Neurulation - Neural Tube formation - Third Week Embryology
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- Опубліковано 8 чер 2024
- In this visual medical lecture, Dr. Aizaz from MedicoVisual talks about Neurulation or Neural Tube formation. Neural tube is the primordium of CNS i.e. Brain and spinal cord. Neurulation starts during the third week of development of the Embryo
00:00 What is Neurulation and Neural tube
00:54 Notochord and Primitive Node are inducers of Neural tube
01:18 Neural plate formation
01:57 Neurulation 3D animation - Neural groove and Neural folds
02:57 Neural Crest formation
03:54 Importance of Neural Crest cells
05:24 Cranial and Caudal Neuropores
06:14 Anencephaly and Spina Bifida
06:57 3D Tour of Neuropores
Why Anterior Visceral Endoderm is called "Anterior": • Gastrulation - Human E...
Website: www.medicovisual.com
Email: draizaz@medicovisual.com
Watch new and improved 3D visual lecture on Neurulation here: ua-cam.com/video/pYFJvdkGj1s/v-deo.html
Always thought having a 3rd image of embryology was impossible , until I found this channel.
Thank you very much for making everything crystal clear❤
Beuty, simplicity , and The best Neurulation teaching animation .
You are a life saver God bless you, you just saved me from stressing my head this night, God bless, my University proffesors really need to teach like this
Happy to help. Thanks a lot for your appreciation
University professor thk prhaty hn tb ap prhny k mood mn nai hoty isi wja sy smjh nai ati.
I actually understand every thing in the third week in just one hour thanks to you may Allah bless you 🧡
I must say...this animation and your way of teaching is on other level👏👏...
Bravo 👏👏 what an animation.. I've watched a lot of videos about this but this one is incredible ✨✨
May Allah bless you!! Ameen
Ameen 💜
You saved me from watching hours of lectures, thankyou!!
Glad to hear that!
I love these videos! You make them possibly complex extremely clear and I am so grateful for this opportunity to learn about embryology.
Bestest Chanel.
i ve been watching some of ur videos and ur amazing i wish i have found u 4 years ago when i was studying for my Anatomy exam
*You explained it well*
*Excellent job*
My teacher teachers us as same as you did
But *your visual understanding is just amazing*
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Excellent Dr aizaz
God bless you wherever you are
Thanks a lot for this explanation
Good explanation Doctor Aizaz , thank you so much..
Video straight from Heaven 😁
Saved my concept
Thnk u so much 👌
Excellent explanation, understood very well 👍
Wow best video ever
Thanks for sharing your knowledge ❤️
superb job
Great , thank you so much
May day started with such an excellent lecture. I am blessed ☺️
Wonderful! Such a nice comment made my day.
Thank you it's very much helpfull
Thank you❤️
Thank you😌🙂
Thank you ❤❤❤
You literally are a lifesaver!!! Thankyouuu
Happy to help!
Thank u sooooooo much sir g
Allah pak Ap ko hmesha Kush Rkhn
U helps a lot us
U are great
Stay blessed alwz
A lot of best wishes and prayers for u
Stay a health and happy life
U are doing a great work
Thanks !
That was a very good explanation! Thank you :)
You're very welcome!
Very good lecture🔥
Amazing ❤️❤️❤️💓 keep it up Sir.
Sir please upload videos for the development of urogenital system, alimentary system, development of male and female external genitalia and gonads, development of kidney etc..,
Big big fan of your videos sir....very much thank you!!!
Awesome👏👍😊
5:24 Neuropores, Anencephaly & Spina bifida
Very professional 🥺
Very amazing 🌍😮😮😮😮
Thank you so much
Thanks u sir
Thank u sir
Im your 900th like. Congrats
Very good presentation .
Thanks a lot
seed men darrs janin💯💯💯
Excellent job 👍
Thanks 👍
Thank you very much for your great works. Anterior neuropore and posterior neuropore emerged from the oropharangeal plate and cloacal plate respectively ?
ITS WOW!!!!
This is AWESOME!!! Don't you have any lectures about formation of the different axes of the body?
Thank you so much. I have not yet recorded a detailed lecture on this topic. But I have discussed it briefly with gastrulation ua-cam.com/video/0n_Ev8DbQgY/v-deo.html
Thanks for sharing.Ramadan Mubarak.
Same to you
Sir are the Anterior neuropore and posterior neuropore derived from the oropharyngeal membrane and cloacal membrane ?
Great video👍 plz make videos on development of body cavities and topics of special embryology.
Thank you so much for your appreciation. Special/systemic Embryology videos will be available as a paid course within few months. UA-cam subscribers will get a special discount.
Sir at the end in the 3rd view,where did the notochord go?
Thanks
Welcome
Thank you so much for the lectures, they are so great!
I have a question:
The caudal/posterior neuropore is localized caudal or cranial to the primitive pit?
Thank you so much for your appreciation.
Great Question Indeed!
The neural plate, and ultimately the neural tube, forms just dorsal to the notochord. This is because notochord induces the ectoderm just overlying it (or just dorsal to it, to be precise) to thicken and form the neural plate, which then rolls to form the neural tube.
As you know Notochord starts from the primitive pit and goes cranially, beginning from this pit. (See the video: ua-cam.com/video/Ouge_rVI2aA/v-deo.html). Thus, whole of the neural tube is cranial to the primitive pit and primitive streak.
Actually, the primitive pit and streak begin to degenerate and by the time full-fledge neural tube is formed, the tube along with whole of the embryo has grown much bigger. Thus, the primitive pit and streak appears to be very small (or even non-existent) in embryos and many textbooks and lectures simply ignore them in the illustrations. (To be honest, they shouldn't be ignored though. I, too missed it. Sorry about that).
I hope I made some sense, as it is very difficult to explain without diagrams in the comments.
So, short answer to your question. *Caudal neuropore is just cranial to the primitive pit. *
@@MedicoVisual I could understand very clearly even without diagrams and images. Thank you so much for your answer. Honestly, I've never understood embryology really well. But after your lectures, I could understand it crystal clear!
The cranial neuropore is localized after or before the buccopharyngeal membrane? Thank you for the lecture by the way!
Anterior (cranial) Neuropore is located caudal (towards the tail end of) to the Buccopharyngeal(Oropharyngeal) membrane, initially. But as the cranial folding occurs, the Oropharyngeal membrane comes to lie ventral to the forebrain swelling and anterior neuropore.
Excellent and very important question, indeed. I must say, I should have discussed it within the lecture. Nontheless, I will talk more about this on the lecture of "Embryonic folding".
Thanks a lot for asking.
Dr. Aizaz
Got it, thanks a lot!
@@felipebressan3578 You are very welcome
Thank you sir for another great video. Sorry sir, but at 5.34, are the neuropores opening that continue into the Neuro pore?? And do they continue to the primitive pit and oropharyngeal membrane?? I still cannot grasp it sir.
Anterior (cranial) Neuropore is located caudal (towards the tail end of) to the Buccopharyngeal(Oropharyngeal) membrane. While the Posterior (Caudal) neuropore is just anterior to the primitive pit.
It's easy to understand. Let me explain. The neural tube forms just ventral to the notochord. Now the notochord forms by the ingression of cells from the primitive pit, till just caudal to the oropharyngeal membrane. (ua-cam.com/video/Ouge_rVI2aA/v-deo.html). Because the notochord is just caudal to the oropharyngeal membrane and ends just at the primitive pit, the neural tube too doesn't outgrow the notochord (because it is induced by the notochord), and neural tube too has similar boundaries. So neural tube, just like notochord, ends just caudal to the oropharyngeal membrane and just cranial to the primitive pit.
Now think of anterior and posterior neuropores as cranial and caudal ends of the neural tube, respectively. So naturally, the cranial end (anterior neurpore) is just caudal to the oropharyngeal membrane and the caudal end (posterior neuropore) is just cranial to the primitive pit.
If you still couldn't understand, feel free to reply.
Great question, indeed.
Thanks a lot for asking.
Dr. Aizaz
Oropharyngeal membrane and cloacal membrane reside in relation to anterior and posterior neuropore
Anterior (cranial) Neuropore is located caudal (towards the tail end of) to the Buccopharyngeal(Oropharyngeal) membrane. While the Posterior (Caudal) neuropore is just anterior to the primitive pit.
In other words, Oropharyngeal membrane is located cranial to the Anterior Neuropore. And because posterior neuropore is located just cranial to the primitive pit, we can say that clocal membrane is caudal to posterior neuropore (as it caudal to primitive node and primitive streak).
It's easy to understand. Let me explain. The neural tube forms just ventral to the notochord. Now the notochord forms by the ingression of cells from the primitive pit, till just caudal to the oropharyngeal membrane. (ua-cam.com/video/Ouge_rVI2aA/v-deo.html). Because the notochord is just caudal to the oropharyngeal membrane and ends just at the primitive pit, the neural tube too doesn't outgrow the notochord (because it is induced by the notochord), and neural tube too has similar boundaries. So neural tube, just like notochord, ends just caudal to the oropharyngeal membrane and just cranial to the primitive pit.
Now think of anterior and posterior neuropores as cranial and caudal ends of the neural tube, respectively. So naturally, the cranial end (anterior neurpore) is just caudal to the oropharyngeal membrane and the caudal end (posterior neuropore) is just cranial to the primitive pit.
If you still couldn't understand, feel free to reply.
Great question, indeed.
Thanks a lot for asking.
Dr. Aizaz
@@MedicoVisuali understand your reply sir... But i was confusing because in the diagram the neural tube looks like long Tube extend from buccopharyngeal membrane to clocal membrane... I know it is not... But if it extend from buccopharyngeal membrane to primitive node then why primitive streak and clocal membrane are not shown in this diagram.... Sorry for long Question but i understand embryology on your videos.. Thank you
@@user-bo9bp9fk5t your point is very valid. I think this is not a perfect model to explain this. I will be creating a new 3D lecture soon. Sorry for the confusion.
@@MedicoVisualoh sir why you are sorry? 😔.. We are grateful to you😊
@@user-bo9bp9fk5t so nice of you dear
that's empresive what is the name of this visualizing program that you used ?
"Blender" for 3D graphics.
"Microsoft PowerPoint 365" for 2D graphics.
❤❤❤❤
Doc saab, if the dorsal surface of intraembryonic mesoderm has the following structures from cranial to caudal region: buccopharyngeal membrane, primitive node and pit, primitive streak and the cloacal membrane, and if the extent of notochord below it is from near buccopharyngeal membrane (pre-chordal mesoderm) (cranial end) to the primitive pit (notochord's origin and caudal end both) as you have explained, and if the the neural tube is sandwiched between the dorsal part of the intraembryonic mesoderm (as described in first sentence of my query) above it, and the notochord below it, how can it cross the primitive pit-notochord junction in the centre, and extend caudally to near the cloacal membrane (posterior neuropore) ? Kindly clear my confusion please
Sorry for the confusion. I am planning to make a new version of this visual lecture that will clear the confusions.
I have a question... Hope you will answer
" After the formation or during the formation of neural tube ?? Primitive groove and primitive node is still present???
Neural tube formation starts at about day 21 or 22. This is the time when primitive node and primitive streak begin to regress. It regress almost completely till day 28.
Thanks so much
But excuse me i have question
Why does the primitive streak disappear ?
Primitive streaks appears when the cells ingressing downwards cause a midline depression. When these ingressed cells have completely displaced the hypoblast and formed a mesodermal layer as well, no more cells ingress downwards so the midline depression is lost
Why can't it open??
Don't you have video about formation of axis
Not a full-fledge lecture, but it has been touched upon in Gastrulation lecture: ua-cam.com/video/0n_Ev8DbQgY/v-deo.html
Human creation in Quran
وَلَقَدۡ خَلَقۡنَا ٱلۡإِنسَٰنَ مِن سُلَٰلَةٖ مِّن طِينٖ
We have created man from an extract of clay.
(Surah Al-Mu'minun, chapter 23, verse 12)
ثُمَّ جَعَلۡنَٰهُ نُطۡفَةٗ فِي قَرَارٖ مَّكِينٖ
Then We made him a sperm-drop in a firm resting place.
(Surah Al-Mu'minun,chapter 23 verse 13)
ثُمَّ خَلَقۡنَا ٱلنُّطۡفَةَ عَلَقَةٗ فَخَلَقۡنَا ٱلۡعَلَقَةَ مُضۡغَةٗ فَخَلَقۡنَا ٱلۡمُضۡغَةَ عِظَٰمٗا فَكَسَوۡنَا ٱلۡعِظَٰمَ لَحۡمٗا ثُمَّ أَنشَأۡنَٰهُ خَلۡقًا ءَاخَرَۚ فَتَبَارَكَ ٱللَّهُ أَحۡسَنُ ٱلۡخَٰلِقِينَ
Then We turned the sperm-drop into a clot, then We turned the clot into a fetus-lump, then We turned the fetus-lump into bones and We clothed the bones with flesh; thereafter We developed it into another creature. So glorious is Allah, the Best of the creators.
(Surah Al-Mu'minun,chapter 23 verse 14)
Those are many other version of Quran translation. But understanding arabic langguage is the best way to get the true meaning of the verses.
Thanks
Got what I want 🫡🫡