Who can guess what I was saying at 06:00 ? Whoops, my audio got corrupted but i tried to fix where possible so hopefully not too big a problem!! :D Plus, i feel like we've only scratched the surface with this topic so hope to explore further
Terrific video! Thanks! This epigenetic editing is so interesting and exciting. Before your interview, I thought the only epigenetic intervention was Yamanaka-style whole epigenome modifications. This precision editing gives us so much greater control over the expression of genes. I was starting to imagine we could just figure out the epigenome of young, healthy people and simply edit our old epigenome right back to youthful healthiness. But, after watching this video, I realize that is still well beyond the capabilities of the current editing techniques. But, who knows, maybe it will come sooner than I think. Technology is exponential after all. Once again, thanks for bringing this to our attention and explaining it (and illustrating it) so well!
You watch these videos and you're like "Damn, this is so in-depth--this rules!" --But then you realize that these are coming out WEEKLY. WITH NO LOSS OF CLARITY OR DEPTH. Absolutely unreal. The research rabbit-holes made by the Sheeky Science Show are the glue that holds the whole online bioverse together. All roads lead to sheeky.
Great video and a decent explanation of the issues. Not sure we should do something because we can as it is clear we dont clearly understand the unintended consequences.
Good question, there are proteins that have been discovered that can can copy marks across during replication but it has been very challenging to study this precisely
Thanks! Multiple rabbit holes, one of which I will go back to and research. But off the top of my head, I recall that some of the non-coding DNA, what might have been termed Junk DNA in the past, has regulatory functions. So, does non-coding DNA affect gene expression in a way the overlaps or complements the epigenome maintenance/marking systems? Not even sure the question makes sense.
Yes, exactly, non-coding sequences contain binding sites for different proteins involved in gene expression! So is definitely bidirectional relationship
Have you read the pre-read of the last study of Horvath? He claims to have discovered the places along the DNA where the methylation is causing the aging of the body. If we can change the methylation precisely in the close future...that would be game changing!
I enjoy MANY UA-cam videos and your SHEEKEY SCIENCE videos are a 10 on a scale of 1-10. These should be required viewing in all schools worldwide to make science interesting, fun and understandable.Thank You for all you do and may you "Live long and prosper" :-)
Hey would you be able to find someone who can dub these in Spanish or do Spanish subtitles? If not maybe I can try but I dunno. Might be easier if you already had these written in English before you made them and just run them through Google translate. (Edit: Nevermind I just saw the subtitles in english are auto generated pretty well, maybe there’s an easy way to convert to Spanish.)
Do we have the capability to do an epigenetic sequencing of all main organ cells? At least people might might be able to catalogue how their cells used to express themselves when they were healthy, before age/disease.
Gee! What is the practical application in your expectations? Can you change a red skin into a brown skin? How about changing hair color (permanently). Maybe an old rat into a young rat?
A lack in expression of certain enzymes can cause all sorts of problems. Lactose intolerance is simply a lack in expression of an enzyme that breaks down lactose. Many issues that people face everyday are results of over or under expression of certain enzymes. Also potentially aging, depression, anxiety. All the neurotransmitters are regulated by gene expression, I cant even imagine how far we could go with understanding epigenetics.
Awesome video. I'd guess that as of now, scientists have not yet mapped out different epigenetic markers to their functions. If you think about it - the real problem is all about the mapping. Once the scientists have the mapping, they can edit the epigenetic markers to produce a particular effect.
@@kral3046 I'd guess so. "Sequencing" epigenetic markers probably won't be enough though. Mapping their functions probably would be far more difficult.
Who can guess what I was saying at 06:00 ? Whoops, my audio got corrupted but i tried to fix where possible so hopefully not too big a problem!! :D Plus, i feel like we've only scratched the surface with this topic so hope to explore further
Please do!
you said epigenome editing :)
Terrific video! Thanks! This epigenetic editing is so interesting and exciting. Before your interview, I thought the only epigenetic intervention was Yamanaka-style whole epigenome modifications. This precision editing gives us so much greater control over the expression of genes. I was starting to imagine we could just figure out the epigenome of young, healthy people and simply edit our old epigenome right back to youthful healthiness. But, after watching this video, I realize that is still well beyond the capabilities of the current editing techniques. But, who knows, maybe it will come sooner than I think. Technology is exponential after all. Once again, thanks for bringing this to our attention and explaining it (and illustrating it) so well!
You watch these videos and you're like "Damn, this is so in-depth--this rules!" --But then you realize that these are coming out WEEKLY. WITH NO LOSS OF CLARITY OR DEPTH. Absolutely unreal. The research rabbit-holes made by the Sheeky Science Show are the glue that holds the whole online bioverse together. All roads lead to sheeky.
Lol, thank you!! 😊
Wondering what your view was on the latest research into NR and NMM in 2021 presented in this video by Dr Brad Stanfield “Why I’ve STOPPED Taking NMN”
Superh! A new video!
I love your videos! The epigenome is not discussed enough in college genetic courses. I found this very helpful.
Australia?
Love your videos! Thank you!!
Great video and a decent explanation of the issues. Not sure we should do something because we can as it is clear we dont clearly understand the unintended consequences.
you lost me at hello. you are very brilliant, but you need to dumb it down a little. kisses
Prior to cell division the DNA is copied. But how is methylation and acetylation copied? What is the machinery?
Good question, there are proteins that have been discovered that can can copy marks across during replication but it has been very challenging to study this precisely
Thanks! Multiple rabbit holes, one of which I will go back to and research. But off the top of my head, I recall that some of the non-coding DNA, what might have been termed Junk DNA in the past, has regulatory functions. So, does non-coding DNA affect gene expression in a way the overlaps or complements the epigenome maintenance/marking systems? Not even sure the question makes sense.
Yes, exactly, non-coding sequences contain binding sites for different proteins involved in gene expression! So is definitely bidirectional relationship
Another great video! Thank you!
so amazing! thanks!
Have you read the pre-read of the last study of Horvath? He claims to have discovered the places along the DNA where the methylation is causing the aging of the body. If we can change the methylation precisely in the close future...that would be game changing!
I enjoy MANY UA-cam videos and your SHEEKEY SCIENCE videos are a 10 on a scale of 1-10. These should be required viewing in all schools worldwide to make science interesting, fun and understandable.Thank You for all you do and may you "Live long and prosper" :-)
Hey would you be able to find someone who can dub these in Spanish or do Spanish subtitles? If not maybe I can try but I dunno. Might be easier if you already had these written in English before you made them and just run them through Google translate. (Edit: Nevermind I just saw the subtitles in english are auto generated pretty well, maybe there’s an easy way to convert to Spanish.)
Do we have the capability to do an epigenetic sequencing of all main organ cells? At least people might might be able to catalogue how their cells used to express themselves when they were healthy, before age/disease.
Nice video, dCAS9 i never heard of that... i am happy that i learnt something new and interesting today :)
Could you make a video on CrisorOFF
Actually just made one on CRISPRa /i, but haven't actually read crispr-off study yet!! ua-cam.com/video/H-szjgeEuoM/v-deo.html
LSD1 is better for us than LSD.
💙💛❤
Gee!
What is the practical application in your expectations? Can you change a red skin into a brown skin? How about changing hair color (permanently). Maybe an old rat into a young rat?
A lack in expression of certain enzymes can cause all sorts of problems. Lactose intolerance is simply a lack in expression of an enzyme that breaks down lactose. Many issues that people face everyday are results of over or under expression of certain enzymes. Also potentially aging, depression, anxiety. All the neurotransmitters are regulated by gene expression, I cant even imagine how far we could go with understanding epigenetics.
Awesome video. I'd guess that as of now, scientists have not yet mapped out different epigenetic markers to their functions. If you think about it - the real problem is all about the mapping. Once the scientists have the mapping, they can edit the epigenetic markers to produce a particular effect.
Would it require something similar to 90's genome sequencing effort?
@@kral3046 I'd guess so. "Sequencing" epigenetic markers probably won't be enough though. Mapping their functions probably would be far more difficult.
Liked it even before watching 😂❤