...Literally, when I hit the 40% pass mark in my exam on Friday - it's going to be because of you... Though, I won't lie, I'm annoyed that a free video on UA-cam helped me more than the £200 worth of books I bought did.
omg you are amazeballlss! everything makes sense now! I was studying for like 2weeks and nothing made sense, and now one day before.. everything is clear. thank you so much xxx
Thank you, your video is very helpful and easy to understand. Books only help to a certain extent. I could not understand it from a book but just a just simple sentence in this vid explained it all :)
From what I learned from Wikipedia, it seems that histone modifications (such as acetylation as described in this video) are considered as epigenetic mechanisms, although it is not clear if histone modifications are inheritable or not. Histone modifications are considered as epigenetic mechanisms since any modification to the histone in the nucleosome invariably has an effect in gene expression or silencing.
Not quite. Chromatin remodeling generally refers to the idea of taking tightly packed DNA and unpacking it so that transcription can occur (since transcriptional machinery cannot act on condensed DNA). Acetylation is involved in the process of unpacking the DNA. So it is involved in chromatin remodeling. Deacetylation, however, is involved in RE-packing the DNA into chromatin. Does that remodel the chromatin? I suppose so, but I think it is convention to consider chromatin remodeling as unpacking the DNA as opposed to re-packing it. In packed DNA, histones carry a positive charge that allows them to bind fairly tightly to the DNA. Acetylation of the lysine residues on the histones gets rid of that positive charge. Thus, DNA is less attracted to the histones, and the DNA separates from the histones -- it gets unpacked. I hope that helps answer your question(s).
and please can you make a video about phosphorylation and acetylation and whar are the different between them,, I mean the action of phosphorylation should be the oppiste of acetylation? in gene expression
Soulaf Kakel Not a problem. If you have questions on a particular video, ask them in the comments section. If I do not get to it or cannot answer it simply in a comment, I'd suggest emailing me. Phosphorylation and acetylation are both post-translational modifications. I'll be making a video on Post-Translational Modifications for sure.
Finally! A video short and simple. I hate videos where they repeat and take forever to get to the point. Thank you!!!
10 years later and this is video is still golden
You rock Moof. I have no clue looking at my class lecture. You make this easy. Thanks a lot!
...Literally, when I hit the 40% pass mark in my exam on Friday - it's going to be because of you... Though, I won't lie, I'm annoyed that a free video on UA-cam helped me more than the £200 worth of books I bought did.
Becky Simpson Lol. My hope is basically to make video databases that essentially function as textbooks. Watching videos > Reading books. :P
Your comment was 5 years back maybe u r last year or already graduated. While I just started 😥
@@kemotaha2381 Good luck on your journey 😎
this is really coming in handy for my molecular biology quiz that I have tomorrow! thanks moof!!!
Sure thing! I hope you rocked that quiz!
brilliant.. short and sweet...thanks😊
Just saw this today. Flat excellent presentation! Thank you.
Such a helpful video, your explanation made it seem really quite simple. Thanks a bunch!
Jack Whittaker Sweet! No prob. I'm happy to help.
AMAZINGLY CLEAR AND SIMPLE EXPLANATION. SUBSCRIBED.
Big gratitude to you. ❤️❤️
omg you are amazeballlss! everything makes sense now! I was studying for like 2weeks and nothing made sense, and now one day before.. everything is clear. thank you so much xxx
flippin legend you are
Thanks for the video! All the process look so easy. :)
Thank you, your video is very helpful and easy to understand. Books only help to a certain extent. I could not understand it from a book but just a just simple sentence in this vid explained it all :)
mia hayes You're very welcome! I'm happy you found the video easy to understand. Mission accomplished. Lol.
This was a very helpful video! Thank you so much :)
But then what does the chromatin remodeling complex does if the histone can be removed by its epigenetic coding?
Amazing video!
I understand this to be "histone modification" not "chromatin remodeling"...any idea what chromatin remodeling is apart from the histone modification?
Thank u so much.
I wish u live in Toronto
This was great! Thank you so much!
What program do you use for writing on the screen while talking?
Joshua Pontier I use Smoothdraw 4 (free) to write/draw everything, and I use SnagIt ($50) to capture/record the screen.
I love Snagit. Such a great tool.
the video wad really helpful, thanks, more power to you :)
Amazing. BIG thank you
This is great! Thanks a lot for sharing.
George misailides Sure thing! Glad you liked it!
Bro I fucking love. That’s all
Thank you ! very helpful
i love you moof
does the actual acetylation occur on the histone tail specifically?
Please upload more videos :(
loai haysam Just uploaded 12 of them. More on the way!
Great!
thank u prof !
bro's god my french teacher just took words from article and let us
Histone modifications clearly play a role in regulation of transcription. What regulates histone modifications? Any thoughts? (I like the video)
Thank you, you are amazing
Mercy Aiyegbusi Lol. Thanks, dude!
Hi moof! Can you please explain what the Histones have to do with epigenetics?
Ktqt, I'm sorry, but I have no idea what epigenetics is. I'd have to do some research before answering that question. My apologies.
From what I learned from Wikipedia, it seems that histone modifications (such as acetylation as described in this video) are considered as epigenetic mechanisms, although it is not clear if histone modifications are inheritable or not.
Histone modifications are considered as epigenetic mechanisms since any modification to the histone in the nucleosome invariably has an effect in gene expression or silencing.
thank you sooooo much
😙thanku
Nice
hi, is that means the chromatin remodelling means acetylation and deacetylation?
is the histone here become negative charge and how?many thanks
Not quite. Chromatin remodeling generally refers to the idea of taking tightly packed DNA and unpacking it so that transcription can occur (since transcriptional machinery cannot act on condensed DNA).
Acetylation is involved in the process of unpacking the DNA. So it is involved in chromatin remodeling. Deacetylation, however, is involved in RE-packing the DNA into chromatin. Does that remodel the chromatin? I suppose so, but I think it is convention to consider chromatin remodeling as unpacking the DNA as opposed to re-packing it.
In packed DNA, histones carry a positive charge that allows them to bind fairly tightly to the DNA. Acetylation of the lysine residues on the histones gets rid of that positive charge. Thus, DNA is less attracted to the histones, and the DNA separates from the histones -- it gets unpacked.
I hope that helps answer your question(s).
many thanks, I highly appreciate your answers....so please how can I keep in touch with you in the next videos
and please can you make a video about phosphorylation and acetylation and whar are the different between them,, I mean the action of phosphorylation should be the oppiste of acetylation? in gene expression
Soulaf Kakel Not a problem. If you have questions on a particular video, ask them in the comments section. If I do not get to it or cannot answer it simply in a comment, I'd suggest emailing me.
Phosphorylation and acetylation are both post-translational modifications. I'll be making a video on Post-Translational Modifications for sure.
Is this transcription or translation? Pls
You must be an imposter because Bill Nye The Science Guy would totally know that chromatin remodeling occurs in eukaryotes prior to transcription.
👌
U rocks!
Cant understand
thanks
Better revise this presentation since the lysine/DNA +/- attraction idea has been modified. See en.wikipedia.org/wiki/Histone_acetyltransferase
omg