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[1] doi:10.1016/j.ajcnut.2023.12.011
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#cognitivefunction #cognitivehealth
*No Amendments & 1 Note*
Note: @mrniceguy4277 brought up a great point I think you may want to know - the effect size is quite small on the results. The tests are based on a 7 point scale, so a 0.05 change may not be clinically significant for some people. That said, the effect might grow over time (maintained on MVM and reduced over time in the placebo), but that's speculation on my part. Either way, while the effects were strongly statistically significant, the effect size is very small.
The statement I saw at the end of the article (and results) was that "the magnitude of effect on global cognition was equivalent to reducing cognitive aging by 2y." So not nothing and interestingly equivalent to the length of the trial.
What I wasn't able to quickly find was the sponsor of the study in pubmed or the clinical trial write-ups:
clinicaltrials.gov/study/NCT02422745
A multivitamin might be terrible for a person on a healthy whole-food plant-only diet, especially if they rely on it solely for vitamin B12. Multivitamins typically have low B12 (
Any studies on choline/inositol that you are familiar with? I've had some no doubt benefits from the supplement in the forty years that I've been dosing myself.
@@jakubchrobry3701 I admire People like You-Who so meticulously measure and calculate how much of what They get from their diet+supplements. -I just eat, and take supplements on whatever days, but don't analyse like this. regards.
@@wolfrahmphosphoros5808 I only measure my food about once per year if that. I'm 60 and when you get peripheral neuropathy, you tried to figure out what's wrong so you can correct it before it's too late and go into old age with health problems that lower your quality of life. A B12 deficiency does this and I wrongly believed that a multivitamin would give me enough B12. Maybe it is enough for some people, especially younger people.
Physionic videos are an important component of a nutritious (information) diet.
Education...
I'm technically, "under-educated." Being ADHD before diagnosis existed, had me labeled, "the dumb one."
To prove "their" point, I did poorly in school. After, I went to community college, did poorly, except physics. I aced physics I & II. Loved it.
I goy lousy grades in everything else. I quit school, got a job at the local steel mill as a laborer... eventually getting fired (long story).
I began playing guitar, got good, quickly... although I didn't think I was at the time.
Eventually, I got a job being a bicycle mechanic for a bicycle magazine. I was asked to jot down some personal impressions of a test bike. The next morning, I was on the writing staff of the magazine... I got D's in English in high school. They didn't care, and the work came in, I wrote, got published, scored a hot GF..
5 years later another GF suggested I get tested for ADD... It was found out I was ADD (now, ADHD). I was given an intelligence test, and was told I had an IQ of b 140... I was astounded. Me? Really? Now what?
The music took off, I did it full-time, but since I'm not organized nor able to schmooze, I couldn't handle the business end... I quit. I welded (self-taught) some rich guy's art... made more money, even though he paid crap.
Now retired... on a pittance of Social Security, I have a small abode, lots of tools, guitars... want to fluff the place up.
I've a small backhoe, and am digging with a plan to lay some concrete slabs.... This is a real learning experience since I've not ever used a backhoe or laid concrete... but I find it like a game of chess. I've the finished product in mind, got instruction on how deep to dig... and I need to figure out a game plan as I go along. First dig, then make the forms... get the pitch right for drainage... etc.
At night I'm here on YT, and learning about health, nutrition, from folks like you...
I'm a fit 73... and want to keep the brain in top shape.... I'm in a band that is introducing new-to-me music, and players (horns)... so inspiring...
Can sympathize. Am in mid-30's and it took me forever to get diagnosed. I had to get a master's in psychology and study the DSM closely to realize... uh-oh... I have ADHD. As a teacher, I can attest school is not favorable for ADHD folks! That's why I don't lecture much and focus on having fun and getting students interactive in class.
Same age , same story here. I thought I was dumb, it was ADHD.
Same here. High IQ, ADHD diagnosed at 55. I was lucky enough to get a degree, but my life had been a constant strife against people that didn’t understand my points, and were happy going the beaten path even when they already knew it was a dead end.
Ya know most people stop actively learning as soon as they can. People with a chip on their shoulder from school develop their own ways to learn and don’t seem to stop. I’m similar to all the above. Hs drop out. Work at national lab, traveled the Country doing high end business conventions and medical continuing education shows. At 58 bought a farm. Now I’m stuck learning and doing for the next 20 years. I’d like to get together with all of you. It’d be nice to have friends I could relate to.
Bravo Physionic! You were two weeks before Dr. Stanfield on providing this information to us! Not only that, you were not even promoting anything.
AGEs, mineralisation leading to decreased blood circulation appears to be a major factor. So to combat the AGEs you need an antioxidant that can cross the blood brain barrier, you need somthing to reduce you're blood glucose level. You could also try taking somthing that can actively remove AGEs that have already been formed like carnosine. Mineralisation can be limited with vitamin K. Finally boost blood circulation via polyphenols, nitrogen containing foods such as beetroot
Does carnosine remove the AGEs that matter? I'm thinking not.
@@incognitotorpedo42 Prevention is a course because once formed these AGEs are difficult to remove however "carnosine has been shown to exert a multimodal activity including inhibition of protein cross-linking and aggregation of amyloid-β and related proteins, free radical generation, nitric oxide detoxification, and an anti-inflammatory activity. It could thus play an important role in the prevention and treatment of neurodegenerative diseases such as Alzheimer’s disease"
Beta alanine is the best form of carnosine. It’s a precursor to carnosine synthesis within the body.
Carnosine alone has a short half-life within the body.
What does AGE stand for?
AGE: Advaced glycation end products
Evidence for carnosine is currently low. There are some promising results but Ill wait until there is kore evidence
Thank you for another great analysis, helping us all to separate the "wheat from the chaff" so to speak. Your work is so helpful and valuable!!
Thorough analysis, including specifying who funded the study. Nice work.
The reason there are no differences between placebo versus multi vitamins, is that no multi vitamin comes with enough potassium, magnesium, and other key nutrients that most people don't get in their diets.
Or the multivitamin companies use the cheaper less absorbable ingredients
And thank god, can you imagine how many hyperkalemic-associated complications would occur from "just a couple multivitamins" a day
Basically we don’t want people getting healthier using vitamins of quality, send them to the doctor for a prescription that cost more and makes the pharmaceutical company rich. 🤑
@@imgonnasneezeachooyes, you're right, much better to keep folks ignorant about how their body works so they can continue making bad decisions rather than teach them moderation, especially with nearly all researchers making it clear that the future of medicine has to be individualized and those individuals are going to have to be highly involved & knowledgeable rather than passively putting their well-being in the hands of others.
@@Holy.HannaH You can do both?
Did you respond to the wrong person?
Ahhh…the joy of trying to control for confounding variables 😖.
Pearl and McElreath FTW
@@asdf8asdf8asdf8asdf'scuse my ignorance, but can you please explain? I tried googling the authors, but cannot find the specific study to which I assume you're referring.
B12, d3, k2, magnesium had no impact on my cognition.
Talking with friends and having a great time has positive impact on my cognition.
I agree, because I have NO Friends !
Bet the amounts you took were low. Also high amounts of B1 in TTFD form. (thiamine tetrahydrofurfuryl disulfide).
@@Epictetus888 i got all vitamins in recommended doses. B12 and d3 were tested in blood exams. I also got entire b complex vitamins, had no benefit. Being sociable and have no stress gives big boost to the brain.
Thank you again! I do take daily multivitamin (I'm 75 years old) and I have a string of degrees and licenses to practice various things. Plus, I'm a lifetime learner. I got my last degree in my 60s. When I moved to Arizona I was kind of bummed because they don't offer free university classes to seniors on an audit basis. All that along with a low sat fat diet and lots of fruits and veggies as well as lots of exercise hopefully will prevent that one pesky Alzheimer's gene I carry from manifesting as a phenotype.
Sat fat is crucial for brain health.
@@MochaZilla Data? See below for a video on fat and brain health.
@@barbarashirland9078 Controversial, but look into the keto diet. I recommend Nicholas Norwitz channel. Physionic has a 1 hour long video talking with him
@@barbarashirland9078 basic biology 101. Sat fat is required for brain health, cell walls, hormone production, etc. I know everyone doesn't take biology but this is truly the very basic biology learned in high school/early college.
@@barbarashirland9078 i would also like to point out that the keto diet, high fat with the inclusion of sat fat, is originally a medical diet for those with brain conditions, like seizures, for example. Fat is necessary for life. Sat fat is a healthy fat and should be in an omnivorous healthy diet.
Always the multi, NIck. Since I was a kid. I'm 64 as of today (whee). I started on Ginko Biloba in my 40's, along with Ginseng. When I noticed some sliding, mentally, over a year ago l started on a cocktail of Benfotiamine (B1), L-Carnitine, Lion's Mane, Bacopa, and Ginko Biloba (upping from just Ginko and Bacopa). Along with a NAD+/NAC supp energy regime. Which seemed to work as my recall and focus went back up. I also take a Magnesium supp as well.
Education
Social connection and sense of purpose
Employment (age of retirement)
Sleep
Stress/trauma (life situation)
Exercise
Sauna
TRE
Nutrition quality and quantity
Chronic diseases
Medication
.... so many compounding variables on Cognition
Gaming. You forgot gaming.
What is TRE?
Also relations with a partner.
I am 75 and resist meeting others of my age because they focus on problems and regrets.All my close friends are much younger because we share activities and interests. I still run 3 businesses daily, had 4 until Covid ended it, a large incoming tour operator business with contracts with cruise ships to provide 2-3 day intensive tours to cruise passengers. Ships stopped coming here.
My primary girlfriend is 43, an athlete(long distance open ocean swimming. We, or others accompany me to ballet, opera, rock clubs to dance until 4am, pro photographer, recording engineer with 197 gold and platinum albums from 1972 to 1993, then gave everything away and moved to St Petersburg Russia in 2000 and started the tour company, photo studio(most actor, ballet and opera portfolios) and conduct popular master classes for actors who what to transition to cinema, 2 times a month 3 day programs for 20-60 actors, and run a repair shop for professional sound systems clubs and musicians and still find time to explore art and the 476 museums in this city...and date 3-5 times a week. Staying active, interested and challenging keeps enthusiasm for life high, having younger friends, never dated anyone over 50 because I never found a women still interest in the present and future, dwelling on the past instead. Energy boosted again when I joined a good gym and work out to failure every other day. A couple years also I stopped eating any processed foods and have learned to cook. My only physical problem is lack enough sleep. The only time I sleep well is after making love. Due to the change in diet and gym I gained muscle mass and look better and my thinning hair grew thicker and darker.
I am convinces that lack of drive and challenges that most people who retire suffer from is a major cause of mental an physical decline most people experience after retiring. Most of my friends are age 20-40, most in their 20s, because we meet due to having similar activities. People who have careers with no age limit such as self employed, creatives like artists and writers, and those who always seek additional challenges. Later today I am teaching a workshop for young people who want start their own business. Since age 13(electronic repair of high-fi and CB radios with a shop and business license and sold it to the parents of my only employee when I graduated midterm from High school and it continued operation for another 26 years). I have spent time in 92 counties and have living, got my pilots license and restored my plane,, build a horse ranch, owned a large famous recording studio complex of 3 studios where we recorded many of the hit of the 70s and 80s, collected and restored classic Maserati GTs of the models years of late 50s to 1975 and had 13 of them, plus a few Ferrari and Jags. I think men especially need to be needed and retirement is a death sentence and why creatives, or self employed who have no retirement age are healthier and live longer. Having a beautiful fit younger partner keeps enthusiasm to stay active and healthy.
Most informative research...!
Do a study to find best multi vitamin.
mmmmm, I spotted a difference that you haven't talked about: 1/3 of the partecipant are ALREADY taking multivitamin. In both placebo and the group!
So: my question is: are they giving double doses to the one already taking it ? Are they removing the multivitamin integration from the people of the placebo group? because in both case the doses( or the absence of) are doubled!
Subbed! Love your data based info! Can School be replaced by Learning? ;) So taking courses, certfications, etc.
Thanks Nic...'er, I forgot my multi-Physionic "vitamins" this week. I gotta binge watch the past two weeks of segments, AND I got to take my MV right now, in order to remember to binge watch! Love the analysis...been one of those multi-vitamin taking fools for many years.
So Goji berries it is! That has both a high Lutein and Lycopene content and goes great with the regular multivitamin 🙂
Interesting - those 2 extra ingredients are antioxidants, which seem to be VERY important for our health.
I'm 60 years old and have taken a multi vitamin since about the age of 20.
I eat right, and exercise - quite a bit in excess of the average 60 year old.
When people say "just eat right, and you will get all of the vitamins you need" they are wrong.
It's essentially impossible to get the RDA from food alone.
Especially the mass produced food today grown in poor or synthetic soil, they barely have taste in them and "designed" to have more sugar to make them sweet.
Arguably it's very possible to hit most RDAs from diet (especially when considering fortified foods), but eating that much in whole foods every day is likely to be pretty uncomfortable.
@@VegetaPrinceOfSaiyans Unfortunately, most of the fortified foods are the ones that are processed and not exactly healthy.
@@goddesstc Exactly, so you're either hypercaloric or uncomfortably full.
We take gender-specific, “over 50” organic food-based multi-vitamins because as a person ages, they are less able to absorb, synthesize, or use some important substances. In addition, unless you are tracking your food with an app that shows all important micronutrients, you will have no idea if you are getting enough of the various nutrients. Youth overcomes a lot of shortcomings and abuses. Over 40 does not. Over 60 and 70 really does not; the opposite.
I have started taking Bacopa Extract. What are your thoughts on it?
Who makes the best multi-vitimin ? This is the question I wish our favorite online Dr Strange Love should delve into one of these days.
Well, from experience, usually the multivitamins made for bodybuilders are good vitamins. Sometimes they are ¨overkill¨ because they are made for people who train hard, like Animal Pak, but Universal and Muscletech have good multivitamins. I don´t take them daily but about 3 times a week. I´m a teacher and I´ve given vitamins to students who´ve come to school sick and they get better instantly. Dr. Brad Stansfield, you can find him on UA-cam created a multivitamin that I would get if I had access (I live in Mexico). I currently take Platinum Multivitamin from Muscletech. I used to take Animal Pak but I don´t train as hard or as much as I used to. Regular daily multivitamins don´t seem to do anything for me.
The Costco one is good
"Nature"? How about a periodic dose of beef liver? [edit: actually, you might want some more iodine and omega 3's, so have sardines sometimes too. oh, and eggs have pretty much every vitamin as well]
Pure encapsulations O. N. E.
Thorne is one of the best. Most NFL and other sports disiplines use them because of the rigorous test they have to go thru for effectivines and purity.
I like digging into the ‘might’. I’ll go with nurture weighted towards continued cognitive engagement. Grandma started doing math problems a long with crosswords in her 70s. Mom just started the math problems as well as drawing at 90. She’s also a bridge master. I contend that the continuing cognitive challenges are related to higher education.
it’s amazing how chronic infections, gut dysbiosis and toxins can cause brain function problems - all without age being a big factor (ie 20’s). with age comes more opportunities for all of these causes to sneak in.
What about sleeping disorders or modern life chronic stress , those are súper important on cognition
Magnesium, potassium, zinc, and vitamin D3/K2 are the most important supplements to take overall.
How are you getting your potassium? Pretty difficult with supplements.
Why? According to current influencer fads?
eat your veggies and take a stroll in the sun.
@@DisgruntledSpam D3 is deficient in more than half the global population, and the most important vitamin by function in an order of magnitude next the nearest important one. So there is that. Magnesium deficiency is common. Other minerals may be able to replace. Not sure about zinc, but potassium is more related to excess sodium. Less sodium, less potassium required. Those are the facts as I understand them. No influencers required.
@@callmeishmael3031 I sometimes supplement with potassium chloride (ie, NoSalt salt substitute), and/or potassium citrate. One must be very careful with potassium supplementation though - too much can slow down the heart lethally, or cause other problems.
Can you compare this study with some on lutein and lycopene to see if the if there is a different effect, if you have time, please?
Can do
I also wonder any type of lycopene and lutein?? Marigolds? Any plant based lycopene? Dosage?
Any recommendations for a good UK brand multivitamin without nasty fillers etc.?
Hey thanks!
What's the exact multivitamin product used? I skimmed the study but couldn't find it referenced.
Was this the Centrum Silver COMOS study?
Its simple, focus on mitochondrial health. If you fix that, you supply energy for all other processes to function according to design.
Were baseline vitamin/mineral tests undertaken? Usually the studies indicate no/little benefit of supplements in the general population, unless a deficiency.
Multivitamin (gummies) vs. Multivitamin/mineral (solid pill) is a big difference. Also, daily fish oils are great!
Nephew is flexing his statistical sampling knowledge every chance he gets.
Agree 100% on education.
Would be interesting to get your views on the genetic testing available now.
Heard about polymorphism affecting methylation from some Gary Brecka videos a few weeks ago. Still learning but there are several companies here in Canada that provide the service for between $80 and $500 CAD.
The latter being a test of over 200 genes to give a 170+ page report thst offers over 70 health insights. A 45min review with a practitioner is included.
The inexpensive one is just testing for methylation of vitamins, and not hormone processes or lactase etc.
Targeted supplementation with methylated versions seems like a good idea for those with specific gene variants. Also avoiding things or taking other measures seems like a way to further improve quality of life.
Thanks.
Love your videos. Can you please review the supplement C15?
On the list :) thank you
Problems with multivitamins in general is dosage. Most of them have so little vitamin that it cannot do any changes in health. When looking for vitamins and minerals, you better look at the % of daily allowance..
I answered cognition!! 😊
Another question. Wouldn’t this also point to the possibility that it’s not the multi vitamin that makes the difference, but rather just the lutein and lycopene that is causing the effect?
Absolutely
Egg yolks and tomato juice 😋
Spinach and tomatoes.
@@k.h.6991 Spinach high in oxalates but (if cooked) also high in lutein. Also tomatoes give more lycopene when cooked.
There is also some data that lutein (trans and cis) and zeaxanthin are associated with a lower "brain age" - also cholin, epa and handful more.
There was a paper looking specific for blood markers.
I scored very high on an aptitude test for engineers recently. I have a great diet, yet I still take a multivitamin that is a 50% rda dose with xylitol, and also take various fadish supplements minimally.
In general, I agree with you; however, saying that you must take a multivitamin is like saying that you must drive a car. You don't tell me if I have to drive a '72 Pinto or 2024 Bentley. There are many poor-quality vitamins with the main ingredient of calcium, which is mostly non absorbable by the body. Good quality, natural sourced, rather than chemical-based vitamins are worthwhile. I have taken all of the above and found that picking quality is essential.
The correct auto is actually a 1964 impala super sport
What are you currently taking?
@@Mythicregard After trying to find the right one, I settled on Narurelo one daily multivitamin. It's got good products in it and is pretty cost effective. I also take their B complex and many other supplements. (but not as many as Jack LaLanne did) 😀
Was this a double bind study and were the multi vitamins masked for taste ? I can easy tell when I take a multivitamin and honestly I don’t like the after taste. With this in mind, now consider that you volunteered for the study and know it a study of cognition and multi vitamins. I bet there is a placebo effect.
Dr Venn Watson indicates that C15 fatty acid is useful for effectivenesse of brain membranes. What do you think of it ? thanx
It depends on what is worth your brain for you and how educated you are on the subject. I would never have a strategy only using multivitamins and hope that it will do the job efficiently... I'm 65 and already buy a bunch of supplements and I entirely changed my diet to low carbs and healthy foods to stack the odds on my side...
Can you please tell us the name of the of the company that makes the Multi Vit in this study?
The problem with that study is that the placebo group were likely to be getting pretty much most of the essential vits and minerals in their regular diet, unless they as a group were eating an abysmally poor junk food diet consistently for those two years.
Interesting timing (for me anyway)..I just went back to using a multi (tricky term only a doctor would understand!) I went away from them as honestly the forms used were rather poor (magnesium oxide for example). There are better forms now and break up to a couple times a day. Appreciate the info and this has quickly become my favorite channel (at least such things as this).
New Chapter and Bluebonnet are decent brands.( I am not a paid marketer. )
NY Times recommended Costco multivitamins as a cheap alternative to pricier brands, and they contain lutein and lycopene.
I wouldn't trust something from NYT on nutrition. They'll just be writing and quoting from mainstream doctors who don't have comprehensive view of supplements. Lutein generally should be taken separately from multivitamin. Like magnesium and calcium, the amount of lutein in a multivitamin is typically way too low.
A good high quality multivitamin would be something from Life Extension, Thorne or Now. It's not just an issue of price, you have to look at the forms of vitamins used like whether they're in a bioavailable form, fillers used etc.
Any testing for toxins, metals, other stuff?
What do you think about reverse diet after a prolonged water fast. To boost your metabolism and start eating normally without the fear of gaining the weight you lost during the water fast?
anything to do with fluid intake restriction sounds super dangerous to me. It's too easy to have a dehydrated cardiac event that way being even a little blocked anywhere.
Can you do a video on how to actually reverse insulin resistance.
Probably needs more than one video, but I'll be covering insulin resistance soon
Learn from Ben Bikman. He’s a graduate professor and researcher of metabolism.
Well that's a departure from the studies that suggests multivitamin use may be associated with an increased risk of all-cause mortality, although, this was a study on cognitive function.
Perhaps it was the Lutein and Lycopene in the supplement used?
Interesting. Although I would be more convinced if they stratified testing by separating drinkers and smokers vs alcohol and tobacco naive subjects. Still, we live in an imperfect world so I will take what I can get. Thanks for the review.
I think it would be interesting to see the difference in cognition between a healthy diet and a poor diet.
What is the supplement brand etc, and a link to the study?
Study reference is posted
Congratulations Doctor, love your channel. Question, you seem to
use the mind and the brain, interchangeably. Are they the same?
Ha! Could catch - I suppose philosophers like Descartes might argue they’re not. It was simply an oversight on my part - the brain is the tissue, in my mind. 😋
Two points. First, what about the studies that show that people taking calcium supplements have higher rates of heart disease and lower overall survival. 2nd, as an RN I have taken care of MANY brilliant people who ended up with dementia. Scientists, doctors, researchers, etc. Also people who ran marathons and "did everything right". I actually question how valid the testing we can do for dementia is. The automatic responses we have learned often cover the deficiencies until a person spends time and even spends time during certain times of the day. The ability to remember a random list of items mentioned 5 minutes later is a very poor test.
Know of those genetically challenged with apoe4/4?
Please note: at around the 2:30 mark, the highlighted numbers in the brackets for age are actually the standard deviations, not percentages. (But I think all others numbers in parentheses are actually percentages.)
B6 should not be taken as harmful effects present even at dose 50? What about vitamin E, as I think I have seen some negative writing about it?
Is this based off metagenics photo multi?
Thanks for another great video. I would also guess that the b vitamins played a strong role in preventing cognitive decline
The point you made about education is interesting because I have observed that the most highly educated people I know are also some of the least intelligent. For example, my friend’s husband the Harvard lawyer and my BIL the aerospace engineer are still getting booster shots. I see that as the most expensive IQ test ever created. Also, the most highly educated people seemed to be the most susceptible and gullible in terms of falling for government propaganda during the pandemic. They lacked logic and critical thinking ability to a degree that was truly alarming. (Believing that cloth masks could block viruses, participating in an experimental gene therapy despite zero evidence of long term safety/efficacy, believing that other people needed to get a vaccine in order to provide protection to a vaccinated person, etc. There were many comically obvious lies. They fell for them all).
Do the findings ever disagree with the person that funded the research?
Unlikely! If corporate ghouls are funding the research then the answers are known before the questions are asked!
Yep - have a few videos on that
Frequently because most research is funded by the taxpayer.
Thank you❤
i always enjoyed watching your content, you make it easy for us and the viewers to understand many of this research. But I have a little concern i hope its easy to be answer... Is taking multivitamins damages your kidneys? im sorry if this maybe out of context but im just curious...
MULTI with mag oxide can deplete stomach acid and stress kidneys
What multivitamin is it?
Which multivitamin? Containing what?
Yep, not all multivitamins are the same.
I would assume the basic common vitamins is what is being studied, and in rda amounts, standard basics only.
Don't most multi-vits contain the artificial form of Vit E? I have seen several videos saying that form of Vit E is not good for you. dl-alpha Tocopheryl vs. d-alpha Tocopheryl, the later without the "l" after the d in the name as the one you should use.
100% true, also b12 and C can be very ordinary
Tocotrianal is the better one, spelt incorrectly lol
Video on oxalates please! Thanks
Maybe a wild horse, but I also heard a lot of good things about coconut and olive oil, taken at the right dose of course.
we have had studies before that showed b vitamins protect the brain, ONLY if omega 3 fats are abundant also. Whereas on their own neither did much.
Am I reading the baseline correctly?? Some of these people were doing over 21 hours of leisure time activity per week, yet still had BMIs up to 30? What constitutes activity here, getting up off the sofa to get another soda?
Diet >> exercise
When I see leisure time activity I think things like reading a book... Not walking 10km.
I am in menopause, I do more than 200 Fitbit zone minutes everyday. My resting heart rate is 60-63 bpm and the zone minutes are counted from 1 for every minute that my heart rate is over 100 and 2 when it is over 125. I have lot of lean mass and my BMI is about 40.
@@jasbenn7872 Nice work on staying active! Carrying a lot of mass is shown to be very correlated with early mortality and diseases, so good on you for working on that change
@@blink182bfsftwSnarky comment vs. not knowing that BMI doesn’t take lean mass into account? Waist to hip ratio might be better assessment. She said she had a lot of lean mass.
Magnesium threeonate also had imimpresive results
My mind is a tissue??
I dunno, it sounds like we should crispem up our definitions!
But no mention of the obvious? Are all multi vitamins that include lutein and lycopene the same? Rhetorical question that wants to get at brand endorsements which I know you won’t do.
What is this difference? Around 0,05? Even if there is a difference statistically speaking, the effect size might be negligible
Great point. That could be argued, definitely. The scale is based on a 7 point scale, so the effect is very small. Then again, the effect may grow over time (as cognition remains stable in the treatment group and the placebo continues to drop). Either way, great point - I'll add a note to the video.
Hahaha I definitely imagine that you _do_ sit around thinking about how amazing _your_ mind is
I see people are already jumping to misinterpreting the results. This was done in elderly people, so it says nothing about any need to take multivitamins for life. You might be wasting your money taking them from an early age. Also because every multivitamin formulation is different you'd have to take the specific one used in the study. Although I think someone needs to test whether it is actually just those two additional ingredients that mattered.
Dementias are being dxd in 45 year olds. Is that old? Takes awhile...
I take a multi-vit because in my mind, what are the chances my body is 100% efficient at processing every nutrient I eat? Why not stack the deck.
In a recent study (within the past few weeks), it was shown that smoking is the largest factor in cognitive decline.
I have long Covid and I keep getting Covid. It has really done a number on my cognitive function, it’s a total nightmare.
A certain President's recent precipitous decline is a warning sign about what can happen to us as we age. It's both sad and terrifying to watch what's happening to him. While many factors can go into dementia, I wonder if his decline could have been prevented or postponed if he had been taking a (better) multivitamin and/or fish oil, or eating a better diet, or exercising more.
He takes medication to lower his cholesterol so his total cholesterol is 115 mg/dL and LDL is 58 mg/dL which is about half the level that Trump has.
Does the formulation matter or is it just any store bought multivitamin?
No link to the paper itself?
It is linked
@@Physionic found it, thanks !
I've been taking multi vitamins since the 5th grade and I haven't looked back
Seems like a lot of nutrients are studied in isolation which doesn't seem like real world data.
For the smudge!
Exercise.
I believe that Life Lessons surpass Acadamia in imparting a usefull education..
If I know something I can't wait to tell everyone and help them out. This may be because I am a nice person, or it could because certain individuals showing this characteristic have been selected for by evolution. In the modern world, we call these people teachers. I am a physics teacher, by the way. Similarly it may be that some people need to maintain brain function more than others. The tribal leaders it may just be that these people are attracted to knowledge, but education is not the source of improved cognitive function. Personally, I think it is a bit of both.
8:28 link not showinng on video
Link to study?
It’s posted
@@Physionicah I see it now.
Guess at unlikely category: how much the subject already intentionally engages their brain in critical/analytical activities, problem solving, learning, creative acts, etc. I made this guess at the 3:00 mark, before Nick did the big reveal. I was in the vicinity of correct. 😁
Taking multivitamins and education both correlate to wealth. Using education level to determine cognition may not be the full picture.
Exercise is also fundamentally important for cognitive function....although Stephen Hawking would of disagreed.
If anyone doubts the unbelievable scope of the human brain, take a look at Tesla building an entire server farm just to have enough computing power that will collectively enable a computer to hopefully match the brain in all conceivable self-driving conditions and scenarios.
Why no comments at 4minutes
He fell off 😞
Still, I do not think I should take one each and everyday.
Super B Complex and some liquid lecithin. And if they don't help you in week, don't take them.
Post College degree 60% in the interventions vs 49% in the placebo group, hmm?