Nina Tandon: Could tissue engineering mean personalized medicine?
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- Опубліковано 28 лип 2024
- Each of our bodies is utterly unique, which is a lovely thought until it comes to treating an illness -- when every body reacts differently, often unpredictably, to standard treatment. Tissue engineer Nina Tandon talks about a possible solution: Using pluripotent stem cells to make personalized models of organs on which to test new drugs and treatments, and storing them on computer chips. (Call it extremely personalized medicine.)
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There is another TED video pretty long ago with similar content but good to know this is still going.
These are the types of videos that made me subscribe to TED. More science and innovative ideas please.
The talk was certainly interesting, although I remain sceptical. One of the biggest challenges of drug development is molecular specificity. For a drug to act on the target site, and the target site alone. It's extremely difficult to localise the effects of a drug to a particular tissue or organ without resulting in a multitude of side effects.
Personalized medicine is the future period. What we envisioned in sci-fi movies and TV shows like Star Trek will become reality this century. I dont think there is any question about the leaps humans can make when they put their collective minds to it. Public support will be the key.
Fantastic, keep up the good work and thank you.
What a remarkably cool subject. I look forward to seeing more on this.
Where do they hold all these talks at?
Sooooooooo cooool !!! Great job!! This things make feel better about human future. A sincere hug to all scientists working in these wonderful projects and the people who support them and.........yes.... she's a cutie.
since it's a short list I'm sure you can enumerate it in a comment or two, and don't dumb it down at all, I want to learn as much as I can
Great point!
she is the most lovely engineer i have seen on ted
Agree if you like learning with good neurons and the right shape around them
try Sheila Patek clocks the fastest animals on ted talks - pistol and manta schrimps.
Cont 3...
This verse is about putting things in perspective: What is truly important when times get tough? It is not saying that we need to stop working, or earning a living, or seeking justice when it is due to us. It says, "Do no worry." It doesn't say, "Don't worry, be happy."
I think this is a difficult for everyone, when push come to shove, but I think there is a natural, situational wisdom to it.
True, but what I got for that part of the talk where they're taking a sample from a patient, they're testing drugs that are already used and the side-effects are known. The point is to determine which drug works best on that strain of the cancer the first time, rather than try one, see how it does, try another if it's not working, etc
The problem of localizing the effects only matters for new drugs, which is the point of the later part of her talk of developing a full system of working tissues.
I'd love to be on TEDtalks one day!
She explained that in the video that development needs to be done to integrate multiple systems. That doesn't make how the drugs would react to that specific tissue unrealistic though.
Where do I sign up?
That's weird. I haven't seen it a lot recently but there have been periods in which TED videos were flooded with hateful, sexist comments and nothing happened to those; this is just a bit of lighthearted, healthy humor.
Wow, this video makes me optimistic. As usual, science has found a way to side step the religious zealots that would like to stymie progress, which would relieve human suffering, in order fulfill some moral code oriented around superstitious and unproven dogma. I am thankful we have people like Dr. Nina Tandon who are continuing humanity's progress to a better day, when physical suffering will be mitigated, if not eliminated.
btw by different i mean you have 2 milks and you can tell which one is which. Or prove that the one from cows treated with rGHB contains rGHB in it.
thoughtful,honest, neccesarry, intelligent, kind.
This was awesome
In an accident, I got fractured in my skull.
After the operation, there will be some empty bone space in the skull.
I want to Epi bone for my skull
I m from India
It was either this or robotics that was gonna be my life story. Sadly, I knew I would envy the other no matter what I chose. So it was ultimately robotics, and I'll just have to go with the fact that development like this will always amaze me. But hey, it makes the world charming.
She said in the beginning that their engineered organs can not yet be used in humans. She didn't say, though, what difference between the real organs and the engineered ones is responsible for this and how this will affect the reliability of the drug testing done on the engineered organs and tissues.
Thank you for rebuffing the troll (and probably conspiracy theorist) with a sensible reply. People think there is a "cover up" or there is some shady business going on behind the scenes. This is totally ridiculous. The amount of prestige, fame, and the cash flow that would come from the cure practically demands that a cure and solution be found! These trolls and conspiracy theories simply don't understand the dynamics of human motivation and efforts.
well, that's an ambitious point, which can neither be proved or disproved. I cant really argue with a "theory". if you are right though, then life is more wonderful than we think.
I agree, the Venus Project is the best I've seen so far.
good !
0:15
It's unrealistic since they are using a model to predict how multiple systems work together, not to directly observe them working together. For example, the model does tell them if two of the systems have enzymes that combine together to form another that chemically shifts the drug. Such things can only be determined by observing all the systems together, at once.
Wow, Nina's Gorgeous...... Please come grace us with a lecture at my astronomy organization here in Mississippi... Rainwater Observatory, French Camp, MS
What is tissue? is it like paper
Wow!
This would come in handy.
It would decrease R&D cost per drug imensely and hence those funds can be allocated to other projects. (The more projects the higher the successpotential. More succes = more money)
Since you still need a lot of scientists for this increasing number of projects, this would be good for the job market as well. (more scientists -> more space -> more "helping" staff from secretery to toilet cleaner => good for a lot of people not only scientists)
And saver drungs, too
I'd say,the girl is amaziiiiing.
Now which TED should I watch after my cig?
I could`nt agree more.Every word that you have written is totally true,unlike the holy books where the opposite is true.
Great comment btw,thumbs up :)
Sincerely
U K
Some one please fund this!
This video is underrated
GOOD STUFF!
cont 2...
"don't be anxious if you start at Matt 6:25"
It's actually just a big long way to say, "don't worry about these things (food, clothes, shelter) because God will provide."
Good luck with that.
"Our Ethics come from His teachings."
Which include things like "give no thought for tomorrow" and "you must love me more than your family." Great examples...
>.>
And it's even more moral , since innocent animals are not suffered in labs anymore
"the video you link to is about the illusion of superiority"
It's more about how one's ability to assess something is directly related to how good you are at that thing. If you're good, you can accurately assess the topic. If you're bad, you can't accurately assess the topic.
Lacking a deep background in biology, you can't possibly guess at the future implications of this technology.
I am all in for unfettered scientific progress, for the good of humankind, animal kind, and all of nature and the physical world.
the only thing that is slowing the process is the law and public healthcare in other countries (soon US) Scientists and pharmacists are going as fast as they can because if they cure cancer they will get so much money and there will always be people getting new cancer so they are guaranteed future income for a while.
Interesting.
I agree with you. But arguments conducted with love can make friends.
She's quite an engineer I give you that!
The Island...
I look forward to a world without the need for animal testing. Just as importantly, I look forward to treatments tested on my cells, quickly, to see what does and doesn't work right away.
Sounds like this will lead to less suffering for everyone, and a better world all round.
"What is truly important when times get tough?"
Family, friends, hard work, welfare... Things that actually are shown to help those who have fallen on hard times...
"It is not saying that we need to stop working, or earning a living, or seeking justice when it is due to us."
That is actually exactly what it says multiple times where he says to get rid of all of your possessions, hate your family, etc.
"I think there is a natural, situational wisdom to it."
There's really not.
cont 2...
A high schooler can understand this talk, but they can't assess the future implications because they lack knowledge of the the drug discovery pipeline, how personalized medicine works, or how microarrays work, among other things.
It's why I, with a background in biology, think this is exciting, new technology that will help many people, and there are other people who are worried about "Frankenstein," despite Frankenstein being the doctor, and not the monster they're afraid of.
two problems: making a fully functional frankenstin
and;
epigenetics of methy-markers on DNA could change during all stages of process.
ROFL. I'm married, I have a successful career at one of the largest DoD contractors in the world, have earned a Master's degree in Computer Science specializing in Bioinformatics, and I'm working on a 2nd Master's in Biotechnology. My Master's degrees are/will be from Johns Hopkins University, the 5th university in the world for life science studies.
That kinda kills your assertion that I "lack education, intelligence, and achievement."
Why do you have to think of it in terms of "side-stepping" rather than a win-win? It's not a fight.
6:10 She was having a good hair day.
Wow, now I can put the chances of my dying at 99.99120%. Whatever they are doing I hope they keep it up for my sake!
1. Quite ironic that the video you link to is about the illusion of superiority, while proudly wearing your banner of atheism in your username (it doesn't make you smarter). 2. Everything in the video is explained in a way that makes it perfectly understandable for anyone who finished high school.
Great
6:02 If this talk weren't so exciting, I'd mad at her for that.
here is another example of good science gone bad by drug companies. piece be with you all. i love you and my best advise to to my my fellow humans who posses primate digestion, your true consciousness and health be in as much fruit as you can eat daily. believe in yourself . and hope this science goes for the good of mankind.
Because they are very small. The human body in all of it's complexity is remarkably similar to every other human body, with very minute differences causing discrepancies.
beauty with brains... im in love..
+tibstar8812 That nose..yuk!
Yeah Im not into medical field or biology. A little about biology but not enough of it. I took the other fields.
Thank you for the compliment. I completely agree.
I just hate people who bash science like this when they obviously have no idea what they're talking about. Plus, I'd bet he's also the kind of guy who would be all for people making money from their own ideas, while also being against universal healthcare...
Yet, somehow, when the scientists, with 10-15 years of research to take a drug to market, are evil for trying to make a profit on it.
The hypocrisy and stupidity makes me sick.
Probably the microchips with the engineered tissues could served for 80% but not 100% drug efficiency, anyway much better than the studies that have been done till now!
Not yet.
Why can't we do both? Learning to take care of our bodies and treating the symptoms and the problems, too? You can not live under a glass bell in a lab, with no pollution and no stress and no accidents!
Before commenting, please take a moment and watch this video about the Dunning-Kruger effect: /watch?v=XyOHJa5Vj5Y
Now ask yourself, "Do I possess the necessary background knowledge to accurately assess this amazing TEDTalk I've just watched on tissue engineering?"
Unless you have a degree or many years of experience in biology, the answer to that question is most likely "no."
Please keep that in mind before posting that stupid, alarmist comment rattling around in your head. Thank you.
True but it would be close.
She didn't say they just wanted to make a bunch of neurons. She said that they want to make organ systems like a real person's so that they could see how drugs act upon them just like in a human body. Thats straight up what she said. I don't smoke pot.
Did I miss where she claimed this would cure all cancer or something?
I actually do believe that greed and selfishness is really beneficial. And no selling poisonous food doesnt bring much profit. First of all unhealthy food is not necessarily cheaper to produce than healthy food. Second of all people will not buy unhealthy food if its labeled properly. Third of all you will get sued and loose all your money and go to jail since its illegal to mislabel products.
&you dont know waht cellulose is. Its not saw dust. Its actually good for you because it acts as fiber
But they're not using it to predict how multiple systems work together. They're only using it to predict how something reacts to that specific tissue. Did you really not get that she listed the lack of a multi-system model as a draw back that's being worked on? Do you seriously think the people actually working on this don't understand the limitations?
twas about damn time
For the same reason you wouldn't call a 9mm bullet huge despite the huge impact it can have.
cont 4...
"Everything in the video is explained in a way that makes it perfectly understandable for anyone who finished high school."
Just to reiterate the point, being able to understand the talk does not allow you to accurately assess the future implications. If you still think it does, then you lack the ability to accurately assess what is required to accurately assess a topic.
Mark my words, your comment will be removed. I made one something like it and it got taken off. Ted is known for not having a sense of humor. :/
Cancer is when cells don't act the way they are supposed to, there is no single thing all cancers have in common, so no curing cancer would in fact be a hard thing to do, even if you focus on one specific type as researchers currently do
oh and if someone did invent a drug that "cured" cancer, it would sell out for sure
Well, this is youtube, just look at the "most subscribed" channels.
I wonder if you can use the same model to see what the body does when you eat food? Why use man made drugs if there are things on this earth that can heal. Drugs are too expensive. I am not a educated in this but I would like to learn more.
I'll try to get to all your comments here soon, but just to begin, how can you accuse me of Cherry picking? I just responded to 2 quotes that you "cherry picked." 2500 characters (If I posted 5 responses) is not enough space to explain the incomplete quotes you chose, in context of the entire scripture as a whole. Do you agree? First of all, I don't see what bad can be drawn from Matt 6:34. Can you explain? To Catholics it means don't be anxious if you start at Matt 6:25
It is not science that is the cause of concern, it's the level of human consciousness behind it. When Giordano Bruno was burnt alive at the stake by the Catholic Church, for believing in life of other planets. It was a discussing use of the science of fire by religion. However the fire was not to blame, it was a lack of spiritual humility & low consciousness, that used fire that way. Science if fine, it's the consciousness behind it, that is the big issue.
Neither is gravity
I was expecting a punch line haha, but I agree
Like "The Island," but without the need to murder and chop to bits a gorgeous Miss Johansson.
Smart and beautiful one hell of a combination.
To finish you first quote, "Give no thought for tomorrow, for tomorrow will worry about itself. Each day has enough trouble of it's own" Matt 6:34 (people who suffer from depression can find some good advice here) If people loved Him, understood, and followed ALL his teachings, they would "Love your neighbor as yourself" Mark 12:31 and "Do unto others as you would have them do to you." Luke 6:31 These are guidelines for loving your family. Do you think these are bad teachings?
EKG Necklace!
I really like where this is going, but it seems an awful lot of research, time, and money for something that we could already do if it weren't for the public's squeamishness about cloning and genetic engineering. We're talking about new technology that could allow us to simulate the systems inside a living organism when we already have the technology to grow living organisms from scratch. With simulated reflexes it needn't have a brain and would only be considered "alive" in the broadest terms.
One day, they'll be able to mass-induce cells to change. If that happens, we could possibly be immortal, just like the immortal jellyfish, which changes the identity of its cells in large quantities.
23,713 views here and a million for the foot ball game. Priorities, it think it might be a while.
It is a fight. The history of religious suppression of the sciences, especially the sciences that have the greatest consequences to the human condition and how we perceive ourselves, is a history where science has had to constantly fight tooth and nail against religious dogma.
Saying that nobody is looking for cure for cancer because there is no profit in that is ridicules.
More biological videos like this please
A real passionate scientist on TED????? what is this 2010?
Debating does not win a man's heart. You win it by becoming his friend.
Humans are animals, therefore humankind = animalkind. Science is awesome.
why dont we learn how to take care of our bodies, rather then coming up for solutions to replace failing body parts because we abuse and neglect our bodies. Obviously the industries that invest into this type of research have no interest in healing the individual, rather they just treat the symptom.
cont 4...
"Drugs are too expensive."
Then you take the risk of putting up 100s of millions of dollars and a decade of an entire team's man-power to develop a drug... and then sell it so cheaply you don't make a profit.
Why is it people only ever get ticked off at the pharmaceutical companies for wanting to make a profit on their investment, especially when their risk is considerably higher than say, Apple's investment in a new iThing?