As a carrier of Haemophilia, I want to point out that while it can be painful and simple bumps can be extremely dangerous , that’s mainly for folk that are severe sufferers and mild suffered don’t suffer in the same way. Also, female carriers do suffer with lower factor levels than “normal” and it does affect our periods
Also, you tend to inherit the type and severity of the illness unless there is some sort of cell mutation. In my case, my grandmother was a mild carrier so my dad is a mild sufferer and I am a mild carrier. If Alexei was found to have type B then chances are the other sufferers and carriers were also type B
The extra info about the type of heritable hemophilia is fascinating. If Alexei was a severe case, its likely that Alexandra had undiagnosed hemophilia health issues. The records show that she was prone to bouts of physical pain that was attributed to her many pregnancies.
@@rosiegomez5809 oh I’d definitely say it was the haemophilia. I have type A, not type B, but I’m quite prone to having random joint bruising - I actually have one on my knee now - which is caused by the disorder so it wouldn’t surprise me if that’s what caused her joint pains
I have a type of ehlers-danlos which also affects my blood's ability to clot and, worse, heal wounds, both in a way similar to haemophilia. I've had several transfusions due to nearly bleeding out on an operating table before they knew what I had, the worst was when I had my tonsils out as a kid and no one believed me till I threw up a litre of blood and passed out. Gnarly stuff.
@@sophroniel that happened to me too! When I was 15 and had my tonsils removed, I had loads of after problems and was in hospital for a bit after because of blood problems
You are so right to encourage folks to give blood, if they can! As a regular whole blood donor with a rare blood type, I know my blood is needed for preemies, newborns, burn victims, AIDS patients, and any match with a compromised immune system. My parents were always regular donors, and I am working on my lifetime 12th gallon - but other family members have deferrals and can’t donate. I am glad to know there are people alive today, because I took the time to donate exactly what they needed to get better.
Thank you for donating! My best friend had leukemia (she died in 2006), but I learned so much about blood donation. I found out that I am CMV negative, so I have also donated platelets. As an American of African decent, I am also on the bone marrow registry. ❤
I wish I could, but i have lots of dizziness due to low iron, like one time I almost fell into a wall because everything got black and I felt super dizzy.
I wish I could still donate blood, but because I married a man who was an IV drug user and has still tested clean for everything even 14 years later, I get turned away. Which stinks because I have O- blood type.
28:20 This actually happened to one of my dad’s college friends. His wife died unexpectedly, and then a few months later he died. I think they were both in their late twenties. At the funeral, his mom told everyone that he had had AIDS, and he’d contracted HIV from blood transfusions for his hemophilia, and then he transmitted it sexually to his wife. It’s super tragic, but it was brave of his mom to come out and say that since there was still such a stigma about the disease at the time 😢
There is an amazing book ‘April Fools Day’ written by Bryce Courtenay which talks about his son Damien who contracted HIV in the ‘80’s from the blood clotting agent Factor 8, the treatment for his haemophilia. It is a beautifully written book. (Bryce Courtenay wrote great novels like Power of One, Jessica, The Potato Factory, Solomons Song and many more.)
This is strikingly similar to how my grandpa died. His wife (not my grandma) died from AIDS, then my grandpa died a few months after - a few days before my birthday in 2011. Unfortunately I never met him.
I can’t get over Alfonso! I know young people act without thinking when they’re in love sometimes, but it’s still gross how he turned on his wife who *he* insisted on marrying, even though his mother warned him!
Alfonso absolutely boils my blood! It wasn't like he went into the love match blind, he was WARNED about likelyhood that the condition could be passed down to his children, and he was the KING! Especially when you compare Nicky's unwavering devotion and love for Alix even after Alexei was diagnosed with the condition she passed down to him. Victoria Ena deserved BETTER than a horrid husband like him!
Oh, and he lost the throne bc he supported the Primo de Rivera's dictatorship, and was a pathologic sex obsessed. He had the biggest porn films colecction of his age in the world, and a good bunch of ilegitimate children. In fact, in his times was very popular this joke: "AXIII is the only man with twins from differents mothers". He didn't lost the throne before, thanks to her mother, who was beloved even for the republicans ("A Republican only hat off in front of God and the Queen Mother"), and his aunt, the incredible Infanta Isabel, dearly nickname by the people La Chata, The Short, who was the heir of the throne twice. If the stupid Salic Law didn't rule in that age, she would be a way better Queen than her mother, brother and nephew. She was beloved at that level, that the Republican Gov garanted her his belongings and security if she want to stay in Spain. Sadly, she was too devoted to her family, than she traveled to Paris despite a serious cold. She reached them, but died few days later.
My two grandsons aged 8 and 5 have haemophilia B. They are both well and have a weekly injection of the missing factor. This means they are able to play games and do rough and tumble games. We all treat him just as other members of the family.
A terrible thing about treatment, at least when I was still working in health insurance around 3 years ago, was the exorbitant cost of the treatment. It is absolutely criminal and I'm so glad to hear that your grand babies get what they need.
Alexei and his cousins, Waldemar, Henry, and Alfonso, had haemophilia when they were little babies, and Friedrich "Frittie" had haemophilia when he was toddling around, but fell and cut his ear.
Both my brothers have hemophilia factor nine, they don’t have to get the factor every day but if they have a serious injury, we have the medicine ready my older brother has it worse than my younger brother
@@ThatOneSandwichGuy- In my father's maternal ancestry, it is Victoria's daughter 'Alice.' In my mother's paternal ancestry, it is Victoria's daughter 'Beatrice.' In my mother's maternal ancestry, it is Victoria's son 'Edward VII.'
Alexandra Feodorovna was actually one of Queen Victoria’s favorite grandchildren, and the Queen decided to watched over Alix and her siblings' education after Alice died. She admired the young, beautiful Alix so much so that she wanted her to marry her cousin, the future George V. It's interesting to hear how history would have turned out if this marriage actually occured. Hemophilia would have been spread to the future monarchs of the United Kingdom. It also would've been interesting if George V had saved his cousins and given them sanctuary (he was a first cousin to the Tsar and Tsarina); maybe the last Romanovs could've survived. Another what if scenario is if Nicolas had changed the succession laws so that Olga could have become empress regnant. History and its many what ifs are fascinating
I thought it was his older brother, Prince Albert Victor, who was considered as a husband for Alix. He was actually seriously interested in her, and hurt that she rejected him in favor for Nicholas.
George V sympathized with his Romanov cousins, but the rescue plans were extremely dangerous and had little chances of success. He knew the British people would not accept the loss of British lives while rescuing another royal family. In addition, some had a problem with Alexandra being a German princess, but most did not realize that her grandmother, Queen Victoria, raised her in the UK, and she was her favorite grandchild.
@@cakt1991 I did my research and yes, you are correct. Alix was first proposed as a bride for Albert Victor, who died of influenza in 1891. Thanks for informing me!
When I learned about x-link recessive in biology class at school, the textbook showed us the family tree of Queen Victoria. I just wondered who are all these people, back then when information was scarce in my country. Who knows years later you would come up with the complete stories of each of the affected family members. What a perfect video
My oldest and dearest friend died from leukemia in 2006 at the age of 40. Since that time, I have been passionate about blood donation. I could always tell when Lisa had had a blood transfusion before my visits to the hospital. She had so much more energy, and looked so much better. Please donate! ❤
Plasma center nurse here!! Thank you for bringing awareness to the need for donations. It can take up to 130 donations for enough medicine for one patient for a year. So it is really important to donate.
I taught elementary school throughout the 1980s. My first year I had a boy in my class who had hemophilia, and trying to keep him safe was almost a full time job on top of my regular duties. If he lost a tooth, got a cut or scrape, fell or bumped into anything I had to immediately call 911 and have the EMTs take him to the nearest hospital ASAP. When he would lose teeth he’d hemorrhage. Because of budget cuts our school didn’t have a full time school nurse, so I had to learn serious first aid skills in order to keep this boy from bleeding out before the EMTS (who were already stretched thin because budget cuts forced them to have fewer teams and very large areas to serve) could get to the school. It was terrifying to witness what is a normal part of childhood turn into a serious medical emergency every time a tooth fell out or he got bumped by another child. A few years later one of my teaching team members had a boy with a even more aggressive form of hemophilia. For his safety he had to use a wheelchair. Even so, he was very athletic and would take dangerous chances by running and playing around when he was outside at recess or PE classes. This was at a time when AIDS was new and blood donors weren’t always screened for AIDS, blood disorders and other illnesses. The fact that an unscreened blood donor might pass AIDS onto him through a transfusion was a very real possibility (until mandatory blood screening became the law of the land), and the thought of that was constantly on his mind. Several times when I was on recess duty I would find him crying in out of the way places on the school grounds. Even though medical research has resulted in many breakthroughs in treating hemophilia I can’t help but feel great sorrow for the parent who inadvertently passes on the hemophilia gene to their child and the children who are born with it and can’t live a “normal” life.😢
I didn't even think about them bleeding after losing each tooth. Omg. Imagine being a woman and this family, watching your brother suffer like this... then your son.... then your grandson. Throughout every pregnancy, wondering if the baby had it or not. And I bet some of the female carriers bled heavily during childbirth. Just awful.
It was in 1970 when a Nobel price came out to find hepatitis in the blood by an analysis. Up to that point people will donate bad blood, my mother had Hemofilia like me and she was giving a transfusion with hepatitis in 1967. She died of hepatitis in less than 3 months, I was 10. Most doctors even today don’t have a clue of what is Hemofilia and often don’t give the respect of a serious medical condition. In 1980’ many people died of transfusions of plasma infected with AIDS.
Thank you for being a great teacher. I had students that needed the epipen and we would pass off the fanny pack each day when we acquired the student, then hand it to the next teacher, and the peanut butter kids (also epipens and huge cleaning requirements, as peanut butter was not yet banned from school), but never anything like that. I hope all the students you taught and their parents saw what a caring and dedicated person you are.
Love this fundraiser and bringing awareness to the importance of donating blood. My dad survived AML in 1984... he was given over 125 units of blood. At a time when AIDS was very much a danger in donated blood, it added another layer of uncertainty of remission. Superb content as always!
When my Mum gave birth to me in Malawi, in 1982, testing was not routinely carried out on blood to be donated. Luckily, my Mum's midwife was an American nun who was also a missionary and knew about HIV. She had her own group of friends whom she called upon, who got tested regularly and one of them donated safe blood for my Mum. Luckily, although I was very premature and sickly at first, I didn't need an exchange transfusion ( own defective blood removed and then replaced with blood from a healthy donor,) and only required some time under bilirubin lights.
I had a coworker who had it, and he was a bit of a daredevil, like some of these princes. He occasionally would be out of work for a week or so at a time but was out longer after he had jumped off of a moving train. He had jumped on it while it was moving slowly through town, not expecting it to speed up outside of town, where he anticipated jumping off of it near his home. Amazingly, he fully recovered.
One of the causes of hemophilia is mutation that can occurs when the father is an older father at conception. Victoria’s father was in his late 50’s when she was conceived. This was most likely the cause of the disease in her family line
Defo the cause. Victoria looked like her dad in a wig and had hanoverian beedy eyes. John conroy was described as attractive and he definitely wasnt a hemophiliac. She looked nothing like Conroy and didn't look like her mother (looking more like the Hanoverians).
Exactly! Victoria looked like her father, with Hanoverian-line genes. I don't believe the theory that Victoria was fathered by someone else her mother was involved with. Nope, re Conroy being Vicky's father. The other historical factor to recognize is that Victoria was specifically conceived to carry on the British monarchical line in the first place! The children of King George III and Queen Charlotte had problems producing legitimate heirs. It's rather amazing how devoted George and Charlotte were to each other, especially considering the libidinous, unfaithful exploits of George's ancestors, siblings, and his own progeny. 😳 It's an eerie, macabre, yet in some ways fitting fate for Edward, Duke of Kent to have finally produced a legitimate heir, but due to his age, a mutation occurred which caused horrible suffering to be passed down. Wow, the tragedies are like a Greek tale of royal hubris. 😮 In any case, Victoria was a very poor mother. Her own mother had treated her like a prized possession to be owned and controlled, so she did not have a good role model. Despite being strong in standing up against her mother and Conroy, she surely suffered emotional and psychological damage from her childhood and teenage experiences, before she inherited the throne. While Victoria herself had more love for her own children, it was an obsessive, overbearing love. Plus, she hated having children, despite adoring and idolizing her husband. She blamed her oldest son for her husband, Albert's, death, and she monopolized her daughters' affections. Victoria not only passed down haemophilia to her descendants, she also passed down toxic family dysfunctions. Porphyria is another disease in the British royal family, with proper diagnosis and treatment unknown until the 20th-century.
My hearth goes specially to poor Alexei. His parents concern and love for him drove them to Rasputin. May the baby of the romanov family rest in peace alongside his loved ones❤❤❤❤❤🙏🙏🙏🙏🙏🙏
🤔 maybe if they didn’t keep it such a secret, the people might have understood WHY he was around? Idk, just a thought. They (meaning anyone, I guess,) STILL don’t know how he helped that poor boy, but he did🤷♀️. Tragedy at the end, no matter what. Brutal.
@sweethistortea He was a con artist and didn’t have any supernatural power. The reason he was able to help Alexi was because the royal doctors kept prescribing him aspirin which actually makes people bleed even more than usual. Rasputin knew this which was why he would tell Alexandra not to let the doctors bother Alexi. He was pretty much trying to tell her to stop letting those idiot “doctors” give her hemophiliac son pills that would make his bleeding worse.
9:36 Ernest, unfortunately, got his wish in a twisted way. Shortly following his death, most of his near relatives were going to Britain to attend the wedding of his second son Louis and his British fiancé, The Hon. Margaret Geddes. Unfortunately, Ernest’s widow Eleonore, son Georg Donatus, daughter-in-law Cecilie, Georg and Cecilie’s 2 sons Alexander and Ludwig, and Cecilie’s unborn son all perished in a plane crash in Belgium. Cecilie and Georg’s only surviving child who had not been present on the plane, Johanna, died a little less then 2 years later due to meningitis.
Thanks as always for such a magnificent video girl! Your work is leagues above all the documentaries on television! Love you, your passion and dedication!
Okay, so I have watched most of your videos, multiple times, I have never given a care, really, about any of what I have seen, heard and learned. I don’t even know how I happened upon your channel, couldn’t tell you! But, I do know you have awakened the thirst for knowledge, I am excited when I see a new video and have shared my new knowledge in conversation with many. Thank you for what you do, truly, you have helped me obtain genuine love for history, something I didn’t think would matter to me as much as it does. You’re a wonderful escape, time traveling with you is awesome!
Actually the treatment now doesn't include plasma transfusion anymore because of the antibodies that can appear with the multitude of transfusion needed . There are synthesized clotting factors which are administered once or twice a week and they can give a life very, very close to normal. The treatment is very expensive , that's true. Genic therapy is still in the earlier stages, but hopefully will get there soon.
Wow Lindsay! What an original & informative slant on hemophilia & Queen Victoria’s descendants, thank you so much for all of your research, not to mention your terrific grammar and wonderful way of speaking. It’s such a pleasure!
I'm honored to donate platelets twice a month.. Platelets can be stored for only 5 days, before they are unusable, so the need is constant. Also, they can be donated up to twice a month, or 24 times a year. It is mere moments of discomfort (with the needles) to literally potentially save a life. Thanks for the great video!
If you think about it, it’s pretty miraculous that hemophilia missed the Habsburgs. Sure…they had other problems from their inbreeding, but hemophilia wasn’t one of them. I just find that interesting.
It’s mostly because the British royals tended to marry other Protestant royals. Only when Victoria Eugenie married into the Spanish royal family did this change. if one of her daughters was a carrier and had married into the Austrian Imperial Family, it could’ve been brought in.
@hotaruchibi1669: Interesting? Whatever floats your boat. Queen Victoria wanted Alix of Hesse to marry the oldest son of Edward Vll, which would have been her first cousin, but he died. Her ‘replacement’ was Mary of Teck (Queen Mary, mother of George Vl, Dukes Kent, Gloucester and Windsor) so it’s possible that hemophilia would have surfaced in the Windsor line.). Everyone in Queen Victoria’s family had enough sense to stay away from the Hapsburgs in marriage.
@@johnpickford4222 and that son was not a Georgie but rather, Albert Victor. Albert Victor was supposedly madly in love with Alix and wanted her but she wanted Nicky.
I so enjoy this channel. I've learned so much here and continue to learn more and more with every video. My grandchildren watch with me and get a history lesson without even trying. Thanks! 💛💛👏👏👏
20:42 Lindsay, your (correct) graphic contradicts what you are saying! A man with hemophilia will always pass the trait on to his daughters because he can only give them his affected X chromosome. Since his Y chromosome is unaffected, he cannot pass it on to his sons.
Ever since I listened to this on your podcast I've been dying to see the video for it. ❤ Thank you for uploading this and all that you do. This one was such a tearjerker when I heard it and the video was amazing. Keep up the great work in everything you do 😊😢❤
“She [Victoria’s Mother] had two offspring with a German prince, a son and a daughter. Few medical details are publicly available about the daughter’s line. The son, however, is reported to have died from bleeding from his internal organs in his early 50s. He had two bleeding attacks weeks apart. The local hospital successfully stopped the first bleed but could not stop the second. He died from apoplectic shock consistent with hemophilia.” Hemophilia of Georgia The Royal Disease: A Family History Update on Queen Victoria
If I remember correctly, the type of hemophilia Queen Victoria passed on was passed onto her by her own father. Something like his age and health affecting Victoria's genes, if I remember correctly. He was in his fifties when she was born
It makes sense. Women have all their eggs for their whole life form when they are in the womb before they are born. A man’s sperm is continuously created then dying before new sperm is created, so it’s easy for any damaged genes from an old father making it’s way to their child.
Not known for sure. Could be a gene mutation on her dna . It could happen with the percentage of 30%. They also said women are carriers and don’t suffer. That’s not exactly neither. I am a female and I have that genetic mutation and Von Villebrand also . Maybe milder than a male but still dangerous.
Rasputin never "cured" or stopped Alexis' bleeding. At most he brought emotional relief to his mother, Alexandra, who had faith in Rasputin; as postulated by the author Robert K. Massie, this probably in turn positively affected Alexis emotionally. There is a well known story of one bleeding incident that happened during WWI. Alexis was at Stavka (army HQ) with his father, and they had to rush back to Tsarskoe Selo because Alexis developed a severe nosebleed. According to accounts by the time they reached the Alexander Palace (the family's home) the boy was at death's door. Alexandra sent for Rasputin, who prayed over Alexis, and the next day he was better. This often-repeated account is attributed to the memoirs of Anna Vyrubova, a somewhat disreputable source, and Grand Duchess Olga, who didn't actually witness it but relied on accounts told to her. However, after the fall of the Soviet Union and the state archives became available, Nicholas' diary and letters from Alexis to his father (who returned to Stavka soon after; that makes me think the episode may not have been as severe as reported) specify that Alexis' recovery was due to the imperial surgeon cauterizing his nostrils; neither of them make any mention of Rasputin. Rasputin was a daring gambler all his life. What did he have to lose to say "your son will not die" to the empress?
yeah. I think you are right, Rasputin was like hypnotherapists or just had psychological effect on Alexandra and Alexey. I don't think he knew about even snake poison. I'm wondering if they write each other royal families about diseases of their kids. I know they tried to hide it as much as possible, but still they could figure out that this is the same disease in the family tree.
I really enjoy your program. I have been watching them for a long time and you are getting better with each one. Thank you for this one on Queen Victoria's descendants with hemophilia. Each program is better than the last..Keep up the good work.
24:31 This could also be the explanation as to why Empress Alexandra’s sister, and Waldemar’s aunt, Grand Duchess Elizabeth Feodorovna and her husband, Nicholas II’s uncle Grand Duke Sergei Alexandrovich, never had any children, despite being very fond of kids. Both of them would have been well aware of potential for any of their children to have the disease or be carriers of it. They did however, effectively becomes second parents to her husbands niece and nephew, Grand Duke Dmitri Pavlovich and his sister Maria Pavlovna, and to one of Nicholas II’s nephews-in-law, Prince Felix Yusupov
Sergei Alexandrovich, not Paul. Paul certainly had children, Maria and Dimitri that you already mentioned 😉 and three more with his second wife later on. More likely Sergei and Ella didn’t have children because Sergei was gay.
@@piratesswoop725 I didn’t mention the last children because they were *morganatic* children, not in line for the throne, and thus irrelevant, and as far as I’m aware, Ella and Sergei had no relationship with them. That and there is no surviving evidence, even society rumours about Sergei. And the lengths he had to go to to marry Elizabeth suggest not. There would’ve been far easier princesses to court if he wanted a sham marriage
possibly one of them had fertility issues. Her eldest sister had healthy babies, and the whole family was in denial of hemophilia. Infertility can occur absolutely independently of the issue of whether she was a carrier or not. this is speculation, but a plausible one.
@@piratesswoop725And you repeat that disgusting fact why? How do you know he was gay? Do you recognize the same traits in yourself?? There are many reasons a couple can’t conceive a child that could be at fault. Grand Duke Serge very likely could initiate intercourse but have a low sperm count when ejaculating. Or there could have been an issue with Grand Duchess Serge (Elizabeth). Grow up and don’t be a cavalier a** on such a sad and tragic history.
@@dorotakarpiel6717That’s fair. I mean the two running theories are either infertility from one of them or preventing their children from suffering from or transmitting incurable disease. It’s hard to deny the possibility Or maybe both, who knows
Girls bleed too! Blieeve her! As both a historian and a female bleeder, I am so glad to see this! I've had over 500 blood transfusions, factor infusions, plasma/cryo and iron infusions, etc. That's a lot of people who have donated to help save others. Thank you!
You're brave to share that female hemophiliacs exist, and it's really awful that female hemophiliacs are underdocumented and not given nearly as much coverage as male hemophiliacs.
This is so fascinating. Thank you for doing this. I love these kinds of knowledgeable period pieces. You did a great job voicing and producing this video. Thank you ❤😊
Also, there is one known modern descendant of Victoria who has hemophilia-Ferdinand Soltmann, who is twice descended via his maternal grandfather, once from Prince Alfred and once from Princess Alice. Here’s what’s interesting though-we know Alfred was not a hemophiliac, so Ferdinand could not have inherited it from him. And we know Alice was a carrier, so that’s the far more likely option. However if he did inherit from this side, it would mean that Alice passed on the trait to at least THREE of her daughters and that there are more carriers and at least one more sufferer that aren’t documented. The line would go like this: Princess Alice > Princess Viktoria of Hesse (later Marchioness of Milford Haven) > Princess Alice of Battenberg > Princess Margarita of Greece and Denmark > Prince Kraft of Hohenlohe-Langenburg > Princess Xenia of Hohenlohe-Langenburg > Ferdinand Soltmann So that would mean that Prince Philip’s mother was actually a carrier and passed the trait on to at least one of his sisters! Allegedly, Kraft’s symptoms were mild, but it was known in the family that he had some clotting issues. Unfortunately he was cremated so we will never know for sure (unless we could exhume Viktoria, Alice or Margarita and test their DNA). Kraft would be the only one of Victoria’s hemophiliac descendants aside from her son Leopold, to father children. Like Leopold, both of Kraft’s daughters would be carriers, but his oldest daughter has no children.
Well the late Dowager Princess of Hohenlohe-Langenburg is buried not far from the H-L family crypt with her husband, Gottfried. Alice is buried in the Church of Mary Magdalene in Jerusalem and the late Marchioness of Milford Haven is buried in St. Mildred’s Church on the Isle of Wight. So one would need permission to crack open a privately owned tomb belonging to a ludicrously wealth German aristocratic family, the subterranean crypt of one of the most prized churches in all of Orthodox Christendom and the cemetery of an English church under the jurisdiction of the Church of England with a very long and extant relationship with the British royal family, both the ecclesiastical hierarchy and St. Mildred’s itself… I wish anyone who wants to undertake such a great deal of luck. And to anyone who is successful… buy a lottery ticket
I knew Prince Kraft since he and his first wife were friends with my parents in the 1970s und 80s and he was a healthy and active man. It was confirmed by genetic testing that Queen Victoria had passed haemophilia B onto her descendants which is the more severe form. Prince Kraft was born in 1935 before effective treatments were available. It is very unlikely that he had this disease without lasting damages to his joints even if he was treated with clotting factor since the 1960s.
@@beefstew4698 Because sons have a 50/50 chance of inheriting it, and Philip luckily landed in the 50% that didn’t inherit the faulty X chromosome from his mother.
@@beefstew4698 50/50 chance for each child to be a carrier if they’re female and someone afflicted if male. 3 of Queen Victoria’s 4 sons didn’t have heamophilia, and Philip was Alice’s only son. It’s fairly reasonable
For anyone wondering, Maria’s primary suitor for most of her life was Lord Louis Mountbatten (yes, the Duke of Edinburgh’s uncle). Since men are responsible for the genetic code that determines a child’s gender, it’s very likely Maria and Louis, had they married, would like Louis and his wife Edwina, would have had 2 daughters. So the effects of the disease and tragedy therein might have been even longer lasting if Maria had lived to marry.
Blue blood wasn't because being royal their blood was blue. It came from the Spaniards with light skin (no Moorish DNA) being able to see their blue veins on their arms, so it originally meant "pure" and later it was a used to any group that only married among themselves, i.e Royalty and the Aristocracy.
Really good video, Lindsay, but to all who haven’t yet, I rly recommend you to listen to the podcast she has on this topic. It’s a real tearful listen, but really good
Thank you for this video. We have hemophilia in my family. I have a similar clotting disorder called Von Willebrands Disease (which women and men can get alike), so this topic fascinates me…
@AimeeRose22 my mother had Von Willebrands as well. She had 5 brothers and sisters, who did not. I was tested as a child, and am a carrier. No one since in our family has any symptoms. I haven't met anyone else with Von Willebrands. I stumbled upon this video by chance. Do they treat you before surgery or dental procedure? They did my mother.
@@rjustr my dad and i have von Willebrands while no one else in the family does. Transfusions of clotting factors are needed before and after surgery. Being careful of bruising and cuts was normal part of my life as well as coping with other aspects of being female.
@@rjustr Myself, my sister and my dad all were diagnosed around the same time, my mom and brother do not have it, so I did have support in the family.... I do get treatments with a medicine called DDAVP before surgery (only two surgeries in my life) and dental has been so far so good, just have to warn the hygienist to be gentle. Also I can use a medicine called tranexamic acid for menstrual bleeds that are heavier than usual
Princess Alice was the strongest carrier. So many hemophilia deaths among her descendants. Heck, even non-hemophilia tragedies rocked her family. Most unlucky among the Saxe-Coburg siblings, definitely.
dying at 35 yrs old on the anniversary of her own fathers death when she was 18, passing the royal disease to ~ 3-4 of her children, watching 2 of her children die before her, and literally being the grandmother of THE romanov imperial family shes literally the unluckiest gal in the royal family
I have the opposite issue. My surgeons said my blood clotted faster than he had ever seen and they don't know why. If I wasn't on blood thinners I would love to donate ❤
Please have yourself checked for a clotting disorder! One of my best friends noted a similar fast clotting issue and it turned out to be a clotting disorder which required a Greenfield filter and other medical treatments to save his life. This is not something to ignore-it can be life threatening. Take care.
There is this book called "The Blood Doctor" I read years ago that piqued my interest in Queen Victoria and hemophilia in her family. Can't remember the author, but as far as fictional works go, it was pretty good. Lily Langtree is mentioned as well.
TBF Alexei died from being executed not because of his hemophilia. It was one of the parts leading to the downfall of the dynasty but the major part of it was because his parents were terrible rulers. Poor Alexei is still awaiting burial
It was a lose lose situation, he was gonna die regardless 🤷🏾♀️ the execution was just the brutal way out, since some of them survived the initial bullets and had to be gunned and beaten down…
@@SomePerson_Online I forget which Grand Duchesses, I'm pretty sure it was Maria and Anastasia, but they survived the initial bullets because they had jewels sewn into their corsets.
@@erinw.9256apparently all 4 survived the initial gun shots due to their corsets along with bayonet stabbings they were shot in the head that finally ended their suffering.
I believe your interpretation of "blue blood" is not correct. The concept likely originates in medieval Spain as ‘sangre azul’, and is attributed to the rich, powerful families of Castile. As part of their ‘pure Gothic’ descent, they would claim never to have intermarried with another race by drawing attention to their pale skin, which made the blueness of their veins visible. Blue blood was actually used to accentuate their "whiteness." In addition, pale skin has been long associated with the upper class, as they did not have to work outside, as the lower classes did, hence they had pale skin. This even continued into the late 1800s in the US, where women wore sun bonnets to maintain a pale, lady-like complexion.
@@Lily-wp8ol My Grandmother always wore a hat as well. I once bought her a sun bonnet just like the pioneer women wore at a farmers' market in Kitchener about 3 h. from here. It was more of a joke than anything. I thought she would laugh about the bonnet, but she loved it and wore it outside all the time. She wanted me to get her another one, but I was nowhere near that farmer's market and couldn't. This was in the 1970's so the tradition of not wanting to be tanned was still alive then.
This was incredibly interesting. I am a nurse with a huge interest in English history. ( my mom descended from England) and also the last czar of Russia and his family.. I've always wondered who all inherited the disease and if it was still present in royal families. You did such a great job in the final summary also. Thank You.
You can have the spontaneous mutation on one of your children and you and your partner don’t have it. The possibility is 30% without be part of any royal family. Although it’s very rare affect 6 people of 100,000 . I have it and I am not Royal and female.
Thank you for reminding people to donate blood. I don't have hemophilia, I have a very rare platelet defect which I passed on to my youngest son. He has need platelet transfusions on a couple of occasions. There are a variety of clotting disorders other than regular hemophilia (Von Willebrand's, Christmas disease, etc.). Everyone who has these will likely need a transfusion at some point in their lives, or blood products. People with leukemia also frequently need transfusions. I am grateful for all the people who do donate. Thank you from me.
Since I am an American cousin to the British Royal family I found this video fascinating. I will be going in for my annual blood tests which now includes Genetics. I will asked the tech to check for hemophilia.
You should ask for a referral to a genetic counsellor, not just the testing. Testing, when not ordered correctly by a genetics professional, can sometimes be misleading
My Mum received a blood transfusion in 1982, in Malawi, where there was no routine screening for HIV. Fortunately, her midwife was an American nun and missionary, who knew about HIV and for that reason, only used donated blood from her group of personal friends, who were all screened routinely, before they gave donations.
Maria's hemorrhage during that tonsillectomy is why some believe that she may have been a carrier. When her family's bones were tested in the 2000s, they not only confirmed that Alexei had hemophilia B (and in the process, confirmed that hemophilia B was what Queen Victoria passed on to her descendants), but that one of his sisters was a carrier. We'll probably never know for sure which of the sisters was a carrier, but historians seem to think it was either Maria or Anastasia. Maria's hemorrhage might indicate it could have been her, but we'll never know for sure. It's sad in hindsight though, because Maria dreamed of marrying and having a large family. If she had survived to marry and have the many children she dreamed of having, then if she was the carrier in the family, she could have passed it on to the next generation.
@@darkbella1552 You're right about the inactivation. It's called skewed X-inactivation, and it exists in females to ensure that there's dosage compensation between males and females. If both X chromosomes were active, then females would have twice the number of active X genes than males do, which is why one X chromosome is randomly chosen for inactivation at approximately the time that embryonic implantation occurs. Most females have some levels of skewing, and it's relatively common in adult females. This means that if female carriers of hemophilia B show symptoms of the disorder despite having that second X chromosome, then it means that the healthy X chromosome might have been randomly selected for inactivation, and the severity of the symptoms may hinge on what the skewed ratio is, because extreme skewing, where over 90% of cells have inactivated the same X chromosome, exists. Skewed X-inactivation has a lot of medical significance, and the fact that it exists in most females indicates the possibility that female carriers among Queen Victoria's descendants may have suffered more from the disorder than was initially assumed. We'll probably never know for sure, but depending on the level of skewing, some of the female carriers in her line could have suffered the symptoms with varying levels of severity. Grand Duchess Maria's hemorrhage during her tonsillectomy not only raises the possibility of her being a carrier (although we'll never know for sure if she was the carrier or one of her sisters was), but also that if she was the carrier (only one of the daughters was confirmed to be one when the family's bones were tested in the 2000s), then what her level of skewing was. Skewed X-inactivation is definitely a very important aspect to consider when it comes to female carriers of not just hemophilia B, but of any other X-linked recessive genetic disorder such as hemophilia A and red-green color blindness. In fact, I wonder if for female carriers of red-green color blindness, their color vision is affected if the X chromosome not carrying the gene is randomly inactivated in favor of the one that has the color blindness gene depending on the level of skewing.
I am really not convinced Maurice had hemophilia. Leopold, yes, but there’s no way they would have allowed a hemophiliac to serve in armed combat. Leopold, for example, only ever had a desk job, but Maurice was in full combat.
A weird nitpick but I feel inclined to mention it - You described Victoria as having "beady eyes" but this is typically used to describe someone with very small eyes. Perhaps you meant protuberant eyes? - which are large eyes that bulge out. That seems to describe Victoria better I think.
I believe there is actually still a haemophiliac living today in amongst the descendants of Queen Victoria, a boy in the Hohenlohe-Langenburg branch whose haemophilia may possibly have arisen by coincidence rather than through this previous haemophiliac lineage. There were also rumours of haemophilia being present in the Weilers (descendants of one of Alphonso XII of Spains' daughters).
I think his last name is Soltmann and yeah he is the last living carrier of Victoria’s descendants. Damn I can’t think of his last name but he’s a handsome young man. German AF. Edit: i looked it up, it’s Ferdinand Soltmann.
The most shocking information I heard on this video was you saying you have a reminder to donate blood every 8-10 weeks because in my country we're only allowed to do it 3 times A YEAR!
She might have confused blood donation with plasma. You can donate plasma much more often, in fact many people sell plasma to pharmaceutical companies for the production of vaccines, blood tests, and treatments.
if i remember correctly, the romanov children’s paternal aunt olga recounted how the girls bled more than normal and how during her tonsil surgery, maria bled excessively.
Now I know it’s Waldemar who last died of hemophilia among descendants of Queen Victoria. I voted for Gonzalo. Thank you dear Lindsay for historic education! ❤😊
Such a GREAT VIDEO! From a health care providers perspective we could almost show this as an explanation. Great job. Love it. Hope the princesses babies have no effect and also don't carry. ❤
As the father of a son with Type A sever Hemophilia less than 1% clotting ability, and all the literal horrors and indescribable suffering that is a part of their lives, not to mention HIV and AIDS related 97.9% death rate of any Hemophiliac receiving Factor 8 (Type A) and/or Factor 9 (Type B) before Nov. 1985 to quell (not cure) the immeasurable suffering we ,son, mother, father, grandparents etc. have lived through I can't watch this without weeping, and reliving untold horrors. All true and valuable information and for the Sons, parents, and all related family these facts are important to hear and know. There have been times when the devastating pain as a parent buckled my knees, made my eyes, involuntarily, cross and roll back into my skull requiring 5 to 10 min of massage to be able to actually see again.....then off to another midnight run to face pain and suffering on an unimaginable scale. I hope and pray you, the reader, never have a chance to know this reality. There are just not enough words.
Absolutely superb!!!! You did it again!!!! Fantastic and I love that this vid also came with purpose!!!!!! Love it please keep up your great work!!!!!!
Our family has hemophilia but luckily I am not a carrier. My grandmother and aunts were. Factor 8 is the clotting medication my uncle and cousin used. They were both affected with HIV due to the blood transfusions. It’s a horrible affliction. For most hemophiliacs the internal bleeding and joint pain is the worst. Luckily we have genetic testing now. I would not have had children if there was any chance of being a carrier. My mother actually flew to Pittsburgh to have her testing done with the man that invented the carrier test! This was a fantastic video. Thank you for educating so many on this!
The Royals Intermarry in order to keep the bloodline pure. But, it causes genetic disorders like hemophilia. How many other genetic conditions did they suffer with?
The Ancient Egyptian royals married siblings, King Tut had two daughters (who were technically also his nieces) with his sister/wife who died as infants.
Royal intermarriage in this case did not cause hemophilia. Most likely it was a spontaneous mutation at Victoria’s conception. She would’ve passed the gene on whether she married Albert or a local fisherman.
And you have to admit that both the late Duke of Edinburgh and Queen Elizabeth II lived long, healthy lives, despite their respective ancestors having married cousins of one degree or another. And their children don't seem to have suffered any concerning medical issues.
I thought they intermarry because of political reasons. I heard the Habsburgs didn’t have any but themselves which explains the constant intermarriage.
I had wondered why the Tsar didn't marry off his older daughters to save them during WWI. The fact that they may have been carriers and marriage contracts would have been difficult to make hadn't occurred to me until I watched this presentation. Thank you.
The girls REFUSED marriage; in the summer of 1914, the Romanian family wanted Olga for their Prince, Carol, but Olga (and her sisters) wanted to stay in Russia. Carol was a scuzz anyway, a horrible person.
I used to donate plasma pretty regularly when I was younger. Sadly the last time I donated (blood that time, not plasma), I nearly passed out afterwards (I recall the staff kept asking me to tell them my name which I thought was strange, I was so out of it). My husband said, "I think they have enough of your blood/plasma now." A few years later when I got pregnant, I was in for a blood test (typical testing for pregnant women), again I nearly passed out and my ears were pounding. It was so weird after years of donating and no issues. Needless to say, every time I needed blood work, I'd have to lay down. So strange and I haven't been able to donate since, for fear of having a similar experience. Wish I could help donate plasma again.
The last boy of Mary of Teck (The lost prince, John Charles Francis 1905-1919) also had Haemophilia. Mary was a first cousin of Victoria and her grandchild became Queen Elizibeth II.
A friend of mine in college had hemophelia. He had to receive clotting injections quite often. He had a twin brother who had excellent health. Difference in height and weight between the 2 was astonishing. The disease had severely hindered my friend's growth. He did eventually marry and had a great profession as a mechanical engineer. I don't know why he committed suicide.... but I can imagine how painful his life was.
My Mom, age 71, who faints over needles, (and even an ear piercing gun at the mall) still donates. She's O negative, the universal donor, and feels it's her duty. I'm O+, but still follow her example and give my blood too.
I am 0-. We can only receive blood from other O- people. We can give blood to all other types, including positive blood types. I give blood. I need to give more often. O- blood is needed so much!
My brother’s childhood friend has hemophilia. He always had to be careful when horse-playing with my brother. Any bump or scrape could be dangerous. He’s living a good life, though. He’s married with children.
In the UK after "mad cow disease" the risk of transmission by transfusion was recognised. In New Zealand I received a British cornea as a transplant. Although I had been a regular blood donar my blood was no longer wanted, this lasted for a number of years.
I had to stop giving blood in Australia, there used to be a rule preventing people who lived in the UK between 1980 and 1996 from giving blood in Australia, but it was changed on 25 July 2022. I am now almost too old.
When growing up in Singapore, they did not accept my blood, because of the risk of BSE transmission risk ( I believe this ruling was changed, just this past October.) In the UK, when I used to visit my family during the summers, I could not donate blood also, because I had spent time in a malarial country within the last 12 months.
I never understood why The Romanovs didn't keep having children. Part of me thinks that, if they had another-healthy- son, things might've gone differently.
Alexandra gave birth to the girls every other year between 1895 and 1901; Alexei was born in 1904. There were also two pregnancy losses. Additionally, she was not particularly healthy. It’s entirely possible that either Alix’s health prevented attempting another pregnancy, or a fear of passing the disease to another child.
To add to that, basically by the time she birthed her last daughter, her body had deteriorated so much from the repeated births that her spine was deformed and she suffered from excruciating pain in her lower body 24/7. That was also one of the reasons why she shunned public duties because she couldn’t stand or sit for long, and was constantly reclining in her private apartments. She took a huge risk trying for a son against the doctor’s advice…So sad nothing worked out for her in the end. If you are interested in her story or Nicky’s, read the book Alexandra And Nicholas by Robert K Massie.
Um probably bc they didn’t want to or couldn’t, it’s exhausting and is and was certainly very painful and could be certainly traumatic in those days. She had many children and suffered from it, lots of pain that didn’t go away in her back. In those days, and even still today sometimes, more children raised the chances of the mother dying during pregnancy, birth or postpartum. As well as risks to the baby. Also there is no guarantee a son would have been born! I truly hope you can understand and be thankful she wasn’t forced to keep pushing out kids and harming her body for a monarchy that was already on it’s way out even before her time! Alix devoted herself to her kids and especially her son and wouldn’t have been able too with more children or if she had died. That would’ve been too much tragedy even for the Romanov’s.
As a carrier of Haemophilia, I want to point out that while it can be painful and simple bumps can be extremely dangerous , that’s mainly for folk that are severe sufferers and mild suffered don’t suffer in the same way. Also, female carriers do suffer with lower factor levels than “normal” and it does affect our periods
Also, you tend to inherit the type and severity of the illness unless there is some sort of cell mutation. In my case, my grandmother was a mild carrier so my dad is a mild sufferer and I am a mild carrier. If Alexei was found to have type B then chances are the other sufferers and carriers were also type B
The extra info about the type of heritable hemophilia is fascinating. If Alexei was a severe case, its likely that Alexandra had undiagnosed hemophilia health issues. The records show that she was prone to bouts of physical pain that was attributed to her many pregnancies.
@@rosiegomez5809 oh I’d definitely say it was the haemophilia. I have type A, not type B, but I’m quite prone to having random joint bruising - I actually have one on my knee now - which is caused by the disorder so it wouldn’t surprise me if that’s what caused her joint pains
I have a type of ehlers-danlos which also affects my blood's ability to clot and, worse, heal wounds, both in a way similar to haemophilia. I've had several transfusions due to nearly bleeding out on an operating table before they knew what I had, the worst was when I had my tonsils out as a kid and no one believed me till I threw up a litre of blood and passed out. Gnarly stuff.
@@sophroniel that happened to me too! When I was 15 and had my tonsils removed, I had loads of after problems and was in hospital for a bit after because of blood problems
You are so right to encourage folks to give blood, if they can! As a regular whole blood donor with a rare blood type, I know my blood is needed for preemies, newborns, burn victims, AIDS patients, and any match with a compromised immune system. My parents were always regular donors, and I am working on my lifetime 12th gallon - but other family members have deferrals and can’t donate. I am glad to know there are people alive today, because I took the time to donate exactly what they needed to get better.
Thank you so much for doing that!
Thank you for donating! My best friend had leukemia (she died in 2006), but I learned so much about blood donation. I found out that I am CMV negative, so I have also donated platelets.
As an American of African decent, I am also on the bone marrow registry. ❤
I have had chemotherapy. Can I donate blood?
I wish I could, but i have lots of dizziness due to low iron, like one time I almost fell into a wall because everything got black and I felt super dizzy.
I wish I could still donate blood, but because I married a man who was an IV drug user and has still tested clean for everything even 14 years later, I get turned away. Which stinks because I have O- blood type.
28:20 This actually happened to one of my dad’s college friends. His wife died unexpectedly, and then a few months later he died. I think they were both in their late twenties. At the funeral, his mom told everyone that he had had AIDS, and he’d contracted HIV from blood transfusions for his hemophilia, and then he transmitted it sexually to his wife. It’s super tragic, but it was brave of his mom to come out and say that since there was still such a stigma about the disease at the time 😢
There is an amazing book ‘April Fools Day’ written by Bryce Courtenay which talks about his son Damien who contracted HIV in the ‘80’s from the blood clotting agent Factor 8, the treatment for his haemophilia. It is a beautifully written book.
(Bryce Courtenay wrote great novels like Power of One, Jessica, The Potato Factory, Solomons Song and many more.)
This is strikingly similar to how my grandpa died. His wife (not my grandma) died from AIDS, then my grandpa died a few months after - a few days before my birthday in 2011. Unfortunately I never met him.
"SUPER" Tragic. The USA hidiously over use this word and in this particular instance it is tragically misused. Awful 🙄
l0
3:02 3:04 3:05 3:06
@@jegsthewegsyou’re super bothered
I can’t get over Alfonso! I know young people act without thinking when they’re in love sometimes, but it’s still gross how he turned on his wife who *he* insisted on marrying, even though his mother warned him!
Alfonso absolutely boils my blood! It wasn't like he went into the love match blind, he was WARNED about likelyhood that the condition could be passed down to his children, and he was the KING! Especially when you compare Nicky's unwavering devotion and love for Alix even after Alexei was diagnosed with the condition she passed down to him. Victoria Ena deserved BETTER than a horrid husband like him!
Alfonso XIII was a spoiled, coward and lazy brat untill his death. He didn't listen to anyone, so... He lost the throne.
Oh, and he lost the throne bc he supported the Primo de Rivera's dictatorship, and was a pathologic sex obsessed. He had the biggest porn films colecction of his age in the world, and a good bunch of ilegitimate children.
In fact, in his times was very popular this joke: "AXIII is the only man with twins from differents mothers".
He didn't lost the throne before, thanks to her mother, who was beloved even for the republicans ("A Republican only hat off in front of God and the Queen Mother"), and his aunt, the incredible Infanta Isabel, dearly nickname by the people La Chata, The Short, who was the heir of the throne twice. If the stupid Salic Law didn't rule in that age, she would be a way better Queen than her mother, brother and nephew.
She was beloved at that level, that the Republican Gov garanted her his belongings and security if she want to stay in Spain. Sadly, she was too devoted to her family, than she traveled to Paris despite a serious cold. She reached them, but died few days later.
The man who was so inbred...hence the famous Hapsburg jaw!! People? Glass Houses??
Grief has a way of estranging people.
My two grandsons aged 8 and 5 have haemophilia B. They are both well and have a weekly injection of the missing factor. This means they are able to play games and do rough and tumble games. We all treat him just as other members of the family.
A terrible thing about treatment, at least when I was still working in health insurance around 3 years ago, was the exorbitant cost of the treatment. It is absolutely criminal and I'm so glad to hear that your grand babies get what they need.
Alexei and his cousins, Waldemar, Henry, and Alfonso, had haemophilia when they were little babies, and Friedrich "Frittie" had haemophilia when he was toddling around, but fell and cut his ear.
glad to read that. thank goodness medicine is so advanced today!
@@share_accidental You are such a friendly commenter!
Both my brothers have hemophilia factor nine, they don’t have to get the factor every day but if they have a serious injury, we have the medicine ready my older brother has it worse than my younger brother
it's always so nice to learn things about Queen Victoria's descendants
I mineself thrice legitimately descend from '(Queen Regnant) Victoria.' 😊 God bless 'the Christian British Empire.' 👑 🦁 🇬🇧 🍵 🏵️ 🌹
@@The-One-True-Emperor Can i ask what child of Vicky you descend from thats so cool
@@ThatOneSandwichGuy- In my father's maternal ancestry, it is Victoria's daughter 'Alice.' In my mother's paternal ancestry, it is Victoria's daughter 'Beatrice.' In my mother's maternal ancestry, it is Victoria's son 'Edward VII.'
Ikr, with the amount of descendants she had I could probably be one of them! 😂
@@The-One-True-Emperorthats really interesting! How did u find out?
Alexandra Feodorovna was actually one of Queen Victoria’s favorite grandchildren, and the Queen decided to watched over Alix and her siblings' education after Alice died. She admired the young, beautiful Alix so much so that she wanted her to marry her cousin, the future George V. It's interesting to hear how history would have turned out if this marriage actually occured. Hemophilia would have been spread to the future monarchs of the United Kingdom. It also would've been interesting if George V had saved his cousins and given them sanctuary (he was a first cousin to the Tsar and Tsarina); maybe the last Romanovs could've survived. Another what if scenario is if Nicolas had changed the succession laws so that Olga could have become empress regnant. History and its many what ifs are fascinating
I thought it was his older brother, Prince Albert Victor, who was considered as a husband for Alix. He was actually seriously interested in her, and hurt that she rejected him in favor for Nicholas.
If they both married, I believe the children would resemble much like the tsar-tsarina’s children; boys and girls
George V sympathized with his Romanov cousins, but the rescue plans were extremely dangerous and had little chances of success. He knew the British people would not accept the loss of British lives while rescuing another royal family. In addition, some had a problem with Alexandra being a German princess, but most did not realize that her grandmother, Queen Victoria, raised her in the UK, and she was her favorite grandchild.
@@cakt1991 I did my research and yes, you are correct. Alix was first proposed as a bride for Albert Victor, who died of influenza in 1891. Thanks for informing me!
I was looking for a comment like this. OTMA and Alexei didn't deserve to die because of their parents.
When I learned about x-link recessive in biology class at school, the textbook showed us the family tree of Queen Victoria. I just wondered who are all these people, back then when information was scarce in my country. Who knows years later you would come up with the complete stories of each of the affected family members. What a perfect video
My oldest and dearest friend died from leukemia in 2006 at the age of 40. Since that time, I have been passionate about blood donation.
I could always tell when Lisa had had a blood transfusion before my visits to the hospital. She had so much more energy, and looked so much better.
Please donate! ❤
rest in peace to your dear friend❤
@@ms.migrant Thank you.
Plasma center nurse here!! Thank you for bringing awareness to the need for donations. It can take up to 130 donations for enough medicine for one patient for a year. So it is really important to donate.
My oldest was born very premature and underweight. She required a blood transfusion.
I am forever grateful for her donor.
I taught elementary school throughout the 1980s. My first year I had a boy in my class who had hemophilia, and trying to keep him safe was almost a full time job on top of my regular duties. If he lost a tooth, got a cut or scrape, fell or bumped into anything I had to immediately call 911 and have the EMTs take him to the nearest hospital ASAP. When he would lose teeth he’d hemorrhage. Because of budget cuts our school didn’t have a full time school nurse, so I had to learn serious first aid skills in order to keep this boy from bleeding out before the EMTS (who were already stretched thin because budget cuts forced them to have fewer teams and very large areas to serve) could get to the school. It was terrifying to witness what is a normal part of childhood turn into a serious medical emergency every time a tooth fell out or he got bumped by another child.
A few years later one of my teaching team members had a boy with a even more aggressive form of hemophilia. For his safety he had to use a wheelchair. Even so, he was very athletic and would take dangerous chances by running and playing around when he was outside at recess or PE classes. This was at a time when AIDS was new and blood donors weren’t always screened for AIDS, blood disorders and other illnesses. The fact that an unscreened blood donor might pass AIDS onto him through a transfusion was a very real possibility (until mandatory blood screening became the law of the land), and the thought of that was constantly on his mind. Several times when I was on recess duty I would find him crying in out of the way places on the school grounds. Even though medical research has resulted in many breakthroughs in treating hemophilia I can’t help but feel great sorrow for the parent who inadvertently passes on the hemophilia gene to their child and the children who are born with it and can’t live a “normal” life.😢
I didn't even think about them bleeding after losing each tooth. Omg. Imagine being a woman and this family, watching your brother suffer like this... then your son.... then your grandson.
Throughout every pregnancy, wondering if the baby had it or not. And I bet some of the female carriers bled heavily during childbirth.
Just awful.
If as a woman you had the Heamophilia gene when you started menstruation well you usually died @
It was in 1970 when a Nobel price came out to find hepatitis in the blood by an analysis. Up to that point people will donate bad blood, my mother had Hemofilia like me and she was giving a transfusion with hepatitis in 1967. She died of hepatitis in less than 3 months, I was 10.
Most doctors even today don’t have a clue of what is Hemofilia and often don’t give the respect of a serious medical condition.
In 1980’ many people died of transfusions of plasma infected with AIDS.
Thank you for being a great teacher. I had students that needed the epipen and we would pass off the fanny pack each day when we acquired the student, then hand it to the next teacher, and the peanut butter kids (also epipens and huge cleaning requirements, as peanut butter was not yet banned from school), but never anything like that. I hope all the students you taught and their parents saw what a caring and dedicated person you are.
Love this fundraiser and bringing awareness to the importance of donating blood. My dad survived AML in 1984... he was given over 125 units of blood. At a time when AIDS was very much a danger in donated blood, it added another layer of uncertainty of remission. Superb content as always!
When my Mum gave birth to me in Malawi, in 1982, testing was not routinely carried out on blood to be donated. Luckily, my Mum's midwife was an American nun who was also a missionary and knew about HIV. She had her own group of friends whom she called upon, who got tested regularly and one of them donated safe blood for my Mum. Luckily, although I was very premature and sickly at first, I didn't need an exchange transfusion ( own defective blood removed and then replaced with blood from a healthy donor,) and only required some time under bilirubin lights.
I had a coworker who had it, and he was a bit of a daredevil, like some of these princes. He occasionally would be out of work for a week or so at a time but was out longer after he had jumped off of a moving train. He had jumped on it while it was moving slowly through town, not expecting it to speed up outside of town, where he anticipated jumping off of it near his home. Amazingly, he fully recovered.
One of the causes of hemophilia is mutation that can occurs when the father is an older father at conception. Victoria’s father was in his late 50’s when she was conceived. This was most likely the cause of the disease in her family line
Interesting!It's in the video I think
There is some speculation her mother had a lover and this where it came into the royal family.
Defo the cause. Victoria looked like her dad in a wig and had hanoverian beedy eyes. John conroy was described as attractive and he definitely wasnt a hemophiliac. She looked nothing like Conroy and didn't look like her mother (looking more like the Hanoverians).
Exactly! Victoria looked like her father, with Hanoverian-line genes. I don't believe the theory that Victoria was fathered by someone else her mother was involved with. Nope, re Conroy being Vicky's father. The other historical factor to recognize is that Victoria was specifically conceived to carry on the British monarchical line in the first place! The children of King George III and Queen Charlotte had problems producing legitimate heirs. It's rather amazing how devoted George and Charlotte were to each other, especially considering the libidinous, unfaithful exploits of George's ancestors, siblings, and his own progeny. 😳 It's an eerie, macabre, yet in some ways fitting fate for Edward, Duke of Kent to have finally produced a legitimate heir, but due to his age, a mutation occurred which caused horrible suffering to be passed down. Wow, the tragedies are like a Greek tale of royal hubris. 😮 In any case, Victoria was a very poor mother. Her own mother had treated her like a prized possession to be owned and controlled, so she did not have a good role model. Despite being strong in standing up against her mother and Conroy, she surely suffered emotional and psychological damage from her childhood and teenage experiences, before she inherited the throne. While Victoria herself had more love for her own children, it was an obsessive, overbearing love. Plus, she hated having children, despite adoring and idolizing her husband. She blamed her oldest son for her husband, Albert's, death, and she monopolized her daughters' affections. Victoria not only passed down haemophilia to her descendants, she also passed down toxic family dysfunctions. Porphyria is another disease in the British royal family, with proper diagnosis and treatment unknown until the 20th-century.
The cause is mutation caused by incest my dear. Victoria and Albert were cousins like most of Royal famililies
My hearth goes specially to poor Alexei. His parents concern and love for him drove them to Rasputin. May the baby of the romanov family rest in peace alongside his loved ones❤❤❤❤❤🙏🙏🙏🙏🙏🙏
Amen
I always thought Rasputin was a con artist who took advantage of sick parents wanting help for their son.
🤔 maybe if they didn’t keep it such a secret, the people might have understood WHY he was around? Idk, just a thought. They (meaning anyone, I guess,) STILL don’t know how he helped that poor boy, but he did🤷♀️. Tragedy at the end, no matter what. Brutal.
🙏🏻 Romanovs...we know.
@sweethistortea He was a con artist and didn’t have any supernatural power. The reason he was able to help Alexi was because the royal doctors kept prescribing him aspirin which actually makes people bleed even more than usual. Rasputin knew this which was why he would tell Alexandra not to let the doctors bother Alexi. He was pretty much trying to tell her to stop letting those idiot “doctors” give her hemophiliac son pills that would make his bleeding worse.
9:36 Ernest, unfortunately, got his wish in a twisted way. Shortly following his death, most of his near relatives were going to Britain to attend the wedding of his second son Louis and his British fiancé, The Hon. Margaret Geddes. Unfortunately, Ernest’s widow Eleonore, son Georg Donatus, daughter-in-law Cecilie, Georg and Cecilie’s 2 sons Alexander and Ludwig, and Cecilie’s unborn son all perished in a plane crash in Belgium. Cecilie and Georg’s only surviving child who had not been present on the plane, Johanna, died a little less then 2 years later due to meningitis.
Thanks as always for such a magnificent video girl! Your work is leagues above all the documentaries on television! Love you, your passion and dedication!
Okay, so I have watched most of your videos, multiple times, I have never given a care, really, about any of what I have seen, heard and learned. I don’t even know how I happened upon your channel, couldn’t tell you! But, I do know you have awakened the thirst for knowledge, I am excited when I see a new video and have shared my new knowledge in conversation with many.
Thank you for what you do, truly, you have helped me obtain genuine love for history, something I didn’t think would matter to me as much as it does. You’re a wonderful escape, time traveling with you is awesome!
Thank you so much!
Actually the treatment now doesn't include plasma transfusion anymore because of the antibodies that can appear with the multitude of transfusion needed .
There are synthesized clotting factors which are administered once or twice a week and they can give a life very, very close to normal. The treatment is very expensive , that's true.
Genic therapy is still in the earlier stages, but hopefully will get there soon.
Wow Lindsay! What an original & informative slant on hemophilia & Queen Victoria’s descendants, thank you so much for all of your research, not to mention your terrific grammar and wonderful way of speaking. It’s such a pleasure!
I'm honored to donate platelets twice a month.. Platelets can be stored for only 5 days, before they are unusable, so the need is constant. Also, they can be donated up to twice a month, or 24 times a year. It is mere moments of discomfort (with the needles) to literally potentially save a life. Thanks for the great video!
If you think about it, it’s pretty miraculous that hemophilia missed the Habsburgs. Sure…they had other problems from their inbreeding, but hemophilia wasn’t one of them. I just find that interesting.
They were having kids with no one but each other. So as long as no one married someone outside the family there wasn’t gonna be an introduction of it
It’s mostly because the British royals tended to marry other Protestant royals. Only when Victoria Eugenie married into the Spanish royal family did this change. if one of her daughters was a carrier and had married into the Austrian Imperial Family, it could’ve been brought in.
@hotaruchibi1669: Interesting? Whatever floats your boat. Queen Victoria wanted Alix of Hesse to marry the oldest son of Edward Vll, which would have been her first cousin, but he died. Her ‘replacement’ was Mary of Teck (Queen Mary, mother of George Vl, Dukes Kent, Gloucester and Windsor) so it’s possible that hemophilia would have surfaced in the Windsor line.). Everyone in Queen Victoria’s family had enough sense to stay away from the Hapsburgs in marriage.
@@jontaedouglas7244: “. . . gonna be . . . “. Well, everyone knows you’re poorly educated!👍
@@johnpickford4222 and that son was not a Georgie but rather, Albert Victor. Albert Victor was supposedly madly in love with Alix and wanted her but she wanted Nicky.
I so enjoy this channel. I've learned so much here and continue to learn more and more with every video. My grandchildren watch with me and get a history lesson without even trying. Thanks! 💛💛👏👏👏
Poor Alexei had so much pain in his short life 😔
20:42 Lindsay, your (correct) graphic contradicts what you are saying! A man with hemophilia will always pass the trait on to his daughters because he can only give them his affected X chromosome. Since his Y chromosome is unaffected, he cannot pass it on to his sons.
Ever since I listened to this on your podcast I've been dying to see the video for it. ❤ Thank you for uploading this and all that you do. This one was such a tearjerker when I heard it and the video was amazing. Keep up the great work in everything you do 😊😢❤
“She [Victoria’s Mother] had two offspring with a German prince, a son and a daughter. Few medical details are publicly available about the daughter’s line. The son, however, is reported to have died from bleeding from his internal organs in his early 50s. He had two bleeding attacks weeks apart. The local hospital successfully stopped the first bleed but could not stop the second. He died from apoplectic shock consistent with hemophilia.”
Hemophilia of Georgia
The Royal Disease: A Family History Update on Queen Victoria
True. Thank you.
If I remember correctly, the type of hemophilia Queen Victoria passed on was passed onto her by her own father. Something like his age and health affecting Victoria's genes, if I remember correctly. He was in his fifties when she was born
It makes sense. Women have all their eggs for their whole life form when they are in the womb before they are born. A man’s sperm is continuously created then dying before new sperm is created, so it’s easy for any damaged genes from an old father making it’s way to their child.
Not known for sure. Could be a gene mutation on her dna . It could happen with the percentage of 30%. They also said women are carriers and don’t suffer. That’s not exactly neither. I am a female and I have that genetic mutation and Von Villebrand also . Maybe milder than a male but still dangerous.
Yes old dads can make this disease, and many other more likely
@@mariapilarmeI have read about that possibility, that it might've been a spontaneous mutation.
It’s crazy the amount of time and effort you put in these videos , you really are one of the best channels for us crazy history ppl. 👌🏾😅💕
I remember first listening to this episode when you first released it on the podcast. Just as heartbreaking listening for a second time.
Rasputin never "cured" or stopped Alexis' bleeding. At most he brought emotional relief to his mother, Alexandra, who had faith in Rasputin; as postulated by the author Robert K. Massie, this probably in turn positively affected Alexis emotionally. There is a well known story of one bleeding incident that happened during WWI. Alexis was at Stavka (army HQ) with his father, and they had to rush back to Tsarskoe Selo because Alexis developed a severe nosebleed. According to accounts by the time they reached the Alexander Palace (the family's home) the boy was at death's door. Alexandra sent for Rasputin, who prayed over Alexis, and the next day he was better. This often-repeated account is attributed to the memoirs of Anna Vyrubova, a somewhat disreputable source, and Grand Duchess Olga, who didn't actually witness it but relied on accounts told to her. However, after the fall of the Soviet Union and the state archives became available, Nicholas' diary and letters from Alexis to his father (who returned to Stavka soon after; that makes me think the episode may not have been as severe as reported) specify that Alexis' recovery was due to the imperial surgeon cauterizing his nostrils; neither of them make any mention of Rasputin.
Rasputin was a daring gambler all his life. What did he have to lose to say "your son will not die" to the empress?
yeah. I think you are right, Rasputin was like hypnotherapists or just had psychological effect on Alexandra and Alexey. I don't think he knew about even snake poison. I'm wondering if they write each other royal families about diseases of their kids. I know they tried to hide it as much as possible, but still they could figure out that this is the same disease in the family tree.
I really enjoy your program. I have been watching them for a long time and you are getting better with each one. Thank you for this one on Queen Victoria's descendants with hemophilia. Each program is better than the last..Keep up the good work.
24:31 This could also be the explanation as to why Empress Alexandra’s sister, and Waldemar’s aunt, Grand Duchess Elizabeth Feodorovna and her husband, Nicholas II’s uncle Grand Duke Sergei Alexandrovich, never had any children, despite being very fond of kids. Both of them would have been well aware of potential for any of their children to have the disease or be carriers of it.
They did however, effectively becomes second parents to her husbands niece and nephew, Grand Duke Dmitri Pavlovich and his sister Maria Pavlovna, and to one of Nicholas II’s nephews-in-law, Prince Felix Yusupov
Sergei Alexandrovich, not Paul. Paul certainly had children, Maria and Dimitri that you already mentioned 😉 and three more with his second wife later on.
More likely Sergei and Ella didn’t have children because Sergei was gay.
@@piratesswoop725 I didn’t mention the last children because they were *morganatic* children, not in line for the throne, and thus irrelevant, and as far as I’m aware, Ella and Sergei had no relationship with them.
That and there is no surviving evidence, even society rumours about Sergei. And the lengths he had to go to to marry Elizabeth suggest not. There would’ve been far easier princesses to court if he wanted a sham marriage
possibly one of them had fertility issues. Her eldest sister had healthy babies, and the whole family was in denial of hemophilia. Infertility can occur absolutely independently of the issue of whether she was a carrier or not. this is speculation, but a plausible one.
@@piratesswoop725And you repeat that disgusting fact why? How do you know he was gay? Do you recognize the same traits in yourself?? There are many reasons a couple can’t conceive a child that could be at fault. Grand Duke Serge very likely could initiate intercourse but have a low sperm count when ejaculating. Or there could have been an issue with Grand Duchess Serge (Elizabeth). Grow up and don’t be a cavalier a** on such a sad and tragic history.
@@dorotakarpiel6717That’s fair. I mean the two running theories are either infertility from one of them or preventing their children from suffering from or transmitting incurable disease. It’s hard to deny the possibility
Or maybe both, who knows
Girls bleed too! Blieeve her!
As both a historian and a female bleeder, I am so glad to see this! I've had over 500 blood transfusions, factor infusions, plasma/cryo and iron infusions, etc. That's a lot of people who have donated to help save others. Thank you!
You're brave to share that female hemophiliacs exist, and it's really awful that female hemophiliacs are underdocumented and not given nearly as much coverage as male hemophiliacs.
This is so fascinating. Thank you for doing this. I love these kinds of knowledgeable period pieces. You did a great job voicing and producing this video. Thank you ❤😊
Also, there is one known modern descendant of Victoria who has hemophilia-Ferdinand Soltmann, who is twice descended via his maternal grandfather, once from Prince Alfred and once from Princess Alice. Here’s what’s interesting though-we know Alfred was not a hemophiliac, so Ferdinand could not have inherited it from him. And we know Alice was a carrier, so that’s the far more likely option. However if he did inherit from this side, it would mean that Alice passed on the trait to at least THREE of her daughters and that there are more carriers and at least one more sufferer that aren’t documented.
The line would go like this:
Princess Alice > Princess Viktoria of Hesse (later Marchioness of Milford Haven) > Princess Alice of Battenberg > Princess Margarita of Greece and Denmark > Prince Kraft of Hohenlohe-Langenburg > Princess Xenia of Hohenlohe-Langenburg > Ferdinand Soltmann
So that would mean that Prince Philip’s mother was actually a carrier and passed the trait on to at least one of his sisters! Allegedly, Kraft’s symptoms were mild, but it was known in the family that he had some clotting issues. Unfortunately he was cremated so we will never know for sure (unless we could exhume Viktoria, Alice or Margarita and test their DNA). Kraft would be the only one of Victoria’s hemophiliac descendants aside from her son Leopold, to father children. Like Leopold, both of Kraft’s daughters would be carriers, but his oldest daughter has no children.
Well the late Dowager Princess of Hohenlohe-Langenburg is buried not far from the H-L family crypt with her husband, Gottfried. Alice is buried in the Church of Mary Magdalene in Jerusalem and the late Marchioness of Milford Haven is buried in St. Mildred’s Church on the Isle of Wight.
So one would need permission to crack open a privately owned tomb belonging to a ludicrously wealth German aristocratic family, the subterranean crypt of one of the most prized churches in all of Orthodox Christendom and the cemetery of an English church under the jurisdiction of the Church of England with a very long and extant relationship with the British royal family, both the ecclesiastical hierarchy and St. Mildred’s itself…
I wish anyone who wants to undertake such a great deal of luck. And to anyone who is successful… buy a lottery ticket
I knew Prince Kraft since he and his first wife were friends with my parents in the 1970s und 80s and he was a healthy and active man. It was confirmed by genetic testing that Queen Victoria had passed haemophilia B onto her descendants which is the more severe form. Prince Kraft was born in 1935 before effective treatments were available. It is very unlikely that he had this disease without lasting damages to his joints even if he was treated with clotting factor since the 1960s.
So, how come Prince Phillip did not have it??
@@beefstew4698 Because sons have a 50/50 chance of inheriting it, and Philip luckily landed in the 50% that didn’t inherit the faulty X chromosome from his mother.
@@beefstew4698 50/50 chance for each child to be a carrier if they’re female and someone afflicted if male. 3 of Queen Victoria’s 4 sons didn’t have heamophilia, and Philip was Alice’s only son. It’s fairly reasonable
For anyone wondering, Maria’s primary suitor for most of her life was Lord Louis Mountbatten (yes, the Duke of Edinburgh’s uncle). Since men are responsible for the genetic code that determines a child’s gender, it’s very likely Maria and Louis, had they married, would like Louis and his wife Edwina, would have had 2 daughters. So the effects of the disease and tragedy therein might have been even longer lasting if Maria had lived to marry.
It wouldn’t be a certainty that Louis and Maria would’ve just had two daughters.
Interesting…however, there is no historical evidence that Maria returned Louis’ affections
Blue blood wasn't because being royal their blood was blue. It came from the Spaniards with light skin (no Moorish DNA) being able to see their blue veins on their arms, so it originally meant "pure" and later it was a used to any group that only married among themselves, i.e Royalty and the Aristocracy.
Really good video, Lindsay, but to all who haven’t yet, I rly recommend you to listen to the podcast she has on this topic. It’s a real tearful listen, but really good
I liked the Doctor Who explanation on where the hemophilia in the royal line came from. It was a very fun episode!
what episode was that?
@@n.gasish7956 S2 E2 "Tooth and Claw"
Fuck yeah!! Alien werewolves!!
Thank you for this video. We have hemophilia in my family. I have a similar clotting disorder called Von Willebrands Disease (which women and men can get alike), so this topic fascinates me…
Mine too.
@AimeeRose22 my mother had Von Willebrands as well. She had 5 brothers and sisters, who did not. I was tested as a child, and am a carrier. No one since in our family has any symptoms. I haven't met anyone else with Von Willebrands. I stumbled upon this video by chance. Do they treat you before surgery or dental procedure? They did my mother.
@@rjustr my dad and i have von Willebrands while no one else in the family does. Transfusions of clotting factors are needed before and after surgery. Being careful of bruising and cuts was normal part of my life as well as coping with other aspects of being female.
@@cat6022 hope all are as well as they can be!
@@rjustr Myself, my sister and my dad all were diagnosed around the same time, my mom and brother do not have it, so I did have support in the family.... I do get treatments with a medicine called DDAVP before surgery (only two surgeries in my life) and dental has been so far so good, just have to warn the hygienist to be gentle. Also I can use a medicine called tranexamic acid for menstrual bleeds that are heavier than usual
Princess Alice was the strongest carrier. So many hemophilia deaths among her descendants.
Heck, even non-hemophilia tragedies rocked her family. Most unlucky among the Saxe-Coburg siblings, definitely.
She died young from diphtheria after caring for her family members who had it. Her youngest daughter, May, also succumbed to it.
Yes, she potentially passed the gene on to three, probably four of her children that we know of.
Really? Can one be a STRONGER carrier than another carrier?
@@silverstuff182Not really, it's just a matter of luck.
dying at 35 yrs old on the anniversary of her own fathers death when she was 18, passing the royal disease to ~ 3-4 of her children, watching 2 of her children die before her, and literally being the grandmother of THE romanov imperial family
shes literally the unluckiest gal in the royal family
These are my favorite types of videos!
Excellent video as always and also raising awareness of donating blood. Congratulations 🎉🎉🎉
I have the opposite issue. My surgeons said my blood clotted faster than he had ever seen and they don't know why. If I wasn't on blood thinners I would love to donate ❤
Please have yourself checked for a clotting disorder! One of my best friends noted a similar fast clotting issue and it turned out to be a clotting disorder which required a Greenfield filter and other medical treatments to save his life. This is not something to ignore-it can be life threatening. Take care.
@freden9234 I am in constant medical care with it should be okay 🥰
My mother's family has suffered from blood clotting disorders, phlebitis being among them. A few of my cousins have them.
There is this book called "The Blood Doctor" I read years ago that piqued my interest in Queen Victoria and hemophilia in her family. Can't remember the author, but as far as fictional works go, it was pretty good. Lily Langtree is mentioned as well.
Barbara Vine was the author. A fascinating tale.
What a grating narrators voice! Thank goodness for subtitles!
Amazing that narration is undertaken at all with a voice such as this: surprising that no-one else noticed. A shame, as the content is excellent.
Maximum rudeness
TBF Alexei died from being executed not because of his hemophilia. It was one of the parts leading to the downfall of the dynasty but the major part of it was because his parents were terrible rulers. Poor Alexei is still awaiting burial
Can't believe he died 105 years ago. I wonder what he would've been like as a grown up
It was a lose lose situation, he was gonna die regardless 🤷🏾♀️ the execution was just the brutal way out, since some of them survived the initial bullets and had to be gunned and beaten down…
good thing lindsay said exactly this in the video.....
@@SomePerson_Online
I forget which Grand Duchesses, I'm pretty sure it was Maria and Anastasia, but they survived the initial bullets because they had jewels sewn into their corsets.
@@erinw.9256apparently all 4 survived the initial gun shots due to their corsets along with bayonet stabbings they were shot in the head that finally ended their suffering.
I believe your interpretation of "blue blood" is not correct. The concept likely originates in medieval Spain as ‘sangre azul’, and is attributed to the rich, powerful families of Castile. As part of their ‘pure Gothic’ descent, they would claim never to have intermarried with another race by drawing attention to their pale skin, which made the blueness of their veins visible. Blue blood was actually used to accentuate their "whiteness." In addition, pale skin has been long associated with the upper class, as they did not have to work outside, as the lower classes did, hence they had pale skin. This even continued into the late 1800s in the US, where women wore sun bonnets to maintain a pale, lady-like complexion.
My grandmother was'nt particularly pale, but she did wear a sunbonnet---to avoid sunburn.
@@Lily-wp8ol My Grandmother always wore a hat as well. I once bought her a sun bonnet just like the pioneer women wore at a farmers' market in Kitchener about 3 h. from here. It was more of a joke than anything. I thought she would laugh about the bonnet, but she loved it and wore it outside all the time. She wanted me to get her another one, but I was nowhere near that farmer's market and couldn't. This was in the 1970's so the tradition of not wanting to be tanned was still alive then.
And continues with Chinese women who actually walk around with umbrellas in the summer to avoid tanning...
"A lady can never be too pale", my grandmother used to say. When you are allergic to the sun (Porphyria), you do not really have a choice.
great work, Lindsay! thank you! 💚
This was incredibly interesting. I am a nurse with a huge interest in English history. ( my mom descended from England) and also the last czar of Russia and his family.. I've always wondered who all inherited the disease and if it was still present in royal families. You did such a great job in the final summary also. Thank You.
You can have the spontaneous mutation on one of your children and you and your partner don’t have it. The possibility is 30% without be part of any royal family. Although it’s very rare affect 6 people of 100,000 . I have it and I am not Royal and female.
My partner has Hemophilia type A! While he thank god has a quite mild case it is still such a scary disorder
You are great! Wonderful research. Awesome video!😊😅
Thank you for reminding people to donate blood. I don't have hemophilia, I have a very rare platelet defect which I passed on to my youngest son. He has need platelet transfusions on a couple of occasions. There are a variety of clotting disorders other than regular hemophilia (Von Willebrand's, Christmas disease, etc.). Everyone who has these will likely need a transfusion at some point in their lives, or blood products. People with leukemia also frequently need transfusions. I am grateful for all the people who do donate. Thank you from me.
This was so grand. Thank you
Since I am an American cousin to the British Royal family I found this video fascinating. I will be going in for my annual blood tests which now includes Genetics. I will asked the tech to check for hemophilia.
You should ask for a referral to a genetic counsellor, not just the testing. Testing, when not ordered correctly by a genetics professional, can sometimes be misleading
My Mum received a blood transfusion in 1982, in Malawi, where there was no routine screening for HIV. Fortunately, her midwife was an American nun and missionary, who knew about HIV and for that reason, only used donated blood from her group of personal friends, who were all screened routinely, before they gave donations.
Grand Duchess Maria Nikolaevna had her tonsils removed as a young teen. She was in danger afterwards due to her blood loss.
She was a carrier not sick..
@@JJ-bo6ncfemale carriers can experience bleeding episodes as well, due to uneven X chromosome inactivation
Maria's hemorrhage during that tonsillectomy is why some believe that she may have been a carrier. When her family's bones were tested in the 2000s, they not only confirmed that Alexei had hemophilia B (and in the process, confirmed that hemophilia B was what Queen Victoria passed on to her descendants), but that one of his sisters was a carrier. We'll probably never know for sure which of the sisters was a carrier, but historians seem to think it was either Maria or Anastasia. Maria's hemorrhage might indicate it could have been her, but we'll never know for sure. It's sad in hindsight though, because Maria dreamed of marrying and having a large family. If she had survived to marry and have the many children she dreamed of having, then if she was the carrier in the family, she could have passed it on to the next generation.
@@darkbella1552 You're right about the inactivation. It's called skewed X-inactivation, and it exists in females to ensure that there's dosage compensation between males and females. If both X chromosomes were active, then females would have twice the number of active X genes than males do, which is why one X chromosome is randomly chosen for inactivation at approximately the time that embryonic implantation occurs. Most females have some levels of skewing, and it's relatively common in adult females. This means that if female carriers of hemophilia B show symptoms of the disorder despite having that second X chromosome, then it means that the healthy X chromosome might have been randomly selected for inactivation, and the severity of the symptoms may hinge on what the skewed ratio is, because extreme skewing, where over 90% of cells have inactivated the same X chromosome, exists.
Skewed X-inactivation has a lot of medical significance, and the fact that it exists in most females indicates the possibility that female carriers among Queen Victoria's descendants may have suffered more from the disorder than was initially assumed. We'll probably never know for sure, but depending on the level of skewing, some of the female carriers in her line could have suffered the symptoms with varying levels of severity. Grand Duchess Maria's hemorrhage during her tonsillectomy not only raises the possibility of her being a carrier (although we'll never know for sure if she was the carrier or one of her sisters was), but also that if she was the carrier (only one of the daughters was confirmed to be one when the family's bones were tested in the 2000s), then what her level of skewing was. Skewed X-inactivation is definitely a very important aspect to consider when it comes to female carriers of not just hemophilia B, but of any other X-linked recessive genetic disorder such as hemophilia A and red-green color blindness. In fact, I wonder if for female carriers of red-green color blindness, their color vision is affected if the X chromosome not carrying the gene is randomly inactivated in favor of the one that has the color blindness gene depending on the level of skewing.
I am really not convinced Maurice had hemophilia. Leopold, yes, but there’s no way they would have allowed a hemophiliac to serve in armed combat. Leopold, for example, only ever had a desk job, but Maurice was in full combat.
The disease we're covered by the royal family so of course they wouldn't know
Consider that hemophilia is a very new disease I'll doubt they know
A weird nitpick but I feel inclined to mention it - You described Victoria as having "beady eyes" but this is typically used to describe someone with very small eyes. Perhaps you meant protuberant eyes? - which are large eyes that bulge out. That seems to describe Victoria better I think.
Her descended family has beady eyes-But yes she has bulbous eyes..
@@beastshawneesome of her descendants like Prince Andrew an Princess Beatrice resemble her.
We refer to them as "Hanoverian".
I believe there is actually still a haemophiliac living today in amongst the descendants of Queen Victoria, a boy in the Hohenlohe-Langenburg branch whose haemophilia may possibly have arisen by coincidence rather than through this previous haemophiliac lineage. There were also rumours of haemophilia being present in the Weilers (descendants of one of Alphonso XII of Spains' daughters).
I think his last name is Soltmann and yeah he is the last living carrier of Victoria’s descendants. Damn I can’t think of his last name but he’s a handsome young man. German AF.
Edit: i looked it up, it’s Ferdinand Soltmann.
The most shocking information I heard on this video was you saying you have a reminder to donate blood every 8-10 weeks because in my country we're only allowed to do it 3 times A YEAR!
She might have confused blood donation with plasma. You can donate plasma much more often, in fact many people sell plasma to pharmaceutical companies for the production of vaccines, blood tests, and treatments.
if i remember correctly, the romanov children’s paternal aunt olga recounted how the girls bled more than normal and how during her tonsil surgery, maria bled excessively.
Now I know it’s Waldemar who last died of hemophilia among descendants of Queen Victoria. I voted for Gonzalo. Thank you dear Lindsay for historic education! ❤😊
I found this video very enlightening and heartbreaking at the same time.
Thank for this video really appreciate it❤️
This is such a beautiful video, wonderfully researched. I have always been so interested in hemophilia and hemophilia in queen victoria's decendants.
Such a GREAT VIDEO! From a health care providers perspective we could almost show this as an explanation. Great job. Love it. Hope the princesses babies have no effect and also don't carry. ❤
As the father of a son with Type A sever Hemophilia less than 1% clotting ability, and all the literal horrors and indescribable suffering that is a part of their lives, not to mention HIV and AIDS related 97.9% death rate of any Hemophiliac receiving Factor 8 (Type A) and/or Factor 9 (Type B) before Nov. 1985 to quell (not cure) the immeasurable suffering we ,son, mother, father, grandparents etc. have lived through I can't watch this without weeping, and reliving untold horrors. All true and valuable information and for the Sons, parents, and all related family these facts are important to hear and know. There have been times when the devastating pain as a parent buckled my knees, made my eyes, involuntarily, cross and roll back into my skull requiring 5 to 10 min of massage to be able to actually see again.....then off to another midnight run to face pain and suffering on an unimaginable scale. I hope and pray you, the reader, never have a chance to know this reality. There are just not enough words.
This was very well done, thank you.
Absolutely superb!!!! You did it again!!!! Fantastic and I love that this vid also came with purpose!!!!!! Love it please keep up your great work!!!!!!
Our family has hemophilia but luckily I am not a carrier. My grandmother and aunts were. Factor 8 is the clotting medication my uncle and cousin used. They were both affected with HIV due to the blood transfusions. It’s a horrible affliction. For most hemophiliacs the internal bleeding and joint pain is the worst. Luckily we have genetic testing now. I would not have had children if there was any chance of being a carrier. My mother actually flew to Pittsburgh to have her testing done with the man that invented the carrier test! This was a fantastic video. Thank you for educating so many on this!
The Royals Intermarry in order to keep the bloodline pure. But, it causes genetic disorders like hemophilia. How many other genetic conditions did they suffer with?
porphyria, mental developmental delays, the habsburg jaw
The Ancient Egyptian royals married siblings, King Tut had two daughters (who were technically also his nieces) with his sister/wife who died as infants.
Royal intermarriage in this case did not cause hemophilia. Most likely it was a spontaneous mutation at Victoria’s conception. She would’ve passed the gene on whether she married Albert or a local fisherman.
And you have to admit that both the late Duke of Edinburgh and Queen Elizabeth II lived long, healthy lives, despite their respective ancestors having married cousins of one degree or another. And their children don't seem to have suffered any concerning medical issues.
I thought they intermarry because of political reasons. I heard the Habsburgs didn’t have any but themselves which explains the constant intermarriage.
I had wondered why the Tsar didn't marry off his older daughters to save them during WWI. The fact that they may have been carriers and marriage contracts would have been difficult to make hadn't occurred to me until I watched this presentation.
Thank you.
The girls REFUSED marriage; in the summer of 1914, the Romanian family wanted Olga for their Prince, Carol, but Olga (and her sisters) wanted to stay in Russia. Carol was a scuzz anyway, a horrible person.
@@meeeka Thank you.
Love your videos
You know I’m surprised that no one in more recent generations have it. Especially considering Charles is his own cousin
I used to donate plasma pretty regularly when I was younger. Sadly the last time I donated (blood that time, not plasma), I nearly passed out afterwards (I recall the staff kept asking me to tell them my name which I thought was strange, I was so out of it). My husband said, "I think they have enough of your blood/plasma now." A few years later when I got pregnant, I was in for a blood test (typical testing for pregnant women), again I nearly passed out and my ears were pounding. It was so weird after years of donating and no issues. Needless to say, every time I needed blood work, I'd have to lay down. So strange and I haven't been able to donate since, for fear of having a similar experience. Wish I could help donate plasma again.
Great video, thank you!
Lindsay, this video is so informative and well done that I am watching it again, 11 months later after its initial release. ❤❤👍👍😊😊
You're quickly becoming one of my favorite channels.
I didn't know blood donation has benefits! Thanks!
Pls do a video on royal families of European countries whom had family members whom had disabilities
*Hapsburgs enter the chat*
Thank you for the information on the Romanovs. I always wondered which (if any) of the girls were carriers.
What would the video will covered next?
Royal blood line of Liechtenstein, Sweden, Spanish, Japan, Luxemburg
Amblosh Royal countries
Royal scandal
Always interesting stories that keep me glued 😊. Thx.
Ooo excited for this one
This video is very well done, but very sad.
The last boy of Mary of Teck (The lost prince, John Charles Francis 1905-1919) also had Haemophilia. Mary was a first cousin of Victoria and her grandchild became Queen Elizibeth II.
Mary was first cousin once removed of Victoria's, John certainly had several health problems but I've never heard of him having haemophilia
Ohhh
A friend of mine in college had hemophelia. He had to receive clotting injections quite often. He had a twin brother who had excellent health. Difference in height and weight between the 2 was astonishing. The disease had severely hindered my friend's growth. He did eventually marry and had a great profession as a mechanical engineer. I don't know why he committed suicide.... but I can imagine how painful his life was.
Maybe he couldnt cope with it anymore
I agree, this was an interesting video. “Thank You!”❤
My Mom, age 71, who faints over needles, (and even an ear piercing gun at the mall) still donates. She's O negative, the universal donor, and feels it's her duty. I'm O+, but still follow her example and give my blood too.
I am 0-. We can only receive blood from other O- people. We can give blood to all other types, including positive blood types. I give blood. I need to give more often. O- blood is needed so much!
The narrator is rolling me with all the Ya's!!! hemophili-YA, ide-YA, YA, YA, YA!😂😂😂
This was really interesting and well done. Thank you.
This video answers the question we all had (honestly tho i love your videos)
My brother’s childhood friend has hemophilia. He always had to be careful when horse-playing with my brother. Any bump or scrape could be dangerous. He’s living a good life, though. He’s married with children.
Very incredible. So glad to have found the channel
Very informative. The Romanoff's were such a beautiful family
In the UK after "mad cow disease" the risk of transmission by transfusion was recognised. In New Zealand I received a British cornea as a transplant. Although I had been a regular blood donar my blood was no longer wanted, this lasted for a number of years.
I had to stop giving blood in Australia, there used to be a rule preventing people who lived in the UK between 1980 and 1996 from giving blood in Australia, but it was changed on 25 July 2022. I am now almost too old.
@@janetpendlebury6808. Same rule here in the US
When growing up in Singapore, they did not accept my blood, because of the risk of BSE transmission risk ( I believe this ruling was changed, just this past October.) In the UK, when I used to visit my family during the summers, I could not donate blood also, because I had spent time in a malarial country within the last 12 months.
I never understood why The Romanovs didn't keep having children. Part of me thinks that, if they had another-healthy- son, things might've gone differently.
Imperial Russia’s throne went to the sons cos Catherine the Great’s son was salty.
Alexandra gave birth to the girls every other year between 1895 and 1901; Alexei was born in 1904. There were also two pregnancy losses. Additionally, she was not particularly healthy. It’s entirely possible that either Alix’s health prevented attempting another pregnancy, or a fear of passing the disease to another child.
To add to that, basically by the time she birthed her last daughter, her body had deteriorated so much from the repeated births that her spine was deformed and she suffered from excruciating pain in her lower body 24/7. That was also one of the reasons why she shunned public duties because she couldn’t stand or sit for long, and was constantly reclining in her private apartments. She took a huge risk trying for a son against the doctor’s advice…So sad nothing worked out for her in the end. If you are interested in her story or Nicky’s, read the book Alexandra And Nicholas by Robert K Massie.
@@SCBlahBLah agree, that book was wonderful! Also recommend Helen Rappaport’s books, “The Romanov Sisters” and “Ekaterinburg.”
Um probably bc they didn’t want to or couldn’t, it’s exhausting and is and was certainly very painful and could be certainly traumatic in those days. She had many children and suffered from it, lots of pain that didn’t go away in her back. In those days, and even still today sometimes, more children raised the chances of the mother dying during pregnancy, birth or postpartum. As well as risks to the baby. Also there is no guarantee a son would have been born! I truly hope you can understand and be thankful she wasn’t forced to keep pushing out kids and harming her body for a monarchy that was already on it’s way out even before her time! Alix devoted herself to her kids and especially her son and wouldn’t have been able too with more children or if she had died. That would’ve been too much tragedy even for the Romanov’s.
What a fascinating video! Thanks so much for sharing how we can help.