for reminding me of the importance of free online medical teaching. Best wishes to you. Also, A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/posts/5084 (dermpath) & kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology).
Glad you enjoyed it! A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/posts/5084 (dermpath) & kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology).
Amazing videos. Thank you. As histopathology Trainee with interest in dermpath I'm loving your videos. BUT I have one question - at ~ 22:38 you mentioned that sebum produced in certain body parts as groin and armpits is broken down by bacteria and create an unpleasant smell... Did you mean apocrine sweat glands and not sebum from sebaceous glands? 🤔🤔🤔
Thank you Dr. Gardner for this incredible video. You have such a gift for making the difficult, easy and the boring, interesting. I know that you are a dermatopathologist but do you have any other organ systems?
Thank you! I also have cartilage and Bone Histology videos on my channel with special guest Andrew Rosenberg. I hope to get my colleague Jeanette Ramos to come back and do a normal bone marrow video with me. I have also been thinking about doing very basic Histology of other organs. Not in depth like this skin one, but basically “how to figure out what you’re looking at” beginner Histology video. Do you think that would be useful for people?
Jerad Gardner I haven’t seen the other videos you mention but I will head over to your channel and take a look. I am an incoming path PGY1 and I will spread the word to my chairman and coresidents. Thank you so much 🙏
*Normal Skin Histology: A Comprehensive Guide* * *0:10** Epidermis Layers:* The epidermis, the skin's outermost protective layer, consists of several layers: * *Stratum basale (Basal Layer):* The deepest layer where new squamous cells (keratinocytes) are produced. * *Stratum spinosum (Spinous Layer):* Characterized by desmosomes, which appear as spines connecting keratinocytes. * *Stratum granulosum (Granular Layer):* Contains keratohyalin granules, contributing to cell death and the formation of the stratum corneum. * *Stratum corneum (Corneal Layer):* The outermost layer composed of dead, flattened keratinocytes that continuously shed. * *Stratum lucidum:* A thin, translucent layer found only in acral skin (palms and soles) and chronically rubbed skin. * *5:16** Melanocytes vs. Keratinocytes:* * *Melanocytes:* Produce melanin pigment and transfer it to keratinocytes for UV protection. Appear as gray cells with a clear halo (artifact of processing). * *Keratinocytes:* The primary cells of the epidermis, containing keratin filaments that provide strength and structure. Have a clear halo around the nucleus. * *10:10** Langerhans Cells:* Immune cells located in the stratum spinosum. They capture antigens and present them to the immune system. Have a bean-shaped nucleus. * *11:50** Dermis Structure:* The dermis, the supporting layer beneath the epidermis, consists of: * *Papillary Dermis:* The upper layer with fine collagen fibers and dermal papillae, which contain blood vessels for nourishing the epidermis. * *Reticular Dermis:* The thicker, lower layer with dense collagen bundles and larger blood vessels. * *15:25** "Empty" Spaces on Slides:* White spaces on slides represent: * *Vascular Channels:* Lined by a single layer of endothelial cells. * *Glands/Ducts/Cysts:* Lined by epithelium (usually thicker than endothelium). * *Artifact:* Tears, folds, or areas where substances (like fat) have been dissolved during processing. * *18:24** Blood Vessels & Nerves:* * *Blood Vessels:* Supply nutrients and oxygen to the skin. Arteries have a thick muscular wall with an internal elastic lamina. * *Nerves:* Often run alongside blood vessels (neurovascular bundles). Contain axons, Schwann cells, and a protective perineurium. * *20:00** Arrector Pili Muscles:* Smooth muscle bundles responsible for making hair stand erect (goosebumps). * *21:10** Sebaceous Glands:* Produce sebum (oil) that lubricates the skin and hair. Sebocytes (sebaceous cells) contain lipid droplets, appearing as clear vacuoles. * *23:14** Hair Follicle Anatomy:* * *Hair Bulb/Matrix:* The base of the follicle where hair growth originates. Contains actively dividing cells. * *Inner Root Sheath:* Surrounds the developing hair shaft. Contains trichohyaline granules. * *Outer Root Sheath:* A clear layer due to the presence of glycogen. * *Hair Shaft:* The visible part of the hair, composed of compacted, dead keratinized cells. * *Isthmus:* The area where the sebaceous gland duct enters the follicle. * *Infundibulum:* The upper portion of the follicle, resembling the epidermis. * *24:45** Eccrine Sweat Glands:* Produce watery sweat for thermoregulation. Have a coiled structure (eccrine coil) and a duct leading to the skin surface. * *27:20** Glands vs. Blood Vessels:* Eccrine sweat gland ducts have a double layer of cuboidal epithelial cells, while blood vessels are lined by a single layer of endothelial cells. * *27:50** "Pink Bundles":* * *Smooth Muscle:* Found in arrector pili muscles and blood vessel walls. * *Nerve:* Characterized by axons, Schwann cells, and perineurium. * *Dense Connective Tissue:* Found in tendons, fascia, and ligaments. * *29:37** Acral Skin and Contact Dermatitis:* * *Parakeratosis:* Retention of nuclei in the stratum corneum, indicating irritation or abnormal growth. * *Perivascular Lymphocytes:* Inflammatory cells surrounding blood vessels. * *Spongiosis:* Edema (fluid) within the epidermis, causing separation of keratinocytes and highlighting desmosomes. * *34:20** Stratum Lucidum:* Normally found in acral skin, appears as a pale line beneath the stratum corneum. * *35:40** Glomus Body:* A specialized structure in acral skin involved in temperature regulation. Composed of a blood vessel surrounded by modified smooth muscle cells (pericytes). * *37:55** Subcutis and Adipose Tissue:* The subcutis lies beneath the dermis and contains fat cells (adipocytes). Adipocyte nuclei may show a "lockhern" (nuclear lake), a clear space representing dissolved lipid. * *50:40** Pacinian Corpuscle:* A sensory receptor for deep pressure and vibration, located in the deep dermis and subcutis. Has a distinctive onion-like appearance. * *1:02:28** Meissner Corpuscle:* A sensory receptor for fine touch, located in the papillary dermis of acral skin. Has an oval shape with internal lines. * *53:00** Dense Regular Connective Tissue:* Composed of dense collagen bundles and fibroblasts. Found in tendons, ligaments, and fascia. Can be distinguished from smooth muscle by the presence of extracellular collagen bundles. * *55:33** Immunohistochemistry Highlights:* * *Cytokeratin:* Stains epithelial cells, highlighting the epidermis, hair follicles, and sweat glands. * *S100:* Stains melanocytes, Langerhans cells, and adipocytes. * *Desmin:* Stains smooth muscle cells, highlighting arrector pili muscles and blood vessel walls. * *CD31:* Stains endothelial cells lining blood vessels. * *SOX-10:* Stains melanocyte nuclei. * *1:04:10** Digit Histology:* Amputated toe specimens demonstrate acral skin, bone, tendons, arteries, and the nail matrix (where nail growth occurs). * *1:11:50** Solar Elastosis:* Accumulation of blue-gray elastic fibers in the dermis due to chronic sun exposure. Causes wrinkles and skin aging. I used gemini-1.5-pro-exp-0801 on rocketrecap dot com to summarize the transcript. Cost (if I didn't use the free tier): $0.18 Input tokens: 48147 Output tokens: 1473
Hi in Minute 39:00 you say that there is a "lockhern" inside of an apipocyte nucleus. Thats a typo. It`s actually a "lochkern". Lochkern means in german "hole in a nucles". Nevertheless thx for that great video!
A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/posts/5084 (dermpath) & kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology). Also, Correction - I made a mistake in the video. I said that sebaceous gland secretions are turned into smelly substances by bacteria and that this makes body odor. That is incorrect. That is actually true of APOCRINE gland secretions not sebaceous secretions. Sorry about that!
Jerad Gardner, MD yes I thought so too thanks for correcting.. u usually keep the arrow to point out minor structures plz keep arrows pointing on each structure to make it more clear.sometimes the arrow is lost..thanks so much for wonderful videos
Спасибо за ваш труд (Thank you for your work.)
Thank you so much!!
Hey, Doctor Jerad. How are you? I'm from Brasil and I have a channel on youtube. Could I use this video, without the audio, to explain the skin? I mean, I just want the images of the tissues, I will take off your voice and I will explain this all in my voice. I'll put the creditis down bellow the video and a link for your channel and this video. What do you say?
Dude, you displayed a shit ton of notions/informations, how are we supposed to judge you from this small mistake? XD
I am a professor of pathology in Brazil. I always watch your videos, because it is a mirror where I can try to level myself. You have a didactic talent, showing in a simple and direct way how it works and how our body is attacked. Congratulations.
🙏🏻🙏🏻🙏🏻
I'm a medical student in Portugal and I could not be more grateful for your effort. It enabled me not just to learn some concepts that will be essential for my studies, but also allowed me to start liking this. It is amazing to learn all this material by listening to your explanations rather than reading a book and finding all this boring, when it is great fun. Thanks, Sir. 😊
factos
Dermatology Resident here, OMG I want to thank you so much for recording and uploading these videos. Better than my teachers, for sure :P
So glad you enjoy them!
I'm a layman with nerdy hobbies like Microscopy. I have a Lomo Research Microscope circa 1960
that I've used to examine many tissue slides over the years and I loved your video.
I'm 76 years old and I just subscribed to your channel and watch more of your videos
in an effort to continue my education.
Thank you.
Nerdy hobbies are the best! Glad you enjoy the videos!
I am a pathology resident and your videos really helped me. Thank you for the great lessons!
This is absolutely wonderful. I wish there were great videos like this for every organ and their major diseases. Thank you so much!!!
Thank you! Check out WashingtonDeceipt channel. He has tons of great pathology and histology videos. He's an excellent educator.
Went through the whole video once again.
It is so packed with "pearls of wisdom" that every time I see it, I get something new out of it.
So thanks once again Dr Jerad Gardner.
Thank you! Also you might find this helpful...A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/posts/5084 (dermpath) & kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology).
Thank you so much for making these videos. I appreciate it so much!!!!! I am a dermatology resident in Germany and this is so much better than most clinics teach their residents. I love these videos and will hopefully get through all of them step by step. Greetings from Germany
Mr. Gardner, I am really excited that I can finally attend your video! So happy to find that there are closed subtitles, it was very difficult for me to attend the video without subtitles because of my hearing impairment. Thus, I would like to thank you and the volunteer medical student Abigail Cline for the amazing work. Thank you very much!
My pleasure. More subtitles are in the works currently.
is there any chance you will make more videos like this? you are a natural gifted teacher. we would definitely appreciate videos in pathology ...
thanks for this one!
Thanks for the kind words. More videos in the works soon.
A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/posts/5084 (dermpath) & kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology)
Thank you for making this video. It's what a proper histology lesson should look like.
Thank you for this. I am a first year pathology trainee and I so appreciate you taking the time to go through what normal looks like. I find a lot of people skip what normal looks like and go straight to the pathology of whatever organ they are teaching on, which makes it difficult to recognise normal down the microscope
I am a Turkish medical student and i want to thank you for bringing this amazing video. Its really better than other videos, showing us whole content in a video directly from microscopic view is truely educational.
Thank you very much for your excellent videos. I am a senior dermatologist living in Italy and recently happened to read your book “survival guide to dermatopathology” that is in my opinion the very best introduction to this subject I had ever seen out there. I appreciate your teaching skill. You make a difficult subject easy to understand. Sincerely yours, Riccardo
Thank you! Can I ask a small favor? Since you liked my #dermpath survival guide book, could you please rate it & write a short honest review on Amazon? Thank you! 🙏🏻 buff.ly/366R7va
How can you be so generous in sharing what you know? I have great respect and admiration for you. Your contribution to the world's pathologists and patients is very sacred. You are a very special scientist.
I love this video. I hope that in the future you might make a video on the normal hair follicle anatomy, stages, how to differentiate different types of alopecia... I love your book too!Thanks for all you do
Thank you! And I’m so glad you like the book. Hair follicle Histology I could do, but alopecia is still so complicated for me. Maybe once I get a better grasp of it can make a video! What I should do is partner up with Len Sperling or one of the other alopecia gurus to make a video. That would be pretty awesome. If I get a chance to make that happen, I will go for it.
No words can describe my gratitude! I'm sure those lectures will help not only students but dermatologists all over the world. Thanks a million!
Thank you for publishing these! I am a beginning A&P student. Histology is brand new to me and I was struggling to find it relevant to put in the time to figure it out. I found your videos on synovial sarcoma. My cousin (same age) passed over 10 years ago from synovial sarcoma so that video anchored my learning to something that I care about, but many concepts went over my head (which is great since you made me curious). Then I found this video which is really bringing alive the concepts I am learning in class. THANK YOU!
Holy smokes, Doc. Do you have podcast? You will make an exceptional podcast speaker for sure! Thank you for this, Doc. I'm a first year medical student and our exams this dec 17. Understanding the concepts will surely boost my memory retention.
Reviewing and rethinking of normal histology always make me fresh !!
Dear Professor Gardner, I have learned numerous things from this video. Thanks for sharing your experiences.
WHAT A LECTURE! WOW! I've studied histology in biology school, for 2 years now in medical school, and never have i ever seen the skin explained so thoroughly and so well. I'm currently studying the histology of skin carcinomas and i thought I'd go back a little and refresh my memory on what normal looks like and found your video. man, it's the basics! and i didn't know that i didn't know shit about the basics. NOW I know the basics, thanks to you! so grateful! and so wowed! thank you!
So glad you found it helpful. Thanks for the kind words! A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/posts/5084 (dermpath) & kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology).
Hi Dr. Gardner! I am a sophomore in High School where I was selected to be in the Advanced Science Research Program. Over this course of this upcoming summer I will be conducting my own graduate-level dermatology research which will transpire to the next 3 years of my high school career. Your videos have taught me so much and vastly increased my background knowledge on dermatology which will surely help assist me through my research path. I have such a passion for dermatology and hope you keep making these videos!
That is awesome! Bravo on being selected for such an ambitious research program at such a young age. You are way ahead of where I was at your age! I’m so glad my videos helped you. Thanks so much for giving me that feedback. Knowing that I can help even a few high school students as they pursue a STEM career is so meaningful to me. If you need any other help along the way, just let me know and I’ll do my best. Best of luck!
It’s been 2 yrs how’s the research going
wish i had the ability to spot a monocyte amidst all that mess, it's a talent
Same 😄👍
you are such an amazing educator. i love these. residents, please look at these!!
Thank you for the kind compliment, carnol10!
great video o dermal histology, laying the foundation right. waiting for more........
Great job Jerad! You don't see glass slides being used for creating videos nowadays! This is old-school histology teaching and it's great to see.
First year pathology resident here. Your content is amazing.
Thank you!!!
Thanks Jerad. I really appreciate your work a lot. I am a pathologist in Nicaragua.
I have seen many of your videos and for me they are truly invaluable for colleagues, Pathology residents and Medical students.
Gracias, amigo!
Gracias a ti. Un día quizás logremos conectar para un evento de Patología en Nicaragua. Tienes un don maravilloso. Sigue brillando
Thank you so much for your lessons. I am a pathology resident and i think i would not have known the subject as i do now had not seen your videos. Honestly, cannot thank you enough. May Allah bless you. Love your work.
Sir I have watched the whole video but in the 15th minute i had to come to the comment section to tell you how amaizing and professional lecturer you are. Thank you so much. I will be watching many od your other videos as comming medical student........
This video is really GREAT! I'm a dermatology resident and really learnt a lot from this video. Thank you!
Awesome thanks! Be sure to check out this one also. 100 classic Dermpath entities are covered. ua-cam.com/video/Q88yDU-Pyis/v-deo.html
YOU ARE THE CUTEST PATHOLOGIST I'VE EVER SEEN!!! So well explained presentation and it really helped me a lot w understanding the content!!!
Excellent video! Laying the foundations right. Can't wait for more from dermpath.
I am a dermatology attending in my country and now aspiring to be a pathologist in US. Your videos have taught me alot about dermpath. So thanks for such great teaching🙏
I'm very keen on skin pathology and I am going to train to become a pathologist, so I find this extremely helpful! Thank you!
im a first year dentistry student at wits university and this is my first time encountering this content and i already feel like i mastered it. that you Dr Gardner.
I just started my pathology residency in germany, and your videos are helping me a lot to understand the fundamentals, thank you for your clear and good explanations
You channel is awesome for any pathologist esp in derm and bone soft tissue pathology.
I no more find it difficult as it used to be for me.
You way of showing no.of cases gives a lot more confidence about the tumors.
Your way of teaching the aproach to see any slide is soo good.
Thank you so much.
Thank you very much dear Dr Gardner!I am now a faithful fans of you.Your teaching is so excellent and you try your best to share what you know,to help people who want to learn dermpath and those lovely petients.Your English is so beautiful and perfect for us non-English-speaking doctors to learn professional English.Wait for your subsequent update.May god bless you.Take care!
Thank you so so much for this incredible video. I am a Derm Resident in South Africa and this is so so helpful!
Glad you like it! Have you seen this one too? ua-cam.com/video/Q88yDU-Pyis/v-deo.html
Great lecture.
Learnt many things in spite of having been in Pathology for over 25 years.
Thank you! I'm so happy to know it is useful to learners at all experience levels!
Lo and behold! Now our entire department is hooked to your videos.
Stay blessed and keep posting please.
I’ve never seen better histology video and explanation than this one . Thank you very much ... I will wait for some new videos )
Hello from Argentina. Great video! It helps understand skin histology clearly! Thank you !
Amazing video,you are a gifted teacher.
Very helpful and a very simple language,so we understand very easily.
Thanks indeed
This is so good! THANK YOU SO MUCH for your effort! This is awesome. Very highly appreciated. Thank you!!
More more more! Great for veterinary pathologists too!
Thank you Jerad! Really helpful for a dermatology resident starting out :)
Great thanks doctor.
I watched the video with my eyes open wide
Wonderful presentation
Bless you !!
💐💐💐💐🙏🙏🙏🙏
I have a skin presentation in 6 hours...
Your teaching is soo good I don't need a notebook. This will give flesh to what I have.
Thank You.
Glad it helped and Hope presentation went well!
@@JMGardnerMD The presentation went well. Thanks again for the video. Will be pointing this way when my sisters start their MBBS.
Excellent videos, so educative indeed, your effort is highly appreciated and please keep it up
Sir actually I had a lot of doubts in histology spotters, but most of doubts got clarified to me after watching this video. Please continue to make more videos like this. Thank u soooooooo much sir.
You r making me fall in love with pathology
Thank you SO MUCH for the video sir. I have never understood histology and pathology so well! 🎉 Now I like this science. Immediately subscribed to your channel ☑️
Thank you Dr.Gardner for providing so comprehensive explaination of features in a histology image of normal skin. This video helped me to clear a few confusions that reside in my mind for a long time. I still have one question, I hope you will see this comments and give me some information. The question is about stratum lucidum. According to text book and also your description that stratum lucidum is only seen at two situations: acral skin and chronically rubbed skin. My question is: have you ever seen stratum lucidum on thin skin? what skin location is the histology slide used in the video acquired from (4:51)? It seems not a typcial thick skin. Thanks!
Thank you! I'm glad the video helped. I guess the stratum lucidum is probably present in all skin, but it is not usually obvious histologically except on acral (palm/sole) skin or on skin that has been rubbed or scratched (lichen simplex chronicus). The skin at 4:51 is from the trunk, if I recall. So either this skin had been rubbed or irritated a little bit before it was removed (I believe it was from a melanoma excision specimen), or maybe this is evidence that the stratum lucidum actually can be seen in normal non-acral skin sometimes. Thanks for pointing this out!
Thank you very much! I appreciate your quick reply! The information is helpful for me.
i am GP from Thailand. This video is fantastic
Appreciate the informal chatting style very much
I am so grateful to find your video. You did amazing job. You have natural yalent to make people understand. Hope you stay healthy and well. Cheers😊
Such a lucid and excellent video
Excellent video, I really enjoyed watching the whole videos at once, you have an amazing teaching skills
Thank you for the great video.
Your teaching just wow sir.I am a first year Pathology student….and i am im love with your teaching and videos🙏💙….thank you so much..Love from India🙏🙏
Thank you! A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/posts/5084 (dermpath) & kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology).
Amazing video. I believe this video will be also very useful for veterinary dermatology residents. Thank you so much!
really great talk. I I wish every teacher was like that. Thank you.
Blessed to see these videos. Heartful thanks to awesome teacher
I don't know how to thank you very much .. in my country there is no senior to help us learning histopathology so your lectures and your amazing explaination do alot for us 🥺 so you are our hero so pls keep updating
I keep doing it because of people like you telling me this. Thank you for reminding me of the importance of free online medical teaching. Best wishes to you. Also, A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/posts/5084 (dermpath) & kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology).
Thank you for the video! It was incredibly informative and helpful. I appreciate your expertise and the effort you put into explaining concepts.
Thanks for the walk through. Really interesting and made me wish I had some slides of my own to explore.
EXCELLENT! You are such a wonderful teacher. Thank you so much!
Top notch lesson, really what I was looking for. Thank you!!
I am à pathology resident in morrocco Casablanca and your video are really 👍
That was simple intertaining learning
Great thanks dr Gardner ❤❤❤🙏🙏🙏🙏
Very helpful, thank you Dr. Gardner for your efforts.
Just spectacular! Thank you a million times sir
What a great way of explanation! Thank you so much.. Please please make more explanatory videos like this about normal histology.
Thanks again
Thank you! Check out this bone histology video w Andrew Rosenberg: ua-cam.com/video/90sx3yrw4t4/v-deo.html
Excellent!...waiting for more
Thank you so much for this video! It helps a lot! You are pretty didactic! Please, don't stop doing these videos
Glad you enjoyed it! A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/posts/5084 (dermpath) & kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology).
Really very helpful. Please continue the teaching
Im in my 2dn year of Dermatology and you have really helped me a lot, thank you
Excellent presentation. So simple and high quality video. Differentiating collagen from muscle.. simply superb...
Thanks! I plan to make a more in-depth fun video about collagen versus nerve vs muscle soon!
That's a real amazing video to start learning dermatopathology. Thank you!
Really very helpful, thanx a lot for ur effort and time explaining this in a simply way
Amazing videos. Thank you. As histopathology Trainee with interest in dermpath I'm loving your videos. BUT I have one question - at ~ 22:38 you mentioned that sebum produced in certain body parts as groin and armpits is broken down by bacteria and create an unpleasant smell... Did you mean apocrine sweat glands and not sebum from sebaceous glands? 🤔🤔🤔
Extremely clear!! Keep on doing this!
Thank you a lot for your great video. It' s very helpful for young dermatopathologist.
As a new pathology resident i cant believe lm lucky enough to find you
Thank you Dr. Gardner for this incredible video. You have such a gift for making the difficult, easy and the boring, interesting. I know that you are a dermatopathologist but do you have any other organ systems?
Thank you! I also have cartilage and Bone Histology videos on my channel with special guest Andrew Rosenberg. I hope to get my colleague Jeanette Ramos to come back and do a normal bone marrow video with me. I have also been thinking about doing very basic Histology of other organs. Not in depth like this skin one, but basically “how to figure out what you’re looking at” beginner Histology video. Do you think that would be useful for people?
Jerad Gardner yes, a video or series demonstrating how to tell which tissue we are looking at would be very helpful. Other than thyroid 😀
Jerad Gardner I haven’t seen the other videos you mention but I will head over to your channel and take a look. I am an incoming path PGY1 and I will spread the word to my chairman and coresidents. Thank you so much 🙏
You are such a good teacher. Keep uploading more video please😊
You’re an amazing teacher. Please make more!
Thank you professor for this highly informative lecture
*Normal Skin Histology: A Comprehensive Guide*
* *0:10** Epidermis Layers:* The epidermis, the skin's outermost protective layer, consists of several layers:
* *Stratum basale (Basal Layer):* The deepest layer where new squamous cells (keratinocytes) are produced.
* *Stratum spinosum (Spinous Layer):* Characterized by desmosomes, which appear as spines connecting keratinocytes.
* *Stratum granulosum (Granular Layer):* Contains keratohyalin granules, contributing to cell death and the formation of the stratum corneum.
* *Stratum corneum (Corneal Layer):* The outermost layer composed of dead, flattened keratinocytes that continuously shed.
* *Stratum lucidum:* A thin, translucent layer found only in acral skin (palms and soles) and chronically rubbed skin.
* *5:16** Melanocytes vs. Keratinocytes:*
* *Melanocytes:* Produce melanin pigment and transfer it to keratinocytes for UV protection. Appear as gray cells with a clear halo (artifact of processing).
* *Keratinocytes:* The primary cells of the epidermis, containing keratin filaments that provide strength and structure. Have a clear halo around the nucleus.
* *10:10** Langerhans Cells:* Immune cells located in the stratum spinosum. They capture antigens and present them to the immune system. Have a bean-shaped nucleus.
* *11:50** Dermis Structure:* The dermis, the supporting layer beneath the epidermis, consists of:
* *Papillary Dermis:* The upper layer with fine collagen fibers and dermal papillae, which contain blood vessels for nourishing the epidermis.
* *Reticular Dermis:* The thicker, lower layer with dense collagen bundles and larger blood vessels.
* *15:25** "Empty" Spaces on Slides:* White spaces on slides represent:
* *Vascular Channels:* Lined by a single layer of endothelial cells.
* *Glands/Ducts/Cysts:* Lined by epithelium (usually thicker than endothelium).
* *Artifact:* Tears, folds, or areas where substances (like fat) have been dissolved during processing.
* *18:24** Blood Vessels & Nerves:*
* *Blood Vessels:* Supply nutrients and oxygen to the skin. Arteries have a thick muscular wall with an internal elastic lamina.
* *Nerves:* Often run alongside blood vessels (neurovascular bundles). Contain axons, Schwann cells, and a protective perineurium.
* *20:00** Arrector Pili Muscles:* Smooth muscle bundles responsible for making hair stand erect (goosebumps).
* *21:10** Sebaceous Glands:* Produce sebum (oil) that lubricates the skin and hair. Sebocytes (sebaceous cells) contain lipid droplets, appearing as clear vacuoles.
* *23:14** Hair Follicle Anatomy:*
* *Hair Bulb/Matrix:* The base of the follicle where hair growth originates. Contains actively dividing cells.
* *Inner Root Sheath:* Surrounds the developing hair shaft. Contains trichohyaline granules.
* *Outer Root Sheath:* A clear layer due to the presence of glycogen.
* *Hair Shaft:* The visible part of the hair, composed of compacted, dead keratinized cells.
* *Isthmus:* The area where the sebaceous gland duct enters the follicle.
* *Infundibulum:* The upper portion of the follicle, resembling the epidermis.
* *24:45** Eccrine Sweat Glands:* Produce watery sweat for thermoregulation. Have a coiled structure (eccrine coil) and a duct leading to the skin surface.
* *27:20** Glands vs. Blood Vessels:* Eccrine sweat gland ducts have a double layer of cuboidal epithelial cells, while blood vessels are lined by a single layer of endothelial cells.
* *27:50** "Pink Bundles":*
* *Smooth Muscle:* Found in arrector pili muscles and blood vessel walls.
* *Nerve:* Characterized by axons, Schwann cells, and perineurium.
* *Dense Connective Tissue:* Found in tendons, fascia, and ligaments.
* *29:37** Acral Skin and Contact Dermatitis:*
* *Parakeratosis:* Retention of nuclei in the stratum corneum, indicating irritation or abnormal growth.
* *Perivascular Lymphocytes:* Inflammatory cells surrounding blood vessels.
* *Spongiosis:* Edema (fluid) within the epidermis, causing separation of keratinocytes and highlighting desmosomes.
* *34:20** Stratum Lucidum:* Normally found in acral skin, appears as a pale line beneath the stratum corneum.
* *35:40** Glomus Body:* A specialized structure in acral skin involved in temperature regulation. Composed of a blood vessel surrounded by modified smooth muscle cells (pericytes).
* *37:55** Subcutis and Adipose Tissue:* The subcutis lies beneath the dermis and contains fat cells (adipocytes). Adipocyte nuclei may show a "lockhern" (nuclear lake), a clear space representing dissolved lipid.
* *50:40** Pacinian Corpuscle:* A sensory receptor for deep pressure and vibration, located in the deep dermis and subcutis. Has a distinctive onion-like appearance.
* *1:02:28** Meissner Corpuscle:* A sensory receptor for fine touch, located in the papillary dermis of acral skin. Has an oval shape with internal lines.
* *53:00** Dense Regular Connective Tissue:* Composed of dense collagen bundles and fibroblasts. Found in tendons, ligaments, and fascia. Can be distinguished from smooth muscle by the presence of extracellular collagen bundles.
* *55:33** Immunohistochemistry Highlights:*
* *Cytokeratin:* Stains epithelial cells, highlighting the epidermis, hair follicles, and sweat glands.
* *S100:* Stains melanocytes, Langerhans cells, and adipocytes.
* *Desmin:* Stains smooth muscle cells, highlighting arrector pili muscles and blood vessel walls.
* *CD31:* Stains endothelial cells lining blood vessels.
* *SOX-10:* Stains melanocyte nuclei.
* *1:04:10** Digit Histology:* Amputated toe specimens demonstrate acral skin, bone, tendons, arteries, and the nail matrix (where nail growth occurs).
* *1:11:50** Solar Elastosis:* Accumulation of blue-gray elastic fibers in the dermis due to chronic sun exposure. Causes wrinkles and skin aging.
I used gemini-1.5-pro-exp-0801 on rocketrecap dot com to summarize the transcript.
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Thanks prof. Such a comprehensive video
Breast acini and glands in the prostate also have two layers of cells
just Amazing ! A BIG THANK YOU SIR ..
Great video, thank you so much!
This helped me clear the concepts of normal skin histology
Can you please do a video on skin reaction patterns
it is really great i wish u were my professor of histology thanks alot
Love the videos. A natural teacher. Do you have a video that provides an overview of the stains etc and how they are used? Thanks
Thanks! Try these videos about basic immunostains in skin. kikoxp.com/posts/3807 & kikoxp.com/posts/3806
This is awesome thank you so much for this!!
Excellent review of normal histology.
Great video...clear and very informative...thank you soooo much
Will you recommend a similar video for basic histology of the brain ???
Hi in Minute 39:00 you say that there is a "lockhern" inside of an apipocyte nucleus. Thats a typo. It`s actually a "lochkern". Lochkern means in german "hole in a nucles". Nevertheless thx for that great video!